This fully-resourced lesson describes the roles of the T and B lymphocytes in the cellular and humoral responses and the development of immunological memory. The detailed PowerPoint and accompanying resources have been designed to cover the third part of point 2.4 of the AQA A-level Biology specification and the structure of antibodies and the roles of plasma cells and memory cells in the primary and secondary immune responses are also included.
Antigen presentation was introduced at the end of the previous lesson so the task at the start of this lesson challenges students to recognise the name of this process and then they have to spot the errors in the passage that describes the details of this event. This reminds them that contact between the APC and T lymphocytes is necessary to elicit a response which they will come to recognise as the cellular response. A series of quick quiz rounds reveals key terms in a memorable way and one that is introduced is helper T cells. Time is then taken to describe the importance of cell signalling for an effective response and students will learn how the release of chemicals by these cells activates other aspects of the response. The role of the killer T cells is also described before an exam-style question is used to check on their understanding at this point of the lesson. This leads into the section of the lesson that deals with the humoral response and students will understand how this involves the antibodies that are produced by the plasma cells that are the result of clonal selection and expansion. The remainder of the lesson focuses on the structure of the antibodies and then explains how the retention of memory B cells after the primary response enables a quicker and more effective secondary response to occur if necessary. Finally, students are challenged with a series of application questions where they have to apply their knowledge to potentially unfamiliar situations.
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Topic 2: Cells (AQA A-level Biology)
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Topic 2.4: Cell recognition and the immune system (AQA A-level Biology)
This bundle contains 6 lesson PowerPoints and their accompanying resources, all of which have been planned at length to contain a wide variety of tasks that will engage and motivate the students whilst the detailed content of topic 2.4 of the AQA A-level Biology specification is covered. The following specification points are covered in this lesson bundle: * The identification of cells including pathogens through use of the surface molecules * The antigen * The effect of antigen variability on disease and disease prevention * The phagocytosis of pathogens and the subsequent destruction by lysozymes * The response of T lymphocytes to a foreign antigen in the cellular response * The role of antigen-presenting cells * The role of helper T cells * The response of B lymphocytes in the humoral response * The definition and structure of an antibody * The formation of an antigen-antibody complex and the destruction by agglutination and phagocytosis * The roles of plasma cells and memory cells in the primary and secondary responses * The use of vaccinations and the concept of herd immunity * The differences between active and passive immunity * The structure of HIV and its replication in helper T cells * How HIV causes the symptoms of AIDS * Why antibiotics are ineffective against viruses * The use of antibodies in the ELISA test The variety of tasks include exam-style questions with detailed mark schemes, class discussion points of selected questions and quiz competitions to introduce values and terms in a memorable way If you would like to sample the quality of this lesson bundle, then download the roles of B and T lymphocytes lesson and the HIV and AIDS lesson as these have both been uploaded for free
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