This fully-resourced lesson uses the lac operon as an example to describe how gene expression is regulated and controls cell processes and structures. The detailed PowerPoint and accompanying resources have been designed to cover the details of specification point 3.12 of the Pearson Edexcel A-level Biology A course. This is one of the more difficult concepts in this A-level course and therefore key points are reiterated throughout this lesson to increase the likelihood of student understanding and to support them when trying to make links to actual biological examples in living organisms. There is a clear connection to transcription and translation as covered in topic 2, so the lesson begins by reminding students that in addition to the structural gene in a transcription unit, there is the promotor region where RNA polymerase binds. Students are introduced to the idea of transcription factors and will understand how these molecules can activate or repress transcription by enabling or preventing the binding of the enzyme. At this point, students are challenged on their current understanding with a series of questions about DELLA proteins so they can see how these molecules prevent the binding of RNA polymerase. The main section of the lesson focuses on the lac operon. Students will be able to visualise the different structures that are found in this unit of DNA and time is taken to go through the individual functions. A step by step guide is used to walk students through the sequence of events that occur when lactose is absent and when it is present before they are challenged to apply their understanding to an exam question. The final section of the lesson looks at one further example with oestrogen and the ER receptor.

This lesson has been written to act as a revision tool for students at the completion of topic P1 of the CIE IGCSE Combined Science specification or in the lead up to mock or terminal exams. This motion topic is extensive and the engaging PowerPoint and accompanying resources have been designed to include a wide range of activities that will allow the students to assess their understanding of the core and supplement sections and to recognise any areas which need further attention. This specification is fairly heavy in mathematical content and so a lot of opportunities are presented for a range of skills to be tested and the PowerPoint guides students through the application of these requirements such as rearranging the formula and converting between units. The following specification points have received a particular focus in this lesson: Calculate average speed using total distance and total time Plot and interpret a speed-time graph Recognise different motions on a speed time graph and relate this to the resultant force Calculate acceleration and distance travelled from a speed-time graph Distinguish between mass and weight Recall and use the equation W = mg to calculate the weight Recall and use the equation to calculate density Interpret extension-load graphs and calculate the spring constant Recognise the significance of the term, “limit of proportionality” Recall and use the equation to calculate pressure A number of quick quiz rounds, such as FILL THE VOID and THE BIG REVEAL, are used to maintain engagement and motivation and to challenge the students on their recall of important points. It is estimated that it will take in excess of 2 hours of IGCSE teaching time to cover the detail included in this lesson

This fully-resourced lesson describes the differences between continuous and discontinuous variation. The engaging PowerPoint and accompanying resources have been designed to cover point 17.1 (a) of the CIE A-level Biology specification but also acts as a revision of topic 16 as it challenges students on their knowledge of gene mutations and meiosis. The students begin the lesson by having to identify phenotype and species from their respective definitions so that a discussion can be encouraged where they will recognise that phenotypic variation within a species is due to both genetic and environmental factors. The main part of the the lesson focuses on these genetic factors, and describes how mutation and the events of meiosis contribute to this variation. A range of activities, which include exam-style questions and quick quiz rounds, are used to challenge the students on their knowledge and understanding of substitution mutations, deletions, insertions, the genetic code, crossing over and independent assortment. Moving forwards, the concept of multiple alleles is introduced and students will learn how the presence of more than 2 alleles at a locus increases the number of phenotypic variants. Another quick quiz round is used to introduce polygenic inheritance and the link is made between this inheritance of genes at a number of loci as an example of continuous variation. In line with the title of the lesson, the next task challenges them to recognise descriptions and examples which apply to the different types of variations. The final part of the lesson introduces a few examples where environmental factors affect phenotype, such as chlorosis in plants, so that students are prepared for the following lesson.

This fully-resourced lesson describes how the cells of multicellular organisms are specialised for particular functions and organised into tissues, organs and organ systems. The detailed and engaging PowerPoint and accompanying resources have been designed to cover points 2.1.6 (h, i, j and k) of the OCR A-level Biology A specification and also describes how stem cells differentiate, including the production of erythrocytes (red blood cells) and neutrophils. The start of the lesson focuses on the difference in the SA/V ratio of an amoeba and a human in order to begin to explain why the process of differentiation is critical for multicellular organisms. Students will discover that a zygote is a stem cell which can express all of the genes in its genome and divide by mitosis. Time is then taken to introduce gene expression as this will need to be understood in the later topics of the course. Moving forwards, the lesson uses the process of haematopoiesis from haematopoietic stem cells to demonstrate how the red blood cell and neutrophil differ significantly in structure despite arising from the same cell along the same cell lineage. A series of exam-style questions will not only challenge their knowledge of structure but also their ability to apply this knowledge to unfamiliar situations. These differences in cell structure is further exemplified by the epithelial cells of the respiratory tract and students will understand why the shape and arrangement of these cells differ in the trachea and alveoli in line with function. The link between specialised cells and tissues is made at this point of the lesson with these examples of epithelium and students will also see how tissues are grouped into organs and then into organ systems. The remainder of the lesson focuses on specialised plant cells and the differing shapes and features of the palisade and spongy mesophyll cells and the guard cells are covered at length and in detail. Step by step guides will support the students so that they can recognise the importance of the structures and links are made to upcoming topics such as the vascular tissues so that students are prepared for these when covered in the future.

