This fully-resourced lesson describes how it’s possible for 1 gene to give rise to multiple products as a result of post-transcriptional modification of mRNA. The detailed PowerPoint and accompanying resources have been designed to cover point 7.2 (iii) of the Edexcel A-level Biology B specification. The lesson begins with a knowledge recall as the students have to recognise the definition of a gene as a sequence of bases on a DNA molecule that codes for a sequence of amino acids in a polypeptide chain. This description was introduced in topic 1 and the aim of the start of the lesson is to introduce the fact that despite this definition, most of the nuclear DNA in eukaryotes doesn’t actually code for proteins. A quick quiz competition is then used to introduce exons as the coding regions within a gene before students are challenged to predict the name of the non-coding regions and then to suggest a function for these introns. At this point, the students will complete a task that acts as a prior knowledge check where they have to identify the 6 errors in the descriptive passage about the lac operon and its role in the regulation of gene expression in prokaryotes. Moving forwards, pre-mRNA as a primary transcript is introduced and students will learn that this isn’t the mature strand that moves off to the ribosome for translation. Instead, a process called splicing takes place where the introns are removed and the remaining exons are joined together. Another quick quiz round leads to an answer of 20000 and students will learn that this is the number of protein-coding genes in the human genome. Importantly, the students are then told that the number of proteins that are synthesised is much higher than this value and a class discussion period encourages them to come up with biological suggestions for this discrepancy between the two numbers. The lesson concludes with a series of understanding and application questions where students will learn that alternative splicing enables a gene to produce more than a single protein and that this natural phenomenon greatly increases biodiversity.

A detailed lesson presentation (37 slides) and associated worksheets that guide students through the DNA sequencing method called pyrosequencing. The lesson focusses on the numerous enzymes and substrates which are involved in the cascade of events which eventually leads to the production of light when the conversion from luciferin to oxyluciferin occurs. A step by step guide is used to show the students how these events occur and the different outcomes are explored. There are regular progress checks throughout the lesson so that students can assess their understanding of this topic and the links to similar topics. This lesson has been designed for A-level students and above

A fully-resourced lesson, which has been designed for GCSE students, and includes an engaging and informative lesson presentation (37 slides) and differentiated worksheets. This lesson explores the type of cell division known as meiosis and focuses on the use of key terminology so that students can apply their knowledge to any organism that carries out this division, and not just humans. For this reason, time is taken at the start of the lesson to go over the meaning of the terms, diploid and haploid. Students are also taught how to think about the quantity of DNA inside a cell in terms of n, so that they can see and understand how this quantity changes through the cell cycle. They are encouraged to fill in a table at each stage of the cycle to show the quantity of DNA. In this way, students will understand how a diploid parent cell goes through interphase and as a result of DNA replication, the quantity of DNA is 4n as the first meiosis division is about to start. Although this could be viewed as high end knowledge, the format of this lesson should allow all abilities to understand and therefore have more chance of being successful with meiosis questions. Students are encouraged to think for themselves to work out how many daughter cells will result at the end of two divisions and to consider the quantity of DNA found inside those cells. At this stage of the lesson, students have to summarise all they have learnt into two key points (as shown on the cover image). The remainder of the lesson gives them the opportunity to apply their knowledge with a range of questions and it is not until right at the end that they are allowed to finally relate this cell division to humans. Although this lesson has been primarily designed for GCSE students (14 - 16 year olds in the UK), it is highly suitable for A-level lessons, especially if a teacher wants to recap on this cell division before extending knowledge.

This lesson uses the example of the genetic engineering of bacteria to produce insulin to walk students through the steps involved in this process. It has been written for GCSE students and therefore includes the detail required at this level, such as the involvement of restriction enzymes and the sticky ends that their cut produces. The lesson begins by challenging students to recognise that insulin is being described by a series of clues. Some further details of this hormone are recalled to test their previous knowledge of the endocrine system and also to lead into the genetic engineering of bacteria to make this protein. Moving forwards, time is taken to go through the details of plasmids and how they act as vectors as well as the enzymes, restriction and ligase. The main task of the lesson uses a series of descriptions to go through the steps involved in the process. Words or phrases are missing from each description so students have to use the terms they’ve encountered in this lesson as well as their prior knowledge to complete the step. Discussion-provoking questions are added to encourage the students to consider why certain parts of the process occur. The lesson concludes by the consideration of other organisms which have been genetically engineered as well as some of the risks of the process, which students are asked to complete for homework. As detailed above, this lesson has been designed for GCSE students but could be used with students taking A-level Biology, who are struggling to understand the detail found at this level and need to revisit the foundations.

