A Science teacher by trade, I've also been known to be found teaching Maths and PE! However, strange as it may seem, my real love is designing resources that can be used by other teachers to maximise the experience of the students. I am constantly thinking of new ways to engage a student with a topic and try to implement that in the design of the lessons.
A Science teacher by trade, I've also been known to be found teaching Maths and PE! However, strange as it may seem, my real love is designing resources that can be used by other teachers to maximise the experience of the students. I am constantly thinking of new ways to engage a student with a topic and try to implement that in the design of the lessons.
This fully-resourced lesson explains how the transcription of target genes can be stimulated or inhibited by transcription factors. Both the PowerPoint and the accompanying resources have been designed to cover the first part of point 8.2.2 of the AQA A-level Biology specification and links are continuously made throughout the lesson to the topic of protein synthesis which was covered in topic 4.2.
The lesson begins with a recall of the meaning of the terms genome and proteome so that a discussion can begin on whether a cell wants to express every gene and produce all of the possible proteins all of the time. As the answer to this is no, the idea of transcription factors is introduced. In order to fully understand this topic, students need to recall that the role of the promoter region is to bind RNA polymerase to initiate transcription. Students will learn that the factors have a DNA-binding domain and that some also have ligand-binding domains which allow molecules like hormones to bind. Moving forwards, the students are introduced to a group of substances called DELLA proteins which inhibit plant development. The way that transcription begins once the inhibition by the proteins has been removed is similar to the action of oestrogen and students are able to use this information as a guide during the final task where they have to order the sequence of events that take place once this steroid hormone binds to its transcription factor.
This detailed and engaging lesson looks at the culture of transformed host cells as an in vivo method to amplify DNA fragments. Both the PowerPoint and accompanying resources have been designed to cover the third part of point 8.4.1 of the AQA A-level Biology specification and ties in with the previous two lessons in this sub-topic on producing DNA fragments and the polymerase chain reaction.
The lesson begins with the introduction of the terms transgenic and transformed. Students will learn that bacterial cells are the most commonly transformed cells so the next task challenges their recall of the structures of these cells so that plasmid DNA can be examined from that point onwards. A quick quiz competition is used to introduce the key term, vector, and then the rest of the lesson looks at the details of the five steps involved in the transformation of the host cell:
Remove and prepare the plasmid to act as a vector
Insert the DNA fragment into the vector
Transfer the recombinant plasmid into the host cell
Identify the cells which have taken up the recombinant plasmid
All the transformed host cells to replicate and express the novel gene
Time is taken to explore the finer details of each step such as the addition of the promoter and terminator regions, use of the same restriction enzyme to cut the plasmid as was used to cut the gene and the different types of marker genes. Links are continuously made to the previous lessons in this topic so that students feel confident to answer assessment questions which bring in knowledge from all of the sections.
Each of the 4 lessons in this bundle are fully-resourced and have been designed to cover the content as detailed in topic 6.2 (Protein synthesis) of the CIE International A-Level Biology specification. The specification points that are covered within these lessons include:
A polypeptide is coded for by a gene
A gene mutation is a change in the sequence of nucleotides
Sickle cell anaemia results from a change in the amino acid sequence
Transcription as the production of mRNA from DNA
Information on DNA is used during translation to construct polypeptides
The lessons have been written to include a wide range of activities and numerous understanding and prior knowledge checks so students can assess their progress against the current topic as well as be challenged to make links to other topics within this topic and earlier topics
If you would like to see the quality of the lessons, download the introduction to gene mutations lesson as this has been shared for free
This lesson looks at the use of the polymerase chain reaction (PCR) as an in vitro method to amplify DNA fragments as part of the recombinant DNA technology process. The clear PowerPoint has been designed to cover the second part of point 8.4.1 of the AQA A-level Biology specification.
A quick quiz competition is used to introduce the PCR abbreviation before students are encouraged to discuss the identity of the enzyme involved and to recall the action of this enzyme. Students will learn that this reaction involves cyclical heating and cooling to a range of temperatures so the next part of this lesson looks at these particular temperatures so the important parts of each of the steps can be understood. Time is taken to examine the key points in detail, such as the specific DNA polymerase that is used and how it is not denatured at the high temperature as well as the involvement of the primers.
