This fully-resourced lesson provides examples of anatomical, behavioural and physiological adaptations of organisms to their environment. The engaging and detailed PowerPoint and accompanying resources have been designed to cover point 4.19 in unit 2 of the Edexcel International A-level Biology specification and also describes the concept of a niche and makes continual links to related topics such as natural selection A quick quiz competition at the start of the lesson introduces the different types of adaptation and a series of tasks are used to ensure that the students can distinguish between anatomical, behavioural and physiological adaptations. The Marram grass is used to test their understanding further, before a step by step guide describes how the lignified cells prevent a loss of turgidity. Moving forwards, the students are challenged to explain how the other adaptations of this grass help it to survive in its environment. A series of exam-style questions on the Mangrove family will challenge them to make links to other topics such as osmosis and the mark schemes are displayed to allow them to assess their understanding. The final part of the lesson focuses on the adaptations of the anteater but this time links are made to the upcoming topic of taxonomy so that students are prepared for this lesson on species and classification hierarchy.

This fully-resourced lesson introduces bacteriostatic and bactericidal antibiotics and describes their differences, focusing on their modes of action. The engaging PowerPoint and accompanying resources have been designed to cover point 6.14 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification but also makes continual links to earlier lessons in topic 6 as well as related topics from the previous year such as protein synthesis from topic 2 The lesson begins by challenging the students to use their knowledge of the previous topic 6 lessons to identify the suffixes cidal and static. Students will learn that when the prefix is added, these form the full names of two types of antibiotics. Their understanding of terminology is tested further as they have to recognise that Polymyxin B is an example of a bactericidal antibiotic as its actions would result in the death of the bacterial cell. Tetracycline is used as the example of a bacteriostatic antibiotic and students will discover that its prevention of the binding of tRNA that inhibits protein synthesis and this reduction and stopping of growth and reproduction is synonymous with these drugs. Students are challenged on their knowledge of translation and will also be given time for a class discussion to understand that these antibiotics encourage the body’s immune system to overcome the pathogen in natural, active immunity. The final part of the lesson uses a quick quiz competition and a series of exam-style questions to ensure that students can recognise the different antibiotics from descriptions.

This lesson describes the characteristic features of the three domains and explains why viruses are not included in this classification. The PowerPoint and accompanying resources have been primarily designed to cover points 18.2 (b) & 18.2 (d) of the CIE A-level Biology specification but also contains tasks that challenge the students on their knowledge of taxonomic hierarchy from this topic and the features of virus from topic 1. The lesson begins with an introduction of the microbiologist Carl Woese and goes on to describe how he is most famous for his definition of the Archaea as a new domain of life. Students were introduced to domains and the other classification taxa in the last lesson, so their recall of this knowledge is continually tested and built upon as details are added. Students will discover the key differences between Archaea and Bacteria that led to the splitting of the prokaryotae kingdom and the addition of this higher classification rank and will understand that it wasn’t until 13 years after the discovery that it was adopted. Moving forwards, the rest of the lesson explains why viruses are not included in this classification and outlines how they are classified, according to the ICTV, through the type of nucleic acid they contain and whether this is single-stranded or double-stranded

This lesson describes the uses and implications of pre-implantation genetic diagnosis, amniocentesis and chorionic villus sampling. The lesson PowerPoint and accompanying worksheets have been primarily designed to cover point 2.15 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification but regular links are made to the earlier content of topics 1 & 2, and their knowledge of topics including the heart and circulation, monohybrid inheritance and cystic fibrosis are tested. The lesson begins by challenging them to use this prior knowledge of topic 2 to identify the letters in the abbreviations PGD and CVS. The involvement of IVF to obtain the embryos (or oocytes) is then discussed and a series of exam-style questions are used to get them to understand how this method screens embryos prior to implantation, so that those identified as having genetic diseases or being carriers are not inserted into the female’s uterus. Mark schemes for all of the questions included in this lesson are embedded into the PowerPoint so students can constantly assess their progress. Moving forwards, Down syndrome (trisomy 21) is used as an example of a chromosomal abnormality that can be tested for using CVS or amniocentesis. Time is taken to describe the key details of both of these procedures so students have a clear understanding of the implications and the invasiveness to the female being tested. The link between amniocentesis and an increased risk of miscarriage is considered and the results of a 2006 study are used to challenge them on their data skills.

