This is a fully-resourced lesson consisting of an engaging PowerPoint and differentiated worksheets which have been designed to cover the content of point 2.5 (i) as detailed on the WJEC GCSE Biology specification. This point states that students should demonstrate and apply their knowledge and understanding of how type I and II diabetes are caused and their respective treatments. There are links made throughout the lesson between this topic and the control of blood glucose concentration from specification point 2.5 (h). The lesson has been designed to take the format of a diabetic clinic where the students perform the duties of the attending doctor. They will move through the different stages of the role which includes identifying symptoms, diagnosis of type I or II and communication with the patients to reveal the findings. The wide range of activities will enable the students to learn how to spot that someone is suffering from diabetes and the similarities and differences between the different types so they can determine which one is being presented. The summary tasks challenge the students to construct a letter to a patient who is suffering from type II and to identify the correct type from another doctor’s letter. Understanding and previous knowledge checks are interspersed with quiz competitions, like the one shown in the cover image, which make the learning fun and memorable and enable the students to assess their progress. This lesson has been designed for students studying the WJEC GCSE Biology course but is suitable for both younger and older students who are focusing on this disease

This fully-resourced lesson has been designed to cover the content found in specification point 2.5 (f) of the WJEC GCSE Biology specification which states that students should understand why animals need to regulate the conditions inside their bodies. This resource contains an engaging and detailed PowerPoint (45 slides) and accompanying worksheets The lesson begins by challenging the student’s literacy skills as they are asked to recognise the key term, optimum, from 6 of its’ synonyms. Moving forwards, a range of quiz competitions are used to introduce the term homeostasis and to provide a definition for this key process. Students are given a newspaper article about water and blood glucose so they can recognise 2 conditions which are controlled in the human body. The next part of the lesson looks at the importance of maintaining the levels of water and glucose by considering the medical problems that could arise if they move away from the optimum levels. Students will learn that body temperature is also controlled and links are made to earlier knowledge as they have to explain why an increase in temperature above the set point would be an issue because of the denaturation of enzymes. The rest of the lesson looks at the three parts that are included in all control systems before a final quiz round introduces the receptors, coordination centre and effectors in the control of body temperature. As stated at the top, this lesson has been designed for GCSE-aged students who are studying the WJEC GCSE Biology course, but it can be used with A-level students who need to go back over the key points before looking at the process in more detail

This lesson describes the evidence that led to the three-domain model of classification as an alternative to the five-kingdom model. The detailed PowerPoint and accompanying resources have been designed to cover point 3.1 (vii) of the Edexcel A-level Biology B specification and focuses on Carl Woese’s detailed study of the ribosomal RNA gene and the need for this evidence to be validated by the scientific community The lesson begins with an introduction of Woese and goes on to describe how he is most famous for his definition of the Archaea as a new domain of life. Students were introduced to domains and the other classification taxa in a lesson at the start of this topic, so their recall of this knowledge is continually tested and built upon as details are added. Students will discover the key differences between Archaea and Bacteria that led to the splitting of the prokaryotae kingdom and the addition of this higher classification rank and will understand that it wasn’t until 13 years after the discovery that it was adopted. Moving forwards, the rest of the lesson describes how molecular phylogeny uses other molecules that can be compared between species for classification purposes. One of these is a protein called cytochrome which is involved in respiration and can be compared in terms of primary structure to determine relationships. At this point in the lesson, the students are also tested on their knowledge of the nature of the genetic code (as covered in topic 1) and have to explain how mutations to DNA can also be used for comparative purposes.