Monosaccharides are the monomers from which larger carbohydrates are formed and this lesson describes their structure and roles in living organisms. The detailed and engaging PowerPoint and accompanying resources have been designed to cover the first part of point 1.2 of the AQA A-level Biology specification and looks at alpha-glucose, beta-glucose, galactose, fructose, deoxyribose and ribose. The lesson begins with a made-up round of the quiz show POINTLESS, where students have to try to identify four answers to do with carbohydrates. In doing so, they will learn or recall that these molecules are made from carbon, hydrogen and oxygen, that they are a source of energy which can sometimes be rightly or wrongly associated with obesity and that the names of the three main groups is derived from the Greek word sakkharon. Using the molecular formula of glucose as a guide, students will be given the general formula for the monosaccharides and will learn that deoxyribose is an exception to the rule that the number of carbon and oxygen atoms are equal. Moving forwards, students have to study the displayed formula of glucose for two minutes without being able to note anything down before they are challenged to recreate what they saw in a test of their observational skills. At this point of the lesson, the idea of numbering the carbons is introduced so that the different glycosidic bonds can be understood in an upcoming lesson as well as the recognition of the different isomers of glucose. The difference between alpha and beta-glucose is provided and students are again challenged to draw a molecule of glucose, this time for the beta form. The remainder of the lesson focuses on the roles of the 6 monosaccharides and the final task involves a series of application questions where the students are challenged to suggest why ribose could be considered important for active transport and muscle contraction

This fully-resourced lesson describes the process of DNA replication and explains how this ensures genetic continuity between generations. Both the detailed PowerPoint and accompanying resources have been designed to cover point 1.5.2 of the AQA A-level Biology specification and also explains why it is known as semi-conservative. The main focus of this lesson is the roles of DNA helicase in the breaking the hydrogen bonds between nucleotide bases and DNA polymerase in forming the growing nucleotide strands. Students are also introduced to DNA ligase to enable them to understand how this enzyme functions to join the nucleic acid fragments. Time is taken to explain key details, such as the assembly of strands in the 5’-to-3’ direction, so that the continuous manner in which the leading strand is synthesised can be compared against that of the lagging strand. The students are constantly challenged to make links to previous topics such as DNA structure and hydrolysis reactions through a range of exam questions and answers are displayed so that any misconceptions are quickly addressed. The main task of the lesson asks the students to use the information provided in the lesson to order the sequence of events in DNA replication before discussing how the presence of a conserved strand and a newly built strand in each new DNA molecule shows that it is semi-conservative.

An engaging lesson presentation (34), accompanied by a summary worksheet, which together explore the factors which change the rate of transpiration and focuses on the explanation behind each factor. The lesson begins by introducing the term, transpiration, and linking this to the structure of a leaf to ensure that students know that water is lost as water vapour out of the stomata. Students are provided with an analogy of plants being like clothes on a washing line to challenge them to come up with some of the factors involved. Time is taken to look specifically at humidity as this is a factor which is commonly misunderstood. Moving forwards, students are challenged to draw sketch graphs to predict whether increasing each of these factors will increase the rate of transpiration or decrease it. A series of questions to lead to answers is used to show the students how to explain the effect of increasing the light intensity. The remainder of the lesson looks at a potometer and how it can be used to calculate the rate. The mathematical skills of the students are challenged during a range of tasks and then linked back to the Science so they can recognise which features of plants will help to reduce water loss. Progress checks are written into this lesson at regular intervals to allow students to assess their understanding and a number of quick competitions act to maintain engagement. This lesson has been written for GCSE students but is suitable for A-level students who are studying the plants topic

This lesson introduces the key inorganic ions that are involved in biological processes and includes cations and anions. The engaging PowerPoint and accompanying resources have been designed to cover point 2.1.2 § of the OCR A-level Biology A specification but also makes links to topics in upcoming modules such as respiration, photosynthesis and neuronal communication. The roles of the following ions are covered in this lesson: phosphate nitrate chloride hydroxide hydrogencarbonate hydrogen ammonium sodium potassium calcium Extra time is taken during the lesson to describe how these ions are involved in the transport of carbon dioxide, the conduction of nervous impulses and blood clotting as well as other processes and a number of quiz competitions have been included to introduce key terms in a fun and memorable way

