This fully-resourced lesson has been designed to cover the content of specification point 5.2.2 (The brain) as found in topic 5 of the AQA GCSE Biology specification. This resource contains an engaging PowerPoint (33 slides) and accompanying worksheets, some of which have been differentiated so that students of different abilities can access the work. The resource is filled with a wide range of activities, each of which has been designed to engage and motivate the students whilst ensuring that the key Biological content is covered in detail. Understanding checks are included throughout so that the students can assess their grasp of the content. In addition, previous knowledge checks make links to content from earlier topics such as cancer. The following content is covered in this lesson: The functions of the cerebral cortex, medulla and cerebellum Identification of the regions of the brain on an external and internal diagram The early use of stroke victims to identify functions The key details of the MRI scanning technique The difficulties of diagnosing and treating brain disorders and disease As stated at the top, this lesson has been designed for GCSE-aged students who are studying the AQA GCSE Biology course, but it can be used with A-level students who need to go back over the key points before looking at the functionality of the regions in more detail

This lesson describes the main characteristics of benign and malignant tumours. The PowerPoint and accompanying resource are part of the 1st lesson in a series of 2 lessons which have been planned to cover the content of point 8.2.3 of the AQA A-level biology specification. This lesson begins by challenging the students to recognise the process of mitosis from a single clue. This single clue is “a controlled process” and has been designed to remind them that mitosis is a process controlled by genes. A quick quiz round challenges their recall of the details of the mitotic cell cycle to reveal the key term, tumour, and this introduces the idea that a mutation to one of the genes leads to uncontrolled cell division and the formation of tumours. Moving forwards, the lesson considers the features of benign tumours, beginning with the key point that these masses of cells are not cancerous. Students will learn that their growth rate is slower than malignant tumours, and due to a covering of fibrous connective tissue, the cells do not invade neighbouring tissues. However, the lesson points out that due to mass effect, benign tumours can cause secondary pathological effects such as organ damage. This leads into a task where the students are challenged on their knowledge of osmoregulation, digestion and blood glucose regulation to identify the tissues which are impacted. The rest of the lesson describes the features of malignant tumours and time is spent considering how the ability of these cells to metastasise makes them so dangerous.

This lesson has been designed to cover the content of the 1st part of specification point 6.1.2 of the AQA A-level Biology specification which states that students should know the basic structure of a Pacinian corpuscle and be able to use its function as a representation of sensory receptors. By the end of the lesson students will understand that sensory receptors respond to specific stimuli and how a generator potential is established. The lesson begins by using a quiz to get the students to recognise the range of stimuli which can be detected by receptors. This leads into a task where the students have to form 4 sentences to detail the stimuli which are detected by certain receptors and the energy conversion that happen as a result. Students will be introduced to the idea of a transducer and learn that receptors always convert to electrical energy which is the generator potential. The remainder of the lesson focuses on the Pacinian corpuscle and how this responds to pressure on the skin. The involvement of sodium and potassium ions is introduced so discussions on how the membrane potential changes from resting potential in the establishment of a generator potential are encouraged. This lesson has been written for students studying on the AQA A-level Biology course and ties in nicely with other uploaded lessons which cover the content of topic 6

This fully-resourced lesson describes how the functional differences of the retinal rod and cone cells is related to their structures. The detailed PowerPoint and accompanying resources are part of the 2nd in a series of 2 lessons that have been designed to cover the details included in point 6.1.2 of the AQA A-level Biology specification. However, as explained at the start of the lesson, it has been specifically planned to be taught after the lessons in topic 6.3, so that students are aware and understand the meaning of terms such as depolarisation and hyperpolarisation. It is likely that students will be aware that the human retina contains rod and cone cells, so this lesson builds on that knowledge and adds the detail needed at this level. Over the course of the lesson, students will learn that these cells contain different optical pigments and that this feature along with their differing connectivity to the bipolar neurones means that they have different sensitivities to light, colour perception and visual acuity. Exam-style questions are interspersed throughout to check on current understanding and also make links to previously covered topics. For example, students are challenged to recognise a description of the mitochondria so they can discover that this cell structure is found in the inner segment where it is responsible for generating the ATP needed to pump sodium ions out of the cells. As detailed above, this lesson ties in closely with topic 6.3 and students will be expected to make links to synapses and to the changes in membrane potential that occur when sodium ions move in or out of a cell