This fully-resourced lesson looks at the structures of the sensory, relay and motor neurones and explains how the presence of a myelin sheath increases the speed of conduction of an impulse. The engaging PowerPoint and accompanying resources have been designed to cover point 8.1 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification which states that students should be able to apply their understanding of the structures and functions of sensory, relay and motor neurones as well as the differences between myelinated and unmyelinated neurones. This lesson also covers 8.2 (i) as the students will be able to see how conduction along a motor neurone stimulates effectors to respond to a stimulus. The PowerPoint has been designed to contain a wide range of activities that are interspersed between understanding and prior knowledge checks that allow the students to assess their progress on the current topics as well as challenge their ability to make links to topics from earlier in the modules. Quiz competitions like SAY WHAT YOU SEE are used to introduce key terms in a fun and memorable way. The students will be able to compare these neurones based on their function but also distinguish between them based on their structural features. Time is taken to look at the importance of the myelin sheath for the sensory and motor neurones. Students will be introduced to the need for the entry of ions to cause depolarisation and will learn that this is only possible at the nodes of Ranvier when there is a myelin sheath. Key terminology such as saltatory conduction is introduced and explained. The final task involves a comparison between the three neurones to check that the students have understood the structures and functions of the neurones. Throughout the lesson, links are made to related topics such the organisation of the nervous system and students will be given additional knowledge such as the differences between somatic and autonomic motor neurones.

This lesson describes the importance of the cytoskeleton, and focuses on the role of these proteins in the transport within cells and cell movement. The PowerPoint and accompanying resource have been designed to cover point 2.1.1 (j) of the OCR A-level Biology A specification and has been specifically designed to tie in with The previous lesson covered the ultrastructure of eukaryotic cells and the function of the different cellular components and this lesson has been planned to build on that knowledge to show how the cytoskeleton allows for the movement of these organelles from one part of the cell to another. In particular, the students will recognise how the dragging movement of the motor proteins along the microtubule track is important for the proteins produced at the RER to move to the Golgi before the vesicles are then moved to the membrane for exocytosis. In this way, this lesson also covers specification point 2.1.1 (i). Other examples such as the movement of the synaptic vesicles and the contraction of the spindle fibres during anaphase are used to consolidate understanding further. The cilia and the flagellum are also described and links are made to related topics such as the primary non-specific defences against pathogens. In order to engage and motivate the students during the 7 lessons in this module, a running quiz competition has been written into each of the lessons and 3 rounds are incorporated into this lesson. A quiz scoresheet to keep track of the points is included in this resource.

This engaging and detailed lesson looks at the roles of the Link reaction and the Krebs cycle as the stages of aerobic respiration which occur in the mitochondrial matrix. Both the PowerPoint and the accompanying resource have been designed to cover point 7.5 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification. The lesson begins with a challenge, where the students have to recall the details of glycolysis in order to form the word matrix. This introduces the key point that these two stages occur in this part of the mitochondria and time is taken to explain why the reactions occur in the matrix as opposed to the cytoplasm like glycolysis. Moving forwards, the Link reaction is covered in 5 detailed bullet points and students have to add the key information to these points using their prior knowledge as well as knowledge provided in terms of NAD. The students will recognise that this reaction occurs twice per molecule of glucose and a quick quiz competition is used to test their understanding of the numbers of the different products of this stage. This is just one of the range of methods that are used to check understanding and all answers are explained to allow students to assess their progress. The rest of the lesson focuses on the Krebs cycle. In line with the detail of the specification, students will understand how decarboxylation and dehydrogenation reactions result in the regeneration of the 4C compound. It is estimated that it will take about 2 hours of A-level teaching time to cover the detail of the lesson and therefore the detail of the specification point 7.5

