This revision lesson provides students with the opportunity to assess their understanding of homeostasis (topic 14). The lesson includes a multiple-choice assessment of 10 questions and a PowerPoint containing the answers, where each answer slide shows the exact specification code to enable students to note the areas which may require extra attention. The PowerPoint also contains additional questions to challenge content from topic 14 of the CIE A-level biology specification (2025 - 2027 update) that isn’t directly covered by the 10 questions, and prior knowledge checks to encourage students to make links to content from any of topics 1 - 13.

This lesson describes the main characteristics of benign and malignant tumours. The PowerPoint and accompanying resource are part of the 1st lesson in a series of 2 lessons which have been planned to cover the content of point 8.2.3 of the AQA A-level biology specification. This lesson begins by challenging the students to recognise the process of mitosis from a single clue. This single clue is “a controlled process” and has been designed to remind them that mitosis is a process controlled by genes. A quick quiz round challenges their recall of the details of the mitotic cell cycle to reveal the key term, tumour, and this introduces the idea that a mutation to one of the genes leads to uncontrolled cell division and the formation of tumours. Moving forwards, the lesson considers the features of benign tumours, beginning with the key point that these masses of cells are not cancerous. Students will learn that their growth rate is slower than malignant tumours, and due to a covering of fibrous connective tissue, the cells do not invade neighbouring tissues. However, the lesson points out that due to mass effect, benign tumours can cause secondary pathological effects such as organ damage. This leads into a task where the students are challenged on their knowledge of osmoregulation, digestion and blood glucose regulation to identify the tissues which are impacted. The rest of the lesson describes the features of malignant tumours and time is spent considering how the ability of these cells to metastasise makes them so dangerous.

This lesson describes how the loop of Henle acts as a countercurrent multiplier to increase the reabsorption of water. The PowerPoint and accompanying resource are part of the 2nd lesson in a series of 2 lessons which have been designed to cover point 9.9 (iii) of the Edexcel A-level biology B specification but also considers the structure of the kidney in the kangaroo rat and therefore also covers point 9.9 (v). The lesson begins by challenging the students to recognise that the glomerular filtrate entering the loop will only contain water, ions and urea if the kidneys are functioning properly. Time is then taken to look at the structure of the loop of Henle, focusing on the descending and ascending limbs, and their differing permeabilities. Students will be reminded that this part of the nephron is located in the renal medulla, before a step-by-step guide is used to describe how the transfer of ions, particularly sodium ions, from the ascending limb to the descending limb, creates a very negative water potential in this region of the kidney. This allows water to move out of the descending limb to the tissue fluid and then into the capillaries. The next part of the lesson challenges students to consider the bigger picture as they learn that this decreasing water potential in the medulla allows water to be reabsorbed from the filtrate in the collecting duct too. The remainder of the lesson uses the real-world examples of the hopping mouse and kangaroo rat to check student understanding, and there are also prior knowledge checks to encourage students to make links to relevant content from earlier topics. All answers are embedded into the PowerPoint.

This lesson describes the protective effect of a simple reflex, as exemplified by those which involve the sensory, relay and motor neurones. The PowerPoint and accompanying resources are part of the final lesson in a series of 3 lessons which have been planned to cover the content of point 6.1.1 of the AQA A-level biology specification, titled “Survival and response”. As shown on the cover image, the lesson begins with a challenge, where the students have to recognise the connection between key terms which have been grouped together. This will remind them of the names of three types of neurones, the three types of muscle tissue and some reflexes. Time is taken at the start to ensure that students understand that although the brain might be informed of a reflex, it isn’t involved in the processing to coordinate the movement. At the same time, the role of the other part of the CNS, the spinal cord in spinal reflexes, is emphasised. This lesson has been specifically planned to build on their knowledge of reflex actions from GCSE and to build in the detail that will support them in this lesson and as they move through the content of topic 6. Ultimately, students will understand how the rapid response of a simple reflex allows organisms to avoid damage and survive, due to the nervous pathway only consisting of three neurones, and therefore less synapses than other reactions. Understanding checks, in the form of exam-style questions are written into the lesson and the answers embedded into the PowerPoint to allow students to assess their progress against the current topic. The two other lessons in this series covering the detail of specification point 6.1.1 are named “responses in flowering plants” and “taxes and kineses”.

