This is an engaging and discussion filled lesson which looks at the menstrual cycle and specifically focuses on the interaction of the four hormones in the cycle. This lesson has been designed for GCSE students (ages 14 - 16 in the UK) but is suitable for older students who want a recap on this topic before going into more depth. In order to understand the cycle, it is critical that students know the roles that each of the hormones perform and also can describe how one hormone affects another. The main task of the lesson goes through the steps in the cycle, but challenges the students to use their prior knowledge of the endocrine system to add in the name of the correct hormone. At appropriate points of the lesson, time is taken to relate this topic to others in Biology, such as the use of oestrogen in the contraceptive pill and also hCG as the hormone which is detected by pregnancy tests. Students will know key landmarks in the 28 day cycle and be able to relate this back to the hormones. There are progress checks throughout the lesson but the final part of the lesson involves three understanding checks where students are challenged to apply their knowledge.

This extensive and fully-resourced lesson describes the principles and explains the techniques used in the production of recombinant DNA in genetic engineering. Both the engaging PowerPoint and accompanying resources have been written to cover points 6.1.3 (f) (i & ii) of the OCR A-level Biology A specification. The lesson begins with a definition of genetic engineering and recombinant DNA to allow students to begin to understand how this process involves the transfer of DNA fragments from one species to another. Links are made to the genetic code and transcription and translation mechanisms, which were met in module 2, in order to explain how the transferred gene can be translated in the transgenic organism. Moving forwards, the method involving reverse transcriptase and DNA polymerase is introduced and their knowledge of the structure of the polynucleotides and the roles of enzymes is challenged through questions and discussion points. Restriction enzymes are then introduced and time is taken to look at the structure of a restriction site as well as the production of sticky ends due to the staggered cut on the DNA. A series of exam-style questions with displayed mark schemes are used to allow the students to assess their current understanding. The second half of the lesson looks at the culture of transformed host cells as an in vivo method to amplify DNA fragments. Students will learn that bacterial cells are the most commonly transformed cells so the next task challenges their recall of the structures of these cells so that plasmid DNA can be examined from that point onwards. The following key steps are described and explained: • Remove and prepare the plasmid to act as a vector • Insert the DNA fragment into the vector • Transfer the recombinant plasmid into the host cell • Identify the cells which have taken up the recombinant plasmid • Allow the transformed host cells to replicate and express the novel gene Time is taken to explore the finer details of each step such as the addition of the promoter and terminator regions, use of the same restriction enzyme to cut the plasmid as was used to cut the gene and the different types of marker genes. As well as understanding and prior knowledge checks, quick quiz competitions are used throughout the lesson to introduce key terms such as cDNA and EcoR1 in a memorable way.

This is a fast-paced lesson which uses a range of tasks and quick competitions to compare the diagnosis, symptoms and treatment of Diabetes mellitus Type I and II. Students are continually challenged throughout the lesson to build and deepen their knowledge of these conditions and consider how they can be controlled through hormone injections or lifestyle changes. Clear links are made to related topics such as auto-immune diseases and the endocrine system and progress checks have been written into the lesson to allow students to assess their understanding of all of these topics. The final part of the lesson involves the students writing a letter to an individual who has type II, explaining how this diagnosis was done, giving details of the condition and recommending lifestyle changes. This task is differentiated so that students who are finding it difficult can still access the learning. This lesson has been written for A-level students. If you are looking for a lesson for younger students on this topic, then my other upload “Diabetes Type I and II” will be more suitable.

This lesson explains the principles of the polymerase chain reaction (PCR) and the PowerPoint has been designed to cover point 6.1.3 (d) of the OCR A-level Biology A specification A quick quiz competition is used to introduce the PCR abbreviation before students are encouraged to discuss the possible identity of the enzyme involved and to recall the action of this enzyme. Students will learn that this reaction involves cyclical heating and cooling to a range of temperatures so the next part of this lesson focuses on each temperature and specifically the reasons behind the choice. Time is taken to examine the key points in detail, such as why Taq polymerase has to be used as it is not denatured at the high temperature as well as the involvement of the primers. This process is closely linked to other techniques like electrophoresis which is covered in a later lesson and ties are continuously made throughout the lesson This process is mentioned in other uploaded lessons in this module such as electrophoresis and genetic engineering to allow students to understand how it is critical for DNA analysis

