This fully-resourced lesson describes how it’s possible for 1 gene to give rise to multiple products as a result of post-transcriptional modification of mRNA. The detailed PowerPoint and accompanying resources have been designed to cover point 7.2 (iii) of the Edexcel A-level Biology B specification.
The lesson begins with a knowledge recall as the students have to recognise the definition of a gene as a sequence of bases on a DNA molecule that codes for a sequence of amino acids in a polypeptide chain. This description was introduced in topic 1 and the aim of the start of the lesson is to introduce the fact that despite this definition, most of the nuclear DNA in eukaryotes doesn’t actually code for proteins. A quick quiz competition is then used to introduce exons as the coding regions within a gene before students are challenged to predict the name of the non-coding regions and then to suggest a function for these introns. At this point, the students will complete a task that acts as a prior knowledge check where they have to identify the 6 errors in the descriptive passage about the lac operon and its role in the regulation of gene expression in prokaryotes. Moving forwards, pre-mRNA as a primary transcript is introduced and students will learn that this isn’t the mature strand that moves off to the ribosome for translation. Instead, a process called splicing takes place where the introns are removed and the remaining exons are joined together. Another quick quiz round leads to an answer of 20000 and students will learn that this is the number of protein-coding genes in the human genome. Importantly, the students are then told that the number of proteins that are synthesised is much higher than this value and a class discussion period encourages them to come up with biological suggestions for this discrepancy between the two numbers. The lesson concludes with a series of understanding and application questions where students will learn that alternative splicing enables a gene to produce more than a single protein and that this natural phenomenon greatly increases biodiversity.
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Topic 7: Modern genetics (Edexcel A-level biology B)
This bundle contains 7 detailed and engaging lessons which guide students through the key processes involved in modern genetics. Each lesson contains a variety of tasks, including exam-style questions (and answers), guided discussion points, and quick quiz rounds which will introduce the following content in topic 7 and challenge the students on their understanding: * Understand what is meant by the genome * The PCR can be used to amplify DNA samples * DNA samples can be used for gene sequencing and DNA profiling * The role of transcription factors * Post-transcription modification of mRNA * Gene expression can be changed by epigenetic modification * The differences between totipotent, pluripotent and multipotent stem cells * The formation of iPS cells and why their use is less controversial than embryonic cells * The production of recombinant DNA If you would like to view the quality of these lessons, then download the epigenetic modification lesson as this has been shared for free.
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Topic 7.2: Factors affecting gene expression (Edexcel A-level biology B)
All 3 lessons included in this bundle are highly detailed and contain multiple biological examples to challenge the students to apply their understanding of a potentially difficult topic. A variety of tasks are embedded throughout the lessons and cover all of the content of topic 7.2 of the Edexcel A-level biology B specification (Factors affecting gene expression). If you would like to view the quality of the lessons before deciding on the bundle, then download the epigenetic modification lesson as this has been shared for free.
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