This fully-resourced lesson describes the different effects that gene mutations can have on the amino acid sequence of a protein. The engaging and detailed PowerPoint and accompanying resources have been designed to cover points 1.4 (viii) & (ix) as detailed in the Edexcel A-level Biology B specification and includes substitutions, deletions and insertions and considers a real life example in sickle cell anaemia. In order to understand how a change in the base sequence can affect the order of the amino acids, students must be confident in their understanding and application of protein synthesis which was covered earlier in this topic. Therefore, the start of the lesson focuses on transcription and translation and students are guided through the use of the codon table to identify amino acids. Moving forwards, a task called known as THE WALL is used to introduce to the names of three types of gene mutation whilst challenging the students to recognise three terms which are associated with the genetic code. The main focus of the lesson is substitutions and how these mutations may or may not cause a change to the amino acid sequence. The students are challenged to use their knowledge of the degenerate nature of the genetic code to explain how a silent mutation can result. Students will learn that a substitution is responsible for the new allele that causes sickle cell anaemia and they are tested on their understanding through an exam-style question. As with all of the questions, a mark scheme is included in the PowerPoint which can be displayed to allow the students to assess their understanding. The rest of the lesson looks at base deletions and base insertions and students are introduced to the idea of a frameshift mutation. One particular task challenges the students to evaluate the statement that base deletions have a bigger impact on primary structure than base substitutions. This is a differentiated task and they have to compare the fact that the reading frame is shifted by a deletion against the change in a single base by a substitution

A fully resourced revision lesson which uses a range of exam questions (with explained answers), quick tasks and quiz competitions to enable the students to assess their understanding of the topics found within module 3 (Exchange and transport) of the OCR A-level Biology specification. The topics tested within this lesson include: Exchange surfaces Mammalian gaseous exchange system Tissues in the gaseous exchange system Transport in animals Blood vessels Exchange at the capillaries ECG Transport of oxygen Transport in plants Transport tissues Movement of water through plants Transpiration Translocation Student will enjoy the range of tasks and quiz rounds whilst crucially being able to recognise any areas which require further attention

An engaging lesson presentation (43 slides) that uses exam questions, quick tasks and competitions to enable students to assess their understanding of the topics within module 6.1.3 of the OCR A-Level Biology A specification. All of the exam questions have displayed mark schemes and explanations so that students can recognise any errors or misconceptions. Competition rounds included in this lesson are "From numbers 2 letters" and "Is this SEQUENCED correctly".

This detailed lesson describes the pressure changes that occur during the cardiac cycle and explains how ECG traces can be interpreted. The PowerPoint and accompanying resources have been designed to cover points 4.4 (iii) & (v) of the Edexcel A-level Biology B specification and focuses on the importance of the valves in ensuring unidirectional movement of blood during the cycle. The start of the lesson introduces the cardiac cycle as well as the key term systole, so that students can immediately recognise that the three stages of the cycle are atrial and ventricular systole followed by diastole. Students are challenged on their prior knowledge of the structure of the heart as they have to name and state the function of an atrioventricular and semi-lunar valve from an internal diagram. This leads into the key point that pressure changes in the chambers and the major arteries results in the opening and closing of these sets of valves. Students are given a description of the pressure change that results in the opening of the AV valves and shown where this would be found on the graph detailing the pressure changes of the cardiac cycle. They then have to use this as a guide to write descriptions for the closing of the AV valve and the opening and closing of the semi-lunar valves and to locate these on the graph. By providing the students with this graph, the rest of the lesson can focus on explaining how these changes come about. Students have to use their current and prior knowledge of the chambers and blood vessels to write 4 descriptions that cover the cardiac cycle. The final part of the lesson covers the changes in the volume of the ventricle. The remainder of the lesson focuses on the ECG and explains how these traces can be interpreted to diagnose heart problems. A quiz competition is used to introduce the reference points of P, QRS and T on a normal sinus rhythm before time is taken to explain their representation with reference to the cardiac cycle. Moving forwards, a SPOT the DIFFERENCE task is used to challenge the students to recognise differences between sinus rhythm and some abnormal rhythms including tachycardia and atrial fibrillation. Bradycardia is used as a symptom of sinus node disfunction and the students are encouraged to discuss this symptom along with some others to try to diagnose this health problem.