This lesson uses a 10 question multiple-choice assessment to provide students with the opportunity to assess their knowledge of neuronal communication. Module 5.1.3 of the OCR A-level biology A specification covers the role of mammalian sensory receptors, the structure and function of neurones, the generation and transmission of nerve impulses and the structure and roles of synapses and these 10 questions attempt to challenge their overall understanding of this content. The lesson also includes a PowerPoint with the answers to the questions and also further understanding checks to challenge knowledge not directly covered by the multiple-choice assessment. There are also some prior knowledge checks and links to the future.

This lesson describes how epigenetics is the control of gene expression by factors other than changes in the DNA sequence. The PowerPoint and accompanying resources have been planned to cover the content of point (h) from topic 3 of A2 unit 4 of the WJEC A-level biology specification. As shown in the cover image, the lesson began with a challenge, where the students had to recognise that the prefix epi could go before 4 terms. They will learn that this prefix means on or above in Greek meaning epigenetics can be described as factors causing changes to gene function beyond the genetic code. One of several discussion periods is used to encourage them to identify what is not involved here (i.e. gene mutations), and so, epigenetics is introduced as heritable changes in gene function without changes to the base sequence. Moving forwards, the process of DNA methylation is introduced, and students are challenged to predict how the addition of a methyl group could inhibit transcription before they have to use their prior knowledge of key terms to complete a passage about this concept. The details of a study which considered the correlation between DNA methylation and atherosclerosis are provided to broaden their knowledge and then they have to answer questions about the study using their knowledge of content from previously covered topics. The remainder of the lesson discusses acetylation and students will learn that the removal of acetyl groups from histones causes the chromatin to become highly condensed and prevents the transcription of the gene.

This lesson focuses on the main areas of the spinal cord but also introduces key nervous system structures to prepare students for upcoming topic 8 lessons. The PowerPoint and accompanying resource have been planned to cover the content of points (b & c) of topic 8 of A2 unit 3 of the WJEC A-level biology specification. The lesson begins with a challenge, where students must use their knowledge of content from earlier topics to reveal 5 numbers that add up to 33. They will learn that this is the normal number of vertebrae in the human vertebral column and this leads into the recognition that these bones act to surround and protect the spinal cord. The meninges are introduced and then a quick quiz round is used to reveal the term, grey matter. Students will see that this is found in the centre of the spinal cord and is surrounded by an outer region of white matter. The idea of myelination is introduced, and initial details provided about the increased conductance speed in myelinated neurones because of saltatory conduction. Moving forwards, students will meet the terms dorsal and ventral and see on a diagram that nerves enter and leave the cord by these roots. The role of cerebrospinal fluid is explored and a series of exam-style questions are used to challenge their knowledge from topic 4 as well as their mathematical skills. The answers are embedded into the PowerPoint to allow the students to assess their progress. The lesson finishes with the introduction of the cauda equina as the bundle of nerves at the distal end of the spinal cord.

This lesson describes the simple reflex arc as a basis for rapid, involuntary and protective actions. The PowerPoint and accompanying resources have been designed to cover the content of point (d) of topic 8 of A2 unit 3 of the WJEC A-level biology specification. At the start of the lesson, the students are challenged to recognise the connections between three groups of key terms, and this acts to remind them of the sensory, motor and relay neurone, different types of muscle tissue and some reflexes. Time is taken to ensure that students understand that a simple spinal reflex arc is a direct neural pathway through the spinal cord and does not involve processing by the brain. Some of the content was covered at GCSE and in the first lessons of topic 8, so this lesson has been specifically planned to challenge their recall of this content and then to build upon it, and understanding and prior knowledge checks are used throughout to allow them to assess their progress. The students will be able to recognise the different matter of the spinal cord, which is named according to the presence of myelinated or unmyelinated neurones and they will also understand how sensory neurones enter via the dorsal root and motor neurones exit via the ventral root. Moving forwards, two examples of real biological reflexes are used to increase relevance, and students will see how the knee jerk reflex is unusual as it doesn’t contain a relay neurone. References to synapses, myelination and saltatory conduction are included in the lesson and brief details provided before these are covered in upcoming topic 8 lessons.

