This fully-resourced lesson describes how vaccinations are used to control disease and how immunity can be natural, artifical, active and passive. The engaging PowerPoint and accompanying resources have been designed to cover points 6.7 (v) & (vi) of the Edexcel A-level Biology B specification and there is also a description and discussion on the development of herd immunity. The previous lesson finished with a series of exam questions where students observed differences between the primary and secondary immune responses so the start of this lesson uses an imaginary game of TOP TRUMPS to challenge them on the depth of their understanding. This will act to remind them that a larger concentration of antibodies is produced in a quicker time in the secondary response. The importance of antibodies and the production of memory cells for the development of immunity is emphasised and this will be continually referenced as the lesson progresses. The students will learn that this response of the body to a pathogen that has entered the body through natural processes is natural active immunity. Moving forwards, time is taken to look at vaccinations as an example of artificial active immunity. Another series of questions focusing on the MMR vaccine will challenge the students to explain how the deliberate exposure to antigenic material activates the immune response and leads to the retention of memory cells. A quick quiz competition is used to introduce the variety of forms that the antigenic material can take along with examples of diseases that are vaccinated against using these methods. The eradication of smallpox is used to describe the concept of herd immunity and the students are given time to consider the scientific questions and concerns that arise when the use of this pathway is a possible option for a government. The remainder of the lesson looks at the different forms of passive immunity and describes the drawbacks in terms of the need for a full response if a pathogen is re-encountered.

This fully-resourced lesson introduces bacteriostatic and bactericidal antibiotics and describes their differences, focusing on their modes of action. The engaging PowerPoint and accompanying resources have been designed to cover point 6.14 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification but also makes continual links to earlier lessons in topic 6 as well as related topics from the previous year such as protein synthesis from topic 2 The lesson begins by challenging the students to use their knowledge of the previous topic 6 lessons to identify the suffixes cidal and static. Students will learn that when the prefix is added, these form the full names of two types of antibiotics. Their understanding of terminology is tested further as they have to recognise that Polymyxin B is an example of a bactericidal antibiotic as its actions would result in the death of the bacterial cell. Tetracycline is used as the example of a bacteriostatic antibiotic and students will discover that its prevention of the binding of tRNA that inhibits protein synthesis and this reduction and stopping of growth and reproduction is synonymous with these drugs. Students are challenged on their knowledge of translation and will also be given time for a class discussion to understand that these antibiotics encourage the body’s immune system to overcome the pathogen in natural, active immunity. The final part of the lesson uses a quick quiz competition and a series of exam-style questions to ensure that students can recognise the different antibiotics from descriptions.

This fully-resourced lesson describes the structure and general properties of slow and fast skeletal muscle fibres. The detailed PowerPoint and accompanying resources are the second in a series of 2 lessons that cover the content detailed in point 6.3 of the AQA A-level Biology specification and due to the obvious links, this lesson also challenges the students on their knowledge of respiration, cell structures and biological molecules like glycogen and haemoglobin The following structure and properties are covered over the course of this lesson: Reliance on the aerobic or anaerobic pathways to generate ATP Resistance to fatigue mitochondrial density capillary density myoglobin content (and colour) fibre diameter phosphocreatine content glycogen content A wide variety of tasks are used to cover this content and include knowledge recall and application of knowledge exam-style questions with fully-displayed mark schemes as well as quick quiz competitions to maintain motivation and engagement. This lesson has been specifically planned to tie in with the previous lesson in topic 6.3, titled “Contraction of skeletal muscles”, and this lesson has been uploaded for free

This lesson describes the role of the hypothalamus and the mechanisms of thermoregulation that maintain the body in dynamic equilibrium during exercise. The PowerPoint has been designed to cover point 7.12 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification. Students were introduced to homeostasis at GCSE and this lesson has been written to build on that knowledge and to add the key detail needed at this level. Focusing on the three main parts of a homeostatic control system, the students will learn about the role of the internal and peripheral thermoreceptors, the thermoregulatory centre in the hypothalamus and the range of effectors which bring about the responses to restore optimum levels. The following responses are covered in this lesson: Vasodilation Increased sweating Body hairs In each case, time is taken to challenge students on their ability to make links to related topics such as the arterioles involved in the redistribution of blood and the high specific latent heat of vaporisation of water.

