This is a fully-resourced lesson that covers the details of specification point 5.1.2 (e) of the OCR A-level Biology A specification which states that students should be able to demonstrate and apply an understanding of the effects of kidney failure and its potential treatments. This lesson consists of an engaging PowerPoint (55 slides) and associated differentiated worksheets that look at the diagnosis of a number of different kidney-related conditions and the potential treatments for kidney failure. This lesson is designed to get the students to take on the numerous roles of a doctor who works in the renal ward which include testing, diagnosis and treatment. Having obtained measurements by GFR and results by taking urine samples, hey are challenged to use their knowledge of the function of the kidney to study urine samples (and the accompanying GP’s notes) to diagnose one of four conditions. They then have to write a letter to the patient to explain how they made this diagnosis, again focusing on their knowledge of the structure and functions of the Bowman’s capsule and PCT. The rest of the lesson focuses on haemodialysis, peritoneal dialysis and kidney transplant. There are regular progress checks throughout the lesson so that students can assess their understanding and there are a number of homework activities included in the lesson. This lesson is designed for A-level students who are studying the OCR A-level Biology specification and ties in nicely with the other uploaded lessons on this organ which include the structure and function of the nephron, ultrafiltration, selective reabsorption and osmoregulation.

A fully resourced revision lesson that uses a combination of exam questions, understanding checks, quick tasks and quiz competitions to help the students to assess their understanding of the topics found within modules B1, B2 and B3 of the OCR Gateway A GCSE Biology specification as will be covered in Biology paper 1 The topics that are tested within the lesson include: Cell structures What happens in cells Respiration Photosynthesis Supplying the cell The challenge of size The nervous system The endocrine system Maintaining internal environments Students will be engaged through the numerous quiz rounds whilst crucially being able to recognise those areas which require further attention

A fully- resourced lesson which looks at the chemical reaction that is anaerobic respiration and ensures that students can understand why this form of respiration can only be used for short periods of time. The lesson includes an engaging lesson presentation (39 slides), a newspaper article and application questions. The lesson begins by challenging the students to recall information about aerobic respiration to recognise that the sole reactant of anaerobic respiration is glucose. A newspaper article about two atheletes from the 10000m race has been written to challenge the students to recognise why one of the athletes wouldnt be able to compete again in the near future whilst the other could. As a result, students will be introduced to lactic acid and will learn how this poisonous substance prevents muscle contraction and causes cramps. Time is taken to ensure that students are familiar with ATP and specifically that they recognise that a much lower yield is produced in this type of respiration. A perfect opportunity is taken to get the students to carry out a mathematical calculation to compare the yields. Oxygen debt is discussed and related back to the original newspaper article. Finally, anaerobic respiration in plants and yeast is considered in terms of fermentation and the word and symbol equation is written so that it can be compared to those from animals. There are regular progress checks throughout the lesson to allow the students to check on their understanding. The lesson has been written for GCSE students but could be used with higher ability KS3 students or A-level students who want a recap before covering the topic in greater detail on their course.

This REVISION resource has been written with the aim of motivating the students whilst they are challenged on their knowledge of the content in Biology TOPIC 8 (Exchange and transport in animals) of the Edexcel GCSE Combined Science specification. The resource contains an engaging and detailed PowerPoint (90 slides) and accompanying worksheets, most of which are differentiated to allow all abilities to access the work. The wide range of activities, which include exam questions and quiz competitions, have been designed to cover as much of topic 8 as possible but the following sub-topics have been given a particular focus: Surface area to volume ratio Gas exchange at the alveoli The structure of the blood vessels The gross structure of the heart and the major blood vessels Calculating the cardiac output The functions of the components of the blood Aerobic vs anaerobic respiration There is a large emphasis on mathematical skills in the new specification and these are tested throughout the lesson. This resource is suitable for use at the end of topic 8, in the lead up to mocks or in the preparation for the final GCSE exams.

This fully-resourced lesson looks at the type of circulatory system found in a mammal (double, closed) and considers how the pulmonary circulation differs from the systemic circulation. The engaging PowerPoint and accompanying resources have been designed to cover point 3.1.2 (b) of the OCR A-level Biology A specification The lesson begins with a focus on the meaning of a double circulatory system and checks that students are clear in the understanding that the blood passes through the heart twice per cycle of the body. Beginning with the pulmonary circulation, students will recall that the pulmonary artery carries the blood from the right ventricle to the lungs. An opportunity is taken at this point to check on their knowledge of inhalation and the respiratory system as well as the gas exchange between the alveoli and the capillary bed. A quick quiz is used to introduce arterioles and students will learn that these blood vessels play a crucial role in the changes in blood pressure that prevent the capillaries from damage. When looking at the systemic circulation, time is taken to look at the coronary arteries and renal artery as students have to be aware of these vessels in addition to the ones associated with the heart. In the final part of the lesson, students are challenged to explain how the structure of the heart generates a higher pressure in the systemic circulation and then to explain why the differing pressures are necessary. This lesson has been written to tie in with the other uploaded lessons from topic 3.1.2 (transport in animals)

