pptx, 3.1 MB
pptx, 3.1 MB
docx, 14.76 KB
docx, 14.76 KB
docx, 18.09 KB
docx, 18.09 KB
docx, 17.92 KB
docx, 17.92 KB

This lesson describes how epigenetic changes like DNA methylation and histone modification can modify the activation of certain genes. The PowerPoint and accompanying resources have been planned to cover points 3.14 ii & iii of the Pearson Edexcel A-level biology (Salters-Nuffield) specification.

The lesson begins by introducing the prefix epi- as meaning on or above in Greek to allow students to recognise that epigenetics refers to changes in gene function due to factors beyond the genetic code. Moving forwards, they will learn that DNA methylation involves the attachment of a methyl group to cytosine and will come to understand how this inhibits transcription. They are challenged to recognise the pathogenesis of atherosclerosis through a variety of tasks before reading through a source detailing the results of a study between this cardiovascular condition and DNA methylation.

The remainder of the lesson considers how the acetylation of histone proteins affects the expression of genes.

Understanding and prior knowledge checks are embedded throughout the lesson (along with the answers) to allow the students to assess their progress on this topic and to encourage them to make links to the content of topics 1 - 2.

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Topic 3: Voice of the Genome (Edexcel SNAB)

This bundle contains 13 detailed lesson PowerPoints, which together with their accompanying resources, have been planned to include a wide variety of tasks that will engage and motivate the students whilst covering the content of topic 3 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification. The voice of the genome topic content includes key biological concepts such as eukaryotic cells, cell division and genetics and the following specification points are covered by these lessons: * All living organisms are made of cells, sharing common features * The ultrastructure of eukaryotic cells and the role of the organelles * The role of the rER and the Golgi body in protein transport * The relationship between the features of the mammalian gametes and their functions * The loci is the location of a gene on a chromosome * The linkage of genes on a chromosome and sex linkage * The role of meiosis in ensuring genetic variation * The role of mitosis and the cell cycle * The meaning of the terms stem cell, pluripotency and totipotency * The decisions about the use of stem cells in medical therapies * The specialisation of cells through differential gene expression * Understand how the cells of multicellular organisms are organised into tissues, tissues into organs and organs into systems * Phenotype is the interaction between genotype and the environment * Epigenetic changes can modify the activation of certain genes * Some phenotypes are affected by multiple alleles for the same gene at many loci as well as the environment and this gives rise to continuous variation If you would like to sample the quality of lessons in this bundle, then download the ultrastructure of eukaryotic cells, mitosis and the cell cycle and gene expression lessons as these have been uploaded for free

£20.00

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