This detailed and clear lesson describes and explains how the electron transport chain and the chemiosmotic theory are involved in the synthesis of ATP by oxidative phosphorylation. The PowerPoint has been designed to cover the sixth part of point 5.2 of the AQA A-level Biology A specification and also looks at the role of the enzyme, ATP synthase. The lesson begins with a discussion about the starting point of the reaction. In the previous stages, the starting molecule was the final product of the last stage but in this stage, it is the reduced coenzymes which release their hydrogen atoms. Moving forwards, the process of oxidative phosphorylation is covered in 7 steps and at each point, key facts are discussed and explored in detail to enable a deep understanding to be developed. Students will see how the proton gradient is created and that the flow of protons down the channel associated with ATP synthase results in a conformational change and the addition of phosphate groups to ADP. Understanding checks are included throughout the lesson to enable the students to assess their progress. This lesson has been written to tie in with the other uploaded lessons on glycolysis, the Link reaction and Krebs cycle and anaerobic respiration.

This fully-resourced lesson looks at the series of oxidation-reduction reactions that form the Krebs cycle and focuses on the products in terms of reduced NAD, FAD and ATP. The engaging PowerPoint and accompanying resource have both been designed to cover the fifth part of point 5.2 of the AQA A-level Biology specification. The lesson begins with a version of the Impossible game where students have to spot the connection between 8 of the 9 terms and will ultimately learn that this next stage is called the Krebs cycle. The main part of the lesson challenges the students to use descriptions of the main steps of the cycle to continue their diagram of the reactions. Students are continually exposed to key terminology such as decarboxylation and dehydrogenation and they will learn where carbon dioxide is lost and reduced NAD and FAD are generated. They will also recognise that ATP is synthesised by substrate level phosphorylation. The final task challenges them to apply their knowledge of the cycle to work out the numbers of the different products and to calculate the number of ATP that must be produced in the next stage This lesson has been designed to tie in with the other uploaded lessons on glycolysis, anaerobic respiration, the Link reaction and oxidative phosphorylation.

This clear and concise lesson looks at the role of the Link reaction in the conversion of pyruvate to acetyl coenzyme A which will then enter the Krebs cycle. The PowerPoint has been designed to cover the fourth part of point 5.2 of the AQA A-level Biology specification which states that students should know about this conversion and the production of reduced NAD The lesson begins with a challenge, where the students have to recall the details of glycolysis in order to form the word matrix. This introduces the key point that this stage occurs in this part of the mitochondria and time is taken to explain why the reactions occur in the matrix as opposed to the cytoplasm like glycolysis. Moving forwards, the Link reaction is covered in 5 detailed bullet points and students have to add the key information to these points using their prior knowledge as well as knowledge provided in terms of NAD. The students will recognise that this reaction occurs twice per molecule of glucose and a quick quiz competition is used to test their understanding of the numbers of the different products of this stage. This is just one of the range of methods that are used to check understanding and all answers are explained to allow students to assess their progress. This lesson has been written to tie in with the other uploaded lessons on glycolysis and the Krebs cycle and oxidative phosphorylation.

This fully-resourced lesson explores how pyruvate can be converted to lactate or ethanol using reduced NAD and that the reoxidation of the coenzyme allows glycolysis to continue. The engaging and detailed PowerPoint and accompanying differentiated resources have been designed to cover the third part of point 5.2 of the AQA A-level Biology specification which states that students should know the fate of pyruvate if respiration is only anaerobic. The lesson begins with a focus on the coenzyme, NAD, and students are challenged to recall details of its role in the oxidation of triose phosphate. Students will learn that oxidative phosphorylation in aerobic respiration allows these coenzymes to be reoxidised but that another metabolic pathway has to operate when there is no oxygen. Time is taken to go through the lactate and ethanol fermentation pathways and students are encouraged to discuss the conversions before applying their knowledge to complete diagrams and passages about the pathways. Understanding checks in a range of forms are used to enable the students to assess their progress whilst prior knowledge checks allow them to recognise the links to earlier topics. This lesson has been written to tie in with the other uploaded lesson on glycolysis