This lesson describes how the use of excess fertilisers to replace lost ions and then leaching can lead to environmental issues like eutrophication. The PowerPoint and accompanying resources are part of the final lesson in a series of 3 lessons which have been designed to cover point 5.4 (Nutrient cycles) of the AQA A-level biology specification. The lesson begins with a reminder of the key term, continuous monoculture, which students encountered during a lesson on conservation and farming in topic 4. This process, where the same crops are planted season after season leads to the same mineral ions being removed from the soil and not replenished, and this introduces the idea that the harvesting of crops removes minerals from the ecosystem. Students will understand that removing livestock has a similar effect, before they are challenged to recognise that the addition of natural and artificial fertilisers can replace these ions. At this stage, a series of prior knowledge checks are used to challenge their ability to make links to the nitrogen and phosphorus cycle. All answers are embedded in the PowerPoint to allow the students to assess their progress. Moving forwards, a quick task challenges their knowledge of biological numbers to flow through the alphabet and this reveals the key term, leaching. This leads into a step-by-step guide through the stages of eutrophication. The other two lessons in this series describe the nitrogen and phosphorus cycle.

This fully-resourced lesson explores the contributions of chromosome mutations to genetic variation. The engaging PowerPoint and accompanying worksheets have been designed and written to cover the part of point 6.1.2 (a) of the OCR A-level Biology A specification which states that students should be able to demonstrate and apply their knowledge and understanding of the contribution of genetic factors to phenotypic variation Over the course of the lesson, students will encounter a number of chromosome mutations and see the conditions which they cause. Time is taken to look at non-disjunction and how this can result in Down, Turner’s and Klinefelter’s syndromes. Students are guided through a description of the formation of gametes and zygotes with abnormal numbers of chromosomes before being challenged to describe the formation of a zygote with Turner’s syndrome. Moving forwards, translocation and polyploidy are also discussed. Progress checks are written into the lesson at regular intervals, that not only check the learning from this lesson but also from related topics (such as meiosis) and this enables the students to constantly assess their understanding.

This is a fully-resourced revision lesson that uses a combination of exam questions, understanding checks, quick tasks and quiz competitions to enable students to assess their understanding of the content found within Module 5.1.3 (Neuronal communication) of the OCR A-level Biology A specification. The sub-topics and specification points that are tested within the lesson include: The structure and function of sensory, motor and relay neurones The generation and transmission of nerve impulses in mammals The structure and roles of synapses in neurotransmission Students will be engaged through the numerous quiz rounds such as “Communicate the word” and “Only CONNECT” whilst crucially being able to recognise those areas which require their further attention during general revision or during the lead up to the actual A-level terminal exams

This revision resource has been designed with the simple aim of motivating the students whilst they assess their understanding of the content found in module 4.2.2 (Classification and evolution) of the OCR A-level Biology A specification. This module is often brushed over by students which leads to misconceptions and therefore time has been taken to explain the important concepts so that key points are recalled and retained. The resource includes a detailed and engaging Powerpoint (85 slides) and associated worksheets, some of which are differentiated to allow students of differing abilities to access the work. The range of activities have been designed to cover as much of the content as possible but the following sub-topics have been given particular attention: The biological classification of a species Classification hierarchy The three-domain and five-kingdom classification The features of the five kingdoms Phylogenetic trees Anatomical, physiological and behavioural adaptations Calculating the standard deviation Continuous and discontinuous variation In addition to these topics, some topics from other modules such as cell division and prokaryotic cells are tested in order to challenge the students on their ability to make links between the modules. The range of activities include exam questions and understanding checks as well as quiz competitions to maintain student engagement.

This revision resource has been written to include a range of activities that motivate the students whilst they assess their understanding of the content found in module 2.1.5 (Biological membranes) of the OCR A-level Biology A specification. The resource includes a detailed and engaging Powerpoint (71 slides) and associated worksheets The range of activities have been designed to cover as much of the content as possible but the following sub-topics have been given particular attention: The movement of molecules by active transport which requires ATP as an immediate source of energy The movement of molecules by passive processes The use of membrane-spanning proteins in facilitated diffusion and active transport Factors that increase the rate of simple diffusion The movement of water across membranes by osmosis The effects that solutions of different water potentials can have on animal and plant cells The fluid mosaic model of membrane structure The roles of the components of the plasma cell membrane In addition to these topics, some topics from other modules such as organelles, synapses and autoimmune diseases are tested in order to challenge the students on their ability to make links between the modules. The range of activities include exam questions and understanding checks as well as quiz competitions to maintain student engagement.

