This is a fully-resourced lesson which uses exam-style questions, quiz competitions, quick tasks and discussion points to challenge students on their understanding of topics B1 - B5, that will assessed on PAPER 1. It has been specifically designed for students on the Pearson Edexcel GCSE Combined Science course who will be taking the FOUNDATION TIER examinations but is also suitable for students taking the higher tier who need to ensure that the fundamentals are known and understood. The lesson has been written to take place at the local hospital where the students have to visit numerous wards and clinics and the on-site pharmacy so that the following sub-topics can be covered: Cancer as the result of uncontrolled cell division The production of gametes by meiosis Mitosis and the cell cycle Sex determination The difference between communicable and non-communicable diseases The pathogens that spread communicable diseases Identification of communicable diseases Treating bacterial infections with antibiotics Evolution of antibiotic resistance in bacteria Vaccinations Genetic terminology Genetic diagrams Structures involved in a nervous reaction A Reflex arc Risk factors Chemical and physical defences Osmosis and percentage gain and loss Fossils as evidence for human evolution In order to maintain challenge whilst ensuring that all abilities can access the questions, the majority of the tasks have been differentiated and students can ask for assistance sheets when they are unable to begin a question. Step-by-step guides have also been written into the lesson to walk students through some of the more difficult concepts such as genetic diagrams and evolution by natural selection. Due to the extensiveness of this revision lesson, it is estimated that it will take in excess of 3 teaching hours to complete the tasks and therefore this can be used at different points throughout the duration of the course as well as acting as a final revision before the PAPER 1 exam.

A highly engaging lesson presentation (74 slides) and accompanying worksheets that uses exam questions (with explained answers), quick tasks and quiz competitions to allow students to assess their understanding of the topic of Biological molecules (Topic 3.1). Students will have fun whilst recognising those areas of the specification which need further attention.

A fun and engaging lesson presentation (33 slides) and associated worksheet that uses exam questions, with fully explained answers, quick tasks and competitions to allow students to assess their understanding of Module 3.1.2 (Transport in Animals). The students will enjoy the lesson whilst being able to recognise which areas of the specification need further attention. Competitions included in the lesson are “SPOT THE ERROR”, “Where’s Lenny” and “Crack the code”

A detailed lesson presentation (37 slides) and associated worksheets that guide students through the DNA sequencing method called pyrosequencing. The lesson focusses on the numerous enzymes and substrates which are involved in the cascade of events which eventually leads to the production of light when the conversion from luciferin to oxyluciferin occurs. A step by step guide is used to show the students how these events occur and the different outcomes are explored. There are regular progress checks throughout the lesson so that students can assess their understanding of this topic and the links to similar topics. This lesson has been designed for A-level students and above

An informative and engaging lesson (46 slides) that looks at the topic of immobilised enzymes and focusses on ensuring that students understand this topic around three main ideas. By the end of the lesson, students will be able to explain why immobilised enzymes are used, describe the different methods by which they are produced and describe some of their uses in biotechnology. Time is taken throughout the lesson to make sure that students understand the disadvantages associated with this process and that they are able to explain the specific limitations of each method. This lesson has been designed for students studying A-level Biology

This lesson describes the structure and ultrastructure of plant cells to allow students to compare this structure against animal cell structure. The detailed PowerPoint and accompanying resources have been designed to cover points 4.1 (i) & (ii) in unit 2 of the Edexcel International A-level Biology specification and also describes the functions of the cell wall, chloroplast, amyloplast, vacuole, tonoplast, plasmodesmata, pits and middle lamella The lesson begins with a task called REVERSE GUESS WHO which will challenge the students to recognise a particular organelle from a description of its function. This will remind students that plant cells are eukaryotic and therefore contain a cell-surface membrane, a nucleus (+ nucleolus), a mitochondria, a Golgi apparatus, ribosomes and rough and smooth endoplasmic reticulum like the animal cells. Moving forwards, the next part of the lesson focuses on the relationship between the structure and function of the vacuole, chloroplast, plasmodesmata and cellulose cell wall. When considering the vacuole, key structures such as the tonoplast are described as well as critical functions including the maintenance of turgor pressure. A detailed knowledge of the structure of the chloroplast at this early stage of their A-level studies will increase the likelihood of a clear understanding of photosynthesis when covered in topic 5. For this reason, time is taken to consider the light-dependent and light-independent reactions and to explain how these stages are linked. Students will learn that chloroplasts and amyloplasts can contain stores of starch so an opportunity is taken to challenge them on their knowledge of this polysaccharide as it was covered in topic 1. The final task challenges them to recognise descriptions of the cell wall, chloroplast, amyloplasts, vacuole, tonoplast and plasmodesmata which will leave 2 remaining which describe the pits and middle lamella.