This fully-resourced lesson looks at the details of glycolysis as the first stage of aerobic and anaerobic respiration and explains how the sequence of reactions results in glucose being converted to pyruvate. The engaging PowerPoint and accompanying differentiated resources have been designed to cover the second part of point 5.2 of the AQA A-level Biology specification which states that students should know glycolysis as the phosphorylation of glucose and the production and subsequent oxidation of triose phosphate. The lesson begins with the introduction of the name of the stage and then explains how the phosphorylation of the hexoses and the production of the ATP, coenzymes and pyruvate are the stages that need to be known for this specification. Time is taken to go through each of these stages and key points such as the use of ATP in phosphorylation are explained so that students can understand how this affects the net yield. A quick quiz competition is used to introduce NAD and the students will learn that the reduction of this coenzyme, which is followed by the transport of the protons and electrons to the cristae for the electron transport chain is critical for the overall production of ATP. Understanding checks, in a range of forms, are included throughout the lesson so that students can assess their progress and any misconceptions are immediately addressed. This lesson has been written to tie in with the other uploaded lessons on anaerobic respiration and the different stages of aerobic respiration (the Link reaction, Krebs cycle and oxidative phosphorylation)

This detailed, concise lesson describes and explains how the electron transport chain and chemiosmosis are involved in the synthesis of ATP by oxidative phosphorylation. The PowerPoint has been designed to cover point 7.6 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification and also looks at the role of the enzyme, ATP synthase. The lesson begins with a discussion about the starting point of the reaction. In the previous stages, the starting molecule was the final product of the last stage but in this stage, it is the reduced coenzymes which release their hydrogen atoms. Moving forwards, the process of oxidative phosphorylation is covered in 7 steps and at each point, key facts are discussed and explored in detail to enable a deep understanding to be developed. Students will see how the proton gradient is created and that the flow of protons down the channel associated with ATP synthase results in a conformational change and the addition of phosphate groups to ADP. Understanding checks are included throughout the lesson to enable the students to assess their progress. This lesson has been written to tie in with the other uploaded lessons on glycolysis, the Link reaction and Krebs cycle and anaerobic respiration.

This engaging and detailed lesson looks at the roles of the Link reaction and the Krebs cycle as the stages of aerobic respiration which occur in the mitochondrial matrix. Both the PowerPoint and the accompanying resource have been designed to cover point 7.5 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification. The lesson begins with a challenge, where the students have to recall the details of glycolysis in order to form the word matrix. This introduces the key point that these two stages occur in this part of the mitochondria and time is taken to explain why the reactions occur in the matrix as opposed to the cytoplasm like glycolysis. Moving forwards, the Link reaction is covered in 5 detailed bullet points and students have to add the key information to these points using their prior knowledge as well as knowledge provided in terms of NAD. The students will recognise that this reaction occurs twice per molecule of glucose and a quick quiz competition is used to test their understanding of the numbers of the different products of this stage. This is just one of the range of methods that are used to check understanding and all answers are explained to allow students to assess their progress. The rest of the lesson focuses on the Krebs cycle. In line with the detail of the specification, students will understand how decarboxylation and dehydrogenation reactions result in the regeneration of the 4C compound. It is estimated that it will take about 2 hours of A-level teaching time to cover the detail of the lesson and therefore the detail of the specification point 7.5

This fully-resourced lesson looks at the roles of glycolysis in aerobic and anaerobic respiration and explains how the sequence of reactions results in glucose being converted to pyruvate. The engaging PowerPoint and accompanying differentiated resources have been designed to cover point 7.4 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification. The lesson begins with the introduction of the name of the stage and then explains how the phosphorylation of the hexoses and the production of the ATP, coenzymes and pyruvate are the stages that need to be known for this specification. Time is taken to go through each of these stages and key points such as the use of ATP in phosphorylation are explained so that students can understand how this affects the net yield. A quick quiz competition is used to introduce NAD and the students will learn that the reduction of this coenzyme, which is followed by the transport of the protons and electrons to the cristae for the electron transport chain is critical for the overall production of ATP. Understanding checks, in a range of forms, are included throughout the lesson so that students can assess their progress and any misconceptions are immediately addressed. This lesson has been written to tie in with the other uploaded lessons on the Link reaction, Krebs cycle, oxidative phosphorylation and the production of lactate.

