This lesson describes the principles of cell fractionation and ultracentrifugation as used to separate cell components. The engaging PowerPoint and accompanying resources are part of the final lesson in a series of 4 lessons which have been planned to cover the details of point 2.1.3 of the AQA A-level biology specification. This lesson begins by informing the students that several of the key terms in this lesson, including the lesson title, end in -ation, and therefore they have to use the clues to work out that the 1st one is cell fractionation. A quiz round like this runs throughout the lesson, introducing homogenisation, filtration and ultracentrifugation in a memorable way. Time is taken to explain each of the processes in detail, and where possible, links are made to previously covered content as well as content that will be met in future lessons. For example, students will learn that the solution must be kept ice-cold and isotonic, and they are challenged to recognise that the low temperature is to reduce the activity of potentially damaging enzymes, before being told that there will be no net movement of water by osmosis because of the isotonic solution. The answers to all understanding and prior knowledge checks are embedded into the PowerPoint to allow students to assess their progress. When explaining the process of ultracentrifugation, the students are given an opportunity to predict which of 6 listed organelles will be found in the 1st pellet because it is the heaviest, right down to the lightest organelle. The lesson finishes with several exam-style questions to check that they’ve understood this separation technique and have a strong knowledge of cells and their organelles. This lesson has been planned to continously link with the other lessons in topic 2.1 (Cell structure).

This lesson guides students through the calculation of mitotic indices and explores what a high value may indicate about the sampled tissue. The PowerPoint and accompanying resources have been planned to cover the content of point 3.16 of the Edexcel International A-level biology specification. The lesson begins with a bit of fun, as the students are challenged to use three clues to identify three uses of the term index in biology. They’ll learn that the index of diversity is covered in a topic 4 lesson and that this lesson focuses on the mitotic index. The students are challenged on their knowledge of the mitotic cell cycle throughout the lesson and one of these questions is used to introduce the meaning of the index and the formula. A series of exam-style questions challenge them to apply their understanding, and the answers are embedded into the PowerPoint to enable the students to assess their progress. Moving forwards, the different meanings of high values are considered, including growing and repairing tissues, and then to explain how an elevated mitotic index can indicate that cell division has become uncontrolled which can lead to tumour formation.

This lesson explains how uncontrolled cell division can lead to the formation of tumours and considers the differences between benign and malignant. The PowerPoint and accompanying resources have been planned to cover point 5.1 (6) of the CIE A-level biology specification (for assessment in 2025 - 2027), The lesson begins with the introduction of the meaning of the mitotic index as well as its formula and the students are then challenged to apply their understanding of this unfamiliar formula to a series of exam-style questions. This will challenge their mathematical skills along with the recollection of the details of the cell cycle that were met in the earlier lessons in topic 5.1. Moving forwards, the potential meanings of a high mitotic index are explored, including high rates of growth and tissue repair, before students are supported to understand that this could indicate that cell division has become uncontrolled. The key term tumour is revealed during a quick quiz round and then the remaining part of the lesson considers how benign and malignant tumours differ. Understanding checks and prior knowledge checks are found throughout the lesson and the answers are embedded into the PowerPoint to allow the students to assess their progress.

This lesson explains how to calculate the mitotic index and then explores what a high value may indicate about the tissue that was sampled. The PowerPoint and accompanying resources are part of the 2nd lesson in a series of 3 which have been planned to cover the content of point 2.2 of the AQA A-level biology specification. As shown in the cover image, the lesson begins with a bit of fun, as the students are challenged to use three clues to identify three uses of the term index in biology. They’ll learn that the index of diversity is covered in a topic 4 lesson and that this lesson focuses on the mitotic index. The students are challenged on their knowledge of the mitotic cell cycle throughout the lesson and one of these questions is used to introduce the meaning of the index and the formula. A series of exam-style questions challenge them to apply their understanding, and the answers are embedded into the PowerPoint to enable the students to assess their progress. Moving forwards, the different meanings of high values are considered, including growing and repairing tissues, and then to explain how an elevated mitotic index can indicate that cell division has become uncontrolled. This prepares students for the next lesson where tumour formation and cancer will be covered.

