This lesson describes the main stages of meiosis, focusing on the events which contribute to genetic variation and explains its significance in life cycles. The detailed PowerPoint and accompanying resources have been designed to cover points 2.1.6 (f) & (g) of the OCR A-level Biology A specification and includes description of crossing over, independent assortment, independent segregation and the production of haploid gametes In order to understand how the events of meiosis like crossing over and independent assortment and independent segregation can lead to variation, students need to be clear in their understanding that DNA replication in interphase results in homologous chromosomes as pairs of sister chromatids. Therefore the beginning of the lesson focuses on the chromosomes in the parent cell and this first part of the cycle and students will be introduced to non-sister chromatids and the fact that they may contain different alleles which is important for the exchange that occurs during crossing over. Time is taken to go through this event in prophase I in a step by step guide so that the students can recognise that the result can be new combinations of alleles that were not present in the parent cell. Moving forwards, the lesson explores how the independent assortment and segregation of chromosomes and chromatids during metaphase I and II and anaphase I and II respectively results in genetically different gametes. The key events of all of the 8 phases are described and there is a focus on key terminology to ensure that students are able to describe genetic structures in the correct context. The final part of the lesson looks at the use of a mathematical expression to calculate the possible combinations of alleles in gametes as well as in a zygote following the random fertilisation of haploid gametes. Understanding and prior knowledge checks are interspersed throughout the lesson as well as a series of exam-style questions which challenge the students to apply their knowledge to potentially unfamiliar situations. This lesson has been specifically planned to lead on from the previous two lessons on the cell cycle and the main stages of mitosis and constant references are made throughout to encourage students to make links and also to highlight the differences between the two types of nuclear division

This fully-resourced lesson describes the behaviour of chromosomes during the mitotic cell cycle and explains the importance of this type of nuclear division. The PowerPoint and accompanying resources have been designed to cover points 5.1 (b) & 5.2 (a) of the CIE A-level Biology specification and make direct links to a previous lesson which covered the outline of cell cycle Depending upon the exam board taken at iGCSE, the knowledge and understanding of mitosis will differ considerably between students and there may be a number of misconceptions. This was considered at all points during the planning of the lesson so that existing errors are addressed and key points are emphasised throughout. Their understanding of interphase is challenged at the start of the lesson to ensure that they realise that it is identical pairs of sister chromatids that enter the M phase. The main part of the lesson focuses on prophase, metaphase, anaphase and telophase and describes how the chromosomes behave in these stages. There is a focus on the centrioles and the spindle fibres that they produce which contract to drag one chromatid from each pair in opposite directions to the poles of the cell. The remainder of the lesson is a series of understanding and application questions where students have to identify the various roles of mitosis in living organisms as well as tackling a Maths in a Biology context question. The lesson concludes with a final quiz round of MITOSIS SNAP where they only shout out this word when a match is seen between the name of a phase, an event and a picture.

This REVISION lesson contains an engaging powerpoint (45 slides) and is fully-resourced with associated worksheets. The lesson uses a range of activities which include exam questions (with displayed answers), differentiated tasks and quiz competitions to engage students whilst they assess their knowledge of the content that is found within topics P12 (Magnetism and the motor effect) and P13 (Electromagnetic induction) of the Edexcel GCSE Combined Science specification. Generally, these topics are poorly understood by students but are regularly assessed through questions in the GCSE exams and so time has been taken to design the lesson so that the key points are covered and common misconceptions addressed. The following specification points are covered in this lesson: Recall that unlike magnetic poles attract and like magnetic poles repel Explain the difference between permanent and induced magnets Describe the use of plotting compasses to show the shape and direction of the field of a magnet and the Earth’s magnetic field Explain how the behaviour of a magnetic compass is related to evidence that the core of the Earth must be magnetic Explain that magnetic forces are due to interactions between magnetic fields Recall and use Fleming’s left-hand rule to represent the relative directions of the force, the current and the magnetic field for cases where they are mutually perpendicular Use the equation which connects force on a conductor, magnetic flux density, current and length Recall that a transformer can change the size of an alternating voltage Explain why, in the national grid, electrical energy is transferred at high voltages from power stations, and then transferred at lower voltages in each locality for domestic uses as it improves the efficiency by reducing heat loss in transmission lines Explain where and why step-up and step-down transformers are used in the transmission of electricity in the national grid Use the power equation (for transformers with 100% efficiency) This lesson is suitable for use throughout the duration of the GCSE course, as an end of topic revision lesson or as a lesson in the lead up to mocks or the actual GCSE exams

