This lesson evaluates the methods used by zoos and seed banks in the conservation of endangered species. The PowerPoint and accompanying resources have been primarily designed to cover point 4.16 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification but as this is potentially the last lesson in this topic, lots of questions and activities have been included that will challenge the students on their knowledge of topic 4 (Biodiversity and Natural Resources). Hours of research went into the planning of this lesson to source interesting examples to increase the relevance of the biological content and although the main focus of the lesson is the two ex situ conservation methods, the lesson begins with a consideration of the importance of the in situ methods that are used in the Lake Télé Community reserve in the Republic of Congo and the marine conservation zone in the waters surrounding Tristan da Cunha. Students will learn how this form of active management conserves habitats and species in their natural environment, with the aim of minimising human impact whilst maintaining biodiversity. To enrich their understanding of ex situ conservation, the well-known examples of ZSL London zoo, Kew Gardens and the Millennium Seed Bank Project in Wakehurst are used. Students will understand how conserving animal species outside of their natural habitat allows for human intervention that ensures the animals are fed and given medical assistance when needed as well as reproductive assistance to increase the likelihood of the successful breeding of endangered species. An emphasis is placed on the desire to reintroduce the species into the wild and the example of some initial successes with the mountain chicken frog in Dominica and Montserrat is discussed. As stated in the specification point, these methods must be evaluated and therefore the issues are also considered and there is a focus on the susceptibility of captive populations to diseases as a result of their limited genetic diversity. The final part of the lesson considers how seed banks can be used to ensure that plant species, which may contain the molecules for medicine development, avoid extinction, and how the plants can be bred asexually to increase plant populations quickly. Due to the extensiveness of this lesson, it is estimated that it will take in excess of 2/3 hours of allocated A-level teaching time to cover the tasks and content included in the lesson and as explained above, it can also be used as revision of topic 4 content

This lesson explains that autosomal linkage results from the presence of alleles on the same chromosome and uses biological examples to demonstrate this concept. The PowerPoint and accompanying worksheets have been designed to cover point 8.2 (iv) of the Edexcel A-level Biology B specification and supports students in the formation of their descriptions of how these results of these crosses can be explained by the events of meiosis (crossing over) This is a difficult topic which can be poorly understood by students so extra time was taken during the planning to split the concept into small chunks. There is a clear focus on using the number of parent phenotypes and recombinants in the offspring as a way to determine linkage and suggest how the loci of the two genes compare. Important links to other topics such as crossing over in meiosis are made to enable students to understand how the random formation of the point of contact (chiasma) determines whether new phenotypes will be seen in the offspring or not. Linkage is an important cause of variation and the difference between observed and expected results and this is emphasised on a number of occasions and a link to the chi squared test which is covered in an upcoming lesson is also made. The main task of the lesson act as understanding check where students are challenged to analyse the results of genetic crosses involving the inheritance of the ABO blood group gene and the nail-patella syndrome gene n humans and also the inheritance of body colour and wing length in Drosophila.

This lesson explains the difference between non-infectious and infectious diseases and names the pathogens that cause examples of the latter. The PowerPoint and accompanying worksheets have been primarily designed to cover points 10.1 (a & b) of the CIE A-level Biology specification but as this is the first lesson in topic 10, links to upcoming topics such as the immune response and vaccinations are introduced. The lesson begins with a challenge where the students have to use descriptions to recognise CHD, HIV and TB as diseases that are commonly referred to by their abbreviations. This leads into a description of the meaning of disease before the students are challenged to use any prior knowledge of this topic to recognise that CHD is an examples of a non-infectious disease whereas HIV and TB are examples of infectious diseases. Specification point 10.1 (a) states that students should know about sickle cell anaemia and lung cancer so the next section of the lesson focuses on the key details of these diseases and when considering the former, their knowledge of gene mutations, protein synthesis and haemoglobin is tested. viruses - HIV/AIDS, influenza, measles, smallpox bacteria - TB, cholera, protoctista - malaria The infectious diseases shown above are covered by the remainder of this lesson and the differing mechanisms of action of these three types of pathogens are discussed and considered throughout. For example, time is taken to describe how HIV uses a glycoprotein to attach to T helper cells whilst toxins released by bacteria damage the host tissue and the Plasmodium parasite is transmitted from one host to another by a vector to cause malaria. The accompanying worksheets contain a range of exam-style questions, including a mathematical calculation, and mark schemes are embedded into the PowerPoint to allow students to immediately assess their understanding.