This lesson has been designed to cover the content of specification point 4.1.2.1 (Chromosomes) and 4.1.2.2 (Mitosis and the cell cycle) of the AQA GCSE Biology and Combined Science course. Cell division is a topic which can cause students a number of problems so this lesson has been designed to ensure that the key details are covered and checked constantly. As well as the understanding and previous knowledge checks, quiz competitions are written into the lesson to maintain engagement and motivation. The lesson begins with the introduction of the term cell cycle and students will learn that the cycle consists of three stages. The key details of each of these stages is covered during the main part of the lesson so that students can meet the specification requirements of being able to describe the main events. Time is allotted for discussion to encourage students to converse about important points such as what happens to the replicated chromosomes during mitosis to enable identical daughter cells to be produced. Opportunities are taken to make links to other topics such as animal and plant cells as students are challenged to recall the functions of some sub-cellular structures. The final part of the lesson involves a series of summary questions which challenges the students to not only recall content but also to apply to unfamiliar organisms and it is not until the final question that they will answer a question about the cell cycle in humans.

This detailed and engaging lesson describes the basic structure of a mononucleotide and the similarities and differences between DNA and RNA. The PowerPoint and accompanying worksheet containing exam-style questions have been designed to cover points 2.5 (i) & (ii) of the Pearson Edexcel A-level Biology A specification. In topic 1, the students were introduced to a number of monomers and the start of the lesson challenges them to recognise the key term nucleotide when only the letters U, C and T are shown. The next part of the lesson describes the structure of a DNA nucleotide and an RNA nucleotide so that the pentose sugar and the bases adenine, cytosine and guanine can be recognised as similarities whilst deoxyribose and ribose and thymine and uracil are seen as the differences. Time is taken to discuss how a phosphodiester bond is formed between adjacent nucleotides and their prior knowledge and understanding of condensation reactions is tested through a series of questions. Students are then introduced to the purine and pyrimidine bases and this leads into the description of the double-helical structure of DNA and the hydrogen bonds between complementary bases. The final section of the lesson describes the structure of mRNA, tRNA and rRNA and students are challenged to explain why this single stranded polynucleotide is shorter than DNA In addition to the current understanding and prior knowledge checks, a number of quiz rounds have been written into the lesson to introduce key terms in a fun and memorable way and the final round acts as a final check on the structures of DNA and RNA.

This fully-resourced lesson describes the events of the cell cycle so that students can understand how the genetic material behaves in interphase, mitosis and cytokinesis. The detailed PowerPoint and accompanying resources have been designed to cover specification points 2.3 (i), (ii) and (iii) as detailed in the Edexcel A-level Biology B specification. Depending upon the exam board taken at GCSE, the knowledge and understanding of mitosis and the cell cycle will differ considerably between students and there may be a number of misconceptions. This was considered at all points during the planning of the lesson and to address existing errors, key points are emphasised throughout. The cell cycle is introduced at the start of the lesson and the quantity of DNA inside the parent cell is described as diploid and as 2n. A quiz competition has been written into the lesson and this runs throughout, challenging the students to identify the quantity of DNA in the cell (in terms of n) at different points of the cycle. Moving forwards, the first real focus is interphase and the importance of DNA replication is explained so that students can initially recognise that there are pairs of identical sister chromatids and then can understand how they are separated later in the cycle. The main part of the lesson focuses on prophase, metaphase, anaphase and telophase and describes how the chromosomes behave in these stages. An exam style question will check on their knowledge of the organelles from 2.1 and this acts to remind them that centrioles are responsible for the production of the spindle apparatus, Students will understand how the cytoplasmic division that occurs in cytokinesis results in the production of genetically identical daughter cells. This leads into a series of understanding and application questions where students have to identify the various roles of mitosis in living organisms as well as tackling a Maths in a Biology context question. The lesson concludes with a final round of MITOSIS SNAP where they only shout out this word when a match is seen between the name of a phase, an event and a picture

This fully-resourced lesson has been designed to cover specification points 2.2 (a and b) about chromosomes and their role in mitosis as detailed in topic 2.2 (Cell division and stem cells) of the WJEC GCSE Biology specification. The wide range of activities will engage and motivate the students whilst ensuring that the content is covered in detail. In order for a deep understanding to be achieved, the other stages of the cell cycle (interphase and cytokinesis) are discussed so that students can recognise how th events that happen before and after this form of cell division results in genetically identical cells. A selection of summary questions will challenge the students on their understanding and ability to apply their knowledge to unfamiliar situations with questions about organisms other than humans. The lesson finishes by looking at the functions of mitosis in living organisms. This lesson has been designed for GCSE-aged students studying the WJEC GCSE Biology course but is also suitable for older students who are learning about mitosis and the cell cycle at A-level and need to go back over the key points