This is a concise REVISION lesson that contains an engaging powerpoint (43 slides) and associated worksheets. The lesson uses a range of activities which include exam questions (with displayed answers), differentiated tasks and quiz competitions to engage students whilst they assess their knowledge of the content that is found within topic P8 (Space Physics) of the AQA 9-1 GCSE Physics specification. The following sub-topics in the specification are covered in this lesson: Our Solar System The life cycle of a star Natural satellites Red-shift This lesson can be used throughout the duration of the GCSE course, as an end of topic revision lesson or as a lesson in the lead up to mocks or the actual GCSE exams

This is a concise REVISION lesson that contains an engaging powerpoint (28 slides) and is fully-resourced with associated worksheets. The lesson uses a range of activities which include exam questions (with displayed answers), differentiated tasks and quiz competitions to engage students whilst they assess their knowledge of the content that is found within topic P15 (Forces and matter) of the Edexcel GCSE Combined Science specification. The following sub-topics in the specification are covered in this lesson: Describe the difference between elastic and inelastic distortion Recall and use the equation for linear elastic distortion including calculating the spring constant Use the equation to calculate the work done in stretching a spring Describe the difference between linear and non-linear relationships between force and extension Investigate the extension and work done when applying forces to a spring This lesson can be used throughout the duration of the GCSE course, as an end of topic revision lesson or as a lesson in the lead up to mocks or the actual GCSE exams

This is a fully-resourced REVISION lesson that consists of an engaging PowerPoint (129 slides) and associated worksheets that challenge the students on their knowledge of topics 4 - 6 (Community-level systems, Interaction between systems and Global challenges) of the OCR Gateway A GCSE Combined Science specification and can be assessed on PAPER 2. A wide range of activities have been written into the lesson to maintain motivation and these tasks include exam questions (with answers), understanding checks, differentiated tasks and quiz competitions. The lesson has been designed to include as much which of the content from topic 1, but the following sub-topics have been given particular attention: Identifying bacterial, fungal and viral diseases The steps in the process of genetic engineering Evolution by natural selection The development of antibiotic resistance in bacteria The prevention and reduction of the spread of pathogens Vaccinations The risk factors of CHD Genetic terminology Predicting the results of single-gene crosses Sex determination Ecological terms The carbon cycle The mathematic elements of the Combined Science specification are challenged throughout the resource. Due to the size of this resource, it is likely that it’ll be used over the course of a number of lessons and it is suitable for use as an end of topic revision aid, in the lead up to the mocks or in the lead up to the actual GCSE exams.

This is a fully-resourced REVISION lesson that consists of an engaging PowerPoint (154 slides) and associated worksheets that challenge the students on their knowledge of topics B1 - B4 (Cell Biology, Organisation, Infection and response and Bioenergetics) of the AQA GCSE Combined Science Trilogy specification and can be assessed on PAPER 1. A wide range of activities have been written into the lesson to maintain motivation and these tasks include exam questions (with answers), understanding checks, differentiated tasks and quiz competitions. The lesson has been designed to include as much which of the content that can be assessed in paper, but the following sub-topics have been given particular attention: Eukaryotic and prokaryotic cells Structure of a bacterium The functions of the components of blood Specialised cells Active transport Osmosis Structure of DNA Mitosis and the cell cycle Functions of the organelles of animal and plant cells Electron microscopy Calculating size Arteries and veins The risk factors of CHD CHD treatments The structure of the heart Bacterial, fungal and viral diseases The mathematic elements of the Combined Science specification are challenged throughout the resource. Due to the size of this resource, it is likely that teachers will choose to use it over the course of a number of lessons and it is suitable for use in the lead up to the mocks or in the lead up to the actual GCSE exams.

