This is a highly-detailed and fully-resourced lesson which covers the detail of specification point 5.1.2 (d) of the OCR A-level Biology A specification which states that students should be able to demonstrate and apply an understanding of the roles of the hypothalamus, posterior pituitary, ADH and the collecting duct in the control of the water potential of the blood. Students learnt about the principles of homeostasis and negative feedback in an earlier module, so this lesson acts to build on that knowledge and challenges them to apply their knowledge. A wide range of activities have been included in the lesson to maintain motivation and engagement whilst the understanding and prior knowledge checks will allow the students to assess their progress as well as challenge themselves to make links to other Biology topics. The lesson begins with a discussion about how the percentage of water in urine can and will change depending on the blood water potential. Students will quickly be introduced to osmoregulation and they will learn that the osmoreceptors and the osmoregulatory centre are found in the hypothalamus. A considerable amount of time is taken to study the cell signalling between the hypothalamus and the posterior pituitary gland by looking at the specialised neurones (neurosecretory cells). Links are made to the topics of neurones, nerve impulses and synapses and the students are challenged to recall the cell body, axon and vesicles. The main section of the lesson forms a detailed description of the body’s detection and response to a low blood water potential. The students are guided through this section as they are given 2 or 3 options for each stage and they have to use their knowledge to select the correct statement. The final task asks the students to write a detailed description for the opposite stimulus and this task is differentiated so those who need extra assistance can still access the work. This lesson has been written for students studying on the OCR A-level Biology A course and ties in nicely with the other uploaded lessons in module 5.1.2 which include the structure of the nephron, ultrafiltration and selective reabsorption.

This fully-resourced lesson uses real-life examples in plants and animals to explain why cellular respiration is so important. The PowerPoint and accompanying resources have been designed to cover point 5.2.2 (a) of the OCR A-level Biology A specification but can also be used as a revision tool to challenge the students on their knowledge of active transport, nervous transmission and muscle contraction. As the first lesson in this module, it has been specifically planned to act as an introduction to this cellular reaction and provides important details about glycolysis, the Krebs cycle and oxidative phosphorylation that will support the students to make significant progress when these stages are covered during individual lessons. Students met phosphorylation in module 5.2.1 when considering the light-dependent reactions of photosynthesis and their knowledge of the production of ATP in this plant cell reaction is called on a lot in this lesson to show the similarities. The students are also tested on their recall of the structure and function of ATP, as covered in module 2.1.3, through a spot the errors task. By the end of the lesson, the students will be able to explain why the ATP produced in cellular respiration is needed by root hair cells, by companion cells and in the selective reabsorption of glucose in the proximal convoluted tubule. They will also be able to name and describe the different types of phosphorylation and will know that ATP is produced by substrate-level phosphorylation in glycolysis and the Krebs cycle and by oxidative phosphorylation in the final stage of aerobic respiration with the same name.

This fully-resourced lesson describes the main stages of mitosis and explains the significance of this type of nuclear division in life cycles. The PowerPoint and accompanying resources have been designed to cover points 2.1.6 (c & e) of the OCR A-level Biology A specification and make direct links to the previous lesson which covered the cell cycle Depending upon the exam board taken at GCSE, the knowledge and understanding of mitosis will differ considerably between students and there may be a number of misconceptions. This was considered at all points during the planning of the lesson so that existing errors are addressed and key points are emphasised throughout. Their understanding of interphase is challenged at the start of the lesson to ensure that they realise that it is identical pairs of sister chromatids that enter the M phase. The main part of the lesson focuses on prophase, metaphase, anaphase and telophase and describes how the chromosomes behave in these stages. There is a focus on the centrioles and the spindle fibres that they produce which contract to drag one chromatid from each pair in opposite directions to the poles of the cell. The remainder of the lesson is a series of understanding and application questions where students have to identify the various roles of mitosis in living organisms as well as tackling a Maths in a Biology context question. The lesson concludes with a final quiz round of MITOSIS SNAP where they only shout out this word when a match is seen between the name of a phase, an event and a picture.

