A Science teacher by trade, I've also been known to be found teaching Maths and PE! However, strange as it may seem, my real love is designing resources that can be used by other teachers to maximise the experience of the students. I am constantly thinking of new ways to engage a student with a topic and try to implement that in the design of the lessons.
A Science teacher by trade, I've also been known to be found teaching Maths and PE! However, strange as it may seem, my real love is designing resources that can be used by other teachers to maximise the experience of the students. I am constantly thinking of new ways to engage a student with a topic and try to implement that in the design of the lessons.
This bundle of 6 revision lessons challenges the students on their knowledge of the content of topics B1 - B7, C1 - C10 and P1 - P7 of the AQA GCSE Combined Science specification which will be assessed on the 6 terminal GCSE papers. Specifically, the range of tasks which include exam-style questions (with displayed answers), quiz competitions and discussion points, have been designed for students taking the FOUNDATION TIER papers but could also be used with students taking the higher tier who need to ensure that the key points are embedded on some topics.
The majority of the tasks are differentiated 2 or 3 ways so that a range of abilities can access the work whilst remaining challenged by the content.
If you would like to see the quality of these lessons, download the paper 2 and 5 revision lessons as these have been shared for free.
This is a fully-resourced lesson which uses exam-style questions, quiz competitions, quick tasks and discussion points to challenge students on their understanding of topics B5 - B7, that will assessed on PAPER 2. It has been specifically designed for students on the AQA GCSE Combined Science course who will be taking the FOUNDATION TIER examinations but is also suitable for students taking the higher tier who need to ensure that the fundamentals are known and understood.
The lesson has been written to take place at a health clinics day at the local hospital so that the following sub-topics could be covered:
Control of blood glucose concentration
Diabetes type I and II
The endocrine system
The menstrual cycle
Roles of the female and male reproductive hormones
Sexual and asexual reproduction
Meiosis and gametes
Sex determination
Contraception
Evolution of antibiotic-resistant bacteria
Genetic terminology
Inheritance of genetic disorders
The central nervous system
A reflex arc
Classification systems and the binomial naming system
Structural adaptations
Carbon cycle and climate change
In order to maintain challenge whilst ensuring that all abilities can access the questions, the majority of the tasks have been differentiated and students can ask for extra support when they are unable to begin a question. Step-by-step guides have also been written into the lesson to walk students through some of the more difficult concepts such as genetic diagrams and interpreting the results and evolution by natural selection.
Due to the extensiveness of this revision lesson, it is estimated that it will take in excess of 3 teaching hours to complete the tasks and therefore this can be used at different points throughout the course as well as acting as a final revision before the PAPER 2 exam.
All 6 lessons included in this bundle have been written to cover the detailed content of topics 8.3 and 8.4 of the AQA A-level Biology specification. These topics can provide a series of problems for students so clear explanations are used throughout the lesson as well as regular understanding checks so any misconceptions are immediately addressed. The variety of tasks will maintain engagement whilst displayed mark schemes allow students to assess their answers and add detail where it is missing.
The following specification points are covered:
8.3: Using genome projects
8.4.1: Recombinant DNA technology
8.4.2: Differences in DNA between individuals of the same species can be exploited
8.4.3: Genetic fingerprinting
If you would like to sample the quality of the lessons first, why not download the lesson on producing DNA fragments which has been uploaded for free
This fully-resourced lesson explores how projects to sequence the genomes of both simple and complex organisms can be used. Both the detailed PowerPoint and accompanying resources have been designed to cover the content of point 8.3 of the AQA A-level Biology specification.
The start of the lesson describes each step of Sanger’s chain termination method and demonstrates how this method has paved the way for other projects. The use of the modified nucleotides are explained and links are made to the topic 4 and 2 where protein synthesis and DNA replication were first introduced. Students will learn how the radioactively-labelled nucleotide at the end of each fragment allows the next base to be determined. Key processes like gel electrophoresis are introduced and details provided to support the students when this is encountered in greater detail in 8.4.3. Moving forwards, the applications of sequencing in simple organisms like viruses and bacteria are explored and the students are challenged on their prior knowledge of bacterial pathogenesis and current understanding of sequencing through a series of exam-style questions. The final part of the lesson looks at the difficulties of translating genome knowledge into proteome knowledge and considers the development of automated methods.