This fully-resourced lesson explains how gel electrophoresis is used to separate DNA fragments or proteins and explores its applications in genetic fingerprinting. The engaging and detailed PowerPoint and accompanying resources have been written to cover point 6.1.3 (e) of the OCR A-level Biology A specification The steps of the genetic fingerprinting process is covered the whole lesson but the main focus is the use of gel electrophoresis within this process. Students will be introduced to STRs and will come to recognise their usefulness in human identification as a result of the variability between individuals. Moving forwards, the involvement of the PCR is discussed and students are challenged on their knowledge of this process as it was encountered in a previous lesson. A brief outline of the role of restriction enzymes is provided to support students when these key gene technology enzymes are met in more detail later in the module. The main section of the lesson focuses on the use of gel electrophoresis to separate DNA fragments (as well as proteins) and the key ideas of separation due to differences in base pair length or molecular mass are discussed and explained. As well as current understanding checks, an application question involving Huntington’s disease is used to challenge their ability to apply their knowledge of the process to an unfamiliar situation. The remainder of the lesson describes how the DNA is transferred to a membrane and hybridisation probes are used to create a pattern on the X-ray film. Time has been taken to make continuous links to the previous lessons in module 6.1.3 as well as those from module 2.1.3 where DNA, RNA and protein synthesis were introduced.

This is an engaging revision lesson which uses a range of exam questions, understanding checks, quick differentiated tasks and quiz competitions to allow students to assess their knowledge of the topic of cells and related topics as covered in the GCSE Biology and GCSE Combined Science courses. As cells are the building blocks of living organisms, a strong understanding of this topic is critical for the success of a student on these two courses. The following topics are covered in this revision lesson: The key differences between eukaryotic and prokaryotic cells The structure of a bacterial cell Specialised cells The individual functions of the organelles Calculating size Students will be engaged through the range of activities which includes quiz competitions such as “CELL, CELL, CELL” where students have to compete to identify specialised cells from descriptions. This lesson can be used at any time during the year as a revision material, in the lead up to mocks or as a final revision lesson before the GCSE terminal exams.

This is a highly-detailed revision resource which has been designed to be used over a number of lessons and allows teachers to dip in and out of the material as fits to the requirements of their classes and students. The resource consists of an engaging and detailed powerpoint (148 slides) and worksheets which have been differentiated to allow students of differing abilities to be challenged whilst accessing the work. The lesson consists of a wide range of activities which will engage and motivate the students and includes exam questions, quiz competitions and quick tasks and mathematical skills are challenged throughout. The lesson has been designed to cover as many of the sub-topics within topics 1, 2 and 3 of the OCR Gateway GCSE Biology A specification but the following sub-topics have been given particular attention: Topic B1: Cell-level systems Eukaryotic and prokaryotic cells Respiration Functions of the organelles of animal and plant cells Microscopy and calculating size Topic B2: Scaling up The functions of the components of blood Specialised cells Osmosis Mitosis and the cell cycle The heart and blood vessels Topic B3: Organism-level systems The nervous system The structures and functions of the eye IVF This revision resource can be used in the lead up to mocks or the actual GCSE exams and due to its size, it could be repeatably used to ensure that students develop a deep understanding of these topics.

This is a highly-detailed revision resource which has been designed to be used over a number of lessons and allows teachers to dip in and out of the material as fits to the requirements of their classes and students. The resource consists of an engaging and detailed powerpoint (132 slides) and worksheets which have been differentiated to allow students of differing abilities to be challenged and access the work. The lesson consists of a wide range of activities which will engage and motivate the students and includes exam questions, quiz competitions and quick tasks. The mathematical element of the course is challenged throughout the lesson The lesson has been designed to cover as many of the sub-topics within topics 5, 6 and 7 of the AQA GCSE Biology specification, and will be covered in paper 2, but the following sub-topics have been given particular attention: Topic B5: Homeostasis and response IVF The central nervous system The structure and functions of the eye Diabetes Control of blood glucose concentration Topic B6: Inheritance, variation and evolution The structure and function of DNA Mutations and their effects on phenotypes Genetic terminology Inherited disorders Classification Topic B7: Ecology Ecological terms The Carbon cycle This revision resource can be used in the lead up to mocks or the actual GCSE exams and due to its size, it could be repeatably used to ensure that students develop a deep understanding of these topics.