This lesson describes the structure and functions of the adrenal glands, and includes the hormones secreted by the cortex and the medulla. The detailed PowerPoint and accompanying resources have been designed to cover point 5.1.4 (b) of the OCR A-level Biology A specification This lesson has been planned to closely tie in with the previous lesson on endocrine communication, and specifically the modes of action of peptide and steroid hormones. At the start of the lesson, the students have to use the knowledge acquired in this last lesson to reveal the key term cortex and this leads into the description of the structure of the adrenal glands in terms of the outer region and the inner region known as the medulla. The main part of the lesson focuses on the range of physiological responses of the organs to the release of adrenaline. Beginning with glycogenolysis, the need for adrenaline to bind to adrenergic receptors is described including the activation of cyclic AMP. A quiz competition is used to introduce other responses including lipolysis, vasodilation, bronchodilation and an increase in stroke volume. Links to previous topics are made throughout the lesson and students are challenged on their knowledge of heart structure and polysaccharides. The final part of the lesson introduces the three zones of the adrenal cortex and the steroid hormones that they produce along with their functions. Once again, a series of exam-style questions are used to challenge their ability to apply their understanding to an unfamiliar situation and to make biological links and the mark schemes are embedded in the PowerPoint.

This fully-resourced lesson describes the ultrastructure of a prokaryotic cell including the cell wall, capsule,plasmid, flagellum, pili, ribosomes, mesosomes and circular DNA. The engaging PowerPoint and accompanying resources have been designed to cover the specification point 3.4 that is detailed in the Pearson Edexcel A-level Biology A specification but also makes continual references to eukaryotic cells as covered in 3.1 - 3.3 so that comparisons can be made. A clear understanding of terminology is important for A-level Biology so this lesson begins with a challenge, where the students have to come up with a 3-letter prefix that they believe will translate as before or in front of . This leads into the discovery of the meaning of prokaryote as before nucleus which acts to remind students that these types of cell lack this cell structure. Links to the previous lessons on the eukaryotic cells are made throughout the lesson and at this particular point, the students are asked to work out why the DNA would be described as naked and to state where it will be found in the cell. Moving forwards, the students will discover that these cells also lack membrane bound organelles and a quick quiz competition challenges them to identify the specific structure that is absent from just a single word. In addition to the naked DNA, students will learn that there are also ribosomes in the cytoplasm and will discover that these are smaller than those found in the cytoplasm of an eukaryotic cell (but the same size as those in chloroplasts and mitochondria). The remainder of the lesson focuses on the composition of the cell wall, the additional features of prokaryotic cells such as plasmids and there is also the introduction of binary fission as the mechanism by which these organisms reproduce so that students can recognise that prokaryotic cells do not contain centrioles

This fully-resourced lesson describes the structure, different roles and modes of action of the B and T lymphocytes in the specific immune response. The detailed PowerPoint and accompanying resources have been designed to cover point 4.1.1 (f) as detailed in the OCR A-level Biology A specification and the structure of antibodies and the roles of memory cells is also briefly introduced so that students are prepared for an upcoming lesson on the secondary immune response (4.1.1 g) Antigen presentation was introduced at the end of the previous lesson so the task at the start of this lesson challenges students to recognise the name of this process and then they have to spot the errors in the passage that describes the details of this event. This reminds them that contact between the APC and T lymphocytes is necessary to elicit a response which they will come to recognise as the cellular response. A series of quick quiz rounds reveals key terms in a memorable way and one that is introduced is helper T cells. Time is then taken to describe the importance of cell signalling for an effective response and students will learn how the release of chemicals by these cells activates other aspects of the response. The role of the killer T cells and their production of cytotoxins is also described before an exam-style question is used to check on their understanding at this point of the lesson. This leads into the section of the lesson that deals with the humoral response and students will understand how this involves the antibodies that are produced by the plasma cells that are the result of clonal selection and expansion. The T and B memory cells are also introduced so that students can understand how they are retained in the body even after the pathogen has been overcome and will play a critical role in the development of immunity. The remainder of the lesson focuses on the role of the antibodies and the attachment of phagocytes to opsonins

This is a fully-resourced revision lesson that uses a combination of exam questions, understanding checks, quick tasks and quiz competitions to enable students to assess their understanding of the content found within Module 5.1.3 (Neuronal communication) of the OCR A-level Biology A specification. The sub-topics and specification points that are tested within the lesson include: The structure and function of sensory, motor and relay neurones The generation and transmission of nerve impulses in mammals The structure and roles of synapses in neurotransmission Students will be engaged through the numerous quiz rounds such as “Communicate the word” and “Only CONNECT” whilst crucially being able to recognise those areas which require their further attention during general revision or during the lead up to the actual A-level terminal exams

