This engaging lesson describes how chromosome mutations result in changes to the number or structure of chromosomes The PowerPoint and accompanying resources are part of the second lesson in a series of 2 lessons that have been designed to cover specification points (f) in topic 3 of A2 unit 4 of the WJEC A-level Biology specification, and there is a key focus on Down syndrome
A human karyotype which has not been altered by a mutation is studied at the start of the lesson to allow students to recall the usual number of chromosomes as well as the sex chromosomes. They are then challenged to identify the differences when presented with the karyotypes of sufferers of Down, Turner’s and Klinefelter’s syndrome. Students will learn that in the majority of cases, these conditions are the result of non-disjunction and having been assisted in the explanation of the outcome for Down and Klinefelters, they have to form their own for Turner’s. The remainder of the lesson looks at other types of mutations, including translocation, and students will also see how whole sets of chromosomes can be duplicated in polyploidy
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