This fully-resourced lesson describes the structural and physiological differences between fast and slow twitch muscle fibres. The detailed PowerPoint and accompanying resources have been designed to cover point 7.10 (ii) of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification and due to the obvious links, this lesson also challenges the students on their knowledge of respiration from earlier in topic 7 and cell structures and biological molecules from topics 1, 2 and 3 The following structural and physiological characteristics are covered over the course of this lesson: Reliance on the aerobic or anaerobic pathways to generate ATP Resistance to fatigue mitochondrial density capillary density myoglobin content (and colour) fibre diameter phosphocreatine content glycogen content A wide variety of tasks are used to cover this content and include knowledge recall and application of knowledge exam-style questions with fully-displayed mark schemes as well as quick quiz competitions to maintain motivation and engagement. This lesson has been specifically planned to tie in with the previous lesson in this topic covering the contraction of skeletal muscles by the sliding filament mechanism

This lesson describes the overall reaction of aerobic respiration, introducing the 4 stages before the finer details are covered in the upcoming lessons. The engaging PowerPoint and accompanying resource have been designed to cover points 7.1 (i) and (ii) of the Edexcel International A-level Biology specification and explains how each step in this many-stepped process is catalysed by a specific intracellular enzyme. The lesson begins with an introduction to glycolysis and students will learn how this first stage of aerobic respiration is also the first stage when oxygen is not present. This stage involves 10 reactions and an opportunity is taken to explain how each of these reactions is catalysed by a different, specific intracellular enzyme. A version of “GUESS WHO” challenges students to use a series of structural clues to whittle the 6 organelles down to just the mitochondrion so that they can learn how the other three stages take place inside this organelle. Moving forwards, the key components of the organelle are identified on a diagram. Students are introduced to the stages of respiration so that they can make a link to the parts of the cell and the mitochondria where each stage occurs. Students will learn that the presence of decarboxylase and dehydrogenase enzymes in the matrix along with coenzymes and oxaloacetate allows the link reaction and the Krebs cycle to run and that these stages produce the waste product of carbon dioxide. Finally, time is taken to introduce the electron transport chain and the enzyme, ATP synthase, so that students can begin to understand how the flow of protons across the inner membrane results in the production of ATP and the the formation of water when oxygen acts as the final electron acceptor.

This detailed lesson describes the roles of the link reaction and the Krebs cycle in the complete oxidation of glucose which occur in the mitochondrial matrix. The PowerPoint and the accompanying resource have been designed to cover point 7.3 of the Edexcel International A-level Biology specification and includes descriptions of the formation of carbon dioxide, ATP, reduced NAD and FAD The lesson begins with a challenge, where the students have to recall the details of glycolysis in order to form the word matrix. This introduces the key point that these two stages occur in this part of the mitochondria and time is taken to explain why the reactions occur in the matrix as opposed to the cytoplasm like glycolysis. Moving forwards, the Link reaction is covered in 5 detailed bullet points and students have to add the key information to these points using their prior knowledge as well as knowledge provided in terms of NAD. The students will recognise that this reaction occurs twice per molecule of glucose and a quick quiz competition is used to test their understanding of the numbers of the different products of this stage. This is just one of the range of methods that are used to check understanding and all answers are explained to allow students to assess their progress. The rest of the lesson focuses on the Krebs cycle. In line with the detail of the specification, students will understand how decarboxylation and dehydrogenation reactions result in the regeneration of the oxaloacetate

This fully-resourced lesson describes how the functional differences of the retinal rod and cone cells is related to their structures. The detailed PowerPoint and accompanying resources are part of the 2nd in a series of 2 lessons that have been designed to cover the details included in point 6.1.2 of the AQA A-level Biology specification. However, as explained at the start of the lesson, it has been specifically planned to be taught after the lessons in topic 6.3, so that students are aware and understand the meaning of terms such as depolarisation and hyperpolarisation. It is likely that students will be aware that the human retina contains rod and cone cells, so this lesson builds on that knowledge and adds the detail needed at this level. Over the course of the lesson, students will learn that these cells contain different optical pigments and that this feature along with their differing connectivity to the bipolar neurones means that they have different sensitivities to light, colour perception and visual acuity. Exam-style questions are interspersed throughout to check on current understanding and also make links to previously covered topics. For example, students are challenged to recognise a description of the mitochondria so they can discover that this cell structure is found in the inner segment where it is responsible for generating the ATP needed to pump sodium ions out of the cells. As detailed above, this lesson ties in closely with topic 6.3 and students will be expected to make links to synapses and to the changes in membrane potential that occur when sodium ions move in or out of a cell

