This engaging lesson explains why coenzymes, cofactors and prosthetic groups are needed in some enzyme-controlled reactions. The PowerPoint and accompanying resource have been primarily designed to cover point 2.1.4 (e) of the OCR A-level Biology specification but can also be used as a revision lesson for the roles of ions as was covered back in module 2.1.2.
The lesson begins with an introduction of the description of a cofactor and students will learn that some are permanently bound to the enzyme whilst others only form temporary associations. A quick quiz competition runs over the course of the lesson and is used to introduce prosthetic groups, mineral ion cofactors and organic coenzymes and zinc ions with carbonic anhydrase, chloride ions with amylase and NAD are used as examples of each type. The lesson has been planned to make links to related topics such as cations, anions, transport of carbon dioxide and respiration which will test students on their prior knowledge as well as prepare them for these topics in modules 3 and 5.
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