This lesson has been designed to cover the content as detailed in points 7.9 & 7.10 (The importance of homeostasis) of the Edexcel GCSE Biology specification. Consisting of a detailed and engaging PowerPoint and accompanying worksheets, the range of activities will motivate the students whilst ensuring that the content is covered in detail. Students will learn how a constant internal environment is maintained by homeostasis before being introduced to some of the factors which are regulated by these systems. Time is taken to look into osmoregulation and thermoregulation in more detail, so that students can explain that maintenance of the body temperature at the set-point allows enzymes to function at their maximum rate. Progress checks are included throughout the lesson so that students can assess their understanding of the content and any misconceptions can be addressed whilst quiz competitions, like SAY WHAT YOU SEE and YOU DO THE MATH, are used to introduce new terms and important values in a fun and memorable way. This lesson has been written for GCSE-aged students who are studying the Edexcel GCSE Biology specification but can be used with older students who need to recall the idea of homeostasis before taking it to greater depths in their studies.

This is an engaging revision lesson which uses a range of exam questions, understanding checks, quick differentiated tasks and quiz competitions to allow students to assess their knowledge of the topic of cells and related topics as covered in the GCSE Biology and GCSE Combined Science courses. As cells are the building blocks of living organisms, a strong understanding of this topic is critical for the success of a student on these two courses. The following topics are covered in this revision lesson: The key differences between eukaryotic and prokaryotic cells The structure of a bacterial cell Specialised cells The individual functions of the organelles Calculating size Students will be engaged through the range of activities which includes quiz competitions such as “CELL, CELL, CELL” where students have to compete to identify specialised cells from descriptions. This lesson can be used at any time during the year as a revision material, in the lead up to mocks or as a final revision lesson before the GCSE terminal exams.

This is a fully-resourced revision lesson that has been written to challenge students on their knowledge and understanding of the PAPER 2 topics. The range of tasks will prepare the students to answer the range of questions that they may encounter on topics B1 and B6 - B9 as detailed in the Pearson Edexcel GCSE Combined Science specification. The lesson has been designed to take place on the PAPER 2 HIGH STREET and the tasks include exam-style questions with displayed mark schemes, engaging quiz competitions and discussion points to allow the following points to be covered: Eukaryotic vs Prokaryotic cells Converting between units of size The structures of the animal and plant cells The structure of the human heart Calculating the surface area to volume ratio Adaptations of the gas exchange system The blood vessels associated with the human heart Calculating the cardiac output The features of the root hair cell to allow for absorption The nitrogen cycle The relationship between the rate of photosynthesis and light intensity and distance Using the inverse square law calculation Temperature and photosynthesis The regulation of blood glucose by the release of insulin and glucagon Diabetes type I and II Calculating the BMI The interaction of the reproductive hormones in the menstrual cycle IVF as assisted reproductive technology The hormonal and barrier methods of contraception Eutrophication as a negative human interaction in an ecosystem The carbon cycle In order to cater for the range of abilities that can be found in Combined Science classes, most of the tasks have been differentiated. There are also a number of step by step guides to demonstrate how to tackle some of the more difficult concepts including the mathemetical elements If you would like to see the quality of these revision lessons, download the PAPER 1 REVISION LESSON which has been shared for free