This is a fully-resourced lesson that explores the meaning of irradiation and contamination and challenges the students to make links to the different types of radiation in order to state which type of radiation is most dangerous outside of the body and inside the body. This lesson includes an engaging lesson presentation (28 slides) and a differentiated worksheet which gives assistance to those students who find the task of writing the letter difficult. The lesson has been written to include real life examples to try to make the subject matter more relevant to the students. Therefore, whilst meeting the term contamination, they will briefly read about the incident with Alexander Litvinenko in 2006 to understand how the radiation entered the body. Moving forwards, students will learn that there are examples of consensual contamination such as the injection of an isotope to act as a tracer. At this point of the lesson, links are made to the topic of decay and half-lives and students are challenged to pick an appropriate isotope based on the half-life and then to write a letter to the patient explaining why they made their choice. The remainder of the lesson challenges students to decide which type or types of radiation are most dangerous when an individual is irradiated or contaminated and to explain their answers. This type of progress check can be found throughout the lesson along with a number of quick competitions which act to maintain engagement as well as introduce new terms. This lesson has been written for GCSE aged students

This lesson describes how biodiversity is generated through natural selection and leads to behavioural, anatomical and physiological adaptations. The PowerPoint and accompanying resources have been designed to cover specification points (m) & (n) in AS unit 2, topic 1 of the WJEC A-level Biology specification President Trump’s error ridden speech about antibiotics is used at the beginning of the lesson to remind students that this is a treatment for bacterial infections and not viruses as he stated. Moving forwards, 2 quick quiz competitions are used to introduce MRSA and then to get the students to recognise that they can use this abbreviation to remind them to use mutation, reproduce, selection (and survive) and allele in their descriptions of evolution through natural selection. The main task of the lesson challenges the students to form a description that explains how this strain of bacteria developed resistance to methicillin to enable them to see the principles of natural selection. This can then be used when describing how the anatomy of the modern-day giraffe has evolved over time. The concept of convergent evolution is introduced and links are made to the need for modern classification techniques as covered earlier in topic 1. Moving forwards, students will understand how natural selection leads to adaptations and a quick quiz competition introduces the different types of adaptation and a series of tasks are used to ensure that the students can distinguish between anatomical, behavioural and physiological adaptations. The Marram grass is used to test their understanding further, before a step by step guide describes how the lignified cells prevent a loss of turgidity. Moving forwards, the students are challenged to explain how the other adaptations of this grass help it to survive in its environment. A series of exam-style questions on the Mangrove family will challenge them to make links to other topics such as osmosis and the mark schemes are displayed to allow them to assess their understanding. The final part of the lesson focuses on the adaptations of the anteater but this time links back to the topic of taxonomy and students have to answer questions about species and classification hierarchy. Due to the extensiveness of this lesson and the detail contained within the resources, it is estimated that it will take in excess of 2 hours of allocated A-level teaching time to deliver this lesson.