This lesson focuses on the structure of RNA and specifically the similarities and differences between this nucleic acid and DNA. The engaging and detailed PowerPoint and accompanying resource have been designed to cover part 1 of point 4.2 of the AQA A-level Biology specification which states that students should be able to describe the structure of molecules of messenger RNA and transfer RNA as well as understand the concept of a genome and proteome. Students were introduced to the detailed structure of DNA in previous lessons covering specification point 4.1, so this lesson is written to tie in with those and continuously challenge prior knowledge as well as understanding of the current topic. The lesson begins with the introduction of the term genome and proteome and students are challenged to make the link between the genes in an organism and all of the proteins that can be produced by these sequence of bases. Moving forwards, students will learn that RNA is a member of the family of nucleic acids and therefore has a number of structural features that were previously seen in DNA. A quiz round called “A FAMILY AFFAIR” is used to challenge their knowledge of DNA to recognise those features that are also found on RNA such as the chain of linked nucleotides, pentose sugars, nitrogenous bases and phosphodiester bonds. The next task pushes them to consider features that have not been mentioned and therefore are differences as they answer a structured exam-style question on how RNA differs from DNA. Students will learn that RNA is shorter than DNA and this leads into the final part of the lesson where mRNA and tRNA are introduced and again they are challenged to use the new information explain the difference in size. Brief details of transcription and then translation are provided so that students are prepared for the upcoming lessons on protein synthesis.

This lesson describes the general structure of the 20 amino acids found in proteins and makes clear links to related topics such as genes. The PowerPoint has been designed to cover specification point 2.1.2 (k) of the OCR A-level Biology A course and provides a clear introduction to the following lesson on the formation of dipeptides and polypeptides. The lesson begins with a prior knowledge check, where the students have to use the 1st letters of 4 answers to uncover a key term. This 4-letter key term is gene and the lesson begins with this word because it is important for students to understand that these sequences of bases on DNA determine the specific sequence of amino acids in a polypeptide. Moving forwards, students are given discussion time to work out that there are 64 different DNA triplets and will learn that these encode for the 20 amino acids that are common to all organisms. The main task of the lesson is an observational one, where students are given time to study the displayed formula of 4 amino acids. They are not allowed to draw anything during this time but will be challenged with 3 multiple choice questions at the end. This task has been designed to allow the students to visualise how the 20 amino acids share common features in an amine and an acid group. A quick quiz round introduces the R group and time is taken to explain how the structure of this side chain is the only structural difference. Students will be introduced to the existence of hydrophobic, hydrophilic, acidic and basic R groups so that they are able to apply this knowledge in future lessons where structure and shape is considered. Some time is also given to look at cysteine in greater detail due to the presence of sulfur atoms and once again a link is made to disulfide bridges for upcoming lessons. The lesson concludes with one more quiz round called LINK TO THE FUTURE where the students will see the roles played by amino acids in the later part of the course such as translation and in the formation of dipeptides.

This fully-resourced lesson describes the beneficial, neutral and harmful effects of gene mutations on the primary structure of a polypeptide. The engaging and detailed PowerPoint and accompanying resources have been designed to cover point 6.1.1 (a) of the OCR A-level Biology A specification which states that students should be able to understand how substitutions, deletions and insertions change the base sequence and describe how this affects protein production and function. In order to understand how a change in the base sequence can affect the order of the amino acids, students must be confident in their understanding and application of protein synthesis which was covered in module 2.1.3. Therefore, the start of the lesson focuses on transcription and translation and students are guided through the use of the codon table to identify amino acids. Moving forwards, a task called known as THE WALL is used to introduce to the names of three types of gene mutation whilst challenging the students to recognise terms which are associated with the genetic code and were met back in 2.1.3. The main focus of the lesson is base substitutions and how these mutations may or may not cause a change to the amino acid sequence. The students are challenged to use their knowledge of the degenerate nature of the genetic code to explain how a silent mutation can result. The rest of the lesson looks at base deletions and base insertions and students are introduced to the idea of a frameshift mutation. One particular task challenges the students to evaluate the statement that base deletions have a bigger impact on primary structure than base substitutions. This is a differentiated task and they have to compare the fact that the reading frame is shifted by a deletion against the change in a single base by a substitution

This revision resource has been designed to include a range of activities that will engage the students whilst they assess their understanding of the content of topic B8 (Gas exchange and respiration) of the CIE IGCSE Combined Science specification for examination in June and November 2020 and 2021. Exam questions, quick tasks and quiz competitions such as “The BIG REVEAL” will challenge the students on their recall of the content as well as their ability to apply this knowledge. The lesson was written to cover as much of the content as possible, but the following topics have received particular attention: The role of cilia, goblet cells and mucus in the trachea and bronchi The effects of the chemicals in tobacco smoke on gas exchange Efficient gas exchange at the alveoli The composition of inhaled and exhaled air Aerobic respiration as the chemical reaction that releases energy The uses of energy in the human body This resource contains an engaging PowerPoint (54 slides) and associated worksheets and is ideal for use at the end of this topic or in the lead up to mocks or the actual terminal exams