This detailed lesson describes the fluid mosaic model of membrane structure and also describes the roles of its components. The detailed and engaging PowerPoint and accompanying worksheets have been designed to cover specification point 2.1.5 (b) of the OCR A-level Biology A specification and clear links are made to related topics such as the binding of peptide hormones The fluid mosaic model is introduced at the start of the lesson so that it can be referenced at appropriate points throughout the lesson. Students were introduced to phospholipids in module 2.1.2 and an initial task challenges them to spot the errors in a passage describing the structure and properties of this molecule. This reminds them of the bilayer arrangement, with the hydrophilic phosphate heads protruding outwards into the aqueous solutions on the inside and the outside of the cell. In a link to some upcoming lessons on the transport mechanisms, the students will learn that only small, non-polar molecules can move by simple diffusion and that this is through the tails of the bilayer. This introduces the need for transmembrane proteins to allow large or polar molecules to move into the cell by facilitated diffusion and active transport. Proteins that act as receptors as also introduced and an opportunity is taken to make a link to an upcoming topic so that students can understand how hormones or drugs will bind to target cells in this way. Moving forwards, the structure of cholesterol is covered and students will learn that this hydrophobic molecule sits in the middle of the tails and therefore acts to regulate membrane fluidity. The final part of the lesson challenges the students to apply their newly-acquired knowledge to a series of questions where they have to explain why proteins may have moved when two cells are used and to suggest why there is a larger proportion of these proteins in the inner mitochondrial membrane than the outer membrane.

This fully-resourced lesson distinguishes between active and passive, natural and artificial immunity and explains how vaccinations can be used to control disease. The engaging and detailed PowerPoint and accompanying resources have been designed to cover point 11.2 (d) of the CIE A-level Biology specification and there is also a description and discussion on the concept of herd immunity. In topic 11.1, students were introduced to the primary and secondary immune responses so the start of this lesson uses an imaginary game of TOP TRUMPS to challenge them on the depth of their understanding. This will act to remind them that a larger concentration of antibodies is produced in a quicker time in the secondary response. The importance of antibodies and the production of memory cells for the development of immunity is emphasised and this will be continually referenced as the lesson progresses. The students will learn that this response of the body to a pathogen that has entered the body through natural processes is natural active immunity. Moving forwards, time is taken to look at vaccinations as an example of artificial active immunity. Another series of questions focusing on the MMR vaccine will challenge the students to explain how the deliberate exposure to antigenic material activates the immune response and leads to the retention of memory cells. A quick quiz competition is used to introduce the variety of forms that the antigenic material can take along with examples of diseases that are vaccinated against using these methods. The eradication of smallpox is used to describe the concept of herd immunity and the students are given time to consider the scientific questions and concerns that arise when the use of this pathway is a possible option for a government. The remainder of the lesson looks at the different forms of passive immunity and describes the drawbacks in terms of the need for a full response if a pathogen is re-encountered

This lesson explains the effects of temperature on the rate of enzyme activity and describes how to calculate the temperature coefficient. The PowerPoint and the accompanying resources have been designed to cover point 5.21 of the Edexcel International A-level Biology specification and this lesson has been specifically planned to tie in with a lesson in topic 2 where the roles and mechanism of action of enzymes were introduced. The lesson begins by challenging the students to recognise optimum as a key term from its 6 synonyms that are shown on the board. Time is taken to ensure that the students understand that the optimum temperature is the temperature at which the most enzyme-product complexes are produced per second and therefore the temperature at which the rate of an enzyme-controlled reaction works at its maximum. The optimum temperatures of DNA polymerase in humans and in a thermophilic bacteria and RUBISCO in a tomato plant are used to demonstrate how different enzymes have different optimum temperatures and the roles of the latter two in the PCR and photosynthesis are briefly described to prepare students for these lessons in modules 6 and 5. Moving forwards, the next part of the lesson focuses on enzyme activity at temperatures below the optimum and at temperatures above the optimum. Students will understand that increasing the temperature increases the kinetic energy of the enzyme and substrate molecules, and this increases the likelihood of successful collisions and the production of enzyme-substrate and enzyme-product complexes. When considering the effect of increasing the temperature above the optimum, continual references are made to the previous lesson and the control of the shape of the active site by the tertiary structure. Students will be able to describe how the hydrogen and ionic bonds in the tertiary structure are broken by the vibrations associated with higher temperatures and are challenged to complete the graph to show how the rate of reaction decreases to 0 when the enzyme has denatured. The final part of the lesson introduces the Q10 temperature coefficient and students are challenged to apply this formula to calculate the value for a chemical reaction and a metabolic reaction to determine that enzyme-catalysed reactions have higher rates of reaction

A fun and highly engaging lesson presentation (37 slides) and associated worksheets that combines exam questions and progress checks along with competition rounds to enable students to assess their understanding of the specification content within units B1 - 3 of the OCR Gateway A 9 - 1 GCSE Science. All of the exam questions and progress checks have displayed answers as well as sections where content is recapped so that students can understand how an answer was obtained. The revision rounds in the competition include “Blockbusters”, “Doctor, Doctor” and “Crack the CODE”. This lesson has been designed for GCSE students.