This fully-resourced lesson describes the differences between the roles of the B cells and T cells in the body’s immune response. The PowerPoint and accompanying resources have been designed to cover points 6.9 & 6.10 in unit 4 of the Edexcel International A-level Biology specification and includes descriptions of the role of the antigens and the production of antibodies by plasma (effector) cells In the previous lesson on the non-specific responses, the students were introduced to macrophages and dendritic cells as antigen-presenting cells and the start of this lesson challenges their recall and understanding of this process. Time is taken to discuss how the contact between these cells and lymphocytes is critical for the initiation of the body’s (specific) immune response. Moving forwards, a quick quiz competition is used to introduce the names of the different T cells that result from differentiation. Their specific roles are described including an emphasis on the importance of the release of cytokines in cell signalling to activate other immune system cells. T memory cells are also introduced so that students can understand their role in immunological memory and active immunity as described in an upcoming lesson. The next part of the lesson focuses on the B cells and describes how clonal selection and clonal expansion results in the formation of memory B cells and effector cells. A series of understanding and application questions are then used to introduce the structure of antibodies and to explain how the complementary shape of the variable region allows the antigen-antibody complex to be formed. The lesson concludes by emphasising that the pathogen will be overcome as a result of the combination of the actions of phagocytes, T killer cells and the antibodies released by the effector cells

This fully-resourced lesson describes the relationship between the structure, properties and functions of triglycerides in living organisms. The engaging PowerPoint and accompanying worksheets have been designed to cover the first part of point (f) as detailed in AS unit 1, topic 1 of the WJEC A-level Biology specification and links are also made to related future topics such as the importance of the myelin sheath for the conduction of an electrical impulse which is covered in A2. The lesson begins with a focus on the basic structure and roles of lipids, including the elements that are found in this biological molecule and some of the places in living organisms where they are found. Moving forwards, the students are challenged to recall the structure of the carbohydrates from earlier in topic 1 so that the structure of a triglyceride can be introduced. Students will learn that this macromolecule is formed from one glycerol molecule and three fatty acids and have to use their understanding of condensation reactions to draw the final structure. Time is taken to look at the difference in structure and properties of saturated and unsaturated fatty acids and students will be able to identify one from the other when presented with a molecular formula. The final part of the lesson explores how the various properties of a triglyceride mean that it has numerous roles in organisms including that of an energy store and source and as an insulator of heat and electricity.

This fully-resourced lesson describes the action of enzymes as biological catalysts and explains how their specificity is related to their 3D structure. The engaging PowerPoint and accompanying resources have been designed to cover points 2.10 (i) and (ii) of the Pearson Edexcel A-level Biology A specification but also introduces some examples of intracellular and extracellular enzymes to prepare students for the next lesson which covers 2.10 (iii). The lesson has been specifically planned to tie in with related topics that were previously covered such as protein structure, globular proteins and intracellular enzymes. This prior knowledge is tested through a series of exam-style questions along with current understanding and mark schemes are included in the PowerPoint so that students can assess their answers. Students will learn that enzymes are large globular proteins which contain an active site that consists of a small number of amino acids. Emil Fischer’s lock and key hypothesis is introduced to enable students to recognise that their specificity is the result of an active site that is complementary in shape to a single type of substrate. Time is taken to discuss key details such as the control of the shape of the active site by the tertiary structure of the protein. The induced-fit model is described so students can understand how the enzyme-susbtrate complex is stabilised and then students are challenged to order the sequence of events in an enzyme-controlled reaction. The lesson finishes with a focus on ATP synthase and DNA polymerase so that students are aware of these important intracellular enzymes when learning about the details of respiration and DNA replication.

This fully-resourced lesson describes the major routes that pathogens take when entering the body and the body’s barriers to this infection. The engaging and detailed PowerPoint and accompanying resources have been designed to cover points 6.7 (i) & (ii) of the Edexcel International A-level Biology specification and includes descriptions of the following barriers: skin the blood clotting process mucous membranes stomach acid vaginal acid and flora skin and gut flora wax in the ear canal There are clear links to topics 1, 2 and 3 in each of these barriers, so these are considered and discussed during each of the descriptions. For example, the presence of keratin in the cytoplasm of the skin cells allows the student knowledge of the properties of this fibrous protein to be checked. Other topics that are revisited during this lesson include protein structure, key terminology and the epithelium that lines the different parts of the airways. All of the exam-style questions have mark schemes that are embedded into the PowerPoint and a number of the tasks have been differentiated to allow students of differing abilities to access the work.