Each of the 3 lessons in this bundle are fully-resourced and have been designed to cover the content as detailed in topic 4.2 (DNA and protein synthesis) of the AQA A-Level Biology specification. The specification points that are covered within these lessons include:
The concept of the genome and the proteome
The structure of mRNA
The structure of tRNA
Transcription as the production of mRNA from DNA
The differences between the outcome of transcription in porkaryotes and eukaryotes
Splicing
Translation as the production of polypeptides from the sequence of codons on mRNA
The lessons have been written to include a wide range of activities and numerous understanding and prior knowledge checks so students can assess their progress against the current topic as well as be challenged to make links to other topics within this topic and earlier topics
If you would like to see the quality of the lessons, download the structure of RNA lesson as this has been shared for free
This detailed lesson describes the role of the mRNA, tRNA, amino acids and the ribosome during the second stage of protein synthesis - translation. Both the PowerPoint and accompanying resources have been designed to cover the third part of point 4.2 of the AQA A-level Biology specification and ties in with the previous lessons in this topic on RNA and transcription.
Translation is a topic which is often poorly understood and so this lesson has been written to enable the students to understand how to answer the different types of questions by knowing and including the key details of the structures involved. The lesson begins by challenging the students to consider why it is so important that the amino acids are assembled in the correct order during the formation of the chain. Moving forwards, a quick quiz round called “LOST IN TRANSLATION” is used to check on their prior knowledge of the mRNA strand, the tRNA molecules, the genetic code and the ribosomes. The next task involves a very detailed description of translation that has been divided into 14 statements which the students have to put into the correct order. By giving them a passage that consists of this considerable detail, they can pick out the important parts to use in the next task where they have to answer shorter questions worth between 3 and 4 marks. These types of questions are common in the assessments and by building up through the lesson, their confidence to answer this type should increase. The final two tasks of the lesson involve another quiz, where the teams compete to transcribe and translate in the quickest time before using all that they have learnt to answer some questions which involve the genetic code and the mRNA codon table.
This bundle of 6 revision lessons challenges the students on their knowledge of the content of topics B1 - B7, C1 - C10 and P1 - P7 of the AQA GCSE Combined Science specification which will be assessed on the 6 terminal GCSE papers. Specifically, the range of tasks which include exam-style questions (with displayed answers), quiz competitions and discussion points, have been designed for students taking the FOUNDATION TIER papers but could also be used with students taking the higher tier who need to ensure that the key points are embedded on some topics.
The majority of the tasks are differentiated 2 or 3 ways so that a range of abilities can access the work whilst remaining challenged by the content.
If you would like to see the quality of these lessons, download the paper 2 and 5 revision lessons as these have been shared for free.
A fully-resourced lesson, which explores how changes to the sequence of bases on DNA may or may not alter protein structure. The engaging PowerPoint and accompanying resources have been designed to cover point 8.1 of the AQA A-level Biology specification and it builds on the knowledge gained during topic 4 when gene mutations were first introduced.
A quiz runs throughout the lesson where students compete to recognise key terms from their definitions and the lesson begins with an edition of this round as they are challenged to recognise the definition for primary structure. Other terms that arise during the lesson relate to the different gene mutations, the genetic code and mutagenic agents. The focus of the lesson is to support students in their explanations of how a particular mutation can result in a change in the primary structure as well as being able to explain why a substitution mutation may not. In this way, their understanding of the degenerate and non-overlapping nature of the genetic code will be tested and any misconceptions can be addressed. The main section of the lesson covers substitution, deletion and addition mutations before translocation, inversion and duplication mutations are introduced. Links are made to the latter parts of topic 8 so students can understand how the change in the sequence of bases may disrupt gene expression. The final part of the lesson looks at a range of mutagenic agents that can increase the rate of mutation.
All 6 lessons included in this bundle have been written to cover the detailed content of topics 8.3 and 8.4 of the AQA A-level Biology specification. These topics can provide a series of problems for students so clear explanations are used throughout the lesson as well as regular understanding checks so any misconceptions are immediately addressed. The variety of tasks will maintain engagement whilst displayed mark schemes allow students to assess their answers and add detail where it is missing.
