This fully-resourced lesson describes how DNA is replicated during interphase of the cell cycle and explains why it is known as semi-conservative replication. Both the detailed PowerPoint and accompanying resources have been designed to cover the details of point 2.1.3 (e) of the OCR A-level Biology A specification and the occurrence of spontaneous mutations is also discussed in the latter part of the lesson. As detailed in the specification, the focus of this lesson is the role of the enzymes DNA helicase and polymerase and students are also introduced to DNA ligase to enable them to understand how this enzyme functions to join the nucleic acid fragments. Time is taken to explain key details such as the assembly of strands in the 5’-to-3’ direction so that the continuous manner in which the leading strand is synthesised can be compared against that of the lagging strand. The students are constantly challenged to make links to previous topics such as DNA structure, phosphorylated nucleotides and hydrolysis reactions through a range of exam questions and answers are displayed so any misconceptions are quickly addressed. The final part of the lesson focuses on the occurrence of mistakes by DNA polymerase and also on the quantity of DNA in the cell following replication so that future links can be made to the cell cycle (as covered in module 2.1.6)

This detailed lesson describes the role of the mRNA, tRNA, rRNA and amino acids during the second stage of protein synthesis - translation. Both the PowerPoint and accompanying resources have been designed to cover the second part of point 2.1.3 (g) of the OCR A-level Biology A specification and continually links back to the previous lessons in this module on the structure of DNA and RNA and the genetic code Translation is a topic which is often poorly understood and so this lesson has been written to enable the students to understand how to answer the different types of questions by knowing and including the key details of the structures involved. The lesson begins by challenging the students to consider why it is so important that the amino acids are assembled in the correct order during the formation of the chain. Moving forwards, a quick quiz round called “LOST IN TRANSLATION” is used to check on their prior knowledge of the mRNA strand, the tRNA molecules, the genetic code and the ribosomes. The next task involves a very detailed description of translation that has been divided into 14 statements which the students have to put into the correct order. By giving them a passage that consists of this considerable detail, they can pick out the important parts to use in the next task where they have to answer shorter questions worth between 3 and 4 marks. These types of questions are common in the assessments and by building up through the lesson, their confidence to answer this type should increase. The final two tasks of the lesson involve another quiz, where the teams compete to transcribe and translate in the quickest time before using all that they have absorbed to answer some questions which involve the genetic code and the mRNA codon table

This lesson focuses on the structure of RNA and specifically the similarities and differences between this nucleic acid and DNA so that students are prepared for the upcoming lessons on transcription and translation. The engaging and detailed PowerPoint and accompanying resource have been designed to cover part 1 of point 2.1.3 (g) of the OCR A-level Biology A specification which states that students should be able to describe the structure of molecules of messenger RNA, transfer RNA and ribosomal RNA. Students were introduced to nucleotides and the detailed structure of DNA in previous lessons, so this lesson is written to tie in with those and continuously challenge prior knowledge as well as understanding of the current topic. The lesson begins by reminding students that RNA is a member of the family of nucleic acids and therefore has a number of structural features that are commonly shared with DNA. A quiz round called “A FAMILY AFFAIR” is used to challenge their knowledge of DNA to recognise those features that are also found on RNA such as the chain of linked nucleotides, pentose sugars, nitrogenous bases and phosphodiester bonds. The next task pushes them to consider features that have not been mentioned and therefore are differences as they answer a structured exam-style question on how RNA differs from DNA. Students will learn that RNA is shorter than DNA and this leads into the final part of the lesson where mRNA and tRNA are introduced and again they are challenged to use the new information explain the difference in size. Brief details of transcription and then translation are provided so that students are prepared for the upcoming lessons on protein synthesis.

