An informative lesson presentation (20 slides) and associated worksheet that looks at how negative feedback loops act as a final control in homeostatic mechanisms. This is a topic which is poorly understood by students at both GCSE and even A-level, so whilst designing this lesson, the focus was on a few key points and applying it to a range of actual examples. Students will see how a negative feedback loop is used in the control of adrenaline release and temperature regulation and they will also be shown what would happen if this loop didn’t exist. Students are then challenged to apply their knowledge by putting the order of the regulation of metabolic rate into the correct order. The final part of the lesson briefly looks at how positive feedback loops also exist by using the example of the release of oxytocin during birth. This lesson has primarily been designed for GCSE students but is suitable for A-level Biology students too.

A fast-paced lesson that explores the meaning of “health” and introduces the idea of communicable and non-communicable diseases. The lesson begins by showing the students an example of a health survey so they can complete a definition of the meaning of this term. Despite being widely used in the English language, the actual Scientific definition is not always well known by students so this 1st task is an important one. Moving forwards, students are given 5 minutes to see if they can fill an A-Z with the names of different diseases. Students will learn that diseases can be grouped as communicable or non-communicable and will be encouraged to discuss what the determining factor is on this classification. A quiz competition called “TO COM or NOT TO COM” is a play on words of Shakespeare’s famous saying but acts to test whether the students can distinguish a number of diseases as being spread by pathogens or not. After each disease is revealed, time is taken to look at the details of some of them like cystic fibrosis and the zika virus. The lesson concludes with the example of the human-papilloma virus and the connection between this and cervical cancer so that students can recognise that sometimes both types of disease are involved. This lesson has been written for GCSE students (14 - 16 year olds in the UK) but could be used with younger students who are looking at the healthy living topic.

This fully-resourced lesson is clear and concise and has been written to explain how the inheritance of two or more genes that have loci on the same chromosome demonstrates linkage. The engaging PowerPoint and associated resource have been designed to cover point 3.8 (i and ii) of the Pearson Edexcel A-level Biology (Salters Nuffield) specification which states that students should know the meaning of a gene locus and understand the linkage of genes on a chromosome. This is a topic which can cause confusion for students so time was taken in the design to split the concept into small chunks. There is a clear focus on how the number of original phenotypes and recombinants can be used to determine linkage and suggest how the loci of the two genes compare. Important links to other topics such as crossing over in meiosis are made to enable students to understand how the random formation of the chiasma determines whether new phenotypes will be seen in the offspring or not. Linkage is an important cause of variation and the difference between observed and expected results and this is emphasised on a number of occasions. The main task of the lesson acts as an understanding check where students are challenged to analyse a set of results involving the inheritance of the ABO blood group gene and the nail-patella syndrome gene to determine whether they have loci on the same chromosome and if so, how close their loci would appear to be.

This lesson describes the key structural features of viruses and challenges the students to compare them against those of a bacteria as covered in topic 3. The PowerPoint and accompanying resource have primarily been designed to cover point 6.5 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification but can be used a revision tool for point 3.4 as students need to recall the structures of a prokaryotic cell. Details of the COVID-19 epidemic are included in the lesson to increase relevance and to help students to understand this biological topic in greater depth. They will understand that a virus’ lack of cell structures results in an non-cellular classification and the fact that it is unable to reproduce without a host is one of the additional reasons that renders it as non-living. The main focus of the lesson is the nucleic acid, the capsid and the attachment proteins that are present in these microorganisms and time is taken to explain how these structures are involved in the infection of a host cell. The lipid membrane is also introduced and links are made to the previous lessons on eukaryotic cells. The final section of the lesson challenges the students to recognise the following prokaryotic cell structures from their descriptions: plasmid pili capsule cell wall flagellum circular DNA ribosomes mesosomes This lesson has been specifically planned to link to the next lesson which covers point 6.6 on the infection of human cells by Mycobacterium tuberculosis and human immunodeficiency virus

