This fully-resourced lesson explores how projects to sequence the genomes of both simple and complex organisms can be used. Both the detailed PowerPoint and accompanying resources have been designed to cover the content of point 8.3 of the AQA A-level Biology specification.
The start of the lesson describes each step of Sanger’s chain termination method and demonstrates how this method has paved the way for other projects. The use of the modified nucleotides are explained and links are made to the topic 4 and 2 where protein synthesis and DNA replication were first introduced. Students will learn how the radioactively-labelled nucleotide at the end of each fragment allows the next base to be determined. Key processes like gel electrophoresis are introduced and details provided to support the students when this is encountered in greater detail in 8.4.3. Moving forwards, the applications of sequencing in simple organisms like viruses and bacteria are explored and the students are challenged on their prior knowledge of bacterial pathogenesis and current understanding of sequencing through a series of exam-style questions. The final part of the lesson looks at the difficulties of translating genome knowledge into proteome knowledge and considers the development of automated methods.
Due to the detail and extensiveness of this lesson, it is estimated that it will take in excess of 2 hours of allocated A-level teaching time to cover all of the points which have been written into the various tasks
Get this resource as part of a bundle and save up to 30%
A bundle is a package of resources grouped together to teach a particular topic, or a series of lessons, in one place.
Bundle
Topic 8: The control of gene expression (AQA A-level Biology)
Each of the 12 lessons included in this bundle have been written to specifically cover the content as detailed in topic 8 of the AQA A-level Biology specification (The control of gene expression). The wide range of activities will maintain engagement whilst supporting the explanations of the biological knowledge to allow the students to build a deep understanding of this potentially difficult topic! Lessons which cover the following specification points are included in this bundle: * Gene mutations and their effect on the structure of proteins * Most of a cell's DNA is not translated * Totipotent, pluripotent, multipotent and unipotent stem cells * Regulation of transcription by transcription factors * The role of oestrogen in initiating transcription * Epigenetic control of gene expression in eukaryotes * Inhibition of transcription by increased DNA methylation or decreased acetylation of histones * Translation of mRNA can be inhibited by RNA interference * The main characteristics of benign and malignant tumours * Determining the genome of simpler organisms to determine the proteome and its applications * The development of DNA sequencing methods * The production of DNA fragments through use of enzymes or a gene machine * The role of the PCR to amplify DNA fragments * The transfer of DNA into a host cell * The use of labelled DNA probes to screen patients for heritable conditions, drug responses and to identify health risks * VNTRs * The technique of genetic fingerprinting to analyse DNA fragments If you would like to see the quality of the lessons, download the producing DNA fragments and DNA methylation and acetylation lessons as these have been uploaded for free
£21.75
Bundle
Topics 8.3 & 8.4: Genome projects and gene technologies (AQA A-level Biology)
All 6 lessons included in this bundle have been written to cover the detailed content of topics 8.3 and 8.4 of the AQA A-level Biology specification. These topics can provide a series of problems for students so clear explanations are used throughout the lesson as well as regular understanding checks so any misconceptions are immediately addressed. The variety of tasks will maintain engagement whilst displayed mark schemes allow students to assess their answers and add detail where it is missing. The following specification points are covered: 8.3: Using genome projects 8.4.1: Recombinant DNA technology 8.4.2: Differences in DNA between individuals of the same species can be exploited 8.4.3: Genetic fingerprinting If you would like to sample the quality of the lessons first, why not download the lesson on producing DNA fragments which has been uploaded for free
£10.85
Something went wrong, please try again later.
This resource hasn't been reviewed yet
To ensure quality for our reviews, only customers who have purchased this resource can review it
Report this resourceto let us know if it violates our terms and conditions.
Our customer service team will review your report and will be in touch.
£4.00