This lesson describes and explains how increasing the concentration of inhibitors affects the rate of an enzyme-controlled reaction. The PowerPoint and accompanying resource are the last in a series of 5 lessons which cover the content detailed in point 1.4.2 of the AQA A-level Biology specification and describes the effect of both competitive and non-competitive inhibitors.
The lesson begins with a made up round of the quiz show POINTLESS called “Biology opposites” and this will get the students to recognise that inhibition is the opposite of stimulation. This introduces inhibitors as substances that reduce the rate of a reaction and students are challenged to use their general knowledge of enzymes to identify that inhibitors prevent the formation of the enzyme-substrate complex. Moving forwards, a quick quiz competition generates the abbreviation EIC (representing enzyme-inhibitor complex) and this introduces competitive inhibitors as substances that occupy the active site. The students are asked to apply their knowledge to a new situation to work out that these inhibitors have a similar shape to the enzyme’s substrate molecule. A series of exam-style questions are used throughout the lesson and at this point, the students are challenged to work out that an increase in the substrate concentration would reduce the effect of a fixed concentration of a reversible competitive inhibitor. The rest of the lesson focuses on non-competitive inhibitors and time is taken to ensure that key details such as the disruption of the tertiary structure is understood and biological examples are used to increase the relevance. Again, students will learn that increasing the concentration of the inhibitor results in a greater inhibition and a reduced rate of reaction but that increasing the substrate concentration cannot reduce the effect as was observed with competitive inhibitors.
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Topic 1: Biological molecules (AQA A-level Biology)
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Topic 1.4: Proteins (AQA A-level Biology)
All 8 of the lessons that are included in this lesson bundle are highly detailed and will engage and motivate the students whilst covering the content of topic 1.4 of the AQA A-level Biology specification. With proteins playing critical roles in a wide range of living organisms, a clear understanding of the structure and functions of these biological molecules is important for all of the other topics. The following specification points are covered by the lessons in this bundle: * The general structure of an amino acid * A condensation reaction between two amino acids forms a peptide bond * The formation of dipeptides and polypeptides * The role of the tertiary structure bonds in the structure of a protein * The variety of functions of proteins in living organisms * The relationship between protein structure and function * The biuret test for proteins * Enzymes lower the activation energy of the reaction it catalyses * The induced fit model of enzyme action * The specificity of enzymes * The effects of temperature, pH, enzyme and substrate concentration and inhibitors on the rate of enzyme-controlled reactions If you would like to sample the quality of lessons in this bundle, then download the dipeptides & polypeptides lesson and the biuret test lesson as these have been uploaded for free
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