This lesson describes how to calculate the standard deviation to measure the spread of a set of data and to compare means using the t-test. The detailed PowerPoint and accompanying resources have been designed to cover the part of point 4.2.2 (f) of the OCR A-level Biology A specification that includes these two statistical tests. A step by step guide walks the students through each stage of the calculation of the standard deviation and gets them to complete a worked example with the class before applying their knowledge to another set of data. This data looks at the birth weights of humans on one day in the UK and this is used again later in the lesson to compare against the birth weights of babies in South Asia when using the student’s t-test. The null hypothesis is introduced and students will learn to accept or reject this based upon a comparison of their value against one taken from the table based on the degrees of freedom.

This lesson describes the gross structure of the human gas exchange system and the functions of the structural components like goblet cells. The PowerPoint and accompanying resources have been designed to cover points 9.1 (a & c) of the CIE A-level Biology specification and has been specifically planned to prepare students for an upcoming lesson where the gas exchange between the alveoli and the blood is described. The lesson is filled with a range of activities such as guided discussion periods, exam-style questions (with markschemes) and quiz competitions and these run alongside the slides containing the detailed A-level Biology content to cover the following features: The incomplete rings of cartilage, ciliated pseudostratified columnar epithelium and goblet cells in the trachea The narrowing airways of the primary, secondary and tertiary bronchi The elastic fibres and smooth muscle in the terminal and respiratory bronchioles The pleural cavity and fluid of the lungs When describing the production of mucus by the goblet cells in the trachea, time is taken to consider cystic fibrosis and the inheritance of this autosomal recessive disorder. Students will be supported in working out genotypes from a pedigree tree to prepare them for topic 16 (Inherited change)

This lesson describes the process of gas exchange between air in the alveoli and the blood. The PowerPoint and accompanying worksheet have been designed to cover point 9.1 (d) of the CIE A-level Biology specification Gas exchange at the alveoli is a topic that was covered at GCSE so this lesson has been written to challenge the recall of that knowledge and to build on it. The main focus of the lesson is the type of epithelium found lining the alveoli and students will discover that a single layer of flattened cells known as simple, squamous epithelium acts to reduce the diffusion distance. The following features of the alveolar epithelium are also covered: Surface area Moist lining Production of surfactant The maintenance of a steep concentration gradient As a constant ventilation supply is critical for the maintenance of the steep concentration gradient, the final part of the lesson considers the mechanism of ventilation

This lesson describes the uses and implications of pre-implantation genetic diagnosis, amniocentesis and chorionic villus sampling. The lesson PowerPoint and accompanying worksheets have been primarily designed to cover point 2.15 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification but regular links are made to the earlier content of topics 1 & 2, and their knowledge of topics including the heart and circulation, monohybrid inheritance and cystic fibrosis are tested. The lesson begins by challenging them to use this prior knowledge of topic 2 to identify the letters in the abbreviations PGD and CVS. The involvement of IVF to obtain the embryos (or oocytes) is then discussed and a series of exam-style questions are used to get them to understand how this method screens embryos prior to implantation, so that those identified as having genetic diseases or being carriers are not inserted into the female’s uterus. Mark schemes for all of the questions included in this lesson are embedded into the PowerPoint so students can constantly assess their progress. Moving forwards, Down syndrome (trisomy 21) is used as an example of a chromosomal abnormality that can be tested for using CVS or amniocentesis. Time is taken to describe the key details of both of these procedures so students have a clear understanding of the implications and the invasiveness to the female being tested. The link between amniocentesis and an increased risk of miscarriage is considered and the results of a 2006 study are used to challenge them on their data skills.

