This lesson describes how iPS cells are formed from fibroblasts and discusses why this method is less controversial than the use of embryonic stem cells. The PowerPoint and accompanying resources are part of the 2nd lesson in a series of 2 lessons which covers the content of point 7.3 (stem cells) of the Edexcel A-level biology B specification. The lesson begins with a SPOT THE ERRORS task, where students have to use their knowledge of pluripotent cells from the previous lesson to identify the 3 errors and make corrections. The aim of this task is to remind them that pluripotent cells are found in embryos and can divide in unlimited numbers before finally becoming fully differentiated somatic cells. Moving forwards, the students are introduced to fibroblasts as examples of these somatic cells and the opportunity is taken to challenge their knowledge of collagen as this is a substance produced by these cells. The answers are embedded into the PowerPoint to allow the students to assess their recall of this topic 1 content. A quick quiz is used to introduce the acronym iPS and students will learn that fibroblasts can be reprogrammed to form induced pluripotent cells using specific transcription factors. The remainder of the lesson challenges them to answer questions about the use of iPS cells in regenerative medicine after reading a passage about an example. This allows them to recognise that deriving these cells from adult tissues as opposed to embryonic stem cells raises less problems and the transplant into the same person reduces the risk of rejection.

At the end of topic 3, or in the lead up to mocks or final A-level exams, students can use this lesson to assess their understanding of topic 3 content. The lesson consists of 20 multiple-choice questions, which have been written to challenge the students on the detail of their knowledge, as well as a PowerPoint which contains the answers, explanations and key points related to the specification. The PowerPoint also contains other topic 3 knowledge checks on content which isn’t directly questioned in the multiple-choice assessment, and prior knowledge checks to encourage the students to recognise the links to topic 1 and 2. The following topics are challenged by the multiple-choice questions: Surface area to volume ratio Gas exchange (in animals and plants) Digestion and absorption Mass transport in animals Mass transport in plants

This revision lesson contains an assessment of 20 multiple-choice questions and a PowerPoint with the answers and related key points from the specification. The 20 questions have been written to cover the content of topic 4 of the AQA A-level biology specification, providing the students with an opportunity to assess their understanding and highlight those areas which need further attention. All 7 sub-topics of topic 4 are covered by at least one question and there are several questions which challenge mathematical skills, which aligns with the high mathematical content of the final assessments.

This lesson describes how recombinant DNA can be produced, including the role of restriction endonucleases and DNA ligase. The PowerPoint and accompanying resources have been designed to cover the content of point 7.4 (i) of the Edexcel A-level Biology B specification. This lesson begins with the introduction of recombinant DNA technology as a process where fragments of DNA are transferred from one species to another. Over the course of the lesson, the students are guided through 5 steps in the production of the recombinant DNA, with a focus on the enzymes involved, which are reverse transcriptase, DNA polymerase, restriction endonuclease, and DNA ligase. Understanding checks and prior knowledge checks are used throughout the lesson and the answers are embedded into the PowerPoint to allow the students to assess their progress.

This detailed lesson describes the processes of PCR and electrophoresis to allow students to understand how gene sequencing can be used. The engaging PowerPoint and accompanying resource have been planned to cover the content of point 7.1 of the Edexcel A-level biology B specification. The lesson begins by comparing the number of genes in the genome with the number of base pairs, to allow students to learn that the bases in the genes only accounts for about 1.5% of the genome. This challenges them to recall that most is non-coding DNA, and the importance and usefulness of these sections are explored during the lesson. Moving forward, a step-by-step guide describes the key steps in the polymerase chain reaction, and time is taken at each step to qualify the fine details such as the use of Taq polymerase instead of human DNA polymerase. The remainder of the lesson focuses on the various uses of these DNA samples once they’ve been amplified by the PCR. The steps of the electrophoresis process are described and students will see how DNA profiling can be used in forensic science to identify criminals and for paternity tests. Understanding and prior knowledge checks are found throughout the lesson, along with the answers, to allow students to assess their grasp of the current topic as well as their ability to identify the links with previously covered topics.

This revision lesson uses a 20 question multiple-choice assessment to challenge the students on their understanding of the topic 2 content (Cells). It has been written to check their knowledge from across the AQA A-level biology topic 2 specification and includes questions on the structure of eukaryotic and prokaryotic cells, the methods of studying cells, mitosis and binary fission, transport across cell membranes and the immune system. The lesson includes a PowerPoint where the answers to the 20 questions are revealed, along with their respective specification codes, to allow the students to pinpoint areas of the specification that require extra attention. The PowerPoint also includes extra questions and tasks to challenge some of the content not directly questioned in the MC assessment. Lessons challenging their knowledge of topics 1, 3 and 4 have also been uploaded.