This lesson describes the organisation of the mammalian nervous system, focusing on the CNS and the numerous divisions and subdivisions of the PNS. The PowerPoint and accompanying resource have been planned to cover the content of points 9.4 (i) and (iv) of the Edexcel A-level biology B specification. The lesson begins by challenging the students to recognise 6 organ systems from their descriptions, with the final description relating to the nervous system. A prior knowledge check of the classification topic introduces the lesson topic as the structure of the mammalian nervous system and then the lesson moves through the different divisions, completing the diagram in the cover image as each one is explored. The brain, spinal cord, neurones and autonomic nervous system are described in depth in upcoming lessons, so this lesson has been designed to introduce key information and to challenge students to build on the details they have from GCSE studies!

This lesson focuses on the structure of the spinal cord but also introduces key nervous system structures to prepare students for upcoming topic 9 lessons. The PowerPoint and accompanying resource have been planned to cover the content of point 9.4 (ii) of the Edexcel A-level biology B specification. As shown on the cover image, the lesson begins with a challenge, where students must use their knowledge of content from earlier topics to reveal 5 numbers that add up to 33. They will learn that this is the normal number of vertebrae in the human vertebral column and this leads into the recognition that these bones act to surround and protect the spinal cord. The meninges are introduced and then a quick quiz round is used to reveal the term, grey matter. Students will see that this is found in the centre of the spinal cord and is surrounded by an outer region of white matter. The idea of myelination is introduced, and initial details provided about the increased conductance speed in myelinated neurones because of saltatory conduction. Moving forwards, students will meet the terms dorsal and ventral and see on a diagram that nerves enter and leave the cord by these roots. The role of cerebrospinal fluid is explored and a series of exam-style questions are used to challenge their knowledge from topic 2 and 6 as well as their mathematical skills. The answers are embedded into the PowerPoint to allow the students to assess their progress. The lesson finishes with the introduction of the cauda equina as the bundle of nerves at the distal end of the spinal cord.

This lesson describes the nervous pathways of a range of reflex actions, including spinal reflex arcs and a cranial reflex, and their survival value is explored. The PowerPoint and accompanying resources have been planned to cover the content of point 5.1.5 (i) of the OCR A-level biology A specification. The lesson begins with a challenge, where the students have to spot the connections between 3 groups of 3 terms, and this will introduce different neurones, muscle tissues and reflexes for reference throughout. There are prior knowledge checks throughout the lesson, and one is immediately used to check on the students’ knowledge of the functions of the different structures in a nervous pathway and the order they are involved. The spinal reflex after an individual presses on a sharp pin is used to check that they can apply their knowledge to a real biological example. At this point, the potential for a reflex to be overridden if an unmyelinated relay neurone is involved is introduced and this is explained in detail later in the lesson. The knee jerk reflex is then discussed and students will understand that this is the choice for a reflex test because of the direct communication between the sensory and motor neurone. The final part of the lesson describes the corneal reflex as a cranial reflex and students will learn how it can be inhibited through conscious control by the higher part of the brain, as happens when an individual puts contact lenses on.

This lesson uses a 10 question multiple-choice assessment to provide students with the opportunity to assess their knowledge of neuronal communication. Module 5.1.3 of the OCR A-level biology A specification covers the role of mammalian sensory receptors, the structure and function of neurones, the generation and transmission of nerve impulses and the structure and roles of synapses and these 10 questions attempt to challenge their overall understanding of this content. The lesson also includes a PowerPoint with the answers to the questions and also further understanding checks to challenge knowledge not directly covered by the multiple-choice assessment. There are also some prior knowledge checks and links to the future.

This lesson describes the course of events that lead to atherosclerosis and explains how the human body can be affected by this inflammatory disease. The engaging PowerPoint and accompanying resources have been planned to cover the content of point 1.10 of the Edexcel International A-level biology specification and therefore includes descriptions of endothelial dysfunction, plaque formation and raised blood pressure. The lesson begins with a task where the students have to use their knowledge of the numbers associated with biology to move forwards and backwards through the alphabet to reveal the name of the disease, atherosclerosis. Students will learn that this is a chronic inflammatory disease. As shown in the cover image, the main part of the lesson uses a step-by-step guide to go through the events, from endothelium damage, monocyte recruitment, macrophage differentiation and eventually the protrusion of plaques into the lumen of the artery. Understanding and prior knowledge checks and quiz quiz competitions are used during this section of the lesson to allow the students to assess their progress and to introduce key terms in a memorable fashion. All answers to any questions are embedded into the PowerPoint. The final part of the lesson uses a series of exam-style questions to consider how atherosclerosis in different blood vessels could lead to medical issues such as myocardial infarctions and strokes.