This detailed lesson looks at the structural organisation of the mammalian nervous system into the CNS and the PNS as detailed in point 5.1.5 (g) of the OCR A-level Biology A specification. Students will see how the PNS is divided into the sensory and motor systems and then further divided into the somatic and autonomic nervous systems. Prior knowledge checks are included throughout the lesson to make links to earlier topics such as the structure of neurones and the function of the hypothalamus in thermoregulation and osmoregulation. This lesson has been designed to tie in with the uploaded lesson on the autonomic nervous system which is also covered in specification point 5.1.5 (g)

This clear and concise lesson looks at the calculation of cardiac output as the product of stroke volume and heart rate. This engaging PowerPoint and accompanying resource have both been designed to cover point 7.9 (i) of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification which states that students should be able to calculate cardiac output. The lesson begins by challenging the students to recall that the left ventricle is the heart chamber with the thickest myocardial wall. This leads into the introduction of stroke volume as the volume of blood which is pumped out of the left ventricle each heart beat. A quick quiz game is used to introduce a normative value for the stroke volume and students are encouraged to discuss whether males or females would have higher values and to explain why. A second edition of this quiz reveals a normative value for resting heart rate and this results into the introduction of the equation to calculate cardiac output. A series of questions are used to challenge their ability to apply this equation and percentage change is involved as well. The final part of the lesson looks at the hypertrophy of cardiac muscle and students will look at how this increase in the size of cardiac muscle affects the three factors and will be challenged to explain why with reference to the cardiac cycle that was covered in an earlier topic.

This detailed lesson looks at the structure and function of the motor neurones that form the autonomic nervous system and is responsible for automatic responses. The engaging PowerPoint and accompanying resource have both been designed to cover the second part of point 5.1.5 (g) of the OCR A-level Biology A specification which states that students should be able to demonstrate and apply their knowledge and understanding of the functional organisation of the motor system into somatic and autonomic systems. Students will discover that this system is further divided into sympathetic and parasympathetic systems to control different aspects of a particular involuntary response. The lesson begins with a focus on the types of effectors that will be connected to the CNS by autonomic motor neurones. Students will learn that effectors which are not under voluntary control such as cardiac muscle, smooth muscle and glands will be innervated by these neurones. Moving forwards, a quick quiz competition is used to introduced ganglia as a structure which connects the two or more neurones involved in the cell signalling between the CNS and the effector. This leads into the discovery of the two divisions and students will begin to recognise the differences between the sympathetic and parasympathetic systems based on function but also structure. The remainder of the lesson looks at the differing effects of these two systems. This lesson has been written to tie in with the lesson on the organisation of the mammalian nervous system which covers the first part of specification point 5.1.5 (g)

This fully-resourced lesson looks at the detailed structure of a muscle fibre, and focuses on the proteins, bands and zones that are found in the myofibril. The engaging PowerPoint and acccompanying resource have been designed to cover point 7.10 (i) of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification. The lesson begins with an imaginary question from the quiz show POINTLESS, where students have to recognise a range of fields of study. This will reveal myology as the study of muscles so that key terms like myofibril, myofilament and myosin can be introduced. Students should have met these terms as well as actin when learning about the sliding filament theory in topic 7.2, so this acts as a recall. Moving forwards, students will be shown the striated appearance of this muscle so they can recognise that some areas appear dark where both myofilaments are found and others as light as they only contain actin or myosin. A quiz competition is used to introduce the A band, I band and H zone and students then have to use the information given to label a diagram of the myofibril. The final task challenges the students to use their knowledge of the sliding filament theory to recognise which of these bands or zones narrow or stay the same length when muscle is contracted.