Due to the detail and extensiveness of this lesson, it is estimated that it will take in excess of 2 hours of allocated A-level teaching time to cover all of the points which have been written into the various tasks
Each of the 12 lessons included in this bundle have been written to specifically cover the content as detailed in topic 8 of the AQA A-level Biology specification (The control of gene expression). The wide range of activities will maintain engagement whilst supporting the explanations of the biological knowledge to allow the students to build a deep understanding of this potentially difficult topic!
Lessons which cover the following specification points are included in this bundle:
Gene mutations and their effect on the structure of proteins
Most of a cell’s DNA is not translated
Totipotent, pluripotent, multipotent and unipotent stem cells
Regulation of transcription by transcription factors
The role of oestrogen in initiating transcription
Epigenetic control of gene expression in eukaryotes
Inhibition of transcription by increased DNA methylation or decreased acetylation of histones
Translation of mRNA can be inhibited by RNA interference
The main characteristics of benign and malignant tumours
Determining the genome of simpler organisms to determine the proteome and its applications
The development of DNA sequencing methods
The production of DNA fragments through use of enzymes or a gene machine
The role of the PCR to amplify DNA fragments
The transfer of DNA into a host cell
The use of labelled DNA probes to screen patients for heritable conditions, drug responses and to identify health risks
VNTRs
The technique of genetic fingerprinting to analyse DNA fragments
If you would like to see the quality of the lessons, download the producing DNA fragments and DNA methylation and acetylation lessons as these have been uploaded for free
A fully-resourced lesson, which explores how changes to the sequence of bases on DNA may or may not alter protein structure. The engaging PowerPoint and accompanying resources have been designed to cover point 8.1 of the AQA A-level Biology specification and it builds on the knowledge gained during topic 4 when gene mutations were first introduced.
A quiz runs throughout the lesson where students compete to recognise key terms from their definitions and the lesson begins with an edition of this round as they are challenged to recognise the definition for primary structure. Other terms that arise during the lesson relate to the different gene mutations, the genetic code and mutagenic agents. The focus of the lesson is to support students in their explanations of how a particular mutation can result in a change in the primary structure as well as being able to explain why a substitution mutation may not. In this way, their understanding of the degenerate and non-overlapping nature of the genetic code will be tested and any misconceptions can be addressed. The main section of the lesson covers substitution, deletion and addition mutations before translocation, inversion and duplication mutations are introduced. Links are made to the latter parts of topic 8 so students can understand how the change in the sequence of bases may disrupt gene expression. The final part of the lesson looks at a range of mutagenic agents that can increase the rate of mutation.
This extensive and fully-resourced lesson describes the steps in the production of recombinant DNA in genetic technology. Both the engaging PowerPoint and accompanying resources have been written to cover all of the detailed content of topic 19.1 of the CIE International A-level Biology specification apart from the polymerase chain reaction and gel electrophoresis as these are found in other uploaded lessons.
The lesson begins with a definition of recombinant DNA to allow students to begin to understand how this process involves the transfer of DNA fragments from one species to another. Links are made to the genetic code and transcription and translation mechanisms, which were met in topic 6, in order to explain how the transferred gene can be translated in the transgenic organism. Moving forwards, the method involving reverse transcriptase and DNA polymerase is introduced and their knowledge of the structure of the polynucleotides and the roles of enzymes is challenged through questions and discussion points. Restriction enzymes are then introduced and time is taken to look at the structure of a restriction site as well as the production of sticky ends due to the staggered cut on the DNA. A series of exam-style questions with displayed mark schemes are used to allow the students to assess their current understanding.
The second half of the lesson looks at the culture of transformed host cells as an in vivo method to amplify DNA fragments. Students will learn that bacterial cells are the most commonly transformed cells so the next task challenges their recall of the structures of these cells so that plasmid DNA can be examined from that point onwards. The following key steps are described and explained:
• Remove and prepare the plasmid to act as a vector
• Insert the DNA fragment into the vector
• Transfer the recombinant plasmid into the host cell
• Identify the cells which have taken up the recombinant plasmid
• Allow the transformed host cells to replicate and express the novel gene
Time is taken to explore the finer details of each step such as the addition of the promoter and terminator regions, use of the same restriction enzyme to cut the plasmid as was used to cut the gene and the different types of marker genes.