This lesson outlines how bacteria become resistant to antiobiotics and discusses its consequences and the steps taken to reduce its impact. The PowerPoint and accompanying worksheet have been designed to cover specification points 10.2 (b & c) of the CIE A-level Biology specification President Trump’s error ridden speech about antibiotics is used at the beginning of the lesson to remind students that this is a treatment for bacterial infections and not viruses as he stated. Moving forwards, 2 quick quiz competitions are used to introduce MRSA and then to get the students to recognise that they can use this abbreviation to remind them to use mutation, reproduce, selection (and survive) and allele in their descriptions of the development of resistance by evolution through natural selection. The main task of the lesson challenges the students to form a description to explain how this strain of bacteria developed resistance to methicillin, making use of the five key terms emphasised above. Moving forwards, there is a focus on the hospital as the common location for MRSA infections and students will recognise that this opportunistic pathogen can infect through open wounds to cause sepsis and potentially death. Figures from infections and deaths in hospitals in the US are used to increase the relevance and students will learn how a MRSA prevention program in VHA facilities includes screening of surgery patients to try to reduce its impact. The lesson concludes with a discussion about other methods that can be used by hospitals and general practitioners to reduce the impact of MRSA and to try to prevent the development of resistance in other strains.

This lesson looks at the structure of the DNA that is found in the nucleus, mitochondria and chloroplasts of eukaryotic cells and in prokaryotic cells. Both the engaging PowerPoint and accompanying resources have been designed to cover point 2.1.3 (d)(i) of the OCR A-level Biology A specification. As students will already have some knowledge of this nucleic acid from GCSE and from the earlier A-level topics, the lesson has been written to build on this prior knowledge and then to add key detail. As well as focusing on the differences between the DNA found in these two types of cells which includes the length, shape and association with histones, the various tasks will ensure that students are confident to describe how this double-stranded polynucleotide is held together by hydrogen and phosphodiester bonds. This knowledge of phosphodiester bonds means that specification point 2.1.3 © is also covered during this lesson. These tasks include exam-style questions which challenge the application of knowledge as well as a few quiz competitions to maintain engagement.

This detailed lesson describes the role of the mRNA, tRNA, rRNA and amino acids during the second stage of protein synthesis - translation. Both the PowerPoint and accompanying resources have been designed to cover the second part of point 2.1.3 (g) of the OCR A-level Biology A specification and continually links back to the previous lessons in this module on the structure of DNA and RNA and the genetic code Translation is a topic which is often poorly understood and so this lesson has been written to enable the students to understand how to answer the different types of questions by knowing and including the key details of the structures involved. The lesson begins by challenging the students to consider why it is so important that the amino acids are assembled in the correct order during the formation of the chain. Moving forwards, a quick quiz round called “LOST IN TRANSLATION” is used to check on their prior knowledge of the mRNA strand, the tRNA molecules, the genetic code and the ribosomes. The next task involves a very detailed description of translation that has been divided into 14 statements which the students have to put into the correct order. By giving them a passage that consists of this considerable detail, they can pick out the important parts to use in the next task where they have to answer shorter questions worth between 3 and 4 marks. These types of questions are common in the assessments and by building up through the lesson, their confidence to answer this type should increase. The final two tasks of the lesson involve another quiz, where the teams compete to transcribe and translate in the quickest time before using all that they have absorbed to answer some questions which involve the genetic code and the mRNA codon table

This fully-resourced lesson describes the effects of enzyme and substrate concentration on enzyme activity. The PowerPoint and accompanying resources are the third in a series of 3 lessons which cover the details of point 2.1.4 (d) [i] of the OCR A-level Biology A specification and students are also challenged on their recall of the details of transcription and translation as covered in module 2.1.3. The first part of the lesson describes how an increase in substrate concentration will affect the rate of reaction when a fixed concentration of enzyme is used. Time is taken to introduce limiting factors and students will be challenged to identify substrate concentration as the limiting factor before the maximum rate is attained and then they are given discussion time to identify the possible factors after this point. A series of exam-style questions are used throughout the lesson and the mark schemes are displayed to allow the students to assess their understanding and for any misconceptions to be immediately addressed. Moving forwards, the students have to use their knowledge of substrate concentration to construct a graph to represent the relationship between enzyme concentration and rate of reaction and they have to explain the different sections of the graph and identify the limiting factors. The final section of the lesson describes how the availability of enzymes is controlled in living organisms. Students will come to recognise that this availability is the result of enzyme synthesis and enzyme degradation and a SPOT THE ERRORS task is used to challenge their recall of protein synthesis. Please note that this lesson explains the Biology behind the effect of concentration on enzyme activity and not the methodology involved in carrying out such an investigation as this is covered in the lessons designed in line with point 2.1.4 (d) [ii]

