This PowerPoint was planned as part of the IB scheme of work on Medicinal Chemistry, and covers the necessary content for the all of the Standard and Higher Level units. It would also be suitable for other post-16 courses. It includes 9 full PowerPoints, along with student versions to use as notes, which have spaces for the students to add in missing information and activities for them to complete. It also includes exam questions for practice or assessment purposes Topics covered are: Pharmaceutical Products and Drug Design - Routes of drug administration - Theraputic Effects of Drugs - The Placebo Effect - Side Effects - Calculation of the Therapeutic Index - The Therapeutic Window - Bioavailability - Tolerance and Addiction - Drug Action - Drug Development by both Drug Design and Drug Discovery Aspirin and Penicillin - History of Aspirin - Method of Producing Aspirin - Calculating the % Yield of Aspirin produced from Salicyclic Acid - Effects of Aspirin - Soluble Aspirin - Development of Penicillin - Structure of Penicllin - How Penicillin Works - Antibiotic Resistance Opiates - Morphine: Structure and action; side effects; withdrawal - How opiates cross the blood-brain barrier - Diamorphine pH regulation of the stomach - The need for stomach acid - pH calculations to determine the concentration of acid in the stomach - Antacids: equations for their reactions with stomach acid; side effects; calculation of quantity of acid neutralised - Regulation of acid production using both H2-histamine receptor blockers (Zantac) and proton pump inhibitors (Omeprazole and Esomeprazole) - Acid-base buffers: definition and calculations - Hydrogencarbonate and carbonate buffers Antivirals - The differences between viruses and bacteria - The structure of viruses - How viruses reproduce and replicate - How viruses are treated by interrupted stages of the replication process - Oseltamivir and Zanamivir - structure and action - HIV and AIDS - Treatment of HIV and AIDS Environmental impacts of Biochemistry - Effects of PACs on the environment - Antibiotic Resistance - Nuclear Waste (both LLW and HLW) - Chlorinated solvent waste - Supercritical fluid waste - Green Chemistry - Biotechnologies in Green Chemistry Taxol - The Discovery of Paclitaxel - Isolation of Taxol - Structure of Taxol - Semi-synthetic production of Taxol - Clinical use of Taxol - The use of chiral auxiliaries to produce one enantiomer of Taxol - Confirmation of the purity of a single enantiomer drug - Thalidomide Nuclear Medicine - The use of radionuclides in medicine - Types of ionising radiation - Radiotherapy - Radioactive Decay - Targeted alpha therapy - Boron neutron capture therapy - Use of gamma emitters in radiotherapy - Radiodiagnostics - Positron Emission Tomography - Use of Technetium-99m - Half life and decay constant calculations - Magnetic Resonance Imaging Drug Detection and Analysis - Worked example of the identification of aspirin by NMR, IR and Mass Spectrometry - Worked example of the identification of an unknown compound from NMR, IR and Mass Spectrometry - Extraction and purification of organic products - Worked example of hormone concentration using partition coefficients - How polarity affects the partition coefficients - Raoult´s Law - Fractional Distillation - Drug detection in sports - Drug detection in forensic science - Chemistry of breathalyzer tests - HPLC and Gas chromatography

A series of nine homework projects suitable for KS4 students covering Biology, Chemistry and Physics topics. - Genetics - Hydroponics - Extracting Copper - Oil - Analysing Substances - Nanoparticles and Smart Materials - Waves and Communication - Energy and Payback Time - Forces and Momentum

10 homework projects on key stage 3 and 4 Chemistry, linked to the Exploring Science and iGCSE schemes of work. All homework projects are fully differentiated, with level ladders provided to maximise pupil progress 7E - Acids and Alkalis 7F - Chemical reactions 7H - Solutions 8E - Classifying Elements 9E - Metals and their reactions 9G - Environmental Chemistry Extracting Copper Oil Nanoparticles and Smart Materials Analysing Substances