This lesson explains the meaning of biodiversity and describes how it can be assessed in a habitat, in a species level at a genetic level and at a molecular level. The engaging PowerPoint and accompanying resources have been designed to cover points (h-l) in AS unit 2, topic 1 of the WJEC A-level Biology specification but as a lot of genetic content is covered when considering diversity within a species, this lesson can be used as an introduction to the upcoming topics of inheritance A quiz competition called BIOLOGICAL TERMINOLOGY SNAP runs over the course of the lesson and this will engage the students whilst challenging them to recognise key terms from their definitions. This quiz introduces biodiversity, loci, allele and recessive and each of these terms is put into context once introduced. Once biodiversity has been revealed, the students will learn that they are expected to be able to assess the biodiversity within a habitat and within a species and at a molecular level. The variety of alleles in the gene pool of a population increases the genetic diversity so a number of examples are used to demonstrate how the number of phenotypes increases with the number of alleles at a locus. The CFTR gene is used to demonstrate how 2 alleles results in 2 different phenotypes and therefore genetic diversity. Moving forwards, students will discover that more than 2 alleles can be found at a locus and they are challenged to work out genotypes and phenotypes for a loci with 3 alleles (shell colour in snails) and 4 alleles (coat colour in rabbits). Moving forwards, a step by step guide to complete a worked example to calculate a value of D using Simpson’s index of diversity. Students are challenged with a range of exam-style questions where they have to apply their knowledge and all mark schemes are displayed and clearly explained within the PowerPoint to allow students to assess their understanding and address any misconceptions if they arise. The final part of the lesson considers how DNA fingerprinting can be used to assess biodiversity at a molecular level and again a series of exam-style questions are used to challenge the students to apply their newly-acquired knowledge to an unfamiliar situation.

This is a detailed lesson resource that covers the content of point 5.1.3 (a) of the OCR A-level Biology A specification which states that students should be able to demonstrate and apply their understanding of the roles of mammalian sensory receptors. There is a particular focus on the Pacinian corpuscle to demonstrate how these receptors act as transducers by converting one form of energy into electrical energy which is then conducted as an electrical impulse along the sensory neurone. The lesson begins by looking at the different types of stimuli that can be detected. This leads into a written task where students have to form sentences to detail how thermoreceptors, rods and cones, hair cells in the inner ear and vibration receptors in the cochlea convert different forms of energy into electrical energy. Students will be introduced to the term transducer and will be challenged to work out what these cells carry out by using their sentences. As stated above, students will meet a Pacinian corpuscle and learn that this receptors detects pressure changes in the skin using the concentric rings of connective tissue in its structure. The rest of the lesson focuses on how ions are involved in the maintenance of resting potential and then depolarisation. Time is taken to look into the key details of these two processes so students are confident with this topic when met again during a lesson on the generation of action potentials. All of the tasks are differentiated to allow students of different abilities to access the work. As well as understanding checks to allow the students to assess their progress against the current topic, there are also a number of prior knowledge checks on topics like inorganic ions and methods of movement. This lesson has been designed for students studying the OCR A-level Biology course

This fully-resourced lesson looks at the cardiac cycle and relates the structure and operation of the mammalian heart to its function. The engaging and detailed PowerPoint and accompanying resources have been designed to cover point 1.4 (i) of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification As the structure of the heart was covered at GCSE, the lesson has been planned to build on this prior knowledge whilst adding the key details which will enable students to provide A-level standard answers. The primary focus is the identification of the different structures of the heart but it also challenges their ability to recognise the important relationship to function. For example, time is taken to ensure that students can explain why the atrial walls are thinner than the ventricular walls and why the right ventricle has a thinner wall than the left ventricle. Opportunities are taken throughout the lesson to link this topic to the others found in topic 1 including those which have already been covered like circulatory systems as well as those which are upcoming such as the initiation of heart action. There is also an application question where students have to explain why a hole in the ventricular septum would need to be repaired if it doesn’t naturally close over time. The next part of the lesson introduces the cardiac cycle as well as the key term systole, so that students can immediately recognise that the three stages of the cycle are atrial and ventricular systole followed by cardiac diastole. Students are challenged to name and state the function of an atrioventricular and semi-lunar valve from an internal diagram. This leads into the key point that pressure changes in the chambers and the major arteries results in the opening and closing of these sets of valves. Students are given a description of the pressure change that results in the opening of the AV valves and shown where this would be found on the graph detailing the pressure changes of the cardiac cycle. They then have to use this as a guide to write descriptions for the closing of the AV valve and the opening and closing of the semi-lunar valves and to locate these on the graph. By providing the students with this graph, the rest of the lesson can focus on explaining how these changes come about. Students have to use their current and prior knowledge of the chambers and blood vessels to write 4 descriptions that cover the cardiac cycle. The final part of the lesson covers the changes in the volume of the ventricle. It is estimated that it will take in excess of 2 hours of allocated A-level teaching time to cover the detail included in this lesson as required by this specification point