This revision lesson uses a multiple-choice assessment to challenge the students on their understanding of topic 8, the control of gene expression. In addition to the 20 question assessment, this lesson includes a PowerPoint where the answers are revealed and additional questions are posed about the content of topic 8 which isn’t directly challenged in the questions. The PowerPoint also contains prior knowledge checks on content from topics 1, 3, 4 and 6. Revision lessons of this format which challenge topics 1 - 7 are also uploaded.

This revision lesson provides students with the opportunity to assess their understanding of energy transfers in and between organisms (topic 5). The lesson includes a multiple-choice assessment of 20 questions, challenging photosynthesis, respiration, energy and ecosystems, and nutrient cycles, and a PowerPoint containing the answers, where each answer slide shows the exact specification code to enable students to note the areas which may require extra attention. The PowerPoint also contains additional questions to challenge content from topic 5 of the AQA A-level biology specification that isn’t directly covered by the 20 questions, and prior knowledge checks to encourage students to make links to related content from topics 1 - 4. This lesson has been designed to be used at the end of topic 5, and in the build up to mocks and the final A-level examinations.

This lesson explains how labelled DNA probes in microarrays can be used to identify active genes. The PowerPoint and accompanying resources have been designed to cover the content of point 8.20 of the Edexcel International A-level biology specification. The lesson begins by introducing the BRCA genes, and the students will learn how faulty alleles of these two genes can increase an individual’s risk of developing breast cancer. Therefore, there is a need to be able to locate specific alleles like these, and this function is performed by DNA probes. The students are challenged to use the function of the probes to predict their structure and will understand that they are short lengths of single stranded DNA that have a base sequence complementary to the base sequence of part of the target allele. A quick quiz round is used to introduce hybridisation as a key term, to ensure that students recognise that the probe will bind if the complementary base sequence is encountered. Moving forwards, a DNA microarray is introduced to show that it’s possible to screen for multiple genes. The remainder of the lesson considers how the DNA probes are used to screen for heritable conditions and drug responses, and real-life examples are used to increase relevance.

This lesson describes the stages of succession from colonisation to the formation of a climax community. The PowerPoint and accompanying worksheets have been designed to cover the content of point 5.15 of the Edexcel International A-level Biology specification. This lesson uses a step-by-step method to guide the students through each stage of the process of succession, explaining each of the gradual, progressive changes that occur in a community over time. At each stage, time is taken to consider the organisms involved. There is a focus on lichens as examples of pioneer species and students will understand how colonisation by these organisms is critical to provide organic matter and to turn the bare ground into soil so it is habitable by other species. The island of Surtsey in Iceland is used as a real-world example and shows how different parts of an area can be at different stages of succession. Understanding and prior knowledge checks are embedded into the PowerPoint (along with the answers) to allow students to assess their progress against the current topic and to encourage them to make links to previously-covered work.

This revision lesson uses a 15 question multiple-choice assessment to challenge the students on their knowledge of the content of module 5.1.2. In addition to the assessment, this lesson includes a PowerPoint where the answers are revealed, a series of key points linked to the OCR A-level biology A specification, and additional questions to challenge knowledge not directly covered by the 15 multiple-choice questions. The topics challenged by the assessment are: The meaning of the term excretion (as opposed to egestion) The structure of the liver The formation of urea by the ornithine cycle The regions of the kidney Ultrafiltration in the glomerulus The structure and function of the PCT The countercurrent multiplier mechanism in the loop of Henle Osmoregulation Homeostasis The use of renal dialysis Monoclonal antibodies in diagnostic tests

This lesson guides students through the respiratory quotient calculation and explains what the different calculated values indicate. The PowerPoint and accompanying resource have been planned to cover the content of point 7.6 of the Edexcel International A-level biology specification. The lesson begins with a recall challenge, where the students have to demonstrate their knowledge of respiration to reveal the two letters, RQ. The meaning of a quotient is provided and time allocated, where they are encouraged to discuss which two respiratory values might be used. The formula is provided and then a worked example used to model the calculation. The obtained value of 1.0 is explained as the RQ if metabolism consists entirely of carbohydrates. Two exam-style questions are then used to challenge the students to apply their understanding and they’ll reveal the value of 0.7 for lipids. A quick quiz round introduces the range for amino acids as 0.8 - 0.9 before a final task gets them to obtain another value and to recognise that more than one type of molecule is often metabolised. The lesson is full of understanding and prior knowledge checks, and the answers are embedded into the PowerPoint to allow students to assess their progress.