This fully-resourced lesson looks at how heart rate is controlled by the cardiovascular control centre in the medulla oblongata. The engaging and detailed PowerPoint and accompanying resources have been designed to cover the first part of point 7.9 (ii) of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification but also ties in well with previously covered topics and provides a good introduction to control systems which are covered later in topic 7 and 8. This lesson begins with a prior knowledge check where students have to identify and correct any errors in a passage about the conduction system of the heart. This allows the SAN to be recalled as this structure play an important role as the effector in this control system. Moving forwards, the three key parts of a control system are recalled as the next part of the lesson will specifically look at the range of sensory receptors, the coordination centre and the effector. Students are introduced to chemoreceptors and baroreceptors and time is taken to ensure that the understanding of the stimuli detected by these receptors is complete and that they recognise the result is the conduction of an impulse along a neurone to the brain. A quick quiz is used to introduce the medulla oblongata as the location of the cardiovascular centre. The communication between this centre and the SAN through the autonomic nervous system can be poorly understood so detailed explanations are provided and the sympathetic and parasympathetic divisions compared. The final task challenges the students to demonstrate and apply their understanding by writing a detailed description of the control and this task has been differentiated three ways to allow differing abilities to access the work

This fully-resourced lesson looks at the use of electrocardiograms to aid the diagnosis of CVD and other heart conditions. The engaging PowerPoint and accompanying resources have been designed to cover point 7.8 (iii) of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification but also make continual links to earlier specification points like 1.4 and 1.5 where heart topics were previously covered. The lesson has been written to take place in an imaginary cardiology ward where the students are initially challenged on their knowledge of the symptoms and risk factors of CVD before looking at testing through the use of ECGs and diagnosis. The main focus of the lesson is the ECG and a quiz competition is used to introduce the reference points of P, QRS and T before time is taken to explain their representation with reference to the cardiac cycle. Moving forwards, a SPOT the DIFFERENCE task is used to challenge the students to recognise differences between sinus rhythm and some abnormal rhythms including tachycardia and atrial fibrillation. Bradycardia is used as a symptom of sinus node disfunction and the students are encouraged to discuss this symptom along with some others to try to diagnose this health problem. This lesson has been designed to tie in with the lesson that covers the previous specification point on the normal electrical activity of the heart and the myogenic nature of cardiac muscle

This engaging lesson looks at the myogenic nature of cardiac muscle and explores the roles of the SAN, AVN, Bundle of His and Purkyne fibres in the normal electrical activity of the heart. The PowerPoint and accompanying resources have been designed to cover the points 7.8 (i & ii) of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification. The lesson begins with the introduction of the SAN as the natural pacemaker and then time is given to study each step of the conduction of the impulse as it spreads away from the myogenic tissue in a wave of excitation. The lesson has been written to make clear links to the cardiac cycle and the structure of the heart and students are challenged on their knowledge of this system from topic 1. Moving forwards, students are encouraged to consider why a delay would occur at the AVN and then they will learn that the impulse is conducted along the Bundle of His to the apex so that the contraction of the ventricles can happen from the bottom upwards. The structure of the cardiac muscle cells is discussed and the final task of the lesson challenges the students to describe the conducting tissue, with an emphasis on the use of key terminology Due to the detailed nature of this lesson, it is estimated that it will take about 2 hours of A-level teaching time to cover the two specification points

This fully-resourced lesson looks at the coordination and control of heart rate by the cardiovascular centre in the medulla oblongata. The engaging and detailed PowerPoint and accompanying resources have been designed to cover the second part of point 6.1.3 of the AQA A-level Biology specification which states that students should know the roles and locations of the sensory receptors and the roles of the autonomic nervous system and effectors in the control of heart rate. This lesson begins with a prior knowledge check where students have to identify and correct any errors in a passage about the conduction system of the heart. This allows the SAN to be recalled as this structure play an important role as the effector in this control system. Moving forwards, the three key parts of a control system are recalled as the next part of the lesson will specifically look at the range of sensory receptors, the coordination centre and the effector. Students are introduced to chemoreceptors and baroreceptors and time is taken to ensure that the understanding of the stimuli detected by these receptors is complete and that they recognise the result is the conduction of an impulse along a neurone to the brain. A quick quiz is used to introduce the medulla oblongata as the location of the cardiovascular centre. The communication between this centre and the SAN through the autonomic nervous system can be poorly understood so detailed explanations are provided and the sympathetic and parasympathetic divisions compared. The final task challenges the students to demonstrate and apply their understanding by writing a detailed description of the control and this task has been differentiated three ways to allow differing abilities to access the work This lesson has been written to tie in with the previous lesson on the conducting system of the heart which is also detailed in specification point 6.1.3