This revision resource includes exam questions, understanding checks and quiz competitions, all of which have been designed with the aim of motivating and engaging the students whilst they assess their understanding of the content found in topic 3 (Movement in and out of cells) of the CIE IGCSE Biology specification for examination in June and November 2020 and 2021. This revision resource contains a detailed and engaging PowerPoint (42 slides) and associated worksheets, some of which have been differentiated to help and challenge differing abilities. The range of activities have been designed to cover as much of the Core and supplement content as possible but the following sub-topics have been given particular attention: Active transport as the movement of particles against their concentration gradient using energy from respiration The importance of active transport as demonstrated by the absorption of mineral ions by the root hair cells The movement of water across cell membranes by osmosis The importance of osmosis and water potential in the uptake of water by plants The effects on plant cells of immersion into solutions of different concentrations The importance of turgor pressure for a plant Diffusion as the net movement of particles with the concentration gradient Recognising the factors that influence the rate of diffusion In addition, topics from other modules such as specialised plant cells are covered so that students can see the importance of being able to make connections and links between Biological topics.

Water is very important for living organisms because of its numerous properties and this lesson focuses on its role as a solvent in transport. The engaging and detailed PowerPoint and accompanying worksheet have been designed to cover point 1.1 of the Edexcel International A-level Biology specification and also explains the importance of the dipole nature for this role in transport. A mathematical theme runs throughout the lesson as students have to match the numbers calculated in the starter task to water statistics, such as the percentage of the volume of blood plasma that is water. This has been included to try to increase the relevance of each property so that it can be described in a biological context. Time is taken at the beginning of the lesson to describe the structure of water in terms of the covalent bonds between the oxygen and hydrogen atoms as well as the hydrogen bonds which form between molecules because of its polarity. Students will understand how water is a solvent which means that it is critical for transport in animals, a topic covered in the next few lessons but also for transport in plants as discussed in topic 4. The high heat capacity and latent heat of vaporisation of water is also discussed and explained through the examples of thermoregulation and the maintenance of a stable environment for aquatic animals. The final part of the lesson focuses on the involvement of water in condensation and hydrolysis reactions, two reactions which must be well understood for topic 1 and 2 and the formation and breakage of polysaccharides, lipids, polypeptides and polynucleotides.

This fully-resourced lesson describes the non-specific responses of the body to infection and includes details of phagocytosis, inflammation and interferon release. The engaging and detailed PowerPoint and accompanying resources have been primarily designed to cover the content of point 6.7 of the Pearson Edexcel A-level Biology A specification but topics including antigen-presentation are also introduced to prepare students for upcoming lessons on the immune response (6.8 & 6.9). At the start of the lesson, the students are challenged to recall that cytosis is a suffix associated with transport mechanisms and this introduces phagocytosis as a form of endocytosis which takes in pathogens and foreign particles. This emphasis on key terminology runs throughout the course of the lesson and students are encouraged to consider how the start or end of a word can be used to determine meaning. The process of phagocytosis is then split into 5 key steps and time is taken to discuss the role of opsonins as well as the fusion of lysosomes and the release of lysozymes. A series of application questions are used to challenge the students on their ability to make links to related topics including an understanding of how the hydrolysis of the peptidoglycan wall of a bacteria results in lysis. Students will be able to distinguish between neutrophils and monocytes from a diagram and at this point, the role of macrophages and dendritic cells as antigen-presenting cells is described so that it can be used in the next lesson. The importance of cell signalling for an effective immune response is discussed and the rest of the lesson focuses on the release of two chemicals - interferons and histamine. During the interferon section, references are made to a previous lesson on HIV structure and action so students can understand how the release of these signalling proteins helps neighbouring cells to heighten their anti-viral defences. A step by step guide is used to describe the release of histamine in the inflammatory response and the final task challenges students to use this support to form a detailed answer regarding the steps in inflammation.

This engaging and fully-resourced lesson looks at the effects of stabilising, directional and disruptive selection as the three main types of selection. The PowerPoint and accompanying resources have been designed to cover point 17.2 (b) of the CIE International A-level Biology specification which states that students should be able to identify each type of selection by its effect on different phenotypes. The lesson begins with an introduction to the mark, release, recapture method to calculate numbers of rabbits with different coloured fur in a particular habitat. This method is covered later in topic 18 so this section of the lesson is designed purely to generate changes in numbers of the organisms. Sketch graphs are then constructed to show the changes in the population size in this example. A quick quiz competition is used to engage the students whilst introducing the names of the three main types of selection before a class discussion point encourages the students to recognise which specific type of selection is represented by the rabbits. Key terminology including intermediate and extreme phenotypes and selection pressure are used to emphasise their importance during explanations. A change in the environment of the habitat and a change in the numbers of the rabbits introduces directional selection before students will be given time to discuss and to predict the shape of the sketch graph for disruptive selection. Students are challenged to apply their knowledge in the final task of the lesson by choosing the correct type of selection when presented with details of a population and answer related questions.