This detailed revision lesson challenges the students on their understanding of the reactions of acids with metals to produce salts and hydrogen. The PowerPoint and accompanying resources focus on the details of point 4.2.1 in the AQA GCSE chemistry and combined specifications, and time is spent reminding the students that these reactions are redox reactions. The students are given the general word equation for acids reacting with metals and are challenged to recall how to name the salts according to the metal and acid involved in the reaction. They are reminded that redox reactions involve the loss and gain of electrons and are challenged to identify the substances which are reduced or oxidised in specific examples. In addition to the reactions of acids with metals, this revision lesson also challenges them to write chemical formulae, balance symbol equations, and to identify the tests for gases.

This detailed lesson uses haemoglobin and collagen to describe the relationship between the structure and functions of globular and fibrous proteins. The engaging PowerPoint and accompanying worksheet have been primarily designed to cover specification point 2.3 © of the CIE International A-level Biology course but due to the detailed coverage of haemoglobin, this resource could also be used when teaching a lesson on the role of this protein in topic 8. The first part of the lesson looks at the structure of haemoglobin, and describes how the presence of an iron-containing haem group on the outside of the 4 polypeptide chains explains its ability to form oxyhaemoglobin. Moving forwards, the importance of the solubility of this protein is considered and related to the direction that the hydrophobic R groups point. At this point of the lesson, the students are challenged to construct a comparison table which can be filled in as the lesson progresses and as they are given more details of collagen. The section of the lesson concerning collagen begins with the introduction of its function in the artery wall so that students can recognise how fibrous proteins have roles associated with mechanical strength. Time is taken to discuss their solubility as well as the presence of repetitive amino acid sequences. The remainder of the lesson considers four more proteins and the final task challenges the students to use their completed table to write a summary passage comparing globular and fibrous proteins.

This lesson covers a large number of the key topics from the AQA GCSE Combined Physics course in the final weeks before the GCSE examinations. The extensive PowerPoint and accompanying resources use a range of activities and tasks including exam questions and quizzes to challenge the students on their knowledge of the following topics and skills: Units and converting between units Answering calculation questions (with 1 or 2 equations) Newton’s 2nd and 3rd laws of motion Resultant forces Conservation of energy Efficiency and reducing wasted energy Conservation of momentum Scalar and vector quantities Motions on a velocity-time graph The relationship between force and the extension of a spring Setting up electrical circuits Current, potential difference and resistance in series and parallel circuits The properties of ionising radiation Calculating half-lives Constructing decay equations The properties of waves Refraction This resource is likely to take 4 or more lessons to cover all of the content.

This fully-resourced lesson describes the differences between bacteriostatic and bactericidal antibiotics. The engaging PowerPoint and accompanying resources have been designed to cover point 6.13 of the Edexcel International A-level Biology specification but also makes continual links to earlier lessons in topic 6 as well as related topics from the previous year such as protein synthesis from topic 2 The lesson begins by challenging the students to use their knowledge of the previous topic 6 lessons to identify the suffixes cidal and static. Students will learn that when the prefix is added, these form the full names of two types of antibiotics. Their understanding of terminology is tested further as they have to recognise that Polymyxin B is an example of a bactericidal antibiotic as its actions would result in the death of the bacterial cell. Tetracycline is used as the example of a bacteriostatic antibiotic and students will discover that its prevention of the binding of tRNA that inhibits protein synthesis and this reduction and stopping of growth and reproduction is synonymous with these drugs. Students are challenged on their knowledge of translation and will also be given time for a class discussion to understand that these antibiotics encourage the body’s immune system to overcome the pathogen in natural, active immunity. The final part of the lesson uses a quick quiz competition and a series of exam-style questions to ensure that students can recognise the different antibiotics from descriptions.

This lesson describes the relationship between the structure and function of the giant covalent substances, graphite and diamond. The PowerPoint and accompanying resource have been designed to cover points 1.35, 1.36 and 1.37 of the Edexcel GCSE Chemistry specification also covers those same points in the Chemistry section of the Combined Science course As shown in the picture, the lesson begins with a newspaper story about two prisoners who escaped from Pentonville prison by using a diamond-tipped drill and this immediately introduces the use of this allotrope of carbon in cutting tools. There is a clear focus on the link between the structure, bonding and respective uses. Time is taken to focus on the comparison between graphite and diamond in terms of their ability to conduct electricity. A step by step answer is used to explain why diamond cannot conduct electricity so that students can use this when forming their answer for graphite.