This lesson explains the effects of temperature on the rate of enzyme activity and includes examples in plants, animals and microorganisms. The PowerPoint and the accompanying resource have been designed to cover point 5.16 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification and this lesson has been specifically planned to tie in with a lesson in topic 2 where the roles and mechanism of action of enzymes were introduced. The lesson begins by challenging the students to recognise optimum as a key term from its 6 synonyms that are shown on the board. Time is taken to ensure that the students understand that the optimum temperature is the temperature at which the most enzyme-product complexes are produced per second and therefore the temperature at which the rate of an enzyme-controlled reaction works at its maximum. The optimum temperatures of DNA polymerase in humans and in a thermophilic bacteria and RUBISCO in a tomato plant are used to demonstrate how different enzymes have different optimum temperatures and the roles of the former in the PCR is briefly described to prepare students for this lesson in topic 6. Moving forwards, the next part of the lesson focuses on enzyme activity at temperatures below the optimum and at temperatures above the optimum. Students will understand that increasing the temperature increases the kinetic energy of the enzyme and substrate molecules, and this increases the likelihood of successful collisions and the production of enzyme-substrate and enzyme-product complexes. When considering the effect of increasing the temperature above the optimum, continual references are made to the previous lesson and the control of the shape of the active site by the tertiary structure. Students will be able to describe how the hydrogen and ionic bonds in the tertiary structure are broken by the vibrations associated with higher temperatures and are challenged to complete the graph to show how the rate of reaction decreases to 0 when the enzyme has denatured.

A concise, engaging lesson presentation (22 slides) which looks at the different responses of the body as a result of adrenaline release. In line with the actions of adrenaline, the lesson begins with a range of quiz competitions to introduce key terms and responses to the students. Once the students know that it causes both the breathing and heart rate to increase, they are challenged to complete a passage which brings this information together to explain how the increased respiration rate is related to the fight or flight tag line. Moving forwards, students will be introduced to the meaning of the term vasodilation and then asked to consider which organs will need extra blood flow during times of stress and conversely, which tissues can have blood directed away from them. The lesson finishes by looking at how a negative feedback loop is used as the final control to ensure that energy resources are not wasted during times when there is no stress.

This lesson describes how the hydrolysis of ATP supplies energy for biological processes and how the phosphorylation of ADP requires energy. The PowerPoint has been designed to cover point 5.6 of the Pearson Edexcel A-level Biology A specification and also describes how ATP is made in the light-dependent stage of photosynthesis and is needed in the light-independent stage. The start of the lesson focuses on the structure of this energy currency and challenges the students to use their knowledge of nucleotides and specifically RNA nucleotides to recognise the components of ATP. As a result, they will learn that this molecule consists of adenine, ribose and three phosphate groups. In order to release the stored energy, ATP must be broken down and students will be given time to discuss which reaction will be involved as well as the products of this reaction. Time is taken to describe how the hydrolysis of ATP can be coupled to energy-requiring reactions within cells and the examples of skeletal muscle contraction are used as this is covered in greater detail in topic 7. The final part of the lesson considers how ATP is formed when ADP is phosphorylated and students will learn that this occurs in the mitochondria and chloroplast during aerobic respiration and photosynthesis respectively, so that it ties in with the upcoming lessons in topic 5 and 7.

This lesson describes the relationship between gross and net primary productivity and plant respiration and explains how to calculate NPP. The PowerPoint and accompanying resources have been designed to cover points 5.10 (i) and (ii) of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification. Due to the fact that the productivity of plants is dependent on photosynthesis, a series of exam-style questions have been written into the lesson which challenge the students to explain how the structure of the leaf as well as the light-dependent and light-independent reactions are linked to GPP. All of the exam questions have displayed mark schemes which are included in the PowerPoint to allow students to immediately assess their understanding. A number of quick quiz competitions as well as guided discussion points are used to introduce the formulae to calculate NPP and N and to recognise the meaning of the components. Once again, this is immediately followed by the opportunity to apply their understanding to selected questions. As well as linking to photosynthesis from earlier in topic 5, this lesson has been specifically planned to challenge students on their understanding of ecosystem terminology from the start of the topic as well as preparing them for the next lesson on the efficiency of biomass and energy transfer

