This is a fully-resourced lesson which introduces gene mutations and then explores how these base changes affect the primary structure of a polypeptide. The engaging and detailed PowerPoint and accompanying resources have been designed to cover the second part of point 4.3 of the AQA A-level Biology specification which states that students should be able to understand how base substitutions and base deletions change the base sequence and describe how this affects the polypeptide.
In order to understand how a change in the base sequence can affect the order of the amino acids, students must be confident in their understanding and application of protein synthesis which was taught in 4.2. Therefore, the start of the lesson focuses on transcription and translation and students are guided through the use of the codon table to identify amino acids. Moving forwards, a quick quiz competition is used to introduce the names of three types of gene mutation whilst challenging the students to recognise terms which are associated with the genetic code and were met in the previous lesson. The main focus of the lesson is base substitutions and how these mutations may or may not cause a change to the amino acid sequence. The students are challenged to use their knowledge of the degenerate nature of the genetic code to explain how a silent mutation can result. The rest of the lesson looks at base deletions and base insertions and students are introduced to the idea of a frameshift mutation. One particular task challenges the students to evaluate the statement that base deletions have a bigger impact on primary structure than base substitutions. This is a differentiated task and they have to compare the fact that the reading frame is shifted by a deletion against the change in a single base by a substitution.
Get this resource as part of a bundle and save up to 38%
A bundle is a package of resources grouped together to teach a particular topic, or a series of lessons, in one place.
Bundle
Topic 4: Genetic information, variation and relationships between organisms (AQA A-level Biology)
Every one of the lessons included in this bundle is detailed, engaging and fully-resourced, and has been written to cover the content as detailed in topic 4 of the AQA A-level Biology specification. The wide range of activities will maintain engagement whilst supporting the explanations of the content to allow the students to build a deep understanding of genetic information, variation and relationships between organisms. The following 18 lessons covering the 7 sub-topics are included in this bundle: 4.1: DNA, genes and chromosomes * DNA in prokaryotes and eukaryotes * Genes 4.2: DNA and protein synthesis * Genome, proteome and the structure of RNA * Transcription and splicing * Translation 4.3: Genetic diversity can arise as a result of mutation or during meiosis * The genetic code * Gene mutations * Chromosome mutations * Meiosis 4.4: Genetic diversity and adaptation * Genetic diversity * Natural selection * Directional and stabilising selection * Adaptations 4.5: Species and taxonomy * Species and taxonomy 4.6: Biodiversity within a community * Biodiversity within a community * Calculating an index of diversity * The balance between conservation and farming 4.7: Investigating diversity * Investigating diversity * Interpreting mean values and the standard deviation If you would like to sample the quality of the lessons in this bundle, then download the DNA in prokaryotes and eukaryotes, structure of RNA, gene mutations, natural selection and standard deviation lessons as these have been uploaded for free
£27.50
Bundle
Topics 4.1, 4.2 & 4.3 (AQA A-level Biology)
Each of the 9 lessons which are included in this bundle have been written to specifically cover the content as detailed in topics 4.1, 4.2 and 4.3 of the AQA A-level Biology specification. The wide range of activities will maintain engagement whilst supporting the explanations of the biological knowledge to allow the students to build a deep understanding of genetic information Lessons which cover the following specification points are included in this bundle: * DNA in prokaryotes and eukaryotes * Genes * Genome, proteome and the structure of RNA * Transcription and splicing * Translation * The genetic code * Gene mutations * Chromosome mutations * Meiosis If you would like to see the quality of the lessons, download the structure of DNA, RNA and gene mutations lessons as these have been uploaded for free
£13.00
Bundle
AQA A-level Biology Topic 4.3 (Genetic diversity can arise as a result of mutation or meiosis)
Each of the 4 lessons in this bundle are fully-resourced and have been designed to cover the content as detailed in topic 4.3 (Genetic diversity can arise as a result of mutation or meiosis) of the AQA A-Level Biology specification. The specification points that are covered within these lessons include: * Base deletions and base substitutions as examples of gene mutations * The degenerate nature of the genetic code * Mutagenic agents increase the rate of mutation * Chromosome mutations arise spontaneously during meiosis * Meiosis produces genetically different daughter cells * Crossing over and independent segregation as events that contribute to genetic variation The lessons have been written to include a wide range of activities and numerous understanding and prior knowledge checks so students can assess their progress against the current topic as well as be challenged to make links to other topics within this topic and earlier topics If you would like to see the quality of the lessons, download the gene mutations lesson which is free
£5.00
Something went wrong, please try again later.
Great stuff as always, thanks for your expertise
Great for checking understanding - thank you
A great resource, thank you for sharing.
Report this resourceto let us know if it violates our terms and conditions.
Our customer service team will review your report and will be in touch.
£0.00