This is an engaging and discussion filled lesson which looks at the menstrual cycle and specifically focuses on the interaction of the four hormones in the cycle. This lesson has been designed for GCSE students (ages 14 - 16 in the UK) but is suitable for older students who want a recap on this topic before going into more depth. In order to understand the cycle, it is critical that students know the roles that each of the hormones perform and also can describe how one hormone affects another. The main task of the lesson goes through the steps in the cycle, but challenges the students to use their prior knowledge of the endocrine system to add in the name of the correct hormone. At appropriate points of the lesson, time is taken to relate this topic to others in Biology, such as the use of oestrogen in the contraceptive pill and also hCG as the hormone which is detected by pregnancy tests. Students will know key landmarks in the 28 day cycle and be able to relate this back to the hormones. There are progress checks throughout the lesson but the final part of the lesson involves three understanding checks where students are challenged to apply their knowledge.

An engaging lesson presentation (54 slides) that uses a variety of exam questions, quick tasks and competitions to allow students to assess their understanding of the different topics within Module B5 of the Combined Science specification. All of the exam questions have displayed answers and some are differentiated to allow for the differing abilities. The students will enjoy the competitions which include "Take the HOTSEAT" and "This shouldn't be too TAXING" whilst recognising those areas which require further attention.

This lesson describes the active loading of assimilates like sucrose at the source and the translocation along the phloem to the sink. Both the detailed PowerPoint and accompanying resources have been designed to cover point 3.1.3 (f) of the OCR A-level Biology A specification. The lesson begins by challenging the students to recognise the key term translocation when it is partially revealed and then the rest of the lesson focuses on getting them to understand how this process involves the mass flow of assimilates down the hydrostatic pressure gradient from the source to the sink. It has been written to tie in with 3.1.3 (b) where the structure of the phloem tissue was initially introduced and the students are continually challenged on this prior knowledge. A step-by-step guide is used to describe how sucrose is loaded into the phloem at the source by the companion cells. Time is taken to discuss key details such as the proton pumping to create the proton gradient and the subsequent movement back into the cells by facilitated diffusion using co-transporter proteins. Students will learn that the hydrostatic pressure at the source is high, due to the presence of the water and sucrose as cell sap, and that this difference when compared to the lower pressure at the sink leads to the movement along the phloem. A number of quick quiz rounds are included in the lesson to maintain engagement and to introduce key terms and the lesson concludes with a game of SOURCE or SINK as students have to identify whether a particular plant structure is one or the other (or both)

This engaging REVISION LESSON has been designed to cover the content of topic 13 (Photosynthesis) of the CIE International A-level Biology specification. Filled with a wide range of activities, that include exam questions with explanations, quick tasks and quiz competitions, the students will be motivated whilst they assess their ability to apply their knowledge. Due to the obvious importance of this reaction, assessment questions are extremely common and so a deep understanding of this topic is key to success and the lesson has been designed to cover the important ideas. The following sub-topics have received particular attention in this lesson: Photophosphorylation An outline of cyclic and non-cyclic photophosphorylation Photolysis of water The light dependent reaction The structure of the chloroplast and the site of the different reactions The Calvin cycle The limiting factors of photosynthesis Investigating the effect of light intensity using DCPIP as a redox indicator and a Hill suspension The effect of temperature on the rate There is a focus on terminology throughout the lesson so that students are comfortable with the terms that will be encountered in exam questions. Revision lessons on the other topics of the specification are uploaded so please take a moment to look at those too

This fully-resourced REVISION LESSON has been designed to provide the students with numerous opportunities to assess their understanding of the content of topic 12 (Energy and respiration) of the CIE International A-level Biology specification. The importance of this metabolic reaction is obvious and this is reflected in the volume of questions in the terminal exams which require an in depth knowledge of the stages of both aerobic and anaerobic respiration. The lesson contains a wide range of activities that cover the following points of the specification: Glycolysis as a stage of aerobic and anaerobic respiration The use and production of ATP through respiration Anaerobic respiration in mammalian muscle tissue The stages of aerobic respiration that occur in the mitochondrial matrix Oxidative phosphorylation The use of respirometers Calculating the respiratory quotient value for different substrates Revision lessons which cover the other topics of the specification are also uploaded and tie in well with this lesson.