This lesson looks at the structure of the DNA that is found in the nucleus, mitochondria and chloroplasts of eukaryotic cells and in prokaryotic cells. Both the engaging PowerPoint and accompanying resources have been designed to cover point 2.1.3 (d)(i) of the OCR A-level Biology A specification. As students will already have some knowledge of this nucleic acid from GCSE and from the earlier A-level topics, the lesson has been written to build on this prior knowledge and then to add key detail. As well as focusing on the differences between the DNA found in these two types of cells which includes the length, shape and association with histones, the various tasks will ensure that students are confident to describe how this double-stranded polynucleotide is held together by hydrogen and phosphodiester bonds. This knowledge of phosphodiester bonds means that specification point 2.1.3 © is also covered during this lesson. These tasks include exam-style questions which challenge the application of knowledge as well as a few quiz competitions to maintain engagement.

This fully-resourced lesson looks at the effects of nervous mechanisms on the heart rate. The engaging and detailed PowerPoint and accompanying resources have been designed to cover the part of point 5.1.5 (k) of the OCR A-level Biology A specification which states that students should be able to demonstrate and apply their knowledge and understanding of the control of the heart rate by the cardiovascular centre in the medulla oblongata This lesson begins with a prior knowledge check where students have to identify and correct any errors in a passage about the conduction system of the heart. This allows the SAN to be recalled as this structure play an important role as the effector in this control system. Moving forwards, the three key parts of a control system are recalled as the next part of the lesson will specifically look at the range of sensory receptors, the coordination centre and the effector. Students are introduced to chemoreceptors and baroreceptors and time is taken to ensure that the understanding of the stimuli detected by these receptors is complete and that they recognise the result is the conduction of an impulse along a neurone to the brain. A quick quiz is used to introduce the medulla oblongata as the location of the cardiovascular centre. The communication between this centre and the SAN through the autonomic nervous system can be poorly understood so detailed explanations are provided and the sympathetic and parasympathetic divisions compared. The final task challenges the students to demonstrate and apply their understanding by writing a detailed description of the control and this task has been differentiated three ways to allow differing abilities to access the work

This is an engaging lesson that looks at the structures and actions of the two parts of the autonomic nervous system (ANS) and shows students where this particular system fits into the whole organisation of the nervous system. The lesson begins by introducing the students to the idea that motor neurones are not simply somatic motor neurones but will actually be classified as autonomic motor neurones if they innervate the involuntary muscles. A range of tasks, progress checks and quick competitions are used during the lesson to engage the students in this topic and show them how it relates to other topics such as motor neurones and neurotransmitters. Key terminology is used throughout, such as ganglions, so that students can recognise and access the marks if an exam question on this topic arises. This lesson has been written for A-level students

This fully-resourced lesson explores how the structure of arteries, arterioles, capillaries, venules and veins relate to their functions. The engaging and detailed PowerPoint and accompanying resources have been designed to cover point 3.1.2 © of the OCR A-level Biology A specification. This lesson has been written to build on any prior knowledge from GCSE or earlier in this topic to enable students to fully understand why a particular type of blood vessel has particular features. Students will be able to make the connection between the narrow lumen and elastic tissue in the walls of arteries and the need to maintain the high pressure of the blood. A quick version of the GUESS WHO game is used to introduce smooth muscle and collagen in the tunica media and externa and again the reason for their presence is explored and explained. Moving forwards, it is quite likely that some students will not be aware of the transition vessels that are the arterioles. This section begins with an understanding of the need for these vessels because the structural and functional differences between arteries and capillaries is too significant. The action of the smooth muscle in the walls of these vessels is discussed and students will be challenged to describe a number of situations that would require blood to be redistributed. The middle part of the lesson looks at the role of the capillaries in exchange and links are made to diffusion to ensure that students can explain how the red blood cells pressing against the endothelium results in a short diffusion distance. The remainder of the lesson considers the structure of the veins and students are challenged to explain how the differences to those observed in arteries is due to the lower blood pressure found in these vessels. It is estimated that it will take at least 2 hours of allocated A-level Biology teaching time to cover the detail included in this lesson