This lesson describes the course of events that lead to atherosclerosis and explains the issues for the human body related to this inflammatory disease. The engaging PowerPoint and accompanying resources have been planned to cover the content of point 1.5 of the Pearson Edexcel A-level biology A specification. The lesson begins with a task where the students have to use their knowledge of the numbers associated with biology to move forwards and backwards through the alphabet to reveal the name of the disease, atherosclerosis. Students will learn that this is a chronic inflammatory disease. As shown in the cover image, the main part of the lesson uses a step-by-step guide to go through the events, from endothelium damage, monocyte recruitment, macrophage differentiation and eventually the protrusion of plaques into the lumen of the artery. Understanding and prior knowledge checks and quiz quiz competitions are used during this section of the lesson to allow the students to assess their progress and to introduce key terms in a memorable fashion. All answers to any questions are embedded into the PowerPoint. The final part of the lesson uses a series of exam-style questions to consider how atherosclerosis in different blood vessels could lead to medical issues such as myocardial infarctions and strokes.

This revision lesson uses a 15 question multiple-choice assessment to challenge the students on their knowledge of the content of module 5.1.2. In addition to the assessment, this lesson includes a PowerPoint where the answers are revealed, a series of key points linked to the OCR A-level biology A specification, and additional questions to challenge knowledge not directly covered by the 15 multiple-choice questions. The topics challenged by the assessment are: The meaning of the term excretion (as opposed to egestion) The structure of the liver The formation of urea by the ornithine cycle The regions of the kidney Ultrafiltration in the glomerulus The structure and function of the PCT The countercurrent multiplier mechanism in the loop of Henle Osmoregulation Homeostasis The use of renal dialysis Monoclonal antibodies in diagnostic tests

This lesson explains the relative energy values of the respiratory substrates, carbohydrates, lipids and proteins. The PowerPoint and accompanying resources have been planned to cover the content of point 12.1 (4) of the CIE A-level biology specification (for assessment in 2025 - 2027). The lesson begins with a challenge, where the students have to recognise the key term substrate using either 1 or 2 descriptions. The definition of a respiratory substrate is provided and students will learn that although glucose is the chief respiratory substrate, lipids and proteins can be metabolised to generate molecules of ATP. A quick quiz round is used to introduce the relative energy value per gram of carbohydrate and then this is used as a reference value for the remainder of the lesson. Students will learn that the energy value is higher for lipids and this is explained, making reference to the stages of respiration that will be covered in greater depth in the 12.2 lessons. The final part of the lesson considers proteins and makes a link to deamination, which again will be covered later in the course. The lesson contains multiple understanding checks and all answers are embedded into the PowerPoint to allow students to assess their progress.

This lesson describes the meaning of the respiratory quotient and guides students through the calculation of values from respiration equations. The PowerPoint and accompanying resource have been planned to cover the content of points 12.1 (5 & 6) of the CIE A-level biology specification (for assessment in 2025 - 2027). The lesson begins with a recall challenge, where the students have to demonstrate their knowledge of ATP and relative energy values to reveal the two letters, RQ. The meaning of a quotient is provided and time allocated, where they are encouraged to discuss which two respiratory values might be used, using their brief knowledge of aerobic respiration from iGCSE. The formula is provided and then a worked example used to model the calculation. The obtained value of 1.0 is explained as the RQ if metabolism consists entirely of carbohydrates. Two exam-style questions are then used to challenge the students to apply their understanding and they’ll reveal the value of 0.7 for lipids. A quick quiz round introduces the range for amino acids as 0.8 - 0.9 before a final task gets them to obtain another value and to recognise that more than one type of molecule is often metabolised. The lesson is full of understanding and prior knowledge checks, and the answers are embedded into the PowerPoint to allow students to assess their progress.