This fully-resourced REVISION lesson has been written to challenge the students on their knowledge of the content of topic 8 (Transport in mammals) of the CIE International A-level Biology specification. The engaging PowerPoint and accompanying resources will motivate the students whilst they assess their understanding of the content and identify any areas which may require further attention. The wide range of activities have been written to cover as much of the topic as possible but the following specification points have been given particular focus: The significance of the oxygen dissociation curves at different concentrations of carbon dioxide (The Bohr effect) The role of haemoglobin in carrying oxygen The role of haemoglobin in carrying carbon dioxide Draw the structures of red blood cells, neutrophils, monocytes and lymphocytes The relationship between the structure and function of a capillary The internal structure of the heart and its associated blood vessels Explain how heart action is initiated and controlled The pressure changes of the cardiac cycle The relationship between the structure and function of arteries and veins The double, closed circulatory system of a mammal Quiz rounds such as “Does this FLOW correctly” and “YOU DO THE MATH” are used to test the students on the finer details of their knowledge of the blood vessels and numerical facts

This lesson looks at the detailed structure of DNA and builds on the knowledge from topic 1 to explain how this nucleic acid differs in the nucleus, mitochondria and chloroplasts of eukaryotic cells and in prokaryotic cells. Both the engaging PowerPoint and accompanying resources have been designed to cover the first part of point 6.1 (b) of the CIE International A-level Biology specification. As well as focusing on the differences between the DNA found in these two types of cells which includes the length, shape and association with histones, the various tasks will ensure that students are confident to describe how this double-stranded polynucleotide is held together by hydrogen and phosphodiester bonds. These tasks include exam-style questions which challenge the application of knowledge as well as a few quiz competitions to maintain engagement.

This engaging lesson describes the relationship between the structure, properties and functions of a phopholipid and cholesterol. The PowerPoint has been written as the second lesson in a series of two that cover specification points 2.1.2 (h), (i) & (j) of the OCR A-level Biology A course and there is a particular focus on their roles in membranes to link to module 2.1.5. In the previous lesson, the students met triglycerides and a quick quiz round called FAMILY AFFAIR is used at the start of the lesson to challenge the students on their knowledge of the structure of this macromolecule to identify the shared features in a phospholipid. This then allows the differences to be introduced, such as the presence of a phosphate group in place of the third fatty acid. Moving forwards, the students will learn that the two fatty acid tails are hydrophobic whilst the phosphate head is hydrophilic which leads into a key discussion point where the class has to consider how it is possible for the phospholipids to be arranged when both the inside and outside of a cell is an aqueous solution. The outcome of the discussion is the introduction of the bilayer which is critical for the lesson in module 2.1.5 on the fluid mosaic model. Students are briefly introduced to facilitated diffusion and reminded of active transport so they can recognise that proteins will be found in the membrane to allow for movement of large or polar molecules. The remainder of the lesson focuses on cholesterol, beginning with the structure. The hydrophobic nature of this molecule is then considered and discussed so that they can understand its role in the regulation of membrane fluidity. That just leaves one final quiz round which identifies vitamin D, testosterone and oestrogen as three substances that are formed from cholesterol

This fully-resourced lesson describes how polygenic inheritance gives rise to phenotypes that show continuous variation. The engaging PowerPoint and accompanying resources have been primarily designed to cover points 3.20 (i) & 3.21 of the Edexcel International A-level Biology specification but also includes activities to challenge the students on previous concepts in topics 3 and 2. The students begin the lesson by having to identify phenotype and species from their respective definitions so that a discussion can be encouraged where they will recognise that phenotypic variation within a species is due to both genetic and environmental factors. The main part of the the lesson focuses on these genetic factors, and describes how mutation and the events of meiosis contribute to this variation. A range of activities, which include exam-style questions and quick quiz rounds, are used to challenge the students on their knowledge and understanding of substitution mutations, deletions, insertions, the genetic code, crossing over and independent assortment. Moving forwards, the concept of multiple alleles is introduced and students will learn how the presence of more than 2 alleles at a locus increases the number of phenotypic variants. Another quick quiz round is used to introduce polygenic inheritance and the link is made between this inheritance of genes at a number of loci as an example of continuous variation. The final part of the lesson describes a few examples where environmental factors affect phenotype, such as chlorosis in plants. As this is the final lesson in topic 3, the numerous activities can be used for revision purposes and to demonstrate the links between different biological topics.