This lesson describes the principles of ex situ conservation and discusses the advantages and issues surrounding this method. The PowerPoint and accompanying worksheet are part of the second lesson in a series of 2 which have been designed to cover the content of point 3.3 (iii) of the Edexcel A-level Biology B specification and it closely ties in with the previous lesson on in situ conservation. To enrich their understanding of ex situ conservation, the well-known examples of ZSL London zoo, Kew Gardens and the Millennium Seed Bank Project in Wakehurst are used. Students will understand how conserving animal species outside of their natural habitat enables human intervention that ensures the animals are fed and given medical assistance when needed as well as reproductive assistance to increase the likelihood of the successful breeding of endangered species. As with the in situ method in the previous lesson, the issues are also discussed and there is a focus on the susceptibility of captive populations to diseases as a result of their limited genetic diversity. The final part of the lesson considers how seed banks can be used to ensure that plant species avoid extinction and how the plants can be bred asexually to increase plant populations quickly.

This lesson describes the main stages of mitosis and explains the significance of this type of nuclear division for the daughter cells produced by the cycle. The PowerPoint and accompanying resources have been designed to cover points 6 (a & b) in topic 6 of AS unit 1 of the WJEC A-level Biology specification and the process of cytokinesis is also described. Depending upon the exam board taken at GCSE, the knowledge and understanding of mitosis will differ considerably between students and there may be a number of misconceptions. This was considered at all points during the planning of the lesson so that existing errors are addressed and key points are emphasised throughout. Their understanding of interphase is challenged at the start of the lesson to ensure that they realise that it is identical pairs of sister chromatids that enter the M phase. The main part of the lesson focuses on prophase, metaphase, anaphase and telophase and describes how the chromosomes behave in these stages. There is a focus on the centrioles and the spindle fibres that they produce which contract to drag one chromatid from each pair in opposite directions to the poles of the cell. The remainder of the lesson is a series of understanding and application questions where students have to identify the various roles of mitosis in living organisms as well as tackling a Maths in a Biology context question. The lesson concludes with a final quiz round of MITOSIS SNAP where they only shout out this word when a match is seen between the name of a phase, an event and a picture.

This lesson describes the main stages of meiosis and has a specific focus on those events which contribute to genetic variation. The detailed PowerPoint and accompanying resources have been designed to cover point (d) in topic 6 of AS unit 1 of the WJEC A-level Biology specification and includes description of crossing over, independent assortment, independent segregation and the production of haploid gametes In order to understand how the events of meiosis like crossing over and independent assortment and independent segregation can lead to variation, students need to be clear in their understanding that DNA replication in interphase results in homologous chromosomes as pairs of sister chromatids. Therefore the beginning of the lesson focuses on the chromosomes in the parent cell and this first part of the cycle and students will be introduced to non-sister chromatids and the fact that they may contain different alleles which is important for the exchange that occurs during crossing over. Time is taken to go through this event in prophase I in a step by step guide so that the students can recognise that the result can be new combinations of alleles that were not present in the parent cell. Moving forwards, the lesson explores how the independent assortment and segregation of chromosomes and chromatids during metaphase I and II and anaphase I and II respectively results in genetically different gametes. The key events of all of the 8 phases are described and there is a focus on key terminology to ensure that students are able to describe genetic structures in the correct context. The final part of the lesson looks at the use of a mathematical expression to calculate the possible combinations of alleles in gametes as well as in a zygote following the random fertilisation of haploid gametes. Understanding and prior knowledge checks are interspersed throughout the lesson as well as a series of exam-style questions which challenge the students to apply their knowledge to potentially unfamiliar situations. This lesson has been specifically planned to lead on from the previous two lessons on the cell cycle and the main stages of mitosis and constant references are made throughout to encourage students to make links and also to highlight the differences between the two types of nuclear division