As well as understanding and prior knowledge checks, quick quiz competitions are used throughout the lesson to introduce key terms such as cDNA and EcoR1 in a memorable way.
Due to the detail that is included in this lesson, it is estimated that it will take in excess of 3 hours to cover the points
This fully-resourced lesson explains how gel electrophoresis is used to analyse nucleic acids and proteins and explores its applications in forensic science and medical diagnosis. The engaging and detailed PowerPoint and accompanying resource have been written to cover point 19.1 (d) of the CIE International A-level Biology specification
As a whole lesson, each step of the genetic fingerprinting process is covered but with the main focus on gel electrophoresis within this process. Students will be introduced to STRs and will come to recognise their usefulness in human identification as a result of the variability between individuals. Moving forwards, the involvement of the PCR and restriction enzymes are discussed and students are challenged on their knowledge of this process and these substances as they were encountered in a previous lesson. The main section of the lesson focuses on the use of gel electrophoresis to separate DNA fragments (as well as proteins) and the key ideas of separation due to differences in base pair length or molecular mass are discussed and explained. As well as current understanding checks, an application question involving Huntington’s disease is used to challenge their ability to apply their knowledge of the process to an unfamiliar situation. The remainder of the lesson describes how the DNA is transferred to a membrane and hybridisation probes are used to create a pattern on the X-ray film.
Time has been taken to make continuous links to the previous lessons in topic 19.1 as well as those from topic 6 where DNA, RNA and protein synthesis were introduced.
This fully-resourced lesson explains how genetic fingerprinting can be used to analyse DNA fragments and explores its applications in forensic science and medical diagnosis. The engaging and detailed PowerPoint and accompanying resource have been written to cover all of point 8.4.3 of the AQA A-level Biology specification
Each step of the genetic fingerprinting process is covered and time is taken to ensure that key details are understood. Students will be introduced to VNTRs and will come to recognise their usefulness in human identification as a result of the variability between individuals. Moving forwards, the involvement of the PCR and restriction enzymes are discussed and students are challenged on their knowledge of this process and these substances as they were encountered in a previous sub-topic. The main section of the lesson focuses on the use of gel electrophoresis to separate DNA fragments (as well as proteins) and the key ideas of separation due to differences in base pair length or molecular mass are discussed and explained. As well as current understanding checks, an application question involving Huntington’s disease is used to challenge their ability to apply their knowledge of the process to an unfamiliar situation. The remainder of the lesson describes how the DNA is transferred to a membrane and hybridisation probes are used to create a pattern on the X-ray film.
Time has been taken to make continuous links to the previous lessons in topic 8 as well as those from topic 4 where DNA, RNA and protein synthesis were introduced.
This fully-resourced lesson bundle covers the content as detailed in topic 8.4.1 of the AQA A-level Biology specification (recombinant DNA technology). All of the lessons have been written to contain a wide range of activities that will maintain student engagement whilst this potentially difficult concept is explained. Links are continuously made to previous lessons in topic 8 as well as those covered in the AS year (mainly topic 4)
If you would like to see the quality of the lessons, download the producing DNA fragments lesson as this has been uploaded for free
This fully-resourced lesson explains how the transcription of target genes can be stimulated or inhibited by transcription factors. Both the PowerPoint and the accompanying resources have been designed to cover the first part of point 8.2.2 of the AQA A-level Biology specification and links are continuously made throughout the lesson to the topic of protein synthesis which was covered in topic 4.2.