The following specification points are covered:
8.3: Using genome projects
8.4.1: Recombinant DNA technology
8.4.2: Differences in DNA between individuals of the same species can be exploited
8.4.3: Genetic fingerprinting
If you would like to sample the quality of the lessons first, why not download the lesson on producing DNA fragments which has been uploaded for free
This fully-resourced lesson explores how projects to sequence the genomes of both simple and complex organisms can be used. Both the detailed PowerPoint and accompanying resources have been designed to cover the content of point 8.3 of the AQA A-level Biology specification.
The start of the lesson describes each step of Sanger’s chain termination method and demonstrates how this method has paved the way for other projects. The use of the modified nucleotides are explained and links are made to the topic 4 and 2 where protein synthesis and DNA replication were first introduced. Students will learn how the radioactively-labelled nucleotide at the end of each fragment allows the next base to be determined. Key processes like gel electrophoresis are introduced and details provided to support the students when this is encountered in greater detail in 8.4.3. Moving forwards, the applications of sequencing in simple organisms like viruses and bacteria are explored and the students are challenged on their prior knowledge of bacterial pathogenesis and current understanding of sequencing through a series of exam-style questions. The final part of the lesson looks at the difficulties of translating genome knowledge into proteome knowledge and considers the development of automated methods.
Due to the detail and extensiveness of this lesson, it is estimated that it will take in excess of 2 hours of allocated A-level teaching time to cover all of the points which have been written into the various tasks
This is a fully-resourced lesson which uses exam-style questions, quiz competitions, quick tasks and discussion points to challenge students on their understanding of topics B1 - B5, that will assessed on PAPER 1. It has been specifically designed for students on the Pearson Edexcel GCSE Combined Science course who will be taking the FOUNDATION TIER examinations but is also suitable for students taking the higher tier who need to ensure that the fundamentals are known and understood.
The lesson has been written to take place at the local hospital where the students have to visit numerous wards and clinics and the on-site pharmacy so that the following sub-topics can be covered:
Cancer as the result of uncontrolled cell division
The production of gametes by meiosis
Mitosis and the cell cycle
Sex determination
The difference between communicable and non-communicable diseases
The pathogens that spread communicable diseases
Identification of communicable diseases
Treating bacterial infections with antibiotics
Evolution of antibiotic resistance in bacteria
Vaccinations
Genetic terminology
Genetic diagrams
Structures involved in a nervous reaction
A Reflex arc
Risk factors
Chemical and physical defences
Osmosis and percentage gain and loss
Fossils as evidence for human evolution
In order to maintain challenge whilst ensuring that all abilities can access the questions, the majority of the tasks have been differentiated and students can ask for assistance sheets when they are unable to begin a question. Step-by-step guides have also been written into the lesson to walk students through some of the more difficult concepts such as genetic diagrams and evolution by natural selection.
Due to the extensiveness of this revision lesson, it is estimated that it will take in excess of 3 teaching hours to complete the tasks and therefore this can be used at different points throughout the duration of the course as well as acting as a final revision before the PAPER 1 exam.
This is a fully-resourced lesson which uses exam-style questions, quiz rounds, quick tasks and discussion points to challenge students on their understanding of the content of topics B4 - B6, that will assessed on PAPER 2. It has been specifically designed for students on the OCR Gateway A GCSE Combined Science course who will be taking the FOUNDATION TIER examinations but is also suitable for students taking the higher tier who need to ensure that the fundamentals are known and understood.
The lesson has been written to take place at the hospital and the students will visit the various wards and health clinics day to check on their knowledge of the following sub-topics :
Cancer
The production of gametes by meiosis
The meaning of diploid and haploid
Sex determination
The difference between communicable and non-communicable diseases
Diseases caused by bacteria, viruses, fungi and protists
Treatment of bacterial infections using antibiotics
Evolution by natural selection in bacteria
Vaccinations
Genetic terminology
Inheritance of disorders caused by dominant and recessive alleles
Risk factors of non-communicable diseases
Ecosystems
The carbon cycle and the increase in carbon dioxide levels
In order to maintain challenge whilst ensuring that all abilities can access the questions, the majority of the tasks have been differentiated and students can ask for extra support when they are unable to begin a question. Step-by-step guides have also been written into the lesson to walk students through some of the more difficult concepts such as genetic diagrams and interpreting the results and evolution by natural selection.