This lesson describes the location and main functions of the cerebrum, cerebellum, medulla oblongata and hypothalamus. The engaging PowerPoint and accompanying resources have been designed in line with point 9.4 (iii) of the Edexcel A-level biology B specification and also include descriptions of the link between the hypothalamus and the pituitary gland. The lesson begins with a multiple-choice question, where the students will learn that cerebrum is the Latin word for brain. This brain structure is described as two hemispheres and students will be introduced to the localisation of function of the 4 lobes of the cerebral cortex. It moves onto the cerebellum, focusing on its role of perfecting and coordinating movement, and explains how this is achieved through neural connections with the cerebrum. The control of heart rate by the medulla oblongata is described before the lesson concludes with an exploration of the connections between the hypothalamus and the two lobes of the pituitary gland, specifically in the mechanisms of osmoregulation and thermoregulation. As this is an extensive lesson covering a lot of detail, it has been planned to contain 5 quiz rounds as part of a competition which will help to maintain engagement whilst checking on their recall and understanding of content. There are also multiple understanding and prior knowledge checks which allow the students to assess their progress against the current topic and to make links to previously covered content. All answers to these knowledge checks are embedded into the PowerPoint. It is likely that this lesson will take between 2 - 3 hours of teaching time, but sections can be edited and removed if the teacher doesn’t want to look at a particular structure in that detail at this stage of study.

This is a fully-resourced REVISION lesson which challenges the students on their knowledge of the content in TOPIC B5 (Genetics) of the Edexcel GCSE Combined Science specification. The lesson uses an engaging PowerPoint (63 slides) and accompanying worksheets to motivate students whilst they assess their understanding of this topic. A range of exam questions, quick tasks and quiz competitions are used to test the following sub-topics: Recognising and using genetic terminology in context Constructing genetic diagrams to calculate offspring percentages for diseases caused by dominant and recessive alleles The sex chromosomes and sex determination Meiosis and the formation of haploid daughter cells The structure of DNA Extracting DNA from a fruit Genetic and environmental variation Mutations and their effect on the phenotype The mathematical element of the course is also tested throughout the lesson and students are given helpful hints on exam techniques and how to structure answers. This resource is suitable for use at the end of topic B3 or in the lead up to mocks or the actual GCSE exams.

This fully-resourced lesson explores how projects to sequence the genomes of both simple and complex organisms can be used. Both the detailed PowerPoint and accompanying resources have been designed to cover the content of point 8.3 of the AQA A-level Biology specification. The start of the lesson describes each step of Sanger’s chain termination method and demonstrates how this method has paved the way for other projects. The use of the modified nucleotides are explained and links are made to the topic 4 and 2 where protein synthesis and DNA replication were first introduced. Students will learn how the radioactively-labelled nucleotide at the end of each fragment allows the next base to be determined. Key processes like gel electrophoresis are introduced and details provided to support the students when this is encountered in greater detail in 8.4.3. Moving forwards, the applications of sequencing in simple organisms like viruses and bacteria are explored and the students are challenged on their prior knowledge of bacterial pathogenesis and current understanding of sequencing through a series of exam-style questions. The final part of the lesson looks at the difficulties of translating genome knowledge into proteome knowledge and considers the development of automated methods. Due to the detail and extensiveness of this lesson, it is estimated that it will take in excess of 2 hours of allocated A-level teaching time to cover all of the points which have been written into the various tasks

This concise lesson acts as an introduction to topic 5.3, Energy and Ecosystems, and describes how plant biomass is formed, measured and estimated. The engaging PowerPoint is the 1st in a series of 3 lessons which have been designed to cover the detailed content of topic 5.3 of the AQA A-level Biology specification. A quiz round called REVERSE Biology Bingo runs throughout the lesson and challenges students to recognise the following key terms from descriptions called out by the bingo caller: community ecosystem abiotic factor photosynthesis respiratory substrate biomass calorimetry The ultimate aim of this quiz format is to support the students to understand that any sugars produced by photosynthesis that are not used as respiratory substrates are used to form biological molecules that form the biomass of a plant and that this can be estimated using calorimetry. Due to the clear link to photosynthesis, a series of prior knowledge checks are used to challenge the students on their knowledge of this cellular reaction but as this is the first lesson in the topic, the final section of the lesson looks forwards and introduces the chemical energy store in the plant biomass as NPP and students will also meet GPP and R so they are partially prepared for the next lesson.