An engaging lesson presentation (59 slides) and associated worksheets that uses a combination of exam questions, quick tasks and quiz competitions to help the students to assess their understanding of the topics found within unit B2 (Scaling up) of the OCR Gateway A GCSE Biology specification The topics that are tested within the lesson include: Diffusion Osmosis Active transport Exchange and transport Circulatory systems Heart and blood Plant transport systems Transpiration Students will be engaged through the numerous activities including quiz rounds like “Where’s LENNY?" whilst crucially being able to recognise those areas which need further attention

A resourced lesson which looks at the organisation of the human nervous system and explores how these structures are involved in nervous reactions. The lesson includes an engaging lesson presentation (27 slides) and an associated worksheet with an understanding check. The lesson begins by looking at different examples of stimuli and therefore introducing the key term, receptors, as structures which detect these changes in the environment. Moving forwards, a quiz competition is used to introduce the students to the abbreviations CNS and PNS and students will learn the structures that are found in these parts. At this stage of the lesson, a quick understanding check is written into the lesson to see whether students know the functions of each of the structures and check whether they can order them correctly from stimuli to effectors. Students will meet the term synapse and be taught that the conduction across these gaps is slow so that this knowledge can be applied in future lessons on reflexes. The remainder of the lesson challenges the students to apply their new-found knowledge in ordering an example of a nervous reaction.

This fully-resourced lesson covers the content of the first part of specification point 5.1.3 (d) of the OCR A-level Biology A specification that states that students should be able to demonstrate and apply an understanding of the structures and roles of synapses in nervous transmission. The majority of the lesson uses the cholinergic synapse as the example but other neurotransmitters are considered to provide the students with a wider view of this topic. The lesson begins by using a version of the WALL (as shown in the cover image) which asks the students to group 12 words into three groups of 4. Not only will this challenge their prior knowledge from topics earlier in this module but it will also lead to the discovery of four of the structures that are found in a synapse. Moving forwards, students are introduced to aectylcholine as the neurotransmitter involved at cholinergic synapses and they will start to add labels to the structures found in the pre-synaptic bulb. Time is taken to focus on certain structures such as the voltage gated channels as these types of channel were met previously when looking at the depolarisation of a neurone. There is plenty of challenge and discovery as students are pushed to explain why organelles like mitochondria would be found in large numbers in the bulb. With this process being a cascade of events, a bullet point format is used to ensure that the key content is taken in by the students and again key points like exocytosis and the action of acetylcholinesterase are discussed further. The final part of the lesson challenges the application aspect of the specification as students are introduced to unfamiliar situations in terms of synapses with new drugs like MDMA and are asked to work out and explain how these affect the nervous transmission. Understanding checks and prior knowledge checks are included throughout the lesson so that students can not only assess their progress against the current topic but also see whether they can make links to earlier topics. This lesson has been designed for students studying the OCR A-level Biology A course but could be used with very able GCSE students who are keen to develop their understanding of synapses over and above the small detail that is provided at that level. This lesson also ties in nicely with the other uploaded lessons from module 5.1.3 (neuronal communication) which are sensory receptors, neurones, nerve impulses and summation.

This detailed and engaging lesson describes the structural similarities and differences between DNA and RNA. The PowerPoint and accompanying worksheet containing exam-style questions have been designed to cover point 1.5.1 of the AQA A-level Biology specification. In the first lesson of topic 1, the students were introduced to a number of monomers which included a nucleotide. In line with this, the start of the lesson challenges them to recognise the key term nucleotide when only the letters U, C and T are shown. The next part of the lesson describes the structure of a DNA nucleotide and an RNA nucleotide so that the pentose sugar and the bases adenine, cytosine and guanine can be recognised as similarities whilst deoxyribose and ribose and thymine and uracil are seen as the differences. Time is taken to discuss how a phosphodiester bond is formed between adjacent nucleotides and their prior knowledge and understanding of condensation reactions is tested through a series of questions. Students are then introduced to the purine and pyrimidine bases and this leads into the description of the double-helical structure of DNA and the hydrogen bonds between complementary bases. The final section of the lesson describes the structure of mRNA, tRNA and rRNA and students are challenged to explain why this single stranded polynucleotide is shorter than DNA In addition to the current understanding and prior knowledge checks, a number of quiz rounds have been written into the lesson to introduce key terms in a fun and memorable way and the final round acts as a final check on the structures of DNA and RNA.