Due to the extensiveness of this revision lesson, it is estimated that it will take in excess of 3 teaching hours to complete the tasks and therefore this can be used at different points throughout the duration of the course as well as acting as a final revision before the PAPER 2 exam.
This is a fully-resourced revision lesson that has been written to challenge students on their knowledge and understanding of the PAPER 2 topics. The range of tasks will prepare the students to answer the range of questions that they may encounter on topics B1 and B6 - B9 as detailed in the Pearson Edexcel GCSE Combined Science specification.
The lesson has been designed to take place on the PAPER 2 HIGH STREET and the tasks include exam-style questions with displayed mark schemes, engaging quiz competitions and discussion points to allow the following points to be covered:
Eukaryotic vs Prokaryotic cells
Converting between units of size
The structures of the animal and plant cells
The structure of the human heart
Calculating the surface area to volume ratio
Adaptations of the gas exchange system
The blood vessels associated with the human heart
Calculating the cardiac output
The features of the root hair cell to allow for absorption
The nitrogen cycle
The relationship between the rate of photosynthesis and light intensity and distance
Using the inverse square law calculation
Temperature and photosynthesis
The regulation of blood glucose by the release of insulin and glucagon
Diabetes type I and II
Calculating the BMI
The interaction of the reproductive hormones in the menstrual cycle
IVF as assisted reproductive technology
The hormonal and barrier methods of contraception
Eutrophication as a negative human interaction in an ecosystem
The carbon cycle
In order to cater for the range of abilities that can be found in Combined Science classes, most of the tasks have been differentiated. There are also a number of step by step guides to demonstrate how to tackle some of the more difficult concepts including the mathemetical elements
If you would like to see the quality of these revision lessons, download the PAPER 1 REVISION LESSON which has been shared for free
This fully-resourced bundle includes 10 detailed PowerPoint lessons and their accompanying worksheets which cover the content as set out in topic 3.4 (Mass transport) of the AQA A-level Biology specification. This topic includes sections on mass transport in animals (3.4.1) and mass transport in plants (3.4.2).
The lessons have been designed to include a wide range of tasks to maintain motivation whilst ensuring that the understanding of the content is constantly checked and links are made to other topics.
The specification points in topic 3.4 which are covered in these lessons are:
The haemoglobins
The role of haemoglobin in the transport of oxygen
The oxyhaemoglobin dissociation curve
The Bohr effect
The general pattern of blood circulation in a mammal
The gross structure of the human heart
The valve movements in the cardiac cycle
The structure of the blood vessels
The formation of tissue fluid
The transport of water in the xylem
The structure of the phloem tissue
Translocation by mass flow
If you would like to see the quality of these lessons, download the arteries, tissue fluid and translocation lessons as these have been uploaded for free
All 4 of the lessons included in this bundle are fully-resourced with differentiated tasks to cater for all abilities of students whilst containing the detail to push them to the next level. These lessons have been designed to cover the details of topic 6.1 of the CIE International A-level Biology specification which concerns the structure and replication of DNA
The following specification points are covered within these lessons:
The structure of nucleotides
ATP as a phosphorylated nucleotide
The structure of DNA
The structure of mRNA, tRNA and rRNA
DNA replication
Links are continually made throughout the lessons to previously-covered topics as well as to those which will be covered later in the AS course or during the second year
If you would like to sample the quality of the lessons, download the semi-conservative replication lesson as this has been shared for free
This is a fully-resourced lesson bundle, where the detailed and engaging PowerPoints and accompanying worksheets have been designed to cover the details of topic 6 of the CIE International A-level Biology specification which concerns the nucleic acids and protein synthesis. All 7 of the lessons include differentiated tasks to cater for all abilities of students whilst containing the detail to push them to the next level.