This lesson describes the mechanism of breathing, including the roles of the ribcage, intercostal muscles and the diaphragm. The content of the engaging PowerPoint has been designed to cover the details of the fifth part of specification point 3.2 of the AQA A-level Biology specification and introduces the antagonistic interaction of the external and internal intercostal muscles. The lesson begins with a focus on the diaphragm and students will discover that this sheet of muscle is found on the floor of the thoracic cavity. Whilst planning the lesson, it was deemed important to introduce this region of the body at an early stage because the best descriptions will regularly reference the changes seen in this cavity. As the mechanism of inhalation is a cascade of events, the details of this process are covered in a step by step format using bullet points. At each step, time is taken to discuss the key details which includes an introduction to Boyle’s law that reveals the inverse relationship between volume and pressure. It is crucial that students are able to describe how the actions of the diaphragm, external intercostal muscles and ribcage result in an increased volume of the thoracic cavity and a subsequent decrease in the pressure, which is below the pressure outside of the body. At this point, their recall of the structures of the mammalian gas exchange system is tested, to ensure that they can describe the pathway the air takes on moving into the lungs. The remainder of the lesson involves a task which challenges the students to describe exhalation and then the accessory muscles involved in forced ventilation are also considered.

This lesson describes the pathway by which the translation of mRNA into proteins can be prevented by siRNA and miRNA molecules. The engaging and detailed PowerPoint and accompanying resources are part of the final lesson in a series of 4 lessons that cover the detail of point 8.2.2 of the AQA A-level biology specification. The lesson begins with an exisiting knowledge check, as the students are challenged to recognise the processes of DNA methylation and histone acetylation, before RNA interference is introduced as another way by which gene expression is controlled in eukaryotes. Moving forwards, a quick quiz round introduces small interfering RNA (siRNA) and students will learn how this double-stranded, non-coding RNA is normally just 21 base pairs long. A step by step guide then describes the action of siRNA in preventing translation, through the cutting of the target mRNA into fragments which are then degraded. Time is taken to consider the possible application of siRNA molecules in the treatment of HIV and then cystic fibrosis, and the latter involves a series of exam-style questions which challenge the students on their understanding of this topic as well as the recall of content from the other 7 AQA topics. The remainder of the lesson focuses on microRNA (miRNA) and students will understand how this molecule is produced and how its action differs to that of siRNA in mammalian cells.

This revision lesson has been designed to challenge the students on their use of a range of mathematical skills that could be assessed on the AQA GCSE Combined Science papers. The mathematical element of the AQA GCSE Combined Science course has increased significantly since the specification change and therefore success in those questions which involve the use of maths can prove to be the difference between one grade and another or possibly even more. The engaging PowerPoint and accompanying resources contain a wide range of activities that include exam-style questions with displayed mark schemes and explanations so that students can assess their progress. Other activities include differentiated tasks, class discussion points and quick quiz competitions such as “YOU DO THE MATH” and “FILL THE VOID”. The following mathematical skills (in a scientific context) are covered in this lesson: The use of Avogadro’s constant Rearranging the formula of an equation Calculating the amount in moles using mass and relative formula mass Calculating the relative formula mass for formulae with brackets Using the Periodic Table to calculate the number of sub-atomic particles in atoms Changes to electrons in ions Balancing chemical symbol equations Converting between units Calculating concentration in grams per dm cubed and volumes of solutions Calculating size using the magnification equation Using the mean to estimate the population of a sessile species Calculating percentages to prove the importance of biodiversity Calculating percentage change Calculating the acceleration from a velocity-time graph Recalling and applying the Physics equations Understanding prefixes that determine size Leaving answers to significant figures and using standard form Helpful hints and step-by-step guides are used throughout the lesson to support the students and some of the worksheets are differentiated two ways to provide extra assistance. Due to the detail of this lesson, it is estimated that it will take in excess of 3 hours of GCSE teaching time to cover the tasks and for this reason it can be used over a number of lessons as well as during different times of the year for revision.