This fully-resourced lesson describes the structure of the human retina and explains how the rhodopsin in rod cells allows vision in low light intensity. The detailed PowerPoint and accompanying resources have been designed to cover points 9.7 (i), (ii) & (iii) of the Edexcel A-level Biology B specification but also makes links to previously covered topics such as cell structure and nervous transmission. It is likely that students will be aware that the human retina contains rod and cone cells, so this lesson builds on that knowledge and adds the detail needed at this level. Students will discover that the optical pigment in rod cells is rhodopsin and that the bleaching of this into retinal and opsin results in a cascade of events that allows an action potential to be initiated along the optic nerve. Time is taken to go through the events that occur in the dark and then the students are challenged to use this as a guide when explaining how the events differ in the light. Key terms like depolarisation and hyperpolarisation, that were met in topic 9.5, are used to explain the changes in membrane potential and the resulting effect on the connection with the bipolar and ganglion cells is then described. Cone cells are also introduced, with the main focus being their distribution in the centre of the fovea which is used to explain colour vision in bright light.

This fully-resourced lesson uses real-life examples in plants and animals to explain why cellular respiration is so important. The PowerPoint and accompanying resources have been designed to cover point 5.2.2 (a) of the OCR A-level Biology A specification but can also be used as a revision tool to challenge the students on their knowledge of active transport, nervous transmission and muscle contraction. As the first lesson in this module, it has been specifically planned to act as an introduction to this cellular reaction and provides important details about glycolysis, the Krebs cycle and oxidative phosphorylation that will support the students to make significant progress when these stages are covered during individual lessons. Students met phosphorylation in module 5.2.1 when considering the light-dependent reactions of photosynthesis and their knowledge of the production of ATP in this plant cell reaction is called on a lot in this lesson to show the similarities. The students are also tested on their recall of the structure and function of ATP, as covered in module 2.1.3, through a spot the errors task. By the end of the lesson, the students will be able to explain why the ATP produced in cellular respiration is needed by root hair cells, by companion cells and in the selective reabsorption of glucose in the proximal convoluted tubule. They will also be able to name and describe the different types of phosphorylation and will know that ATP is produced by substrate-level phosphorylation in glycolysis and the Krebs cycle and by oxidative phosphorylation in the final stage of aerobic respiration with the same name.

This lesson describes how the electron transport chain and the chemiosmosis are involved in the synthesis of ATP by oxidative phosphorylation. The PowerPoint has been designed to cover point 7.4 of the Edexcel International A-level Biology specification and also looks at the role of the enzyme, ATP synthase. The lesson begins with a discussion about the starting point of the reaction. In the previous stages, the starting molecule was the final product of the last stage but in this stage, it is the reduced coenzymes which release their hydrogen atoms. Moving forwards, the process of oxidative phosphorylation is covered in 7 steps and at each point, key facts are discussed and explored in detail to enable a deep understanding to be developed. Students will see how the proton gradient is created and that the flow of protons down the channel associated with ATP synthase results in a conformational change and the addition of phosphate groups to ADP. Understanding checks are included throughout the lesson to enable the students to assess their progress. This lesson has been specifically written to tie in with the other uploaded lessons on glycolysis, the link reaction and Krebs cycle.

This lesson describes how the sensory receptors of the nervous system detect stimuli by transducing different forms of energy into electrical energy. The PowerPoint has been designed to cover the content of the 1st part of specification point 8.5 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification and acts as an introduction to the next lesson where the roles of the rod cells in the retina is described. The lesson begins by using a quiz to get the students to recognise the range of stimuli which can be detected by receptors. This leads into a task where the students have to form 4 sentences to detail the stimuli which are detected by certain receptors and the energy conversion that happen as a result. Students will be introduced to the idea of a transducer and learn that receptors always convert to electrical energy which is the generator potential. The remainder of the lesson focuses on the Pacinian corpuscle and how this responds to pressure on the skin, resulting in the opening of the sodium channels and the flow of sodium ions into the neurone to cause depolarisation.

This fully-resourced lesson looks at the use of electrocardiograms to aid the diagnosis of abnormal heart rhythms. The engaging PowerPoint and accompanying resources have been designed to cover point 7.12 (iii) of the Edexcel International A-level Biology specification but also can be used as a revision lesson as the students are challenged on their prior knowledge of the cardiac cycle and heart structure as covered in topic 1. The lesson has been written to take place in an imaginary cardiology ward where the students are initially challenged on their knowledge of the symptoms and risk factors of CVD before looking at testing through the use of ECGs and diagnosis. The main focus of the lesson is the ECG and a quiz competition is used to introduce the reference points of P, QRS and T before time is taken to explain their representation with reference to the cardiac cycle. Moving forwards, a SPOT the DIFFERENCE task is used to challenge the students to recognise differences between sinus rhythm and some abnormal rhythms including tachycardia and atrial fibrillation. Bradycardia is used as a symptom of sinus node disfunction and the students are encouraged to discuss this symptom along with some others to try to diagnose this health problem. This lesson has been designed to tie in with the lesson that covers the previous specification point on the normal electrical activity of the heart and the myogenic nature of cardiac muscle