A fully-resourced lesson which looks at how auxins are involved in the response to the stimuli and gravity. The lesson includes an engaging lesson presentation (29 slides) and associated worksheets which have been differentiated. The lesson begins by challenging students to consider the different stimuli that a plant will respond to. There is focus throughout the lesson on the use of key terminology and students will start immediately by meeting the different types of tropisms. A quick competition is used to introduce the students to auxins and the key details of these chemicals are discussed. They will see how they are produced in the tips of shoots and roots and cause cell elongation in the shoots. A summary task is used to get the students to explain how a plant grow towards a light source. The next task challenges the students to apply their knowledge as a range of experimental data is shown to them and they have to predict how the plant would respond and explain - this task has been differentiated two ways so those students who need extra assistance can access the learning. The final part of the lesson looks at gravitropism and all of the learning is brought together to explain how the shoots grow away and the roots towards. This lesson has been written for GCSE students.

This is a fully-resourced lesson which covers the detail of point 5.1.3 (b) of the OCR A-level Biology A specification which states that students should be able to apply their understanding of the structures and functions of sensory, relay and motor neurones as well as the differences between myelinated and unmyelinated neurones. The PowerPoint has been designed to contain a wide range of activities that are interspersed between understanding and prior knowledge checks that allow the students to assess their progress on the current topics as well as challenge their ability to make links to topics from earlier in the modules. Quiz competitions like SAY WHAT YOU SEE are used to introduce key terms in a fun and memorable way. The students will be able to compare these neurones based on their function but also distinguish between them based on their structural features. Time is taken to look at the importance of the myelin sheath for the sensory and motor neurones. Students will be introduced to the need for the entry of ions to cause depolarisation and will learn that this is only possible at the nodes of Ranvier when there is a myelin sheath. Key terminology such as saltatory conduction is introduced and explained. The final task involves a comparison between the three neurones to check that the students have understood the structures and functions of the neurones. Throughout the lesson, links are made to the upcoming topic of the organisation of the nervous system (5.1.5) and students will be given additional knowledge such as the differences between somatic and autonomic motor neurones. This lesson has been designed for students studying on the OCR A-level Biology A course.

This fully-resourced lesson describes the roles of the platelets and plasma proteins in the sequence of events that lead to blood clotting. The engaging PowerPoint and accompanying resources have been primarily designed to cover the content detailed in point 4.4 (viii) of the Edexcel A-level Biology B specification and includes descriptions of the roles of thromboplastin, thrombin and fibrin but time has also been taken to look at haemophilia as a sex-linked disease so that students are prepared for topic 8 (genetic variation). The lesson begins with the introduction of clotting factors as integral parts of the blood clotting process and explains that factor III, thromboplastin, needs to be recalled as well as the events that immediately precede and follows its release. Students will learn how damage to the lining and the exposure of collagen triggers the release of this factor and how a cascade of events then results. Quick quiz rounds and tasks are used to introduce the names of the other substances involved which are prothrombin, thrombin, fibrinogen and fibrin. In a link to the upcoming topic of proteins, students will understand how the insolubility of fibrin enables this mesh of fibres to trap platelets and red blood cells and to form the permanent clot. The final part of the lesson introduces haemophilia as a sex-linked disease and students are challenged to apply their knowledge to an unfamiliar situation as they have to write genotypes and determine phenotypes before explaining why men are more likely to suffer from this disease than women.

This lesson describes the uses and implications of pre-implantation genetic diagnosis, amniocentesis and chorionic villus sampling. The lesson PowerPoint and accompanying worksheets have been primarily designed to cover point 2.17 of the Edexcel International A-level Biology specification but there are regular checks of their knowledge of the content of topic 2, where topics including monohybrid inheritance and cystic fibrosis are tested. The lesson begins by challenging them to use this prior knowledge of topic 2 to identify the letters in the abbreviations PGD and CVS. The involvement of IVF to obtain the embryos (or oocytes) is then discussed and a series of exam-style questions are used to get them to understand how this method screens embryos prior to implantation, so that those identified as having genetic diseases or being carriers are not inserted into the female’s uterus. Mark schemes for all of the questions included in this lesson are embedded into the PowerPoint so students can constantly assess their progress. Moving forwards, Down syndrome (trisomy 21) is used as an example of a chromosomal abnormality that can be tested for using CVS or amniocentesis. Time is taken to describe the key details of both of these procedures so students have a clear understanding of the implications and the invasiveness to the female being tested. The link between amniocentesis and an increased risk of miscarriage is considered and the results of a 2006 study are used to challenge them on their data skills.