This revision resource has been written to include a range of activities that motivate the students whilst they assess their understanding of the content found in module 2.1.5 (Biological membranes) of the OCR A-level Biology A specification. The resource includes a detailed and engaging Powerpoint (71 slides) and associated worksheets The range of activities have been designed to cover as much of the content as possible but the following sub-topics have been given particular attention: The movement of molecules by active transport which requires ATP as an immediate source of energy The movement of molecules by passive processes The use of membrane-spanning proteins in facilitated diffusion and active transport Factors that increase the rate of simple diffusion The movement of water across membranes by osmosis The effects that solutions of different water potentials can have on animal and plant cells The fluid mosaic model of membrane structure The roles of the components of the plasma cell membrane In addition to these topics, some topics from other modules such as organelles, synapses and autoimmune diseases are tested in order to challenge the students on their ability to make links between the modules. The range of activities include exam questions and understanding checks as well as quiz competitions to maintain student engagement.

A resourced lesson which looks at a range of methods that are used to increase biodiversity. The lesson includes an engaging lesson presentation (31 slides) and an associated worksheet The lesson begins by getting students to recall the term biodiversity and time is taken to ensure that the meaning of this word is fully understood. The lesson takes the form of a bus ride around London, looking at some of the attractions which act to increase or maintain biodiversity. Students will “virtually” visit both London Zoo and Kew Gardens and will learn how methods such as the captive breeding programme and the Millenium Seed Bank are used to influence biodiversity. Along with the bus ride, students will compete in a number of quiz competitions which act to maintain engagement whilst introducing key terms or facts. There are regular progress checks throughout the lesson to allow the students to check their understanding. This lesson has been designed for GCSE students.

A fully-resourced lesson which has been designed for GCSE students and includes an engaging lesson presentation and associated worksheets. This lesson looks at the three limiting factors of photosynthesis, focusing on the graphs that they produce and ensures that students can explain why temperature is a factor. This lesson begins by introducing the students to the definition of a limiting factor. They are challenged to recognise that it would be photosynthesis which is limited by carbon dioxide concentration and light intensity. The third factor, temperature, is not introduced until later in the lesson so that students are given thinking time to consider what it might be. Having been presented with two sets of data, students are asked to draw sketch graphs to represent the trend. The limiting factors on the light intensity graph are taught to the students so they can use this when working out the limiting factors on the carbon dioxide graph. The remainder of the lesson focuses on temperature and more specifically why a change in this factor would cause a change in the rate of photosynthesis because of enzymes. The student’s knowledge of that topic is tested alongside. Progress checks have been written into the lesson at regular intervals so that students can constantly assess their understanding.

This is a fully-resourced revision lesson that uses a combination of exam questions, understanding checks, quick differentiated tasks and quiz competitions to enable students to assess their understanding of the content found within Topic 5 (On the wild side) of the Pearson Edexcel A-level Biology A specification. The sub-topics and specification points that are tested within the lesson include: Be able to describe how to carry out a study on the ecology of a habitat Understand the stages of succession Understand the overall reaction of photosynthesis Understand the structure of chloroplasts in relation to their role in photosynthesis Understand the relationship between NPP, GPP and respiration Understand the effect of temperature on enzyme activity and its impact on plants and animals and microorganisms Know how the temperature coefficient Q10 quantifies the rate of an enzyme-catalysed reaction Understand how knowledge of the carbon cycle can be applied to methods to reduce atmopsheric levels of carbon dioxide A number of the tasks have been differentiated to allow all abilities of student to access the work and there is a big emphasis on the mathematical skills that can be tested in this topic. Students will be engaged through the numerous quiz rounds such as “Can you DEPEND on your knowledge” and “From NUMBERS 2 LETTERS” whilst crucially being able to recognise those areas which require their further attention during general revision or during the lead up to the actual A-level terminal exams