This fully-resourced lesson describes the meaning of the terms stem cell, pluripotency and totipotency. The PowerPoint and accompanying worksheets have been designed to cover points 3.11 (i) and (ii) of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification and therefore this lesson also contains discussion periods where the topic is the decisions that the scientific community have to make about the use of stem cells in medical therapies. The lesson begins with a knowledge recall of the structure of eukaryotic cells and the students have to use the first letters of each of the four answers to reveal the key term, stem cell. Time is then taken to consider the meaning of cellular differentiation, and this leads into the key idea that not all stem cells are equal when it comes to the number of cell types that they have the potential to differentiate into. A quick quiz round introduces the five degrees of potency, and then the students are challenged to use their understanding of terminology to place totipotency, pluripotency, multipotency, oligopotency and unipotency in the correct places on the potency continuum. Although the latter three do not have to be specifically known based on the content of specification point 3.11 (i), an understanding of their meaning was deemed helpful when planning the lesson as it should assist with the retention of knowledge about totipotency and pluripotency. These two highest degrees of potency are the main focus of the lesson, and key details are emphasised such as the ability of totipotent cells to differentiate into any extra-embroyonic cell, which the pluripotent cells are unable to do. The morula, and inner cell mass and trophoblast of the blastocyst are used to demonstrate these differences in potency. The final part of the lesson discusses the decisions that the scientific community have to make about the use of embryonic stem cells, adult stem cells and also foetal stem cells which allows for a link to chorionic villus sampling from topic 2. There is also a Maths in a Biology context question included in the lesson (when introducing the morula) to ensure that students continue to be prepared for the numerous calculations that they will have to tackle in the terminal exams. This resource has been differentiated two ways to allow students of differing abilities to access the work

A fully-resourced lesson which has been designed for GCSE students and includes an engaging lesson presentation and associated worksheets. This lesson looks at the three limiting factors of photosynthesis, focusing on the graphs that they produce and ensures that students can explain why temperature is a factor. This lesson begins by introducing the students to the definition of a limiting factor. They are challenged to recognise that it would be photosynthesis which is limited by carbon dioxide concentration and light intensity. The third factor, temperature, is not introduced until later in the lesson so that students are given thinking time to consider what it might be. Having been presented with two sets of data, students are asked to draw sketch graphs to represent the trend. The limiting factors on the light intensity graph are taught to the students so they can use this when working out the limiting factors on the carbon dioxide graph. The remainder of the lesson focuses on temperature and more specifically why a change in this factor would cause a change in the rate of photosynthesis because of enzymes. The student’s knowledge of that topic is tested alongside. Progress checks have been written into the lesson at regular intervals so that students can constantly assess their understanding.

This is a fully-resourced REVISION lesson that consists of a detailed and engaging PowerPoint (86 slides) and associated worksheets that challenge the students on their knowledge of the content of Topic 5 (Health, disease and the development of medicines) of the Edexcel GCSE Biology specification. A wide range of activities have been written into the lesson to maintain motivation and these tasks include exam questions (with answers), understanding checks, differentiated tasks and quiz competitions. The lesson has been designed to include as much which of the content from topic 5, but the following sub-topics have been given particular attention: Identification of bacterial, fungal and viral diseases in animals and plants The treatment of bacterial infections The reduction and prevention of the spread of pathogens The body’s response to immunisation The physical defences of humans and plants The risk factors of CHD and possible treatments BMI The production and use of monoclonal antibodies This lesson can be used at numerous points over the duration of the course, as an end of topic revision aid, in the lead up to the mocks or in the lead up to the actual GCSE exams.

A fully resourced revision lesson which uses a range of exam questions (with explained answers), quick tasks and quiz competitions to enable the students to assess their understanding of the topics found within module 6.3.1 (Ecosystems) of the OCR A-level Biology A specification. The topics tested within this lesson include: Ecosystems Transfer of biomass Recycling within ecosystems Succession Studying ecosystems Student will enjoy the range of tasks and quiz rounds whilst crucially being able to recognise any areas which require further attention

This revision lesson contains an engaging powerpoint (45 slides) and associated worksheets that are incorporated into the lesson to challenge and consolidate the learning. The lesson has been designed to contain a wide range of activities so that students remain motivated and engaged whilst they assess their understanding of the content found in Biology topic 3 (Infection and response) of the AQA GCSE Combined Science specification (Trilogy 9-1) The exam questions, differentiated tasks and quiz competitions found within the lesson challenge the following specification topics: Communicable (infectious) diseases Viral diseases Bacterial diseases Fungal diseases Protist diseases The Human defence system Vaccinations Antibiotics Students will be able to use the lesson to identify the areas of the specification that require further attention and this lesson can be used at the end of the topic, in the lead up to the mocks or in the lead up to the actual GCSE exams.