This lesson describes the structure and functions of the sensory, relay and motor neurones. The engaging PowerPoint and accompanying resources have been designed to cover point 8.1 of the Edexcel International A-level Biology specification but also considers the organisation of the nervous system into the central and peripheral nervous systems and therefore also covers point 8.10. The PowerPoint has been designed to contain a wide range of activities that are interspersed between understanding and prior knowledge checks that allow the students to assess their progress on the current topics as well as challenge their ability to make links to topics from earlier in the modules. Quiz competitions like SAY WHAT YOU SEE are used to introduce key terms in a fun and memorable way. The students will be able to compare these neurones based on their function but time is taken to distinguish between them based on their structural features. The importance of the myelin sheath for the sensory and motor neurones is briefly discussed and students are introduced to key terminology such as saltatory conduction and Schwann cells so they are prepared for the upcoming lesson covering specification point 8.5. The final task involves a comparison between the three neurones to check that the students have understood the structures and functions of the neurones. Throughout the lesson, the organisation of the nervous system is discussed and students are provided with additional knowledge such as the differences between somatic and autonomic motor neurones.

This lesson describes how the nervous system detects stimuli, focusing on the detection of light by the rods in the the retina of mammals. The PowerPoint has been designed to cover the content of specification point 8.8 of the Edexcel International A-level Biology specification and includes descriptions of the roles of rhodopsin, opsin, retinal, sodium ions, cation channels and hyperpolarisation in the formation of action potentials in the optic neurones. The lesson begins by using a quiz to get the students to recognise the range of stimuli which can be detected by receptors. This leads into a task where the students have to form 4 sentences to detail the stimuli which are detected by certain receptors and the energy conversion that happen as a result. Students will be introduced to the idea of a transducer and learn that receptors always convert to electrical energy which is the generator potential. It is likely that students will be aware that the human retina contains rod and cone cells, so the next part of the lesson builds on that knowledge and adds the detail needed at this level. Students will discover that the optical pigment in rod cells is rhodopsin and that the bleaching of this into retinal and opsin results in a cascade of events that allows an action potential to be initiated along the optic nerve. Time is taken to go through the events that occur in the dark and then the students are challenged to use this as a guide when explaining how the events differ in the light. Key terms like depolarisation and hyperpolarisation, that were met earlier in topic 8, are used to explain the changes in membrane potential and the resulting effect on the connection with the bipolar and ganglion cells is then described. The remainder of the lesson focuses on the Pacinian corpuscle and describes how this responds to pressure on the skin, resulting in the opening of the sodium channels and the flow of sodium ions into the neurone to cause depolarisation

This fully-resourced lesson describes the role of barriers in protecting the body from infection by pathogens when entering the body by the major routes. The engaging and detailed PowerPoint and accompanying resources have been designed to cover points 6.11 (i) & (ii) of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification and describe the following barriers: skin key steps of the blood clotting process mucous membranes stomach acid vaginal and skin flora There are clear links to topics 1, 2 and 3 in each of these barriers, so time is taken to consider these during the descriptions. For example, the presence of keratin in the cytoplasm of the skin cells allows the student knowledge of the properties of this fibrous protein to be checked. Other topics that are revisited during this lesson include blood clotting, protein structure, key terminology and the epithelium that lines the different parts of the airways. All of the exam-style questions and tasks have mark schemes that are embedded in the PowerPoint and a number of them have been differentiated to allow students of differing abilities to access the work.

This fully-resourced lesson describes the major routes that pathogens take when entering the body and the body’s barriers to this infection. The engaging and detailed PowerPoint and accompanying resources have been designed to cover points 6.7 (i) & (ii) of the Edexcel International A-level Biology specification and includes descriptions of the following barriers: skin the blood clotting process mucous membranes stomach acid vaginal acid and flora skin and gut flora wax in the ear canal There are clear links to topics 1, 2 and 3 in each of these barriers, so these are considered and discussed during each of the descriptions. For example, the presence of keratin in the cytoplasm of the skin cells allows the student knowledge of the properties of this fibrous protein to be checked. Other topics that are revisited during this lesson include protein structure, key terminology and the epithelium that lines the different parts of the airways. All of the exam-style questions have mark schemes that are embedded into the PowerPoint and a number of the tasks have been differentiated to allow students of differing abilities to access the work.