This lesson describes how to use and manipulate the magnification formula to calculate the magnification or the actual size in a range of units. The PowerPoint and accompanying resources have been designed to cover point 2.1.1 (e) of the OCR A-level Biology A specification and contains a number of quiz rounds as part of the competition that runs throughout all of the module 2.1.1 lessons The students are likely to have met the magnification formula at GCSE so this lesson has been written to build on that knowledge and to support them with more difficult questions when they have to calculate actual size without directly being given the magnification. A step by step guide is used to walk the students through the methodology and useful tips are provided. Students could be asked to calculate the actual size in millimetres, micrometres, nanometres or picometres so time is taken to ensure that they can convert between one and another.

This detailed lesson describes and explains the blood pressure changes that occur during systole and diastole of the cardiac cycle. The PowerPoint and accompanying resource have been designed to cover point 8.2 © of the CIE International A-level Biology specification. The start of the lesson introduces the cardiac cycle as well as the key term systole, so that students can immediately recognise that the three stages of the cycle are atrial and ventricular systole followed by diastole. Students are challenged on their prior knowledge of the structure of the heart as they have to name and state the function of an atrioventricular and semi-lunar valve from an internal diagram. This leads into the key point that pressure changes in the chambers and the major arteries results in the opening and closing of these sets of valves. Students are given a description of the pressure change that results in the opening of the AV valves and shown where this would be found on the graph detailing the pressure changes of the cardiac cycle. They then have to use this as a guide to write descriptions for the closing of the AV valve and the opening and closing of the semi-lunar valves and to locate these on the graph. By providing the students with this graph, the rest of the lesson can focus on explaining how these changes come about. Students have to use their current and prior knowledge of the chambers and blood vessels to write 4 descriptions that cover the cardiac cycle. The final part of the lesson covers the changes in the volume of the ventricle. This lesson has been written to tie in with the other uploaded lessons on the heart as detailed in topic 8.2

This lesson introduces the concept of monomers and polymers and emphasises the importance of condensation and hydrolysis reactions for biological molecules. The PowerPoint and accompanying worksheet have been designed to cover specification point 2.1.2 (b) of the OCR A-level Biology A course, and as this is likely to be one of the very first lessons that the students encounter, the range of engaging tasks have been specifically designed to increase the likelihood of the key points and fundamentals being retained. Monomers were previously met at GCSE and so the beginning of the lesson focuses on the recall of the meaning of this key term before the first in a series of quiz rounds is used to introduce nucleotides, amino acids and monosaccharides as a few of the examples that will be met in this topic. Dipeptides and disaccharides are introduced as structures containing 2 amino acids or sugars respectively and this is used to initiate a discussion about how monomers need to be linked together even more times to make the larger chains known as polymers. At this point in the lesson, the students are challenged to recall the definition of a condensation reaction from the previous lesson on water and are then challenged to identify where the molecule of water is eliminated from when two molecules of glucose join. A series of important prefixes and suffixes are then provided and students use these to remind themselves of the details of a hydrolysis reaction. Links to upcoming lessons are made throughout the PowerPoint to encourage students to begin to recognise the importance of making connections between topics.

