Structure of the mammalian liver (OCR A-level biology)

This lesson describes the structure of the mammalian liver, focusing on the blood vessels and bile canaliculi, as well as the hepatocytes. The PowerPoint and accompanying resources are part of the 1st lesson in a series of 2 lessons which cover point 5.1.2 (b) of the OCR A-level biology A specification.

As shown on the cover image, the lesson begins with a challenge, where the students have to recognise that the liver is supplied with oxygenated blood by the hepatic artery. Three editions of the quiz “SAY WHAT YOU SEE” are used to introduce three key terms in an engaging and memorable fashion which are hepatic portal vein, sinusoids, and bile canaliculi. Following the introduction of the hepatic portal vein and sinusoids, the students will understand that the liver is supplied by two vessels and that the blood mixes in the sinusoids. Time is then taken to focus on the hepatocytes, through 3 exam-style questions that consider the type of epithelium these liver cells are found in, the microvilli on their surface and the organelles which are abundant based on function.

Moving forwards, the lesson discusses the function of the stellate cells that are found in the space of Disse, before a task challenges their recall of content from a previous lesson to reveal the name of the cells that move within the sinusoids, the Kupffer cells. Students will learn that these macrophages breakdown the haemoglobin in old erythrocytes to form bilirubin. This reminds them that liver cells produce bile and the remainder of the lesson discusses how this fluid flows along the bile canaliculi to the ductules which form the common hepatic duct.

The 2nd lesson in this 2-part series describes the functions of the mammalian liver.