A fully resourced revision lesson which uses a range of exam questions (with explained answers), quick tasks and quiz competitions to enable the students to assess their understanding of the topics found within module 6.1.2 (Patterns of inheritance) of the OCR A-level Biology A specification. The topics tested within this lesson include: Genetic variation Monogenic inheritance Dihybrid inheritance Multiple alleles Sex linkage Codominance Epistasis Using the chi-squared test Discontinuous and continuous variation The Hardy Weinberg principle Student will enjoy the range of tasks and quiz rounds whilst crucially being able to recognise any areas which require further attention

A fully resourced lesson which uses a combination of exam questions, quick tasks and quiz competitions to enable students to assess their understanding of the topics found within module 5.2 (Excretion as an example of homeostatic control) of the OCR A-level Biology A specification. The following topics are tested within the lesson: Excretion The structure of the liver Liver function Kidney structure Kidney function Osmoregulation Kidney failure Students will be engaged through the various activities whilst crucially being able to recognise those areas which need further attention.

This fully-resourced lesson explains how gel electrophoresis is used to separate DNA fragments or proteins and explores its applications in genetic fingerprinting. The engaging and detailed PowerPoint and accompanying resources have been written to cover point 6.1.3 (e) of the OCR A-level Biology A specification The steps of the genetic fingerprinting process is covered the whole lesson but the main focus is the use of gel electrophoresis within this process. Students will be introduced to STRs and will come to recognise their usefulness in human identification as a result of the variability between individuals. Moving forwards, the involvement of the PCR is discussed and students are challenged on their knowledge of this process as it was encountered in a previous lesson. A brief outline of the role of restriction enzymes is provided to support students when these key gene technology enzymes are met in more detail later in the module. The main section of the lesson focuses on the use of gel electrophoresis to separate DNA fragments (as well as proteins) and the key ideas of separation due to differences in base pair length or molecular mass are discussed and explained. As well as current understanding checks, an application question involving Huntington’s disease is used to challenge their ability to apply their knowledge of the process to an unfamiliar situation. The remainder of the lesson describes how the DNA is transferred to a membrane and hybridisation probes are used to create a pattern on the X-ray film. Time has been taken to make continuous links to the previous lessons in module 6.1.3 as well as those from module 2.1.3 where DNA, RNA and protein synthesis were introduced.

A resourced lesson which uses a concise lesson presentation (18 slides) and a differentiated diagram to guide students through the method of blood clotting. This lesson has been designed for students studying GCSE (14 - 16 year olds in the UK) and this is reflected in the appropriate detail where only the involvement of fibrin needs to be known. Students are shown how blood clotting is a cascade effect where one event leads on to the next.

An informative lesson presentation (20 slides) and associated worksheet that looks at how negative feedback loops act as a final control in homeostatic mechanisms. This is a topic which is poorly understood by students at both GCSE and even A-level, so whilst designing this lesson, the focus was on a few key points and applying it to a range of actual examples. Students will see how a negative feedback loop is used in the control of adrenaline release and temperature regulation and they will also be shown what would happen if this loop didn’t exist. Students are then challenged to apply their knowledge by putting the order of the regulation of metabolic rate into the correct order. The final part of the lesson briefly looks at how positive feedback loops also exist by using the example of the release of oxytocin during birth. This lesson has primarily been designed for GCSE students but is suitable for A-level Biology students too.

An engaging and detailed lesson presentation (31 slides) that looks at how nitrogen is cycled and focuses on the different bacteria who play key roles in this cycle. The lesson begins by exploring why nitrogen is so critical for living organisms for the synthesis of DNA and proteins. Students are introduced to nitrogen-fixing bacteria to start and challenged to use their knowledge of interdependence to state the type of ecological relationship that is formed between them and the leguminous plant that they live on. Each stage of the cycle is complimented by a diagram highlighting that part so students are able to visualise how the cycle comes together. Time is taken to ensure that students recognise that any non-leguminous plants can only absorb nitrogen when it is nitrates form from the soil. Moving forwards, students will meet decomposers and nitrifying bacteria and again be shown where their function fits into the cycle. As the final part of the learning, students are challenged to consider what else is needed in order for this to be a cycle and will meet the denitrifying bacteria as a result. Progress checks, in a range of forms, have been written into this lesson at regular intervals so that students can assess their understanding and any misconceptions can be immediately addressed. This lesson has been written for GCSE students, but could be used with A-level students who want to have a recap before extending their knowledge further.