This lesson describes the key steps involved in transcription, the 1st stage of protein synthesis. The PowerPoint and accompanying resource are part of the first lesson in a series of 2 lessons which have been designed to cover the content of point 3.8 of the Edexcel GCSE Biology specification. According to the specification, the students are expected to know this process in considerable detail, and the lesson has been planned to reflect this. In a previous lesson in topic 3, the students were introduced to the definition of a gene as a section of a DNA molecule that codes for the sequence of amino acids in a protein. They will learn that this represents coding DNA, so time is then taken to explain that not all DNA codes for proteins and that there are sections of non-coding DNA located in front and behind each gene. This is vital information as it leads into the start of the process, where the binding of RNA polymerase to a section of non-coding DNA located in front of the gene is the trigger for the start of transcription of that particular gene. Moving forwards, a step by step guide describes the key steps which include the lining up of the RNA nucleotides against the exposed bases and the formation of mRNA through the reactions catalysed by RNA polymerase. Students are given key details of RNA nucleotides, specifically the inclusion of uracil bases, and an understanding check challenges them to determine the sequence of RNA bases that will line up against a template strand. These current understanding checks along with prior knowledge checks are found throughout the lesson to allow the students to assess their progress and to challenge them to make links to previous lessons.

This lesson describes how the structure of the heart and the circulatory system is related to its function. The PowerPoint lesson and accompanying resources have been designed to cover the detail of point 8.8 of the Edexcel GCSE Biology and Combined Science specifications and includes descriptions of the role of the major blood vessels, the heart valves, and the relative thickness of the chamber walls. The lesson starts with an extract from Friends and challenges the students to recognise that full sized aortic pumps is a thesaurus version of big hearts. This reiterates the basic function of the heart that was met at KS2 and KS3 and moving forwards, the students will learn that it is the contraction of the cardiac muscle in the walls of the four heart chambers that allows this to happen. Students are provided with a diagram throughout the lesson which will be annotated as new structures are encountered and they begin by labelling the two atria and ventricles. The focus of the lesson is the relationship between structure and function so time is taken to consider the different roles of the atria and ventricles, as well as the right ventricle versus the left ventricle. Students will be able to observe from their diagram that the left ventricle has the thickest wall and they will be challenged to explain why later in the lesson once more detailed knowledge has been added. The next part of the lesson introduces the pulmonary artery and vein and a task challenges the students to consider the relationship between the heart and the lungs, and their prior knowledge of the adaptations of the alveoli is also tested. The remainder of the lesson discusses the double circulatory system and the heart valves. Understanding checks are found throughout the lesson and mark schemes are embedded into the PowerPoint to allow the students to assess their progress.

This lesson describes the principle components of the plasma membrane, focusing on the phospholipid bilayer and membrane proteins. The detailed PowerPoint and accompanying worksheets have been designed to cover the detail in point (a) of AS unit 1, topic 3 of the WJEC A-level Biology specification and clear links are made to Singer and Nicholson’s fluid mosaic model The fluid mosaic model is introduced at the start so that it can be referenced at appropriate points throughout the lesson. Students were introduced to phospholipids in topic 1 and so an initial task challenges them to spot the errors in a passage describing the structure and properties of this molecule. This reminds them of the bilayer arrangement, with the hydrophilic phosphate heads protruding outwards into the aqueous solutions on the inside and the outside of the cell. In a link to some upcoming lessons on the transport mechanisms, the students will learn that only small, non-polar molecules can move by simple diffusion and that this is through the tails of the bilayer. This introduces the need for transmembrane proteins to allow large or polar molecules to move into the cell by facilitated diffusion and active transport. Proteins that act as receptors as also introduced and an opportunity is taken to make a link to an upcoming topic so that students can understand how hormones or drugs will bind to target cells in this way. Moving forwards, the structure of cholesterol is covered and students will learn that this hydrophobic molecule sits in the middle of the tails and therefore acts to regulate membrane fluidity. The final part of the lesson challenges the students to apply their newly-acquired knowledge to a series of questions where they have to explain why proteins may have moved when two cells are used and to suggest why there is a larger proportion of these proteins in the inner mitochondrial membrane than the outer membrane.