This fully-resources lesson looks at the phenomenon known as the Bohr effect and describes and explains how an increased carbon dioxide concentration affects the dissociation of oxyhaemoglobin. The PowerPoint has been designed to cover the second part of point 3.1.2 (j) of the OCR A-level Biology A specification and continually ties in with the previous lesson on the role of haemoglobin. The lesson begins with a terminology check to ensure that the students can use the terms affinity, oxyhaemoglobin and dissociation. In line with this, they are challenged to draw the oxyhaemoglobin dissociation curve and are reminded that this shows how oxygen associates with haemoglobin but how it dissociates at low partial pressures. Moving forwards, a quick quiz is used to introduce Christian Bohr and the students are given some initial details of his described effect. This leads into a series of discussions where the outcome is the understanding that an increased concentration of carbon dioxide decreases the affinity of haemoglobin for oxygen. The students will learn that this reduction in affinity is a result of a decrease in the pH of the cell cytoplasm which alters the tertiary structure of the haemoglobin. Opportunities are taken at this point to challenge students on their prior knowledge of protein structures as well as the bonds in the tertiary structure. The lesson finishes with a series of questions where the understanding and application skills are tested as students have to explain the benefit of the Bohr effect for an exercising individual. These questions are differentiated to allow students of differing abilities to access the work and to be challenged

This is an informative lesson that builds on the knowledge that students gained at GCSE on the topic of inheritance to enable them to carry out genetic crosses for the inheritance of a single gene at A-level. The start of the lesson focuses on the terminology that is associated with this topic which has to be recognised and understood if students are going to be able to begin a cross. Time is taken to go over key points such as the genotypes and working out the different possible gametes that would be produced by meiosis. Students can save time by only showing the different gametes so assistance is given on this. As can be seen from the cover image, a step by step guide is used to go through a number of examples so that students can visualise how to set out their diagrams in order to maximise the marks gained. There are progress checks written into the lesson throughout so that assessment is constant. This lesson can be taught alongside another upload called “understanding genetic trees”

This extensive and fully-resourced lesson describes the principles and explains the techniques used in the production of recombinant DNA in genetic engineering. Both the engaging PowerPoint and accompanying resources have been written to cover points 6.1.3 (f) (i & ii) of the OCR A-level Biology A specification. The lesson begins with a definition of genetic engineering and recombinant DNA to allow students to begin to understand how this process involves the transfer of DNA fragments from one species to another. Links are made to the genetic code and transcription and translation mechanisms, which were met in module 2, in order to explain how the transferred gene can be translated in the transgenic organism. Moving forwards, the method involving reverse transcriptase and DNA polymerase is introduced and their knowledge of the structure of the polynucleotides and the roles of enzymes is challenged through questions and discussion points. Restriction enzymes are then introduced and time is taken to look at the structure of a restriction site as well as the production of sticky ends due to the staggered cut on the DNA. A series of exam-style questions with displayed mark schemes are used to allow the students to assess their current understanding. The second half of the lesson looks at the culture of transformed host cells as an in vivo method to amplify DNA fragments. Students will learn that bacterial cells are the most commonly transformed cells so the next task challenges their recall of the structures of these cells so that plasmid DNA can be examined from that point onwards. The following key steps are described and explained: • Remove and prepare the plasmid to act as a vector • Insert the DNA fragment into the vector • Transfer the recombinant plasmid into the host cell • Identify the cells which have taken up the recombinant plasmid • Allow the transformed host cells to replicate and express the novel gene Time is taken to explore the finer details of each step such as the addition of the promoter and terminator regions, use of the same restriction enzyme to cut the plasmid as was used to cut the gene and the different types of marker genes. As well as understanding and prior knowledge checks, quick quiz competitions are used throughout the lesson to introduce key terms such as cDNA and EcoR1 in a memorable way.

This fully-resourced lesson explores how the structure of arteries, arterioles, capillaries, venules and veins relate to their functions. The engaging and detailed PowerPoint and accompanying resources have been designed to cover point 3.1.2 © of the OCR A-level Biology A specification. This lesson has been written to build on any prior knowledge from GCSE or earlier in this topic to enable students to fully understand why a particular type of blood vessel has particular features. Students will be able to make the connection between the narrow lumen and elastic tissue in the walls of arteries and the need to maintain the high pressure of the blood. A quick version of the GUESS WHO game is used to introduce smooth muscle and collagen in the tunica media and externa and again the reason for their presence is explored and explained. Moving forwards, it is quite likely that some students will not be aware of the transition vessels that are the arterioles. This section begins with an understanding of the need for these vessels because the structural and functional differences between arteries and capillaries is too significant. The action of the smooth muscle in the walls of these vessels is discussed and students will be challenged to describe a number of situations that would require blood to be redistributed. The middle part of the lesson looks at the role of the capillaries in exchange and links are made to diffusion to ensure that students can explain how the red blood cells pressing against the endothelium results in a short diffusion distance. The remainder of the lesson considers the structure of the veins and students are challenged to explain how the differences to those observed in arteries is due to the lower blood pressure found in these vessels. It is estimated that it will take at least 2 hours of allocated A-level Biology teaching time to cover the detail included in this lesson

This is a fast-paced lesson that explores the structural differences (and similarities) between sensory and motor neurones. The lesson uses a range of tasks, progress checks and quick competitions to enable the students to recognise how these neurones differ in terms of the cell body, axon and dendron. Students will also understand that both neurones are myelinated which allows saltatory conduction to occur. Relay neurones are briefly discussed during the final section of the lesson. This lesson has primarily been designed for A-level students but can be used with the content means that it is suitable for use with GCSE students too who are studying the nervous system.