This engaging revision lesson challenges students on their understanding of the homeostatic control system that regulates blood glucose concentration. The PowerPoint and accompanying resources have been designed to check on the understanding of the details in specification point 5.3.2 of the AQA biology and combined science specifications. A common mistake in this topic is that students confuse glycogen with glucagon and use them incorrectly so time is spent to ensure that students recognise the difference between the complex carbohydrate and the hormone. In addition to challenging the students on their knowledge of this control system, the following linked topics are also challenged: key biological terms (beginning with G) the digestive system structures in a control system

This fully-resourced lesson describes the processes of active transport, endocytosis and exocytosis and explains the need for ATP. The PowerPoint and accompanying worksheets have been designed to cover the second part of point 4.2 (a) of the CIE International A-level Biology specification. The first part of 4.2 (a), concerning simple and facilitated diffusion, was covered in the previous lesson. The start of the lesson challenges the students to use their prior knowledge of biological molecules to come up with the abbreviation ATP and they will learn that this is a phosphorylated nucleotide that contains adenine, ribose and three phosphate groups. Students may not have known this as the energy currency from GCSE so time is taken to explain that this molecule must be broken down to release energy and students are challenged to recall which type of reaction will be involved and to predict the products of such a reaction. This hydrolysis of ATP can be coupled to energy-requiring reactions within the cell and the rest of the lesson focuses on the use of this energy for active transport, endocytosis and exocytosis. Students are challenged to answer a series of questions which compare active transport against the forms of passive transport and to use data from a bar chart to support this form of transport. In answering these questions they will discover that carrier proteins are specific to certain molecules and time is taken to look at the exact mechanism of these transmembrane proteins. A quick quiz round introduces endocytosis and the students will see how vesicles are involved along with the energy source of ATP to move large substances in or out of the cell. The lesson concludes with a link to a future topic as the students are shown how exocytosis is involved in a synapse.

This detailed lesson describes how oxygen is transported by haemoglobin and explains the changes in saturation in the oxyhaemoglobin dissociation curve. The informative PowerPoint has been designed to cover the 1st part of the transportation of oxygen section in the applied anatomy and physiology unit of the AQA A-level PE specification. The lesson begins by using a quiz round from the game show POINTLESS to engage students and to introduce haemotology as the study of diseases related to blood. This includes haemoglobin and students will be reminded that this is the protein that is found in the red blood cells of humans. They will learn that it is a protein consisting of four polypeptide chains with a haem group on each chain and that it is this haem molecule which has a high affinity for oxygen to enable oxyhaemoglobin to be formed. Key terminology such as affinity are continually used to deepen understanding of this topic and to make links to those covered in upcoming lessons such as the Bohr shift. Moving forwards, students will plot an oxyhaemoglobin dissociation curve. The understanding of the changes in saturation can be poorly understood so a step-by-step method with simple questions to discuss is used to ensure that the fundamentals are embedded. Ultimately, students will understand that haemoglobin becomes fully saturated at the high partial pressures of oxygen at the alveoli at the lungs, before transporting it to the cells of the working muscles where it dissociates to release the oxygen at the lower partial pressures there.

This lesson describes the secretion of peptide and steroid hormones by endocrine glands and their differing effects on target cells. The detailed PowerPoint and accompanying resources have been primarily designed to cover point 5.1.4 (a) of the OCR A-level Biology A specification but also makes clear links to upcoming lessons in this module as well as to topics such as transcription factors which are covered in module 6.1.1 Students should have a base knowledge of the endocrine system from GCSE so this lesson has been planned to build on that knowledge and to add the detail needed at this level. The lesson begins by challenging this knowledge to check that they understand that endocrine glands secrete these hormones directly into the blood. Students will learn that most of the secreted hormones are peptide (or protein) hormones and a series of exam-style questions are used to challenge them on their recall of the structure of insulin as well as to apply their knowledge to questions about glucagon. Moving forwards, the students are reminded that hormones have target cells that have specific receptor sites on their membrane. The relationship between a peptide hormone as a first messenger and a second messenger on the inside of the cell is covered in detail in an upcoming lesson but students are briefly introduced to G proteins and cyclic AMP so they are prepared. The rest of the lesson focuses on steroid hormones and specifically their ability to pass through the membrane of a cell and to bind to transcription factors, as exemplified by oestrogen.