The lesson begins with a recall of the meaning of the terms genome and proteome so that a discussion can begin on whether a cell wants to express every gene and produce all of the possible proteins all of the time. As the answer to this is no, the idea of transcription factors is introduced. In order to fully understand this topic, students need to recall that the role of the promoter region is to bind RNA polymerase to initiate transcription. Students will learn that the factors have a DNA-binding domain and that some also have ligand-binding domains which allow molecules like hormones to bind. Moving forwards, the students are introduced to a group of substances called DELLA proteins which inhibit plant development. The way that transcription begins once the inhibition by the proteins has been removed is similar to the action of oestrogen and students are able to use this information as a guide during the final task where they have to order the sequence of events that take place once this steroid hormone binds to its transcription factor.
This detailed and engaging lesson looks at the culture of transformed host cells as an in vivo method to amplify DNA fragments. Both the PowerPoint and accompanying resources have been designed to cover the third part of point 8.4.1 of the AQA A-level Biology specification and ties in with the previous two lessons in this sub-topic on producing DNA fragments and the polymerase chain reaction.
The lesson begins with the introduction of the terms transgenic and transformed. Students will learn that bacterial cells are the most commonly transformed cells so the next task challenges their recall of the structures of these cells so that plasmid DNA can be examined from that point onwards. A quick quiz competition is used to introduce the key term, vector, and then the rest of the lesson looks at the details of the five steps involved in the transformation of the host cell:
Remove and prepare the plasmid to act as a vector
Insert the DNA fragment into the vector
Transfer the recombinant plasmid into the host cell
Identify the cells which have taken up the recombinant plasmid
All the transformed host cells to replicate and express the novel gene
Time is taken to explore the finer details of each step such as the addition of the promoter and terminator regions, use of the same restriction enzyme to cut the plasmid as was used to cut the gene and the different types of marker genes. Links are continuously made to the previous lessons in this topic so that students feel confident to answer assessment questions which bring in knowledge from all of the sections.
This lesson looks at the use of the polymerase chain reaction (PCR) as an in vitro method to amplify DNA fragments as part of the recombinant DNA technology process. The clear PowerPoint has been designed to cover the second part of point 8.4.1 of the AQA A-level Biology specification.
A quick quiz competition is used to introduce the PCR abbreviation before students are encouraged to discuss the identity of the enzyme involved and to recall the action of this enzyme. Students will learn that this reaction involves cyclical heating and cooling to a range of temperatures so the next part of this lesson looks at these particular temperatures so the important parts of each of the steps can be understood. Time is taken to examine the key points in detail, such as the specific DNA polymerase that is used and how it is not denatured at the high temperature as well as the involvement of the primers.
This detailed lesson explores how a range of methods are used to produce fragments of DNA as part of the recombinant DNA technology process. Both the engaging PowerPoint and accompanying resources have been written to cover the first part of point 8.4.1 of the AQA A-level Biology specification and also provides information that will prove useful for the other lessons in this sub-topic on the polymerase chain reaction and using transformed host cells.
The lesson begins with a definition of recombinant DNA technology so that students can begin to understand how this process involves the transfer of DNA fragments from one species to another. Links are made to the genetic code and transcription and translation mechanisms, which were met in topic 4, in order to explain how the transferred gene can be translated in the transgenic organism. Moving forwards, the method involving reverse transcriptase and DNA polymerase is introduced and their knowledge of the structure of the polynucleotides and the roles of enzymes is challenged through questions and discussion points. Restriction enzymes are then introduced and time is taken to look at the structure of a restriction site as well as the production of sticky ends due to the staggered cut on the DNA. A series of exam-style questions with displayed mark schemes are used to allow the students to assess their current understanding. The final part of the lesson looks at the production of synthetic genes of any sequence using gene machines and a series of application questions are used to push the students to consider how this advance in technology could be utilised.
As well as understanding and prior knowledge checks, quick quiz competitions are used throughout the lesson to introduce key terms such as cDNA and EcoR1 in a memorable way.