This is a fully-resourced lesson that guides students through the range of calculations involved in calculating speeds in everyday situations. This lesson includes an informative lesson presentation (27 slides) and a question worksheet which has been differentiated two ways. The lesson begins by showing the students a speed camera and challenging them to recall the equation that would be used to calculate the speed as well as asking them to explain where the distance and the time values would come from. This lesson has a high mathematical element to it, to run in line with the questions that were seen in the latest exams this summer. Students will be expected to convert between units and rearrange formula. In this example, students are challenged to convert between m/s and mph in order to determine which of three drivers will receive a speeding ticket for exceeding the limit. This task has been differentiated so that students who find the conversions difficult are given some assistance so they can still access the learning. Moving forwards, students will see how a sensor on a tyre of a bicycle can also be used to calculate the speed by working out the circumference of the tyre to determine the distance. The final part of the lesson gets students to convert between m/s and mph and the other way to find out some typical speeds of everyday motion such as walking, running or a train moving. This lesson has been written for GCSE aged students but could be used with younger students of high ability who need an extra challenge in the calculating speed topic.

This is a fully-resourced lesson that looks at the role of transformers in the National Grid, explains why they increase or decrease potential difference and then uses the given equation to calculate potential difference or the number of turns on the primary or secondary coil. This lesson includes an informative lesson presentation (25 slides) and two question worksheets. The lesson begins by introducing the devices that are transformers and showing the students that there are two types, step-up and step-down. Students will learn that step-up transformers increase the potential difference and step-down transformers decrease the potential difference. Moving forwards, a series of calculations are used to get the students to understand why these changes in potential difference occur. Students are guided through this section so that they are able to complete a summary passage about the roles of these devices. They will then be shown the equation connecting potential difference and number of turns which they do not need to recall but have to apply. Again, a worked example is used to visualise how workings should be set out before students are challenged to answer two sets of questions, the second of which involves the use of a second equation. Progress checks like these are found at regular intervals throughout the lesson so that students can assess their understanding. This lesson has been written for GCSE students

This is a fully-resourced lesson that explores the meaning of irradiation and contamination and challenges the students to make links to the different types of radiation in order to state which type of radiation is most dangerous outside of the body and inside the body. This lesson includes an engaging lesson presentation (28 slides) and a differentiated worksheet which gives assistance to those students who find the task of writing the letter difficult. The lesson has been written to include real life examples to try to make the subject matter more relevant to the students. Therefore, whilst meeting the term contamination, they will briefly read about the incident with Alexander Litvinenko in 2006 to understand how the radiation entered the body. Moving forwards, students will learn that there are examples of consensual contamination such as the injection of an isotope to act as a tracer. At this point of the lesson, links are made to the topic of decay and half-lives and students are challenged to pick an appropriate isotope based on the half-life and then to write a letter to the patient explaining why they made their choice. The remainder of the lesson challenges students to decide which type or types of radiation are most dangerous when an individual is irradiated or contaminated and to explain their answers. This type of progress check can be found throughout the lesson along with a number of quick competitions which act to maintain engagement as well as introduce new terms. This lesson has been written for GCSE aged students

This is a detailed lesson which looks at the topic of reaction times and guides students through calculating a reaction time using the results of the well known ruler-drop test. In addition, students will see how reaction times can be applied in athletics but also in the calculation of the thinking distance for drivers. The lesson includes an engaging lesson presentation (32 slides) and a student task worksheet. The lesson begins by introducing the key term, reaction time, and teaching students that the average reaction time is 0.2 seconds. Moving forwards, a step by step guide is used to show the students how to take the value for distance travelled by a ruler in the drop test and use the equations of motion and change in velocity equation to calculate the reaction time. There is a large mathematical element to the lesson which challenges the students ability to rearrange formula, convert between units and leave answers to a specified number of significant figures. The answers and methods in obtaining these are always displayed at the end of each task so that the students can assess their understanding and recognise where errors were made if any were. Students will have to follow the provided method to obtain 5 results in the ruler drop test and ultimately find out their own reaction time. The remainder of the lesson looks at how the thinking distance at different speeds can be calculated. This lesson has been written for GCSE students due to the high maths content but could be used with younger students of high ability.