The AQA specification states that a minimum of 10% of the marks across the 3 assessment papers will require the use of mathematical skills. This revision lesson has been designed to include a wide range of activities that challenge the students on these exact skills because success in the maths in biology questions can prove the difference between one grade and the next! Step-by-step guides are used to walk students through the application of a number of the formulae and then exam-style questions with clear mark schemes (which are included in the PowerPoint) will allow them to assess their progress. Other activities include differentiated tasks, group discussions and quick quiz competitions such as “FROM NUMBERS 2 LETTERS” and “YOU DO THE MATH”. The lesson has been written to cover as much of the mathematical requirements section of the specification as possible but the following have been given particular attention: Hardy-Weinberg equation Chi-squared test Calculating size Converting between quantitative units Standard deviation Estimating populations of sessile and motile species Percentages and percentage change Cardiac output Geometry Due to the detail and extensiveness of this lesson, it is estimated that it will take in excess of 2/3 hours of A-level teaching time to work through the activities and it can be used throughout the duration of the course

This lesson describes the tests that detect reducing and non-reducing sugars and starch using Benedict’s solution and iodine/potassium iodide. The PowerPoint and accompanying resource are part of the last lesson in a series of 4 lessons which have been designed to cover the content of topic 1.2 (Carbohydrates) of the AQA A-level Biology specification. The lesson begins with an explanation of the difference between a qualitative and quantitative test so that the students recognise that the two tests described within this lesson indicate the presence of a substance but not how much. The students are likely to have met these tests at GCSE so this lesson has been planned to build on that knowledge and to add the knowledge needed at this level. A step by step guide walks the students through each stage of the tests for reducing and non-reducing sugars and application of knowledge questions and prior knowledge checks are included at appropriate points to ensure understanding is complete. Time is also taken to ensure that students understand the Science behind the results. The rest of the lesson focuses on the iodine test for starch and the students will learn that the colour change is the result of the movement of an ion into the amylose helix.

This lesson describes how to use the Spearman’s rank correlation coefficient to consider the relationship between two sets of data. The PowerPoint and accompanying exam-style question are part of the final lesson in a series of 3 which have been designed to cover point 4.2.2 (f) of the OCR A-level Biology A specification. The previous two lessons described the different types of variation and explained how to calculate the standard deviation and how to use the Student’s t-test to compare two means. As with the previous lesson, a step by step guide is used to walk the students through the use of the formula to generate the rank coefficient and to determine whether there is a positive correlation, no correlation or a negative correlation. The students are also reminded of the null hypothesis and will be shown how to accept or reject this hypothesis and to determine significance. The students will work through an example with the class and then are given the opportunity to apply their newly-acquired knowledge to an exam-style question. The mark scheme is displayed on the PowerPoint so they can assess their understanding

This lesson describes the relationship between the size of an organism or structure and its surface to volume ratio. The PowerPoint and accompanying worksheets have been designed to cover point 3.1 of the AQA A-level Biology specification and also have been specifically planned to prepare the students for the upcoming lessons in topic 3 on gas exchange and absorption in the ileum. The students are likely to have been introduced to the ratio at GCSE, but understanding of its relevance tends to be mixed. Therefore, real life examples are included throughout the lesson that emphasise the importance of the surface area to volume ratio in order to increase this relevance. A lot of students worry about the maths calculations that are associated with this topic so a step by step guide is included at the start of the lesson that walks them through the calculation of the surface area, the volume and then the ratio. Through worked examples and understanding checks, SA/V ratios are calculated for cubes of increasing side length and living organisms of different size. These comparative values will enable the students to conclude that the larger the organism or structure, the lower the surface area to volume ratio. A differentiated task is then used to challenge the students to explain the relationship between the ratio and the metabolic demands of an organism and this leads into the next part of the lesson, where the adaptations of larger organisms to increase the ratio at their exchange surfaces is covered. The students will calculate the SA/V ratio of a human alveolus (using the surface area and volume formulae for a sphere) and will see the significant increase that results from the folding of the membranes. This is further demonstrated by the villi and the microvilli on the enterocytes that form the epithelial lining of these folds in the ileum. The final part of the lesson introduces Fick’s law of diffusion so that students are reminded that the steepness of a concentration gradient and the thickness of a membrane also affect the rate of diffusion.