This lesson describes the role of haemoglobin in transport and explains the change in the dissociation curve when there is an increased concentration of carbon dioxide (the Bohr effect). The detailed PowerPoint and accompanying resources have been designed to cover points 1.9 (i) & (ii) of the Edexcel International A-level Biology specification and this lesson also compares the oxyhaemoglobin dissociation curve of foetal haemoglobin against maternal haemoglobin. The lesson begins with a version of the quiz show Pointless and this introduces haemotology as the study of the blood conditions. Students are told that haemoglobin has a quaternary structure as it is formed of 4 polypeptide chains which each contain a haem group with an iron ion attached and that it is this group which has a high affinity for oxygen. Time is taken to discuss how this protein must be able to load (and unload) oxygen as well as transport the molecules to the respiring tissues. Students will plot the oxyhaemoglobin dissociation curve and the S-shaped curve is used to encourage discussions about the ease with which haemoglobin loads each molecule. At this point, foetal haemoglobin and its differing affinity of oxygen is introduced and students are challenged to predict whether this affinity will be higher or lower than adult haemoglobin and to represent this on their dissociation curve. Moving forwards, the different ways that carbon dioxide is transported around the body involving haemoglobin are described and the dissociation of carbonic acid into hydrogen ions is discussed so that students can understand how this will affect the affinity of haemoglobin for oxygen in the final part of the lesson on the Bohr effect. A quick quiz is used to introduce Christian Bohr and the students are given some initial details of his described effect. This leads into a series of discussions where the outcome is the understanding that an increased concentration of carbon dioxide decreases the affinity of haemoglobin for oxygen. The students will learn that this reduction in affinity is a result of a decrease in the pH of the cell cytoplasm which alters the tertiary structure of the haemoglobin. The lesson finishes with a series of questions where the understanding and application skills are tested as students have to explain the benefit of the Bohr effect for an exercising individual.

An engaging lesson presentation (84 slides) and associated worksheets that uses a combination of exam questions, quick tasks and quiz competitions to help the students to assess their understanding of the topics found within unit P5 (Forces) of the AQA GCSE Combined Science specification (specification point P6.5). The topics that are tested within the lesson include: Gravity Speed Velocity Acceleration Newton’s laws Forces and braking Momentum Conservation of momentum Students will be engaged through the numerous activities including quiz rounds like “Can you go the DISTANCE” whilst crucially being able to recognise those areas which need further attention

This detailed lesson describes the role of haemoglobin in the transport of respiratory gases and compares the dissociation curves for foetal and adult haemoglobin. The PowerPoint and accompanying resource have been designed to cover points 4.5 (i), (ii) and (iv) of the Edexcel A-level Biology B specification. The structure of haemoglobin was covered during topic 1, so the start of the lesson acts as a prior knowledge check where the students are challenged to recall that it is a globular protein which consists of 4 polypeptide chains. A series of exam-style questions are then used to challenge them to make the link between the solubility of a globular protein and its role in the transport of oxygen from the alveoli to the respiring cells. Moving forwards, the students will learn that each of the 4 polypeptide chains contains a haem group with an iron ion attached and that it is this group which has a high affinity for oxygen. Time is taken to discuss how this protein must be able to load (and unload) oxygen as well as transport the molecules to the respiring tissues. Students will plot the oxyhaemoglobin dissociation curve and the S-shaped curve is used to encourage discussions about the ease with which haemoglobin loads each molecule. At this point, foetal haemoglobin and its differing affinity of oxygen is introduced and students are challenged to predict whether this affinity will be higher or lower than adult haemoglobin and to represent this on their dissociation curve. The remainder of the lesson looks at the different ways that carbon dioxide is transported around the body that involve haemoglobin. Time is taken to look at the dissociation of carbonic acid into hydrogen ions so that students can understand how this will affect the affinity of haemoglobin for oxygen in an upcoming lesson on the Bohr effect.