The following specification points are covered within these lessons:
The structure of nucleotides
ATP as a phosphorylated nucleotide
The structure of DNA
The structure of mRNA, tRNA and rRNA
DNA replication
Genes and polypeptides
Gene mutations
Sickle cell anaemia
Transcription and translation
Links are continually made throughout the lessons to previously-covered topics as well as to those which will be covered later in the AS course or during the second year
If you would like to sample the quality of the lessons, download the semi-conservative replication and gene mutation lessons as these have been shared for free
This engaging lesson describes the relationship between the structure and properties of a phopholipid and explains the link to its role in membranes. The PowerPoint has been designed to cover the second part of point 1.3 of the AQA A-level Biology specification and includes constant references to the previous lesson on triglycerides.
The role of a phospholipid in a cell membrane provides the backbone to the whole lesson. A quick quiz round called FAMILY AFFAIR, challenges the students to use their knowledge of the structure of a triglyceride to identify the shared features in a phospholipid. This then allows the differences to be introduced, such as the presence of a phosphate group in place of the third fatty acid. Moving forwards, the students will learn that the two fatty acid tails are hydrophobic whilst the phosphate head is hydrophilic which leads into a key discussion point where the class has to consider how it is possible for the phospholipids to be arranged when both the inside and outside of a cell is an aqueous solution. The outcome of the discussion is the introduction of the bilayer which is critical for the lesson in topic 2 on the fluid mosaic model. The final part of the lesson explains how both facilitated diffusion and active transport mean that proteins are found floating in the cell membrane and this also helps to briefly prepare the students for upcoming topic 2 lessons.
Disaccharides are formed from the condensation of two monosaccharides and this lesson describes the formation of maltose, sucrose and lactose. The PowerPoint and accompanying question sheet have been designed to cover the second part of point 1.2 of the AQA A-level Biology specification but also make links to the previous lesson on monosaccharides when considering the different components of these three disaccharides.
The first section of the lesson focuses on a prefix and a suffix so that the students can recognise that the names of the common disaccharides end in -ose. In line with this, a quick quiz round is used to introduce maltose, sucrose and lactose before students are challenged on their prior knowledge as they have to describe how condensation reactions and the formation of glycosidic bonds were involved in the synthesis of each one. The main task of the lesson again challenges the students to recall details of a previous lesson as they have to identify the monomers of each disaccharide when presented with the displayed formula. Time is taken to show how their knowledge of these simple sugars will be important in later topics such as digestion, translocation in the phloem and the Lac Operon in the control of gene expression. The lesson finishes with two exam-style questions where students have to demonstrate and apply their newly acquired knowledge
This bundle of 6 revision lessons challenges the students on their knowledge of the content of all of the topics that are detailed in the Edexcel GCSE Combined Science specification and can be assessed on the 6 terminal GCSE papers. Specifically, the range of tasks which include exam-style questions (with displayed answers), quiz competitions and discussion points, have been designed for students taking the FOUNDATION TIER papers but could also be used with students taking the higher tier who need to ensure that the key points are embedded on some topics.
The majority of the tasks are differentiated 2 or 3 ways so that a range of abilities can access the work whilst remaining challenged by the content.
If you would like to see the quality of these lessons, download the paper 2, 4 and 6 revision lessons as these have been shared for free
This detailed and engaging lesson describes the structural similarities and differences between DNA and RNA. The PowerPoint and accompanying worksheet containing exam-style questions have been designed to cover point 1.5.1 of the AQA A-level Biology specification.
In the first lesson of topic 1, the students were introduced to a number of monomers which included a nucleotide. In line with this, the start of the lesson challenges them to recognise the key term nucleotide when only the letters U, C and T are shown. The next part of the lesson describes the structure of a DNA nucleotide and an RNA nucleotide so that the pentose sugar and the bases adenine, cytosine and guanine can be recognised as similarities whilst deoxyribose and ribose and thymine and uracil are seen as the differences. Time is taken to discuss how a phosphodiester bond is formed between adjacent nucleotides and their prior knowledge and understanding of condensation reactions is tested through a series of questions. Students are then introduced to the purine and pyrimidine bases and this leads into the description of the double-helical structure of DNA and the hydrogen bonds between complementary bases. The final section of the lesson describes the structure of mRNA, tRNA and rRNA and students are challenged to explain why this single stranded polynucleotide is shorter than DNA
In addition to the current understanding and prior knowledge checks, a number of quiz rounds have been written into the lesson to introduce key terms in a fun and memorable way and the final round acts as a final check on the structures of DNA and RNA.