A detailed lesson presentation (37 slides) and associated worksheets that guide students through the DNA sequencing method called pyrosequencing. The lesson focusses on the numerous enzymes and substrates which are involved in the cascade of events which eventually leads to the production of light when the conversion from luciferin to oxyluciferin occurs. A step by step guide is used to show the students how these events occur and the different outcomes are explored. There are regular progress checks throughout the lesson so that students can assess their understanding of this topic and the links to similar topics. This lesson has been designed for A-level students and above

A fully-resourced lesson, which has been designed for GCSE students, and includes an engaging and informative lesson presentation (37 slides) and differentiated worksheets. This lesson explores the type of cell division known as meiosis and focuses on the use of key terminology so that students can apply their knowledge to any organism that carries out this division, and not just humans. For this reason, time is taken at the start of the lesson to go over the meaning of the terms, diploid and haploid. Students are also taught how to think about the quantity of DNA inside a cell in terms of n, so that they can see and understand how this quantity changes through the cell cycle. They are encouraged to fill in a table at each stage of the cycle to show the quantity of DNA. In this way, students will understand how a diploid parent cell goes through interphase and as a result of DNA replication, the quantity of DNA is 4n as the first meiosis division is about to start. Although this could be viewed as high end knowledge, the format of this lesson should allow all abilities to understand and therefore have more chance of being successful with meiosis questions. Students are encouraged to think for themselves to work out how many daughter cells will result at the end of two divisions and to consider the quantity of DNA found inside those cells. At this stage of the lesson, students have to summarise all they have learnt into two key points (as shown on the cover image). The remainder of the lesson gives them the opportunity to apply their knowledge with a range of questions and it is not until right at the end that they are allowed to finally relate this cell division to humans. Although this lesson has been primarily designed for GCSE students (14 - 16 year olds in the UK), it is highly suitable for A-level lessons, especially if a teacher wants to recap on this cell division before extending knowledge.

This lesson uses the example of the genetic engineering of bacteria to produce insulin to walk students through the steps involved in this process. It has been written for GCSE students and therefore includes the detail required at this level, such as the involvement of restriction enzymes and the sticky ends that their cut produces. The lesson begins by challenging students to recognise that insulin is being described by a series of clues. Some further details of this hormone are recalled to test their previous knowledge of the endocrine system and also to lead into the genetic engineering of bacteria to make this protein. Moving forwards, time is taken to go through the details of plasmids and how they act as vectors as well as the enzymes, restriction and ligase. The main task of the lesson uses a series of descriptions to go through the steps involved in the process. Words or phrases are missing from each description so students have to use the terms they’ve encountered in this lesson as well as their prior knowledge to complete the step. Discussion-provoking questions are added to encourage the students to consider why certain parts of the process occur. The lesson concludes by the consideration of other organisms which have been genetically engineered as well as some of the risks of the process, which students are asked to complete for homework. As detailed above, this lesson has been designed for GCSE students but could be used with students taking A-level Biology, who are struggling to understand the detail found at this level and need to revisit the foundations.

This fully-resourced lesson covers the content of the first part of specification point 5.1.3 (d) of the OCR A-level Biology A specification that states that students should be able to demonstrate and apply an understanding of the structures and roles of synapses in nervous transmission. The majority of the lesson uses the cholinergic synapse as the example but other neurotransmitters are considered to provide the students with a wider view of this topic. The lesson begins by using a version of the WALL (as shown in the cover image) which asks the students to group 12 words into three groups of 4. Not only will this challenge their prior knowledge from topics earlier in this module but it will also lead to the discovery of four of the structures that are found in a synapse. Moving forwards, students are introduced to aectylcholine as the neurotransmitter involved at cholinergic synapses and they will start to add labels to the structures found in the pre-synaptic bulb. Time is taken to focus on certain structures such as the voltage gated channels as these types of channel were met previously when looking at the depolarisation of a neurone. There is plenty of challenge and discovery as students are pushed to explain why organelles like mitochondria would be found in large numbers in the bulb. With this process being a cascade of events, a bullet point format is used to ensure that the key content is taken in by the students and again key points like exocytosis and the action of acetylcholinesterase are discussed further. The final part of the lesson challenges the application aspect of the specification as students are introduced to unfamiliar situations in terms of synapses with new drugs like MDMA and are asked to work out and explain how these affect the nervous transmission. Understanding checks and prior knowledge checks are included throughout the lesson so that students can not only assess their progress against the current topic but also see whether they can make links to earlier topics. This lesson has been designed for students studying the OCR A-level Biology A course but could be used with very able GCSE students who are keen to develop their understanding of synapses over and above the small detail that is provided at that level. This lesson also ties in nicely with the other uploaded lessons from module 5.1.3 (neuronal communication) which are sensory receptors, neurones, nerve impulses and summation.