This lesson describes the different types of pathogens that can cause communicable diseases in plants and animals. The PowerPoint and accompanying worksheets have been primarily designed to cover point 4.1.1 (a) of the OCR A-level Biology specification but as this is the first lesson in module 4, it has been specifically planned to make links to upcoming topics such as phagocytosis, vaccinations and classification. viruses - HIV/AIDS, influenza, TMV bacteria - TB, cholera, ring rot protoctista - malaria fungi - athlete’s foot, black sigatoka, ringworm, The diseases shown above are covered by the detailed content of this lesson and the differing mechanisms of action of the four types of pathogens are discussed and considered throughout. For example, time is taken to describe how HIV uses a glycoprotein to attach to T helper cells whilst toxins released by bacteria damage the host tissue and the Plasmodium parasite is transmitted from one host to another by a vector to cause malaria. The accompanying worksheets contain a range of exam-style questions, including a mathematical calculation, and mark schemes are embedded into the PowerPoint to allow students to immediately assess their understanding.

This lesson describes and explains how increasing the concentration of inhibitors affects the rate of an enzyme-catalysed reaction. The PowerPoint and accompanying resource are the last in a series of 4 lessons which cover the content detailed in point 3.2 (a) of the CIE A-level Biology specification but this lesson also covers point 3.2 [c] as competitive and non-competitive inhibitors are introduced and their differing effects on enzyme activity described and explained. The lesson begins with a made up round of the quiz show POINTLESS called “Biology opposites” and this allows students to recognise that inhibition is the opposite of stimulation. This introduces inhibitors as substances that reduce the rate of a reaction and students are challenged to use their general knowledge of enzymes to identify that inhibitors prevent the formation of the enzyme-substrate complex. Moving forwards, a quick quiz competition generates the abbreviation EIC (representing enzyme-inhibitor complex) and this introduces competitive inhibitors as substances that occupy the active site. The students are asked to apply their knowledge to a new situation to work out that these inhibitors must have a similar shape to the enzyme’s substrate molecule. A series of exam-style questions are used throughout the lesson and at this point, the students are challenged to work out that an increase in the substrate concentration would reduce the effect of a fixed concentration of a reversible competitive inhibitor. The rest of the lesson focuses on non-competitive inhibitors and time is taken to ensure that key details such as the disruption of the tertiary structure is understood and biological examples are used to increase the relevance. Again, students will learn that increasing the concentration of the inhibitor results in a greater inhibition and a reduced rate of reaction but that increasing the substrate concentration cannot reduce the effect as was observed with competitive inhibitors.

This fully-resourced lesson describes the behaviour of chromosomes during the mitotic cell cycle and explains the importance of this type of nuclear division. The PowerPoint and accompanying resources have been designed to cover points 5.1 (b) & 5.2 (a) of the CIE A-level Biology specification and make direct links to a previous lesson which covered the outline of cell cycle Depending upon the exam board taken at iGCSE, the knowledge and understanding of mitosis will differ considerably between students and there may be a number of misconceptions. This was considered at all points during the planning of the lesson so that existing errors are addressed and key points are emphasised throughout. Their understanding of interphase is challenged at the start of the lesson to ensure that they realise that it is identical pairs of sister chromatids that enter the M phase. The main part of the lesson focuses on prophase, metaphase, anaphase and telophase and describes how the chromosomes behave in these stages. There is a focus on the centrioles and the spindle fibres that they produce which contract to drag one chromatid from each pair in opposite directions to the poles of the cell. The remainder of the lesson is a series of understanding and application questions where students have to identify the various roles of mitosis in living organisms as well as tackling a Maths in a Biology context question. The lesson concludes with a final quiz round of MITOSIS SNAP where they only shout out this word when a match is seen between the name of a phase, an event and a picture.

This REVISION lesson contains an engaging powerpoint (45 slides) and is fully-resourced with associated worksheets. The lesson uses a range of activities which include exam questions (with displayed answers), differentiated tasks and quiz competitions to engage students whilst they assess their knowledge of the content that is found within topics P12 (Magnetism and the motor effect) and P13 (Electromagnetic induction) of the Edexcel GCSE Combined Science specification. Generally, these topics are poorly understood by students but are regularly assessed through questions in the GCSE exams and so time has been taken to design the lesson so that the key points are covered and common misconceptions addressed. The following specification points are covered in this lesson: Recall that unlike magnetic poles attract and like magnetic poles repel Explain the difference between permanent and induced magnets Describe the use of plotting compasses to show the shape and direction of the field of a magnet and the Earth’s magnetic field Explain how the behaviour of a magnetic compass is related to evidence that the core of the Earth must be magnetic Explain that magnetic forces are due to interactions between magnetic fields Recall and use Fleming’s left-hand rule to represent the relative directions of the force, the current and the magnetic field for cases where they are mutually perpendicular Use the equation which connects force on a conductor, magnetic flux density, current and length Recall that a transformer can change the size of an alternating voltage Explain why, in the national grid, electrical energy is transferred at high voltages from power stations, and then transferred at lower voltages in each locality for domestic uses as it improves the efficiency by reducing heat loss in transmission lines Explain where and why step-up and step-down transformers are used in the transmission of electricity in the national grid Use the power equation (for transformers with 100% efficiency) This lesson is suitable for use throughout the duration of the GCSE course, as an end of topic revision lesson or as a lesson in the lead up to mocks or the actual GCSE exams