This lesson describes how passive transport is brought about (simple) diffusion and facilitated diffusion. The PowerPoint and accompanying resources have been designed to cover the first part of specification point 4.2 (ii) of the Edexcel A-level Biology B specification but also covers 4.2 (iii) as the relationship between the properties of a molecule and the method by which they are transported is discussed. The structure of the cell surface membrane was described in the previous lesson, so this lesson has been written to include continual references to the content of that lesson. This enables links to be made between the movement across a cell membrane with the concentration gradient, the parts of the membrane that are involved and any features that may increase the rate at which the molecules move. A series of questions about the alveoli are used to demonstrate how a large surface area, a short diffusion distance and the maintenance of a steep concentration gradient will increase the rate of simple diffusion. One of two quick quiz rounds is then used to introduce temperature and size of molecule as two further factors that can affect simple diffusion. The remainder of the lesson focuses on facilitated diffusion and describes how transmembrane proteins are needed to move small, polar or large molecules from a high concentration to a lower concentration across a partially permeable membrane

This detailed and engaging lesson describes how the passive transport of water molecules is brought about by osmosis. The PowerPoint and accompanying resources have been designed to cover the second part of specification point 4.2 (ii) as detailed in the Edexcel A-level Biology B specification and water potential is included throughout which will help students to prepare for core practical 6 It’s likely that students will have used the term concentration in their osmosis definitions at GCSE, so the aim of the starter task is to introduce water potential to allow students to begin to recognise osmosis as the movement of water molecules from a high water potential to a lower potential, with the water potential gradient. Time is taken to describe the finer details of water potential to enable students to understand that 0 is the highest value (pure water) and that this becomes negative once solutes are dissolved. Exam-style questions are used throughout the lesson to check on current understanding as well as prior knowledge checks which make links to previously covered topics such as the lipid bilayer of the cell membrane. The remainder of the lesson focuses on the movement of water between cells and a solution when these animal and plant cells are suspended in hypotonic, hypertonic or isotonic solutions.

This fully-resourced lesson describes the action of enzymes as biological catalysts and explains how their specificity is related to their 3D structure. The engaging PowerPoint and accompanying resources have been designed to cover points 2.10 (i) and (ii) of the Pearson Edexcel A-level Biology A specification but also introduces some examples of intracellular and extracellular enzymes to prepare students for the next lesson which covers 2.10 (iii). The lesson has been specifically planned to tie in with related topics that were previously covered such as protein structure, globular proteins and intracellular enzymes. This prior knowledge is tested through a series of exam-style questions along with current understanding and mark schemes are included in the PowerPoint so that students can assess their answers. Students will learn that enzymes are large globular proteins which contain an active site that consists of a small number of amino acids. Emil Fischer’s lock and key hypothesis is introduced to enable students to recognise that their specificity is the result of an active site that is complementary in shape to a single type of substrate. Time is taken to discuss key details such as the control of the shape of the active site by the tertiary structure of the protein. The induced-fit model is described so students can understand how the enzyme-susbtrate complex is stabilised and then students are challenged to order the sequence of events in an enzyme-controlled reaction. The lesson finishes with a focus on ATP synthase and DNA polymerase so that students are aware of these important intracellular enzymes when learning about the details of respiration and DNA replication.

This engaging lesson describes how the structure of the mammalian lung is adapted for rapid gaseous exchange. The PowerPoint has been designed to cover point 2.1 (iii) of the Pearson Edexcel A-level Biology A specification and focuses on the essential features of the alveolar epithelium as well as the mechanism of ventilation to maintain a steep concentration gradient for the simple diffusion of oxygen and carbon dioxide. Gas exchange at the alveoli is a topic that was covered at GCSE and considered during the previous lessons in topic 2.1 so this lesson has been written to challenge the recall of that knowledge and then to build on it. The main focus of the first half of the lesson is the type of epithelium found lining the alveoli and students will discover that a single layer of flattened cells known as simple, squamous epithelium acts to reduce the diffusion distance. The following features of the alveolar epithelium are also covered: Surface area Moist lining Production of surfactant The maintenance of a steep concentration gradient is the role of the respiratory system and the next part of the lesson focuses on the diaphragm and intercostal muscles. As the mechanism of inhalation is a cascade of events, the details of this process are covered in a step by step format using bullet points. At each step, time is taken to discuss the key details which includes an introduction to Boyle’s law that reveals the inverse relationship between volume and pressure. It is crucial that students are able to describe how the actions of the diaphragm, external intercostal muscles and ribcage result in an increased volume of the thoracic cavity and a subsequent decrease in the pressure, which is below the pressure outside of the body. At this point, their recall of the structures of the mammalian gas exchange system is tested, to ensure that they can describe the pathway taken by air when moving into the lungs.