This engaging lesson explores the roles of the SAN, AVN, Bundle of His and Purkyne fibres in the transmission of the wave of excitation through the heart. The PowerPoint and accompanying resources have been designed to cover the first part of point 6.1.3 of the AQA A-level Biology specification which states that students should be able to describe the myogenic stimulation of the heart and the subsequent wave of electrical activity. The lesson begins with the introduction of the SAN as the natural pacemaker and then time is given to study each step of the conduction of the impulse as it spreads away from the myogenic tissue in a wave of excitation. The lesson has been written to make clear links to the cardiac cycle and the structure of the heart and students are challenged on their knowledge of this system from topic 3. Moving forwards, students are encouraged to consider why a delay would occur at the AVN and then they will learn that the impulse is conducted along the Bundle of His to the apex so that the contraction of the ventricles can happen from the bottom upwards. The structure of the cardiac muscle cells is discussed and the final task of the lesson challenges the students to describe the conducting tissue, with an emphasis on the use of key terminology

This fully-resourced lesson looks at how errors in DNA replication can give rise to gene mutations and then links to an earlier topic by exploring how these base changes can affect the primary structure of a polypeptide. The engaging and detailed PowerPoint and accompanying resources have been designed to cover point 2.12 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification and constantly refers back to points 2.7, 2.8 and 2.9 which detail the genetic code, genes and the structure of proteins. In order to understand how a change in the base sequence can affect the order of the amino acids, students must be confident in their understanding and application of protein synthesis which was taught in 2.6. Therefore, the start of the lesson focuses on transcription and translation and students are guided through the use of the codon table to identify amino acids. Moving forwards, a quick quiz competition is used to introduce the names of three types of gene mutation whilst challenging the students to recognise terms which are associated with the genetic code and were met in the previous lesson. The main focus of the lesson is base substitutions and how these mutations may or may not cause a change to the amino acid sequence. The students are challenged to use their knowledge of the degenerate nature of the genetic code to explain how a silent mutation can result. The rest of the lesson looks at base deletions and base insertions and students are introduced to the idea of a frameshift mutation. One particular task challenges the students to evaluate the statement that base deletions have a bigger impact on primary structure than base substitutions. This is a differentiated task and they have to compare the fact that the reading frame is shifted by a deletion against the change in a single base by a substitution.

This fully-resourced lesson explores how reproductive isolation can potentially lead to the formation of a new species by speciation . The engaging PowerPoint and accompanying resources have been designed to cover point 5.19 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification which states that students should understand how isolation reduces gene flow between populations which can lead to allopatric or sympatric speciation. The lesson begins by using the example of a hinny, which is the hybrid offspring of a horse and a donkey, to challenge students to recall the biological classification of a species. Moving forwards, students are introduced to the idea of speciation and the key components of this process, such as isolation and selection pressures, are covered and discussed in detail. Understanding and prior knowledge checks are included throughout the lesson to allow the students to not only assess their progress against the current topic but also to make links to earlier topics in the specification. Time is taken to look at the details of allopatric speciation and how the different mutations that arise in the isolated populations and genetic drift will lead to genetic changes. The example of allopatric speciation in wrasse fish because of the isthmus of Panama is used to allow the students to visualise this process. The final part of the lesson considers sympatric speciation and again a wide variety of tasks are used to enable a deep understanding to be developed.

This fully-resourced lesson guides students through the use of the Hardy-Weinberg equation to see whether a change in allele frequency is occurring in a population over time. The detailed PowerPoint and differentiated practice questions worksheets have been designed to cover point 4.5 (i) of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification which expects students to be able to use this mathematical equation The lesson begins by looking at the equation and ensuring that students understand the meaning of each of the terms. The recessive condition, cystic fibrosis, is used as an example so that students can start to apply their knowledge and assess whether they understand which genotypes go with which term. Moving forwards, a step-by-step guide is used to show students how to answer a question. Tips are given during the guide so that common misconceptions and mistakes are addressed immediately. The rest of the lesson gives students the opportunity to apply their knowledge to a set of 3 questions, which have been differentiated so that all abilities are able to access the work and be challenged