This fully-resourced lesson describes the inheritance of genes with loci on the X chromosomes and considers biological examples. The detailed PowerPoint and accompanying resources have been designed to cover point 2.15 (ii) of the Edexcel International A-level specification and focuses on the inheritance of red-green colour blindness and haemophilia in humans Key genetic terminology is used throughout and the lesson begins with a check on their ability to identify the definition of homologous chromosomes. Students will recall that the sex chromosomes are not fully homologous and that the smaller Y chromosome lacks some of the genes that are found on the X. This leads into one of the numerous discussion points, where students are encouraged to consider whether females or males are more likely to suffer from sex-linked diseases. In terms of humans, the lesson focuses on haemophilia and red-green colour blindness and a step-by-step guide is used to demonstrate how these specific genetic diagrams should be constructed and how the phenotypes should then be interpreted. The final task of the lesson challenge the students to apply their knowledge to an exam question about chickens and how the rate of feather production in chicks can be used to determine gender. All of the tasks are differentiated so that students of differing abilities can access the work and all exam questions have fully-explained, visual mark schemes to allow them to assess their progress and address any misconceptions

This fully-resourced lesson explores the contributions of chromosome mutations to genetic variation. The engaging PowerPoint and accompanying worksheets have been designed and written to cover the part of point 6.1.2 (a) of the OCR A-level Biology A specification which states that students should be able to demonstrate and apply their knowledge and understanding of the contribution of genetic factors to phenotypic variation Over the course of the lesson, students will encounter a number of chromosome mutations and see the conditions which they cause. Time is taken to look at non-disjunction and how this can result in Down, Turner’s and Klinefelter’s syndromes. Students are guided through a description of the formation of gametes and zygotes with abnormal numbers of chromosomes before being challenged to describe the formation of a zygote with Turner’s syndrome. Moving forwards, translocation and polyploidy are also discussed. Progress checks are written into the lesson at regular intervals, that not only check the learning from this lesson but also from related topics (such as meiosis) and this enables the students to constantly assess their understanding.

This fully-resourced lesson looks at the effects of nervous mechanisms on the heart rate. The engaging and detailed PowerPoint and accompanying resources have been designed to cover the part of point 5.1.5 (k) of the OCR A-level Biology A specification which states that students should be able to demonstrate and apply their knowledge and understanding of the control of the heart rate by the cardiovascular centre in the medulla oblongata This lesson begins with a prior knowledge check where students have to identify and correct any errors in a passage about the conduction system of the heart. This allows the SAN to be recalled as this structure play an important role as the effector in this control system. Moving forwards, the three key parts of a control system are recalled as the next part of the lesson will specifically look at the range of sensory receptors, the coordination centre and the effector. Students are introduced to chemoreceptors and baroreceptors and time is taken to ensure that the understanding of the stimuli detected by these receptors is complete and that they recognise the result is the conduction of an impulse along a neurone to the brain. A quick quiz is used to introduce the medulla oblongata as the location of the cardiovascular centre. The communication between this centre and the SAN through the autonomic nervous system can be poorly understood so detailed explanations are provided and the sympathetic and parasympathetic divisions compared. The final task challenges the students to demonstrate and apply their understanding by writing a detailed description of the control and this task has been differentiated three ways to allow differing abilities to access the work

A resourced lesson which uses a concise lesson presentation (18 slides) and a differentiated diagram to guide students through the method of blood clotting. This lesson has been designed for students studying GCSE (14 - 16 year olds in the UK) and this is reflected in the appropriate detail where only the involvement of fibrin needs to be known. Students are shown how blood clotting is a cascade effect where one event leads on to the next.

An engaging lesson presentation which looks at the two types of animal stem cells, exploring their important differences and briefly looking at their potential uses in medicine. The lesson begins by looking at the meaning of the term differentiation and then challenging students to draw a simple conclusion once they know that stems cells are undifferentiated cells. Time is taken to look into this part of the knowledge in depth but then students are given the key points which must be understood for them to move forwards. Students are told that there are two types of animal stem cells before a quiz competition is used to get them to predict which one of the two is being described by the clues. The answers to the competition then have to be used to write a summary passage about the two types. Students are also told that stem cells exist in plants in the form of meristem cells. Finally, Parkinson’s disease and Diabetes mellitus Type I are used as examples of conditions that could be potentially treated with stem cells.