An engaging lesson presentation (63 slides) and associated worksheets that uses a combination of exam questions, quick tasks and quiz competitions to help the students to assess their understanding of the topics found within the Chemistry unit C3 (Quantitative chemistry) of the AQA GCSE Combined Science specification (specification point C5.3). The lesson includes useful hints and tips to encourage success in assessments. For example, students are shown how to recognise whether to use Avogadro’s constant or the moles formula in a moles calculation question. The topics that are tested within the lesson include: Conservation of mass and balanced symbol equations Relative formula mass Mass changes when a reactant or product is a gas Moles Amounts of substances in equations Concentration of solutions Students will be engaged through the numerous activities including quiz rounds like “Number CRAZY” and “Are you on FORM” whilst crucially being able to recognise those areas which need further attention

A fully resourced revision lesson which uses a range of exam questions (with explained answers), quick tasks and quiz competitions to enable the students to assess their understanding of the topics found within module 6.1.2 (Patterns of inheritance) of the OCR A-level Biology A specification. The topics tested within this lesson include: Genetic variation Monogenic inheritance Dihybrid inheritance Multiple alleles Sex linkage Codominance Epistasis Using the chi-squared test Discontinuous and continuous variation The Hardy Weinberg principle Student will enjoy the range of tasks and quiz rounds whilst crucially being able to recognise any areas which require further attention

A fully-resourced lesson that looks at the topic of osmosis and how the movement of water between a cell and the solution can affect the appearance of an animal and a plant cell. This lesson includes a detailed and engaging lesson presentation (42 slides) and differentiated worksheets that include exam questions that can be set as homework. There is a lot of key terminology associated with this topic and time is taken to ensure that students understand the meaning of each of these terms before moving forwards. Students are introduced to the different types of solutions and then a step-by-step guide is used to show them how to compare the water potential of the solution and the cell and then how this will determine which was water moves. The main task is differentiated so that students are challenged and can access the work. This lesson has been designed for GCSE students (14 - 16 year olds in the UK) but is also suitable for A-level students

A detailed lesson presentation and associated question worksheet which uses a step by step guide and numerous worked examples to show students how to draw genetic crosses to calculate offspring percentages. Before students are able to draw genetic diagrams, they need to understand and be able to use genetic terminology so this is the focus for the start of the lesson. Time is taken to go over the meaning of dominant and recessive alleles, genotypes and phenotypes. Moving forwards, students will be challenged to link genotypes to phenotypes for both dominant and recessive disorders and common misconceptions such as carriers in recessive disorders are explained. Finally, a 5 step guide is used to walk students through drawing genetic diagrams. Students are then given a chance to apply their new-found knowledge to questions about the inheritance of cystic fibrosis and polydactyly. Progress checks have been written into the lesson at regular intervals so that students can assess their understanding. This lesson has been designed for GCSE students but is perfectly suitable for A-level students who are studying the topic of monogenic inheritance