Each of the 4 lessons in this bundle are fully-resourced and have been designed to cover the content as detailed in topic 6.2 (Protein synthesis) of the CIE International A-Level Biology specification. The specification points that are covered within these lessons include:
A polypeptide is coded for by a gene
A gene mutation is a change in the sequence of nucleotides
Sickle cell anaemia results from a change in the amino acid sequence
Transcription as the production of mRNA from DNA
Information on DNA is used during translation to construct polypeptides
The lessons have been written to include a wide range of activities and numerous understanding and prior knowledge checks so students can assess their progress against the current topic as well as be challenged to make links to other topics within this topic and earlier topics
If you would like to see the quality of the lessons, download the introduction to gene mutations lesson as this has been shared for free
This detailed lesson describes the role of the strand of mRNA, the tRNA molecules, the amino acids and the ribosome during the second stage of protein synthesis - translation. Both the PowerPoint and accompanying resources have been designed to cover the second part of point 6.2 (d) of the CIE International A-level Biology specification and ties in with the first part of this specification point which covered transcription.
Translation is a topic which is often poorly understood and so this lesson has been written to enable the students to understand how to answer the different types of questions by knowing and including the key details of the structures involved. The lesson begins by challenging the students to consider why it is so important that the amino acids are assembled in the correct order during the formation of the chain. Moving forwards, a quick quiz round called “LOST IN TRANSLATION” is used to check on their prior knowledge of the mRNA strand, the tRNA molecules, the genetic code and the ribosomes. The next task involves a very detailed description of translation that has been divided into 14 statements which the students have to put into the correct order. By giving them a passage that consists of this considerable detail, they can pick out the important parts to use in the next task where they have to answer shorter questions worth between 3 and 4 marks. These types of questions are common in the assessments and by building up through the lesson, their confidence to answer this type should increase. The final two tasks of the lesson involve another quiz called “The protein synthesis game”, where the teams compete to transcribe and translate in the quickest time before using all the information from the lessons on protein synthesis to answer some questions which involve the genetic code and the mRNA codon table.
Each of the 3 lessons in this bundle are fully-resourced and have been designed to cover the content as detailed in topic 4.2 (DNA and protein synthesis) of the AQA A-Level Biology specification. The specification points that are covered within these lessons include:
The concept of the genome and the proteome
The structure of mRNA
The structure of tRNA
Transcription as the production of mRNA from DNA
The differences between the outcome of transcription in porkaryotes and eukaryotes
Splicing
Translation as the production of polypeptides from the sequence of codons on mRNA
The lessons have been written to include a wide range of activities and numerous understanding and prior knowledge checks so students can assess their progress against the current topic as well as be challenged to make links to other topics within this topic and earlier topics
If you would like to see the quality of the lessons, download the structure of RNA lesson as this has been shared for free
This detailed lesson describes the role of the mRNA, tRNA, amino acids and the ribosome during the second stage of protein synthesis - translation. Both the PowerPoint and accompanying resources have been designed to cover the third part of point 4.2 of the AQA A-level Biology specification and ties in with the previous lessons in this topic on RNA and transcription.
Translation is a topic which is often poorly understood and so this lesson has been written to enable the students to understand how to answer the different types of questions by knowing and including the key details of the structures involved. The lesson begins by challenging the students to consider why it is so important that the amino acids are assembled in the correct order during the formation of the chain. Moving forwards, a quick quiz round called “LOST IN TRANSLATION” is used to check on their prior knowledge of the mRNA strand, the tRNA molecules, the genetic code and the ribosomes. The next task involves a very detailed description of translation that has been divided into 14 statements which the students have to put into the correct order. By giving them a passage that consists of this considerable detail, they can pick out the important parts to use in the next task where they have to answer shorter questions worth between 3 and 4 marks. These types of questions are common in the assessments and by building up through the lesson, their confidence to answer this type should increase. The final two tasks of the lesson involve another quiz, where the teams compete to transcribe and translate in the quickest time before using all that they have learnt to answer some questions which involve the genetic code and the mRNA codon table.
Each of the 6 lessons which are included in this bundle have been written to specifically cover the content as detailed in topics 6.1 & 6.2 of the CIE International A-level Biology specification. The wide range of activities will maintain engagement whilst supporting the explanations of the biological knowledge to allow the students to build a deep understanding of nucleic acids and protein synthesis
Lessons which cover the following specification points are included in this bundle:
Structure of DNA and RNA
Genes as base sequences that code for polypeptides
Gene mutations
Transcription
Translation
If you would like to see the quality of the lessons, download the lesson on gene mutations as this have been uploaded for free