This lesson guides students through the respiratory quotient calculation and explains what the different calculated values indicate. The PowerPoint and accompanying resource have been planned to cover the content of point 7.6 of the Edexcel International A-level biology specification. The lesson begins with a recall challenge, where the students have to demonstrate their knowledge of respiration to reveal the two letters, RQ. The meaning of a quotient is provided and time allocated, where they are encouraged to discuss which two respiratory values might be used. The formula is provided and then a worked example used to model the calculation. The obtained value of 1.0 is explained as the RQ if metabolism consists entirely of carbohydrates. Two exam-style questions are then used to challenge the students to apply their understanding and they’ll reveal the value of 0.7 for lipids. A quick quiz round introduces the range for amino acids as 0.8 - 0.9 before a final task gets them to obtain another value and to recognise that more than one type of molecule is often metabolised. The lesson is full of understanding and prior knowledge checks, and the answers are embedded into the PowerPoint to allow students to assess their progress.

This lesson describes the structure and function of a spinal reflex arc, including the grey and white matter of the spinal cord. The PowerPoint and accompanying resources have been designed to cover the content of point 8.3 of the Edexcel International A-level biology specification. At the start of the lesson, the students are challenged to recognise the connections between three groups of key terms, and this acts to remind them of the sensory, motor and relay neurone, different types of muscle tissue and some reflexes. Time is taken to ensure that students understand that a spinal reflex arc is a direct neural pathway through the spinal cord and does not involve processing by the brain. Some of the content was covered at GCSE and in the first two lessons of topic 8, so this lesson has been specifically planned to challenge their recall of this content and then to build upon it, and understanding and prior knowledge checks are used throughout to allow them to assess their progress. The students will be able to recognise the different matter of the spinal cord, which is named according to the presence of myelinated or unmyelinated neurones and they will also understand how sensory neurones enter via the dorsal root and motor neurones exit via the ventral root. Moving forwards, two examples of real biological reflexes are used to increase relevance, and students will see how the knee jerk reflex is unusual as it doesn’t contain a relay neurone. References to synapses, myelination and saltatory conduction are included in the lesson and brief details provided before these are covered in upcoming topic 8 lessons.

This lesson describes the protective effect of a simple reflex, as exemplified by those which involve the sensory, relay and motor neurones. The PowerPoint and accompanying resources are part of the final lesson in a series of 3 lessons which have been planned to cover the content of point 6.1.1 of the AQA A-level biology specification, titled “Survival and response”. As shown on the cover image, the lesson begins with a challenge, where the students have to recognise the connection between key terms which have been grouped together. This will remind them of the names of three types of neurones, the three types of muscle tissue and some reflexes. Time is taken at the start to ensure that students understand that although the brain might be informed of a reflex, it isn’t involved in the processing to coordinate the movement. At the same time, the role of the other part of the CNS, the spinal cord in spinal reflexes, is emphasised. This lesson has been specifically planned to build on their knowledge of reflex actions from GCSE and to build in the detail that will support them in this lesson and as they move through the content of topic 6. Ultimately, students will understand how the rapid response of a simple reflex allows organisms to avoid damage and survive, due to the nervous pathway only consisting of three neurones, and therefore less synapses than other reactions. Understanding checks, in the form of exam-style questions are written into the lesson and the answers embedded into the PowerPoint to allow students to assess their progress against the current topic. The two other lessons in this series covering the detail of specification point 6.1.1 are named “responses in flowering plants” and “taxes and kineses”.

This lesson describes the stages of succession from colonisation to the formation of a climax community. The PowerPoint and accompanying worksheets have been designed to cover the content of point 5.15 of the Edexcel International A-level Biology specification. This lesson uses a step-by-step method to guide the students through each stage of the process of succession, explaining each of the gradual, progressive changes that occur in a community over time. At each stage, time is taken to consider the organisms involved. There is a focus on lichens as examples of pioneer species and students will understand how colonisation by these organisms is critical to provide organic matter and to turn the bare ground into soil so it is habitable by other species. The island of Surtsey in Iceland is used as a real-world example and shows how different parts of an area can be at different stages of succession. Understanding and prior knowledge checks are embedded into the PowerPoint (along with the answers) to allow students to assess their progress against the current topic and to encourage them to make links to previously-covered work.