This fully-resourced lesson explains how genetic fingerprinting can be used to analyse DNA fragments and explores its applications in forensic science and medical diagnosis. The engaging and detailed PowerPoint and accompanying resource have been written to cover all of point 8.4.3 of the AQA A-level Biology specification
Each step of the genetic fingerprinting process is covered and time is taken to ensure that key details are understood. Students will be introduced to VNTRs and will come to recognise their usefulness in human identification as a result of the variability between individuals. Moving forwards, the involvement of the PCR and restriction enzymes are discussed and students are challenged on their knowledge of this process and these substances as they were encountered in a previous sub-topic. The main section of the lesson focuses on the use of gel electrophoresis to separate DNA fragments (as well as proteins) and the key ideas of separation due to differences in base pair length or molecular mass are discussed and explained. As well as current understanding checks, an application question involving Huntington’s disease is used to challenge their ability to apply their knowledge of the process to an unfamiliar situation. The remainder of the lesson describes how the DNA is transferred to a membrane and hybridisation probes are used to create a pattern on the X-ray film.
Time has been taken to make continuous links to the previous lessons in topic 8 as well as those from topic 4 where DNA, RNA and protein synthesis were introduced.
Get this resource as part of a bundle and save up to 30%
A bundle is a package of resources grouped together to teach a particular topic, or a series of lessons, in one place.
Bundle
Topic 8: The control of gene expression (AQA A-level Biology)
Each of the 12 lessons included in this bundle have been written to specifically cover the content as detailed in topic 8 of the AQA A-level Biology specification (The control of gene expression). The wide range of activities will maintain engagement whilst supporting the explanations of the biological knowledge to allow the students to build a deep understanding of this potentially difficult topic! Lessons which cover the following specification points are included in this bundle: * Gene mutations and their effect on the structure of proteins * Most of a cell's DNA is not translated * Totipotent, pluripotent, multipotent and unipotent stem cells * Regulation of transcription by transcription factors * The role of oestrogen in initiating transcription * Epigenetic control of gene expression in eukaryotes * Inhibition of transcription by increased DNA methylation or decreased acetylation of histones * Translation of mRNA can be inhibited by RNA interference * The main characteristics of benign and malignant tumours * Determining the genome of simpler organisms to determine the proteome and its applications * The development of DNA sequencing methods * The production of DNA fragments through use of enzymes or a gene machine * The role of the PCR to amplify DNA fragments * The transfer of DNA into a host cell * The use of labelled DNA probes to screen patients for heritable conditions, drug responses and to identify health risks * VNTRs * The technique of genetic fingerprinting to analyse DNA fragments If you would like to see the quality of the lessons, download the producing DNA fragments and DNA methylation and acetylation lessons as these have been uploaded for free
£21.75
Bundle
Topics 8.3 & 8.4: Genome projects and gene technologies (AQA A-level Biology)
All 6 lessons included in this bundle have been written to cover the detailed content of topics 8.3 and 8.4 of the AQA A-level Biology specification. These topics can provide a series of problems for students so clear explanations are used throughout the lesson as well as regular understanding checks so any misconceptions are immediately addressed. The variety of tasks will maintain engagement whilst displayed mark schemes allow students to assess their answers and add detail where it is missing. The following specification points are covered: 8.3: Using genome projects 8.4.1: Recombinant DNA technology 8.4.2: Differences in DNA between individuals of the same species can be exploited 8.4.3: Genetic fingerprinting If you would like to sample the quality of the lessons first, why not download the lesson on producing DNA fragments which has been uploaded for free
£10.85
Bundle
Gene technologies (Topic 8.4 AQA A-level biology)
This bundle contains 5 detailed lessons which have been intricately planned to cover the content of topic 8.4 of the AQA A-level biology specification, which is titled "Gene technologies allow the study and alteration of gene function allowing a better understanding of organism function and the design of new industrial and medical processes". Each lesson contains real-world examples to increase the relevance of the content and is full of tasks as well as understanding and prior knowledge checks. If you would like to sample the quality of these lessons, download the "producing DNA fragments" lesson as this has been uploaded for free.
£8.40
Something went wrong, please try again later.
This resource hasn't been reviewed yet
To ensure quality for our reviews, only customers who have purchased this resource can review it
Report this resourceto let us know if it violates our terms and conditions.
Our customer service team will review your report and will be in touch.
£3.00