Monosaccharides are the monomers from which larger carbohydrates are formed and this lesson describes their structure and roles in living organisms. The detailed and engaging PowerPoint and accompanying resources have been designed to cover the first part of point 1.2 of the AQA A-level Biology specification and looks at alpha-glucose, beta-glucose, galactose, fructose, deoxyribose and ribose. The lesson begins with a made-up round of the quiz show POINTLESS, where students have to try to identify four answers to do with carbohydrates. In doing so, they will learn or recall that these molecules are made from carbon, hydrogen and oxygen, that they are a source of energy which can sometimes be rightly or wrongly associated with obesity and that the names of the three main groups is derived from the Greek word sakkharon. Using the molecular formula of glucose as a guide, students will be given the general formula for the monosaccharides and will learn that deoxyribose is an exception to the rule that the number of carbon and oxygen atoms are equal. Moving forwards, students have to study the displayed formula of glucose for two minutes without being able to note anything down before they are challenged to recreate what they saw in a test of their observational skills. At this point of the lesson, the idea of numbering the carbons is introduced so that the different glycosidic bonds can be understood in an upcoming lesson as well as the recognition of the different isomers of glucose. The difference between alpha and beta-glucose is provided and students are again challenged to draw a molecule of glucose, this time for the beta form. The remainder of the lesson focuses on the roles of the 6 monosaccharides and the final task involves a series of application questions where the students are challenged to suggest why ribose could be considered important for active transport and muscle contraction

This fully-resourced lesson describes the process of DNA replication and explains how this ensures genetic continuity between generations. Both the detailed PowerPoint and accompanying resources have been designed to cover point 1.5.2 of the AQA A-level Biology specification and also explains why it is known as semi-conservative. The main focus of this lesson is the roles of DNA helicase in the breaking the hydrogen bonds between nucleotide bases and DNA polymerase in forming the growing nucleotide strands. Students are also introduced to DNA ligase to enable them to understand how this enzyme functions to join the nucleic acid fragments. Time is taken to explain key details, such as the assembly of strands in the 5’-to-3’ direction, so that the continuous manner in which the leading strand is synthesised can be compared against that of the lagging strand. The students are constantly challenged to make links to previous topics such as DNA structure and hydrolysis reactions through a range of exam questions and answers are displayed so that any misconceptions are quickly addressed. The main task of the lesson asks the students to use the information provided in the lesson to order the sequence of events in DNA replication before discussing how the presence of a conserved strand and a newly built strand in each new DNA molecule shows that it is semi-conservative.

An engaging lesson presentation (34), accompanied by a summary worksheet, which together explore the factors which change the rate of transpiration and focuses on the explanation behind each factor. The lesson begins by introducing the term, transpiration, and linking this to the structure of a leaf to ensure that students know that water is lost as water vapour out of the stomata. Students are provided with an analogy of plants being like clothes on a washing line to challenge them to come up with some of the factors involved. Time is taken to look specifically at humidity as this is a factor which is commonly misunderstood. Moving forwards, students are challenged to draw sketch graphs to predict whether increasing each of these factors will increase the rate of transpiration or decrease it. A series of questions to lead to answers is used to show the students how to explain the effect of increasing the light intensity. The remainder of the lesson looks at a potometer and how it can be used to calculate the rate. The mathematical skills of the students are challenged during a range of tasks and then linked back to the Science so they can recognise which features of plants will help to reduce water loss. Progress checks are written into this lesson at regular intervals to allow students to assess their understanding and a number of quick competitions act to maintain engagement. This lesson has been written for GCSE students but is suitable for A-level students who are studying the plants topic

This is a fully-resourced lesson which covers the detail of point 5.1.3 (b) of the OCR A-level Biology A specification which states that students should be able to apply their understanding of the structures and functions of sensory, relay and motor neurones as well as the differences between myelinated and unmyelinated neurones. The PowerPoint has been designed to contain a wide range of activities that are interspersed between understanding and prior knowledge checks that allow the students to assess their progress on the current topics as well as challenge their ability to make links to topics from earlier in the modules. Quiz competitions like SAY WHAT YOU SEE are used to introduce key terms in a fun and memorable way. The students will be able to compare these neurones based on their function but also distinguish between them based on their structural features. Time is taken to look at the importance of the myelin sheath for the sensory and motor neurones. Students will be introduced to the need for the entry of ions to cause depolarisation and will learn that this is only possible at the nodes of Ranvier when there is a myelin sheath. Key terminology such as saltatory conduction is introduced and explained. The final task involves a comparison between the three neurones to check that the students have understood the structures and functions of the neurones. Throughout the lesson, links are made to the upcoming topic of the organisation of the nervous system (5.1.5) and students will be given additional knowledge such as the differences between somatic and autonomic motor neurones. This lesson has been designed for students studying on the OCR A-level Biology A course.