This is a highly engaging, detailed and fully-resourced revision lesson which has been designed to test the students on their knowledge and understanding of topic 6 (Radioactivity) of the Pearson Edexcel GCSE Physics specification. The PowerPoint and accompanying resources contain a wide range of resources which include exam-style questions with fully-explained answers, differentiated tasks and quick quiz competitions. The students will be motivated by the range of tasks whilst crucially recognising those areas of the specification which require some extra time before the exams The following specification points are covered in this lesson: Describe the structure of atom and recall the typical size Recall the relative masses and charges of the subatomic particles and use the number of protons and electrons to explain why atoms are neutral Describe the structure of the nuclei of an isotope Explain what is meant by background radiation and recall sources Describe methods for measuring and detecting radioactivity Describe the process of beta minus and beta plus decay Write and balance nuclear decay equations Explain the effects on the proton and nucleon number as a result of decay Recall that the unit of radioactivity is Bq Use the concept of half-life to carry out calculations Describe the use of isotopes in PET scanners Describe the differences between nuclear fission and fusion Explain how the fission of U-235 produces two daughter nuclei, two or three neutrons and releases energy Describe the advantages and disadvantages of nuclear energy Explain why nuclear fusion cannot happen at low temperatures and pressures It is estimated that it will take in excess of 2 hours of GCSE teaching to cover the detail of this lesson and it can be used for effective revision at the end of the topic or in the lead up to mock or terminal exams.

A really engaging and detailed lesson presentation (44 slides) and associated differentiated worksheets that looks at communicable diseases in plants and challenges students to diagnose these diseases in plants. During the lesson the students will take on the role of the “Treeage” (triage) nurse and have to direct each plant to the correct ward in the “CASUALTREE” according to the pathogen which has infected them. They will also have to explain how the symptoms which they have identified were caused and explain the future for this plant, during their time as the “Tree surgeon”. The three diseases included in the lesson are tobacco mosaic virus, crown gall disease and powdery mildew disease. There are regular progress checks throughout the lesson so that students can assess their understanding and there is a set homework included as part of the lesson. This lesson has been designed for GCSE students but is also suitable for A-level students looking at the communicable diseases topic

This lesson describes the extracellular action of peptide hormones and the role played by steroid hormones in binding to DNA transcription factors. The detailed PowerPoint and accompanying resources have been designed to cover point 7.22 of the Edexcel International A-level Biology specification and focuses on the differing effects of these two types of hormones on their target cells Students should have a base knowledge of the endocrine system from GCSE so this lesson has been planned to build on that knowledge and to add the detail needed at this level. The lesson begins by challenging this knowledge to check that they understand that endocrine glands secrete these hormones directly into the blood. Students will learn that most of the secreted hormones are peptide (or protein) hormones and a series of exam-style questions are used to challenge them on their recall of the structure of insulin as well as to apply their knowledge to questions about glucagon. Moving forwards, the students are reminded that hormones have target cells that have specific receptor sites on their membrane. The relationship between a peptide hormone as a first messenger and a second messenger on the inside of the cell is covered in detail in an upcoming lesson but students are briefly introduced to G proteins and cyclic AMP so they are prepared. The rest of the lesson focuses on steroid hormones and specifically their ability to pass through the membrane of a cell and to bind to transcription factors, as exemplified by oestrogen. Students covered transcription and the control of gene expression in topics 2 and 3 so the final tasks challenge their recall of these concepts

This fully-resourced lesson describes the ultrastructure of an eukaryotic cell and describes the relationship between the structure and function of the organelles. The detailed and engaging PowerPoint and accompanying resources have been designed to cover point 2.1 (v) of the Edexcel A-level Biology B specification As cells are the building blocks of living organisms, it makes sense that they would be heavily involved in all of the 10 topics in the Edexcel A-level B course and intricate planning has ensured that links are made to topic 1 and details are provided to link to the upcoming topics. A wide range of activities, that include exam-style questions, class discussion points and quick quiz competitions, will maintain motivation and engagement whilst covering the finer details of the following structures and organelles: nucleus nucleolus ribosomes rough endoplasmic reticulum Golgi apparatus lysosomes smooth endoplasmic reticulum mitochondria cell surface membrane centrioles vacuole (+ tonoplast) chloroplasts cell wall As mentioned above, all of the worksheets have been differentiated to support students of differing abilities whilst maintaining challenge Due to the detail that is included in this lesson, it is estimated that it will take in excess of 3 hours of allocated A-level teaching time to cover the work