This is an engaging lesson that looks at the structures and actions of the two parts of the autonomic nervous system (ANS) and shows students where this particular system fits into the whole organisation of the nervous system. The lesson begins by introducing the students to the idea that motor neurones are not simply somatic motor neurones but will actually be classified as autonomic motor neurones if they innervate the involuntary muscles. A range of tasks, progress checks and quick competitions are used during the lesson to engage the students in this topic and show them how it relates to other topics such as motor neurones and neurotransmitters. Key terminology is used throughout, such as ganglions, so that students can recognise and access the marks if an exam question on this topic arises. This lesson has been written for A-level students

This lesson looks at the structure of the DNA that is found in the nucleus, mitochondria and chloroplasts of eukaryotic cells and in prokaryotic cells. Both the engaging PowerPoint and accompanying resources have been designed to cover point 2.1.3 (d)(i) of the OCR A-level Biology A specification. As students will already have some knowledge of this nucleic acid from GCSE and from the earlier A-level topics, the lesson has been written to build on this prior knowledge and then to add key detail. As well as focusing on the differences between the DNA found in these two types of cells which includes the length, shape and association with histones, the various tasks will ensure that students are confident to describe how this double-stranded polynucleotide is held together by hydrogen and phosphodiester bonds. This knowledge of phosphodiester bonds means that specification point 2.1.3 © is also covered during this lesson. These tasks include exam-style questions which challenge the application of knowledge as well as a few quiz competitions to maintain engagement.

This lesson focuses on the structure of RNA and specifically the similarities and differences between this nucleic acid and DNA so that students are prepared for the upcoming lessons on transcription and translation. The engaging and detailed PowerPoint and accompanying resource have been designed to cover part 1 of point 2.1.3 (g) of the OCR A-level Biology A specification which states that students should be able to describe the structure of molecules of messenger RNA, transfer RNA and ribosomal RNA. Students were introduced to nucleotides and the detailed structure of DNA in previous lessons, so this lesson is written to tie in with those and continuously challenge prior knowledge as well as understanding of the current topic. The lesson begins by reminding students that RNA is a member of the family of nucleic acids and therefore has a number of structural features that are commonly shared with DNA. A quiz round called “A FAMILY AFFAIR” is used to challenge their knowledge of DNA to recognise those features that are also found on RNA such as the chain of linked nucleotides, pentose sugars, nitrogenous bases and phosphodiester bonds. The next task pushes them to consider features that have not been mentioned and therefore are differences as they answer a structured exam-style question on how RNA differs from DNA. Students will learn that RNA is shorter than DNA and this leads into the final part of the lesson where mRNA and tRNA are introduced and again they are challenged to use the new information explain the difference in size. Brief details of transcription and then translation are provided so that students are prepared for the upcoming lessons on protein synthesis.

This detailed lesson describes the role of the mRNA, tRNA, rRNA and amino acids during the second stage of protein synthesis - translation. Both the PowerPoint and accompanying resources have been designed to cover the second part of point 2.1.3 (g) of the OCR A-level Biology A specification and continually links back to the previous lessons in this module on the structure of DNA and RNA and the genetic code Translation is a topic which is often poorly understood and so this lesson has been written to enable the students to understand how to answer the different types of questions by knowing and including the key details of the structures involved. The lesson begins by challenging the students to consider why it is so important that the amino acids are assembled in the correct order during the formation of the chain. Moving forwards, a quick quiz round called “LOST IN TRANSLATION” is used to check on their prior knowledge of the mRNA strand, the tRNA molecules, the genetic code and the ribosomes. The next task involves a very detailed description of translation that has been divided into 14 statements which the students have to put into the correct order. By giving them a passage that consists of this considerable detail, they can pick out the important parts to use in the next task where they have to answer shorter questions worth between 3 and 4 marks. These types of questions are common in the assessments and by building up through the lesson, their confidence to answer this type should increase. The final two tasks of the lesson involve another quiz, where the teams compete to transcribe and translate in the quickest time before using all that they have absorbed to answer some questions which involve the genetic code and the mRNA codon table

This is an engaging lesson that looks at how vaccinations are used in medicine and considers how the introduction of these preventative measures has reduced the incidence of disease. The lesson begins by introducing vaccinations as the deliberate exposure to antigenic material and then reminds students of the meaning of the term, antigen, so that they understand how this will elicit the desired immune response. Lots of opportunities for discussion have been written into the lesson so that key points such as how the vaccination is altered so that isn’t harmful and how memory cells work can be discussed amongst students before being clarified by the teacher and the lesson content. Moving forwards, students will be given some figures on child mortality rate in 1900 and 2000. They are shown how to manipulate this data in order to work out the percentage change. Students are then challenged to use these skills when comparing the children that were vaccinated for whooping cough in 1968 and 1995 and to make a link between vaccinations and mortality rates. These mathematical skills are being tested more and more in Biology so this guidance will help students to understand how to manipulate data when required. Progress checks have been written into the lesson at regular intervals so that students can constantly assess their understanding. This lesson has been designed for GCSE aged students. If you’re looking for a lesson on this same topic but for older students at A-level, then my upload “Vaccinations (A-level)” will be more suitable