This fully-resourced lesson explains how an enzyme’s specificity is related to their 3D structure and enables them to act as biological catalysts. The engaging PowerPoint and accompanying resources have been designed to cover the first parts of specification point 1.4.2 and considers the details of Fischer’s lock and key hypothesis and Koshland’s induced-fit model to deepen student understanding of the mechanism of enzyme action The lesson has been specifically planned to tie in with related topics that were previously covered such as protein structure and globular proteins. This prior knowledge is tested through a series of exam-style questions along with current understanding and mark schemes are included in the PowerPoint so that students can assess their answers. Students will learn that enzymes are large globular proteins which contain an active site that consists of a small number of amino acids. Emil Fischer’s lock and key hypothesis is introduced to enable students to recognise that their specificity is the result of an active site that is complementary in shape to a single type of substrate. Time is taken to discuss key details such as the control of the shape of the active site by the tertiary structure of the protein. The induced-fit model is described so students can understand how the enzyme-susbtrate complex is stabilised and then students are challenged to order the sequence of events in an enzyme-controlled reaction. The lesson finishes with a focus on ATP synthase and DNA polymerase so that students are aware of these important intracellular enzymes when learning about the details of respiration and DNA replication before they are challenged on their knowledge of carbohydrates, lipids and proteins from topics 1.2 - 1.4 as they have to recognise some extracellular digestive enzymes.

This fully-resourced lesson describes the three main stages of the Calvin cycle as fixation, reduction and regeneration. The detailed PowerPoint and accompanying resources have been designed to cover the content of point 13.1 (g) of the CIE A-level Biology specification and detailed planning ensures that continual links are made to the previous lesson on the light-dependent stage so that students understand how the products of that stage, ATP and reduced NADP, are essential for the Calvin cycle The lesson begins with an existing knowledge check where the students are challenged to recall the names of structures, substances and reactions from the light-dependent stage in order to reveal the abbreviations of the main 3 substances in the Calvin cycle. This immediately introduces RuBP, GP and TP and students are then shown how these substances fit into the cycle. The main section of the lesson focuses on the three phases of the Calvin cycle and time is taken to explore the key details of each phase and includes: The role of RuBisCO in carbon fixation The role of the products of the light-dependent stage, ATP and reduced NADP, in the reduction of GP to TP The use of the majority of the TP in the regeneration of RuBP A step-by-step guide, with discussion points where the class are given time to discuss the answer to selected questions, is used to show how 6 turns of the cycle are needed to form the TP that will then be used to synthesise 1 molecule of glucose. A series of exam-style questions are included at appropriate points of the lesson and this will introduce limiting factors as well as testing their ability to answer questions about this stage when presented with an unfamiliar scientific investigation. The mark schemes are included in the PowerPoint so students can assess their understanding and any misconceptions are immediately addressed.

This lesson describes the light-dependent stage, focusing on photoactivation of chlorophyll, photolysis of water and the production of ATP and reduced NADP. The detailed PowerPoint and accompanying resources have been designed to cover the details of point 13.1 (f) of the CIE A-level Biology specification and also describes cyclic and non-cyclic photophosphorylation The light-dependent stage of photosynthesis is a process which students can find difficult to understand in the necessary detail so this lesson has been planned to walk them through all of the key details. Time is taken to describe the roles of the major protein complexes that are embedded in the thylakoid membrane and this includes the two photosystems, the cytochrome proton pump and ATP synthase. A series of exam-style questions have been written that link to other biological topics in this course such as eukaryotic cell structures and membrane transport as well as application questions to challenge them to apply their understanding. Some of these resources have been differentiated to allow students of differing abilities to access the work and to be pushed at the same time. Students will learn that there are two pathways that the electron can take from PSI and at the completion of the two tasks which describe each of these pathways, they will understand how ATP is generated in non-cyclic and cyclic photophosphorylation. The final task of the lesson asks them to compare these two forms of photophosphorylation to check that they understand when photolysis is involved and reduced NADP is formed. Due to the detail included in this lesson, it is estimated that it will take up to 3 hours of allocated A-level teaching time to complete.