This lesson has been designed to cover the higher tier content of specification point 5.3.4 (Hormones in human reproduction) which is found in topic 5 of the AQA GCSE Biology & Combined Science specifications. A wide range of activities will engage and motivate the students whilst the content is covered in detail and understanding checks are included at regular points to enable the students to self-assess their new found knowledge. The following Biology is covered in this lesson: Reproductive hormones in the development of secondary sexual characteristics The role of testosterone as the main male reproductive hormone The role of oestrogen and progesterone in the repair and maintenance of the uterus lining The role of FSH and LH in the maturation of an egg and ovulation The interaction of these four hormones in the control of the menstrual cycle The final part of the lesson involves a number of questions where the students are challenged to apply their knowledge to unfamiliar situations This lesson has been designed for GCSE-aged students who are taking the AQA GCSE Biology or Combined Science course but it is also suitable for younger students who are looking into this topic as part of the reproduction module

This engaging REVISION lesson has been designed to cover the content of topic 3 (Enzymes) of the CIE International A-level Biology specification. A wide range of activities have been written into the lesson to engage the students whilst they assess their understanding of the topic content. All of the exam questions contain detailed answers which students can use to identify missed marks and quiz competitions are used, like FROM NUMBERS 2 LETTERS (shown in the cover image) to recall key concepts and check on the finer details. The lesson has been planned to cover as much of the specification content as possible but the following sub-topics have received particular attention: Enzymes as globular proteins that act as biological catalysts Formation of the enzyme-substrate complex The lock and key theory and induced-fit hypothesis Competitive and non-competitive inhibitors The Michaelis-Menten constant The effect of changes in pH and temperature on the tertiary structure of the enzymes The immobilisation of enzymes using alginate Time has been taken in the design to ensure that links to other topics are made. For example, when checking the knowledge of the denaturation of enzymes due to pH and temperature, the bonds found in the tertiary structure are recalled and considered in depth.

This lesson guides students through the use of genetic diagrams to solve problems involving monohybrid and dihybrid crosses. The engaging PowerPoint and accompanying worksheets have been designed to cover the part of topic 16.2 (b) of the CIE A-level Biology specification which involves the inheritance of one or two genes As you can see from the cover image, this lesson uses a step by step guide to go through each important stage of drawing the genetic cross. Extra time is taken over step 2 which involves writing out the different possible gametes that a parent can produce. This is the step where students most commonly make mistakes so it is critical that the method is understood. Helpful hints are also given throughout, such as only writing out the different possible gametes in order to avoid creating unnecessary work. Students are shown how to answer an example question so that they can visualise how to set out their work before they are challenged to try two further questions. This first of these is differentiated so that even those students who find this very difficult are able to access the learning. The final question will enable the students to come up with the ratio 9:3:3:1 and they will be shown how they can recognise when this should be the expected ratio as this links to the chi-squared test which is covered later in the topic.

This fully-resourced lesson looks at how heart rate is controlled by the cardiovascular control centre in the medulla oblongata. The engaging and detailed PowerPoint and accompanying resources have been designed to cover the first part of point 7.9 (ii) of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification but also ties in well with previously covered topics and provides a good introduction to control systems which are covered later in topic 7 and 8. This lesson begins with a prior knowledge check where students have to identify and correct any errors in a passage about the conduction system of the heart. This allows the SAN to be recalled as this structure play an important role as the effector in this control system. Moving forwards, the three key parts of a control system are recalled as the next part of the lesson will specifically look at the range of sensory receptors, the coordination centre and the effector. Students are introduced to chemoreceptors and baroreceptors and time is taken to ensure that the understanding of the stimuli detected by these receptors is complete and that they recognise the result is the conduction of an impulse along a neurone to the brain. A quick quiz is used to introduce the medulla oblongata as the location of the cardiovascular centre. The communication between this centre and the SAN through the autonomic nervous system can be poorly understood so detailed explanations are provided and the sympathetic and parasympathetic divisions compared. The final task challenges the students to demonstrate and apply their understanding by writing a detailed description of the control and this task has been differentiated three ways to allow differing abilities to access the work