This extensive revision lesson challenges students on their knowledge and understanding of the content of topics 5 - 8 of the AQA A-level specification. The PowerPoint and accompanying resources are detailed and engaging and contain a selection of tasks which challenge the following points: Directional, stabilising and disruptive selection Saltatory conduction and other factors affecting conductance speed The structure of a motor neurone Sensory receptors, depolarisation and initiation of an action potential Hardy-Weinberg principle Genetic terminology Codominance and sex-linkage Autosomal linkage Chi-squared test Phosphorylation The stages of aerobic respiration Explaining lower ATP yields in anaerobic respiration Skeletal muscle contraction Structure and function of slow and fast twitch muscle fibres The control of heart rate Electrophoresis and genetic fingerprinting The secondary messenger model The students are tested through a variety of tasks including exam questions, understanding checks, and quiz rounds to maintain engagement. Due to the mathematical content in all A-level exams, there is also a focus on these skills. The answers to all questions are embedded into the PowerPoint so students can use this resource outside of the classroom. The delivery of the whole lesson will likely need at least 2 or 3 hours of contact time so this resource could be used with students in the final weeks building up to their paper 2 exam, or alternatively with students before their mocks on these topics.

This lesson describes how the role of carrier of proteins and ATP in active transport and the co-transport of sodium ions and glucose in the ileum. The PowerPoint and accompanying resources are part of the final lesson in a series of 3 that have been designed to cover the details of point 2.3 of the AQA A-level Biology specification and also includes descriptions of endocytosis and exocytosis The start of the lesson focuses on the structure of this energy currency and challenges the students prior knowledge as they covered ATP in topic 1.6. As a result, they will recall that this molecule consists of adenine, ribose and three phosphate groups and that in order to release the stored energy, ATP must be hydrolysed. Time is taken to emphasise the key point that the hydrolysis of ATP can be coupled to energy-requiring reactions and this leads into a series of exam-style questions where students are challenged on their knowledge of simple and facilitated diffusion to recognise that ATP is needed for active transport. These questions also challenge them to compare active transport against the forms of passive transport and to use data from a bar chart to support this form of transport. In answering these questions they will discover that carrier proteins are specific to certain molecules and time is taken to look at the exact mechanism of these transmembrane proteins. A quick quiz round introduces endocytosis and the students will see how vesicles are involved along with the energy source of ATP to move large substances in or out of the cell. The students are then shown how exocytosis is involved in a synapse and in the release of ADH from the pituitary gland during osmoregulation which they will cover in later topics. The final part of the lesson describes the movement of sodium ions and glucose from the ileum to the epithelial cells to the blood using a range of proteins which includes cotransporter proteins and students will learn that similar mechanisms are seen in the phloem and in the proximal convoluted tubule.

An engaging lesson presentation (16 slides) which looks at the surface area to volume ratio and ensures that students can explain why this factor is so important to the organisation of living organisms. This is a topic which is generally poorly misunderstood by students and therefore time has been taken to design an engaging lesson which highlights the key points in order to encourage greater understanding. The lesson begins by showing students the dimensions of a cube and two answers and challenges them to work out what the questions were that produced these answers. Students are shown how to calculate the surface area and the volume of an object before it is explained how this can then be turned into a ratio. Time is taken at this point to ensure that students can apply this new-found knowledge as they have to work out which of the three organisms in the “SA: V OLYMPICS” would stand aloft the podium. Students are given the opportunity to draw conclusions from this task so that they can recognise that the larger the organism, the lower the surface area to volume ratio. The lesson finishes by explaining how larger organisms, like humans, have adapted in order to increase the surface area at important exchange surfaces in their bodies. There are regular progress checks throughout the lesson to allow the students to check on their understanding. This lesson has been written for GCSE students but is perfectly suitable for A-level students who want to look at this topic from a basic level

A concise lesson presentation (26 slides) that looks at how sexual reproduction leads to variation and considers the advantages and disadvantages of this form of reproduction. The lesson begins by getting the students to recognise that sexual reproduction needs two parents and therefore two gametes. Time is taken to ensure that students understand that these gametes are produced by meiosis and therefore contain the haploid number of chromosomes. Key terminology like haploid and zygote are used throughout the lesson. This lesson is suitable for both KS3 and GCSE students