An informative lesson presentation (38 slides) that looks at a range of non-communicable diseases and also explores how risk factors can increase the chances of an individual having one of these diseases. The lesson begins by looking at CHD so that students can recognise that this is a non-communicable disease and check on their understanding of this key term. Moving forwards, a step by step question and answer format is used to show students how to form a long answer. Key terminology such as thrombosis and atherosclerosis are introduced using quick quiz competitions which act to maintain the engagement. The rest of the lesson focuses on a range of risk factors for cardiovascular diseases and time is taken to deepen knowledge of the human anatomy by challenging students to link the names of arteries to the organs that they supply. Progress checks have been written into the lesson at regular intervals so that students can constantly assess their understanding and any misconceptions can be addressed. This lesson has been written for GCSE students (14 - 16 year olds in the UK)

An informative lesson that looks at how energy is lost at each stage of a food chain and how this affects the biomass of consumers. This lesson has been written for GCSE students but could be used with A-level students who are revisiting this ecology topic. The lesson begins by posing a question to the students about why herbivores tend to be raised for food rather than carnivores to see how they would tackle it at this early stage. This exact question is revisited at the end of the lesson once learning has occurred so that students can monitor their own progress. Time is taken to look back at pyramids of biomass and food chains so that students are reminded of key terminology such as trophic level and also recognise that the biomass decreases at each level. A number of quick competitions have been written into the lesson to maintain engagement but also to introduce key terms and numbers (like 10%) in a different way. The main part of the lesson looks at how the energy is lost by organisms that leads to the decrease in biomass and links are made to related topics such as respiration and homeostasis.

This lesson uses the example of the genetic engineering of bacteria to produce insulin to walk students through the steps involved in this process. It has been written for GCSE students and therefore includes the detail required at this level, such as the involvement of restriction enzymes and the sticky ends that their cut produces. The lesson begins by challenging students to recognise that insulin is being described by a series of clues. Some further details of this hormone are recalled to test their previous knowledge of the endocrine system and also to lead into the genetic engineering of bacteria to make this protein. Moving forwards, time is taken to go through the details of plasmids and how they act as vectors as well as the enzymes, restriction and ligase. The main task of the lesson uses a series of descriptions to go through the steps involved in the process. Words or phrases are missing from each description so students have to use the terms they’ve encountered in this lesson as well as their prior knowledge to complete the step. Discussion-provoking questions are added to encourage the students to consider why certain parts of the process occur. The lesson concludes by the consideration of other organisms which have been genetically engineered as well as some of the risks of the process, which students are asked to complete for homework. As detailed above, this lesson has been designed for GCSE students but could be used with students taking A-level Biology, who are struggling to understand the detail found at this level and need to revisit the foundations.

This fully-resourced lesson explores how the presence of particular alleles at one locus can mask the expression of alleles at a second locus in epistasis. The detailed and engaging PowerPoint and associated resources have been designed to cover the part of point 6.1.2 (b[ii]) of the OCR A-level Biology A specification which states that students should be able to demonstrate and apply their knowledge and understanding of the use of phenotypic ratios to identify epistasis. This is a topic which students tend to find difficult, and therefore the lesson was written to split the topic into small chunks where examples of dominant, recessive and complimentary epistasis are considered, discussed at length and then explained. Understanding checks, in various forms, are included throughout the lesson so that students can assess their progress and any misconceptions are immediately addressed. There are regular links to related topics such as dihybrid inheritance so that students can meet the challenge of interpreting genotypes as well as recognising the different types of epistasis.

This lesson describes and explains how increasing the concentration of inhibitors affects the rate of an enzyme-controlled reaction. The PowerPoint and accompanying resource are the last in a series of 5 lessons which cover the content detailed in point 1.4.2 of the AQA A-level Biology specification and describes the effect of both competitive and non-competitive inhibitors. The lesson begins with a made up round of the quiz show POINTLESS called “Biology opposites” and this will get the students to recognise that inhibition is the opposite of stimulation. This introduces inhibitors as substances that reduce the rate of a reaction and students are challenged to use their general knowledge of enzymes to identify that inhibitors prevent the formation of the enzyme-substrate complex. Moving forwards, a quick quiz competition generates the abbreviation EIC (representing enzyme-inhibitor complex) and this introduces competitive inhibitors as substances that occupy the active site. The students are asked to apply their knowledge to a new situation to work out that these inhibitors have a similar shape to the enzyme’s substrate molecule. A series of exam-style questions are used throughout the lesson and at this point, the students are challenged to work out that an increase in the substrate concentration would reduce the effect of a fixed concentration of a reversible competitive inhibitor. The rest of the lesson focuses on non-competitive inhibitors and time is taken to ensure that key details such as the disruption of the tertiary structure is understood and biological examples are used to increase the relevance. Again, students will learn that increasing the concentration of the inhibitor results in a greater inhibition and a reduced rate of reaction but that increasing the substrate concentration cannot reduce the effect as was observed with competitive inhibitors.