This detailed lesson has been written to cover the part of specification point 5.1.2 © of the OCR A-level Biology A specification which states that students should be able to demonstrate and apply an understanding of the process of ultrafiltration. The aim of the design was to give the students the opportunity to discover this particular function and to be able to explain how the mechanisms found in the glomerulus and the Bowman’s capsule control the movement of small molecules out of the blood plasma. Key terminology is used throughout and students will learn how the combination of the capillary endothelium and the podocytes creates filtration slits that allow glucose, water, urea and ions through into the Bowman’s capsule but ensure that blood cells and plasma proteins remain in the bloodstream. A number of quiz competitions are used to introduce key terms and values in a fun and memorable way whilst understanding and prior knowledge checks allow the students to assess their understanding of the current topic and to challenge themselves to make links to earlier topics. The final task of the lesson challenges the students to apply their knowledge by recognising substances found in a urine sample that shouldn’t be present and to explain why this would cause a problem This lesson has been written for students studying on the OCR A-level Biology A course and ties in nicely with the other 5.1.2 kidney lessons on the structure of the nephron, selective reabsorption, osmoregulation and kidney failure

This is a highly-detailed and fully-resourced lesson which covers the detail of specification point 5.1.2 (d) of the OCR A-level Biology A specification which states that students should be able to demonstrate and apply an understanding of the roles of the hypothalamus, posterior pituitary, ADH and the collecting duct in the control of the water potential of the blood. Students learnt about the principles of homeostasis and negative feedback in an earlier module, so this lesson acts to build on that knowledge and challenges them to apply their knowledge. A wide range of activities have been included in the lesson to maintain motivation and engagement whilst the understanding and prior knowledge checks will allow the students to assess their progress as well as challenge themselves to make links to other Biology topics. The lesson begins with a discussion about how the percentage of water in urine can and will change depending on the blood water potential. Students will quickly be introduced to osmoregulation and they will learn that the osmoreceptors and the osmoregulatory centre are found in the hypothalamus. A considerable amount of time is taken to study the cell signalling between the hypothalamus and the posterior pituitary gland by looking at the specialised neurones (neurosecretory cells). Links are made to the topics of neurones, nerve impulses and synapses and the students are challenged to recall the cell body, axon and vesicles. The main section of the lesson forms a detailed description of the body’s detection and response to a low blood water potential. The students are guided through this section as they are given 2 or 3 options for each stage and they have to use their knowledge to select the correct statement. The final task asks the students to write a detailed description for the opposite stimulus and this task is differentiated so those who need extra assistance can still access the work. This lesson has been written for students studying on the OCR A-level Biology A course and ties in nicely with the other uploaded lessons in module 5.1.2 which include the structure of the nephron, ultrafiltration and selective reabsorption.

This lesson looks at the structure of the DNA that is found in the nucleus, mitochondria and chloroplasts of eukaryotic cells and in prokaryotic cells. Both the engaging PowerPoint and accompanying resources have been designed to cover point 2.1.3 (d)(i) of the OCR A-level Biology A specification. As students will already have some knowledge of this nucleic acid from GCSE and from the earlier A-level topics, the lesson has been written to build on this prior knowledge and then to add key detail. As well as focusing on the differences between the DNA found in these two types of cells which includes the length, shape and association with histones, the various tasks will ensure that students are confident to describe how this double-stranded polynucleotide is held together by hydrogen and phosphodiester bonds. This knowledge of phosphodiester bonds means that specification point 2.1.3 © is also covered during this lesson. These tasks include exam-style questions which challenge the application of knowledge as well as a few quiz competitions to maintain engagement.

This clear and concise lesson explores the importance of coenzymes in cellular respiration as detailed in point 5.2.2 (f) of the OCR A-level Biology A specification. Students encountered coenzymes in module 2.1.4 as well as looking at the roles of NAD, CoA and FAD whilst learning about glycolysis, the link reaction and Krebs cycle earlier in this module. Therefore this lesson was designed to check on their understanding of the importance of these roles and goes on to explain how the transport of the protons and electrons to the mitochondrial cristae is key for the production of ATP. This lesson has been written to tie in with the other uploaded lessons in module 5.2.2 which include the mitochondria, glycolysis, the link reaction and the Krebs cycle