This lesson describes how to calculate the standard deviation to measure the spread of a set of data and to compare means using the t-test. The detailed PowerPoint and accompanying resources have been designed to cover the part of point 4.2.2 (f) of the OCR A-level Biology A specification that includes these two statistical tests. A step by step guide walks the students through each stage of the calculation of the standard deviation and gets them to complete a worked example with the class before applying their knowledge to another set of data. This data looks at the birth weights of humans on one day in the UK and this is used again later in the lesson to compare against the birth weights of babies in South Asia when using the student’s t-test. The null hypothesis is introduced and students will learn to accept or reject this based upon a comparison of their value against one taken from the table based on the degrees of freedom.

An engaging lesson presentation (39 slides) which explores how cells differentiate in order to specialise to become more effective at carrying out a particular function. This lesson focuses on five cells - red blood cells, sperm cells, fat cells, ciliated cells and palisade cells. The lesson begins by challenging the mathematical skills of the students as they have to convert the number 37 trillion into standard form. Students will learn that although all of the cells found in a human would be eukaryotic animal cells, they wouldn’t all be the same. They are introduced to the key term differentiation through a quiz competition and time is taken to ensure that students understand how this process leads to specialisation. The remainder of the lesson concentrates on looking at the function and features of the five cells. Quiz competitions are used throughout to maintain engagement whilst ample time is given to student discussion where they are challenged to consider why a cell would have specialised in such a way. Key terminology is consistently used so that students are not caught off guard in an exam question when this specialist language is used. Regular progress checks are written into the lesson to allow the students to check on their understanding. This lesson has been written for GCSE students but could be used with higher ability KS3 students who are looking to extend their knowledge on the topic of cells.

This fully-resourced lesson explores the inheritance of sex-linked diseases in humans and then challenges the students to apply their knowledge to examples in other animals. The detailed PowerPoint and associated differentiated resources have been designed to cover the part of point 6.1.2 (b[i]) of the OCR A-level Biology A specification which states that students should be able to demonstrate and apply their knowledge and understanding of genetic diagrams which include sex-linkage. Key genetic terminology is used throughout and the lesson begins with a check on their ability to identify the definition of homologous chromosomes. Students will recall that the sex chromosomes are not fully homologous and that the smaller Y chromosome lacks some of the genes that are found on the X. This leads into one of the numerous discussion points, where students are encouraged to consider whether females or males are more likely to suffer from sex-linked diseases. In terms of humans, the lesson focuses on haemophilia and red-green colour blindness and a step-by-step guide is used to demonstrate how these specific genetic diagrams should be constructed and how the phenotypes should then be interpreted. The final tasks of the lesson challenge the students to carry out a dihybrid cross that involves a sex-linked disease and an autosomal disease before applying their knowledge to a question about chickens and how the rate of feather production in chicks can be used to determine gender. All of the tasks are differentiated so that students of differing abilities can access the work and all exam questions have fully-explained, visual markschemes to allow them to assess their progress and address any misconceptions.

This REVISION resource has been written with the aim of motivating the students whilst they are challenged on their knowledge of the content in TOPIC 4 (Natural selection and modification) of the Edexcel GCSE Biology specification. The resource contains an engaging and detailed PowerPoint (82 slides) and accompanying worksheets, some of which are differentiated to provide extra scaffolding to students when it is required. The wide range of activities have been designed to cover as much of topic 4 as possible but the following sub-topics have been given a particular focus: The discovery of human fossils Stone tools as evidence of human evolution Evolution by natural selection The development of antibiotic resistance in bacteria The three domain and five kingdom classification methods Genetic engineering Selective breeding The benefits and risks of genetic engineering and selective breeding for the growing population The use of fertilisers and biological control There is a large emphasis on mathematical skills in the new specification and these are tested throughout the lesson. This resource is suitable for use at the end of topic 4, in the lead up to mocks or in the preparation for the final GCSE exams.