These PowerPoints were planned as part of the IB schemes of work on Atomic Structure and Periodicity (including transition metal chemistry and coloured complexes) and cover the necessary content for both the Standard and Higher Level topics. They would also be suitable for other post-16 courses. Included are fully completed PowerPoints, student versions of the PowerPoints with sections to complete independently and some exam style questions. Topics included are: - The structure of the atom - The development of the theory of atomic structure from Dalton-present day - Isotopes and their properties - Calculating the R.A.M. of an isotope - Calculating the % abundance of two isotopes, given the R.A.M. - Radioisotopes and their uses - The mass spectrometer: what it is used for, how it works, why it works and how to read mass spectra - How to calculate the energy of a photon of light - Atomic Emission Spectra - How to write full electronic configurations for elements up to the 4p orbital - How to write full electronic configurations for ions of the elements up to the 4p orbital - The convergence limit of energy in energy levels and how this links to First Ionisation Energy - Trends in First Ionisation Energy and how this provided evidence for the presence of orbitals - The development of the Periodic Table - The structure and arrangement of the Periodic Table - How metallic/non-metallic properties change as you go left to right across the periodic table - How atomic radius of elements changes across periods and down groups, and why this occurs - How ionic radius of ions changes across periods and down groups, and why this occurs - How first ionisation energies of elements changes across periods and down groups, and why this occurs - How electron affinity of elements changes across periods and down groups, and why this occurs - How electronegativity of elements changes across periods and down groups, and why this occurs - Properties and reactions of the Group I metals - Properties and reactions of the Group XVII non-metals - The acid-base character and reactions of the period 2 and 3 oxides - Electronic structures of the Transition Metals - Electronic structures of Transition Metal ions - The definition of a Transition Metal - Properties of Transition Metals - Variable oxidation states and the trend in First Ionisation Energies - Paramagnetism and Diamagnetism - Complex Ions - Transition Metals as catalysts - How colour occurs in compounds - Ligand Field Theory - Which Transition Metals are coloured and which are colourless and why - Factors which affect colour - including identity of the metal, charge on the metal and identity of the ligand

These PowerPoints were planned as part of the IB schemes of work on Atomic Structure, Periodicity (including transition metal chemistry and coloured complexes) and Structure and Bonding. They cover the necessary content for both the Standard and Higher Level topics. They would also be suitable for other post-16 courses. Included are fully completed PowerPoints, student versions of the PowerPoints with sections to complete independently and some exam style questions.

These 9 PowerPoints were planned as part of the IB schemes of work on Biochemistry, and covers the necessary content for the all of the Standard and Higher Level units. It would also be suitable for other post-16 courses. It includes 9 full PowerPoints, along with student versions to use as notes, which have spaces for the students to add in missing information and activities for them to complete. It also includes exam questions for practice or assessment purposes Topics covered are: Introduction to Biochemistry - Metabolism - Biochemical reactions in terms of oxidation and reduction - Respiration - Photosynthesis - Hydrolysis and Condensation reactions Proteins - 2 amino acids and their behaviour as zwitterions - Gel electrophoresis - Paper chromatography - Peptides - Hydrolysis of peptides - Proteins - primary, secondary, tertiary and quaternary structures - Acid-base properties of amino acids and proteins - Acid-base buffers - Enzymes - Induced fit theory - Non competitive and competitive inhibition - The Michaelis-Menten equation - Protein Assays Lipids - Fatty acids - Triglycerides - Calculating the iodine number - Hydrolysis of triglycerides - Rancidity of fats - Energy values of fats - Phospholipids - Steroids (including cholesterol) - Sex hormones - Anabolic steroids Carbohydrates - Monosaccharides - Reducing sugars - Disaccharides - Polysaccharides - Starch, glycogen and cellulose Vitamins - Preventing deficiencies - Water and fat solubilities of vitamins - Vitamin A - Vitamin C - Vitamin D - Decomposition of vitamins Environmental Impacts of Biochemistry - Xenobiotics - Metabolism of xenobiotics - DDT - PCBs - Heavy metal toxicity - Pharmaceutically active compounds and detergents - Host-guest complexes - Polymers - Green Chemistry Proteins - 2 amino acids and their behaviour as zwitterions - Gel electrophoresis - Paper chromatography - Peptides - Hydrolysis of peptides - Proteins - primary, secondary, tertiary and quaternary structures - Acid-base properties of amino acids and proteins - Acid-base buffers - Enzymes - Induced fit theory - Non competitive and competitive inhibition - The Michaelis-Menten equation - Protein Assays Nucleic Acids - Nucleic Acids - Nitrogeneous Bases and Nucleotides - ATP - The structure of DNA - DNA profiling - DNA replication - Transcription - Genetic Engineering Biological Pigments - Coloured compounds and biological pigments - Carotenes - Porphyrins - Haemoglobin - Factors affceting oxygen uptake in haemoglobin - Foetal haemoglobin - Cytochromes - Chlorophyll - Anthocyanins - Melanin Stereochemistry in Biomolecules - Stereoisomerism - 2-amino acids - Fischer and CORN projections - Stereochemistry in Carbohydrates - Stereochemistry cyclic forms of monosaccharides - Stereochemistry in cellulose - Stereochemistry in fatty acids - Stereochemistry in retinal and vision chemistry