This fully-resourced lesson describes how enzyme and substrate concentration can affect the rate of an enzyme-controlled reaction. The PowerPoint and accompanying resources are the 4th in a series of 5 lessons which cover the detail of point 1.4.2 of the AQA A-level Biology specification. Transcription and translation are also introduced and therefore this lesson could be used in preparation for the detailed lessons in topic 4.2. The first part of the lesson describes how an increase in substrate concentration will affect the rate of reaction when a fixed concentration of enzyme is used. Time is taken to introduce limiting factors and students will be challenged to identify substrate concentration as the limiting factor before the maximum rate is achieved and then they are given discussion time to identify the possible factors after this point. A series of exam-style questions are used throughout the lesson and the mark schemes are displayed to allow the students to assess their understanding and for any misconceptions to be immediately addressed. Moving forwards, the students have to use their knowledge of substrate concentration to construct a graph to represent the relationship between enzyme concentration and rate of reaction and they have to explain the different sections of the graph and identify the limiting factors. The final section of the lesson describes how the availability of enzymes is controlled in living organisms. Students will recognise that this availability is the result of enzyme synthesis and enzyme degradation and a number of prior knowledge checks challenge students on their knowledge of proteins as covered in topic 1.4.1 Please note that this lesson explains the Biology behind the effect of concentration on enzyme-controlled reactions and not the methodology involved in carrying out such an investigation as this is covered in a core practical lesson.

This lesson describes and explains how temperature affects enzyme activity. The PowerPoint and the accompanying resource are part of the 1st lesson in a series of 3 which cover the content detailed in point 1.5 (iv) of the Edexcel A-level Biology B specification and this lesson has been specifically planned to tie in with the previous lesson covering 1.5 (i, ii & iii) where the structure, properties and mechanism of action of enzymes were introduced. The lesson begins by challenging the students to recognise optimum as a key term from its 6 synonyms that are shown on the board. Time is taken to ensure that the students understand that the optimum temperature is the temperature at which the most enzyme-product complexes are produced per second and therefore the temperature at which the rate of an enzyme-controlled reaction works at its maximum. The optimum temperatures of DNA polymerase in humans and in a thermophilic bacteria and RUBISCO in a tomato plant are used to demonstrate how different enzymes have different optimum temperatures and the roles of the latter two in the PCR and photosynthesis are briefly described to prepare students for these lessons in topics 7 and 5. Moving forwards, the rest of the lesson focuses on enzyme activity at temperatures below the optimum and at temperatures above the optimum. Students will understand that increasing the temperature increases the kinetic energy of the enzyme and substrate molecules, and this increases the likelihood of successful collisions and the production of enzyme-substrate and enzyme-product complexes. When considering the effect of increasing the temperature above the optimum, continual references are made to the previous lesson and the control of the shape of the active site by the tertiary structure. Students will be able to describe how the hydrogen and ionic bonds in the tertiary structure are broken by the vibrations associated with higher temperatures and are challenged to complete the graph to show how the rate of reaction decreases to 0 when the enzyme has denatured. Please note that this lesson has been designed specifically to explain the relationship between the change in temperature and the rate of enzyme activity in a reaction and not the practical skills that would be covered in a core practical lesson

This lesson describes the structure of enzymes and explains how their specificity enables them to act as catalysts intracellularly and extracellularly. The engaging PowerPoint and accompanying resources have been designed to cover points 1.5 (i), (ii), (iii) & (vii) of the Edexcel A-level Biology B specification and describes Fischer’s lock and key hypothesis and Koshland’s induced-fit model to deepen student understanding of the mechanism of enzyme action The lesson has been specifically planned to tie in with topic 1.3 where protein structure and globular proteins were covered. This prior knowledge is tested through a series of exam-style questions along with current understanding and mark schemes are included in the PowerPoint so that students can assess their answers. Students will learn that enzymes are large globular proteins which contain an active site that consists of a small number of amino acids. Emil Fischer’s lock and key hypothesis is introduced to enable students to recognise that their specificity is the result of an active site that is complementary in shape to a single type of substrate. Time is taken to discuss key details such as the control of the shape of the active site by the tertiary structure of the protein. The induced-fit model is described so students can understand how the enzyme-susbtrate complex is stabilised and then students are challenged to order the sequence of events in an enzyme-controlled reaction. The lesson finishes with a focus on ATP synthase, DNA helicase and DNA polymerase and students are challenged on their recall of DNA replication with an exam question before they are challenged on their knowledge of carbohydrates, lipids and proteins from topics 1.1 - 1.3 as they have to recognise some extracellular digestive enzymes from descriptions of their substrates.