This clear and detailed lesson describes the process of oxidative phosphorylation, including the roles of the electron carriers, oxygen and the mitochondrial cristae. The PowerPoint has been designed to cover points 12.2 (f) and (g) of the CIE International A-level Biology specification and includes details of the electron transport system, the flow of protons and ATP synthase. The lesson begins with a discussion about the starting point of the reaction. In the previous stages, the starting molecule was the final product of the last stage but in this stage, it is the reduced coenzymes which release their hydrogen atoms. Moving forwards, the process of oxidative phosphorylation is covered in 7 detailed steps and at each point, key facts are discussed and explored in further detail to enable a deep understanding to be developed. Students will see how the proton gradient across the inner membrane is created and that the flow of protons down the channel associated with ATP synthase results in a conformational change and the addition of phosphate groups to ADP by oxidative phosphorylation. Understanding checks are included throughout the lesson to enable the students to assess their progress and prior knowledge checks allow them to recognise the clear links to other topics and modules. This lesson has been written to tie in with the other uploaded lessons on glycolysis, the Link reaction and the Krebs cycle

This detailed lesson introduces the four stages of aerobic respiration and looks at the relationship between structure and function of the mitochondrion. The engaging PowerPoint and accompanying resource have been designed to cover points 12.2 (a) and (i) of the CIE International A-level Biology specification which states that students should be able to demonstrate and apply an understanding of the inner and outer mitochondrial membranes, cristae, matrix and mitochondrial DNA. The lesson begins with an introduction to glycolysis and students will learn how this first stage of aerobic respiration is also the first stage when oxygen isn’t present. A version of “GUESS WHO” challenges students to use a series of structural clues to whittle the 6 organelles down to just the mitochondrion so that they can learn how the other three stages take place inside this organelle. Moving forwards, the key components of the organelle are identified on a diagram. Students are introduced to the stages of respiration so that they can make a link to the parts of the cell and the mitochondria where each stage occurs. Students will learn that the presence of decarboxylase and dehydrogenase enzymes in the matrix along with coenzymes and oxaloacetate allows the Link reaction and the Krebs cycle to run. Finally, time is taken to introduce the electron transport chain and the enzyme, ATP synthase, so that students can begin to understand how the flow of protons across the inner membrane results in the production of ATP.

This detailed lesson looks at each of the stages of aerobic respiration and explains how this reaction is a multi-stepped process where each step is controlled by an enzyme. The engaging PowerPoint and accompanying resource have been designed to cover points 7.3 (i) and (ii) of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification. The lesson begins with an introduction to glycolysis and students will learn how this first stage of aerobic respiration is also the first stage when oxygen is not present. This stage involves 10 reactions and an opportunity is taken to explain how each of these reactions is catalysed by a different, specific intracellular enzyme. A version of “GUESS WHO” challenges students to use a series of structural clues to whittle the 6 organelles down to just the mitochondrion so that they can learn how the other three stages take place inside this organelle. Moving forwards, the key components of the organelle are identified on a diagram. Students are introduced to the stages of respiration so that they can make a link to the parts of the cell and the mitochondria where each stage occurs. Students will learn that the presence of decarboxylase and dehydrogenase enzymes in the matrix along with coenzymes and oxaloacetate allows the link reaction and the Krebs cycle to run and that these stages produce the waste product of carbon dioxide. Finally, time is taken to introduce the electron transport chain and the enzyme, ATP synthase, so that students can begin to understand how the flow of protons across the inner membrane results in the production of ATP and the atmospheric oxygen being reunited with hydrogen.

This engaging and fully-resourced lesson looks at how genetic drift can arise after a genetic bottleneck or as a result of the Founder effect. The detailed PowerPoint and accompanying resources have been designed to cover point 17.2 © of the CIE International A-level Biology specification which states that students should be able to explain how the Founder effect and genetic drift may affect allele frequencies in populations. A wide range of examples are used to show the students how a population that descends from a small number of parents will have a reduction in genetic variation and a change in the frequency of existing alleles. Students are encouraged to discuss new information to consider key points and understanding checks in a range of forms are used to enable them to check their progress and address any misconceptions. Students are provided with three articles on Huntington’s disease in South Africa, the Caribbean lizards and the plains bison to understand how either a sharp reduction in numbers of a new population beginning from a handful of individuals results in a small gene pool. Links to related topics are made throughout the lesson to ensure that a deep understanding is gained.