This fully-resourced lesson looks at the internal and external structure of the mammalian heart and uses the human heart to represent this anatomy. The engaging and detailed PowerPoint and accompanying resources have been designed to cover point 3.1.2 (e) (i) of the OCR A-level Biology A specification As this topic was covered at GCSE, the lesson has been planned to build on this prior knowledge whilst adding the key details which will enable students to provide A-level standard answers. The primary focus is the identification of the different structures of the heart but it also challenges their ability to recognise the important relationship to function. For example, time is taken to ensure that students can explain why the atrial walls are thinner than the ventricular walls and why the right ventricle has a thinner wall than the left ventricle. Opportunities are taken throughout the lesson to link this topic to the others found in topic 3.1.2 including those which have already been covered like circulatory systems as well as those which are upcoming such as the initiation of heart action. There is also an application question where students have to explain why a hole in the ventricular septum would need to be repaired if it doesn’t naturally close over time.

This fully-resourced lesson describes the relationship between the structure, properties and functions of triglycerides in living organisms. The engaging PowerPoint and accompanying worksheets have been designed to be the first lesson in a series of two that cover specification points 2.1.2 (h), (i) & (j) of the OCR A-level Biology A course and the lesson contains numerous references to relevant future topics such as the importance of the myelin sheath for the conduction of an electrical impulse. The lesson begins with a focus on the basic structure and roles of lipids, including the elements that are found in this biological molecule and some of the places in living organisms where they are found. Moving forwards, the students are challenged to recall the structure of the carbohydrates from earlier in the sub-module so that the structure of a triglyceride can be introduced. Students will learn that this macromolecule is formed from one glycerol molecule and three fatty acids and have to use their understanding of condensation reactions to draw the final structure. Time is taken to look at the difference in structure and properties of saturated and unsaturated fatty acids and students will be able to identify one from the other when presented with a molecular formula. The final part of the lesson explores how the various properties of a triglyceride mean that it has numerous roles in organisms including that of an energy store and source and as an insulator of heat and electricity.

This lesson describes how disaccharides like maltose, sucrose and lactose are formed from the condensation of two monosaccharides and can also be broken down by hydrolysis reactions. The PowerPoint and accompanying question sheet have been designed to cover specification point 2.1.2 (e) of the OCR A-level Biology A specification but also makes repeated links to the previous lesson on monosaccharides when considering the different components of these three disaccharides. The first section of the lesson focuses on a prefix and a suffix so that the students can recognise that the names of the common disaccharides end in -ose. In line with this, a quick quiz round is used to introduce maltose, sucrose and lactose before students are challenged on their prior knowledge as they have to describe how condensation reactions and the formation of glycosidic bonds were involved in the synthesis of each one. The main task of the lesson again challenges the students to recall details of a previous lesson as they have to identify the monomers of each disaccharide when presented with the displayed formula. Time is taken to show how their knowledge of these simple sugars will be important in later topics such as extracellular enzymes, translocation in the phloem and the Lac Operon in cellular control. The lesson finishes with two exam-style questions where students have to demonstrate and apply their newly acquired knowledge when presented with unfamiliar disaccharides

This lesson describes how the polymerase chain reaction (PCR) is used to amplify DNA. The concise PowerPoint has been primarily designed to cover the detail of specification point 6.4 of the Pearson Edexcel A-level Biology A specification but also makes continual links to the previous lesson on DNA profiling where the PCR is important as well as DNA structure. A quick quiz competition is used to introduce the PCR abbreviation before students are encouraged to discuss with the aim of identifying the enzyme involved and to recall the action of this enzyme as covered in DNA replication in topic 2. Students will learn that this reaction involves cyclical heating and cooling to a range of temperatures so another quiz is used to introduce these values. The main part of the lesson describes the main steps in the PCR and the reasons for each temperature is discussed and explained. Links are constantly made to related topics such as DNA structure are students are challenged on their understanding through exam-style questions. Time is taken to examine the key points in detail, such as the fact that the DNA polymerase used is taken from an extremophile so that it is not denatured at the high temperature.