pptx, 1.72 MB
pptx, 1.72 MB
docx, 14.69 KB
docx, 14.69 KB

This lesson describes the main characteristics of benign and malignant tumours. The PowerPoint and accompanying resource are part of the 1st lesson in a series of 2 lessons which have been planned to cover the content of point 8.2.3 of the AQA A-level biology specification.

This lesson begins by challenging the students to recognise the process of mitosis from a single clue. This single clue is “a controlled process” and has been designed to remind them that mitosis is a process controlled by genes. A quick quiz round challenges their recall of the details of the mitotic cell cycle to reveal the key term, tumour, and this introduces the idea that a mutation to one of the genes leads to uncontrolled cell division and the formation of tumours.

Moving forwards, the lesson considers the features of benign tumours, beginning with the key point that these masses of cells are not cancerous. Students will learn that their growth rate is slower than malignant tumours, and due to a covering of fibrous connective tissue, the cells do not invade neighbouring tissues. However, the lesson points out that due to mass effect, benign tumours can cause secondary pathological effects such as organ damage. This leads into a task where the students are challenged on their knowledge of osmoregulation, digestion and blood glucose regulation to identify the tissues which are impacted.

The rest of the lesson describes the features of malignant tumours and time is spent considering how the ability of these cells to metastasise makes them so dangerous.

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Topic 8.2: Gene expression is controlled by a number of features (AQA A-level biology)

This bundle contains 5 detailed and engaging lessons, which have been planned to contain a variety of tasks that enable students to assess their understanding of the current topic and encourages them to make links to previously covered topics. The lessons cover the following content from topic 8.2 of the AQA A-level biology specification: * Totipotent, pluripotent, multipotent and unipotent cells * iPS cells * The stimulation or inhibition of the transcription of target genes * Epigenetic control of gene expression by increased DNA methylation and decreased acetylation of histones * The inhibition of translation of target mRNA by RNA interference * The main characteristics of benign and malignant tumours If you would like to view the quality of these lessons, then download the DNA methylation and acetylation lesson as this has been uploaded for free.

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Topic 8: The control of gene expression (AQA A-level Biology)

Each of the 12 lessons included in this bundle have been written to specifically cover the content as detailed in topic 8 of the AQA A-level Biology specification (The control of gene expression). The wide range of activities will maintain engagement whilst supporting the explanations of the biological knowledge to allow the students to build a deep understanding of this potentially difficult topic! Lessons which cover the following specification points are included in this bundle: * Gene mutations and their effect on the structure of proteins * Most of a cell's DNA is not translated * Totipotent, pluripotent, multipotent and unipotent stem cells * Regulation of transcription by transcription factors * The role of oestrogen in initiating transcription * Epigenetic control of gene expression in eukaryotes * Inhibition of transcription by increased DNA methylation or decreased acetylation of histones * Translation of mRNA can be inhibited by RNA interference * The main characteristics of benign and malignant tumours * Determining the genome of simpler organisms to determine the proteome and its applications * The development of DNA sequencing methods * The production of DNA fragments through use of enzymes or a gene machine * The role of the PCR to amplify DNA fragments * The transfer of DNA into a host cell * The use of labelled DNA probes to screen patients for heritable conditions, drug responses and to identify health risks * VNTRs * The technique of genetic fingerprinting to analyse DNA fragments If you would like to see the quality of the lessons, download the producing DNA fragments and DNA methylation and acetylation lessons as these have been uploaded for free

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