A concise lesson presentation (20 slides) and associated worksheet that guides students through phylogenetic trees and helps them to be able to interpret these diagrams. The lesson begins by stating three key points about the trees which will form the basis of their understanding. Moving forwards, a series of questions with explained answers are used to show how common ancestors in the past can be used to work out which present day organisms are the most closely related. Students are given lots of opportunities to assess their understanding and check that they can explain. This lesson has been written for GCSE but could be used as a recap for those students studying at A-level

A fully-resourced lesson which looks at the structure of DNA in the detail which is required at GCSE level (14 - 16 year olds in the UK). The lesson includes an engaging lesson presentation (35 slides) and associated worksheets. The main aim of the lesson is to ensure that students recognise key terminology that comes with this topic such as nucleotide and (nitrogenous) bases. Engaging tasks have been written into the lesson, in order to maintain the motivation, such as when students are introduced to complimentary base pairing through a version of the gameshow “Take me Out”. Additional knowledge is provided at appropriate times in the lesson to stretch and challenge the more able. There are regular progress checks throughout the lesson so that students can assess their understanding of the structure. As stated above, this lesson has been written for GCSE students but could be used with younger students and also with A-level students as a means of a recap before they learn about this in greater detail.

This engaging lesson explores the roles of the SAN, AVN, Bundle of His and Purkyne fibres in the transmission of the wave of excitation through the heart. The PowerPoint and accompanying resources have been designed to cover the first part of point 6.1.3 of the AQA A-level Biology specification which states that students should be able to describe the myogenic stimulation of the heart and the subsequent wave of electrical activity. The lesson begins with the introduction of the SAN as the natural pacemaker and then time is given to study each step of the conduction of the impulse as it spreads away from the myogenic tissue in a wave of excitation. The lesson has been written to make clear links to the cardiac cycle and the structure of the heart and students are challenged on their knowledge of this system from topic 3. Moving forwards, students are encouraged to consider why a delay would occur at the AVN and then they will learn that the impulse is conducted along the Bundle of His to the apex so that the contraction of the ventricles can happen from the bottom upwards. The structure of the cardiac muscle cells is discussed and the final task of the lesson challenges the students to describe the conducting tissue, with an emphasis on the use of key terminology

This fully-resourced lesson explores the inheritance of genetic characteristics that involve multiple alleles and codominant alleles. The engaging and detailed PowerPoint and differentiated worksheets have been designed to cover the part of point 6.1.2 (b[i]) which states that students should be able to demonstrate and apply their knowledge and understanding of genetic diagrams to show patterns of inheritance including multiple and codominant alleles. The main part of the lesson uses the inheritance of the ABO blood groups to demonstrate how the three alleles that are found at the locus on chromosome 9 and the codominance of the A and B alleles affects the phenotypes. Students are guided through the construction of the different genotypes and how to interpret the resulting phenotype. They are challenged to use a partially completed pedigree tree to determine the blood group for some of the family members and to explain how they came to their answer. To further challenge their ability to apply their knowledge, a series of questions about multiple alleles and codominance in animals that are not humans are used. The final part of the lesson makes a link back to module 4 and the correlation between a high proportion of polymorphic gene loci and an increase in genetic diversity. Students will be expected to make links between module 4 and 6 as part of papers 2 and 3, so this demonstrates how exam questions can do just that

This is a detailed and engaging lesson that looks at how molecules move between areas of differing concentrations by diffusion and then explores how this occurs across cell membranes and focuses on the alveoli. The lesson begins by using a step by step format to write the definition for diffusion so that key terms such as concentration gradient are understood. Students will be introduced to this as a passive process so that they can understand how active transport differs when this is met in another lesson. Progress checks are written into the lesson at regular intervals so that students can assess their understanding against a displayed answer. Moving forwards, the lesson focuses on diffusion across cell membranes and uses the example of the exchange surface of the alveoli and blood capillaries to explore the different features which act to increase the rate of diffusion. The final part of the lesson briefly looks at how the villi in the small intestine increase the rate of diffusion. This lesson has been written for GCSE aged students. If you’re looking for a lesson on this topic but for older students, then my alternative upload “Simple diffusion” will be more suitable

This is a fully-resourced lesson which has been designed to cover specification point 6.4.1 of the AQA A-level Biology specification. The resource contains a detailed and engaging PowerPoint and accompanying worksheets which ensure that students can apply their understanding of the principles of homeostasis to include the regulation by negative feedback. As homeostasis is a topic met at GCSE, this lesson has been written to build on this knowledge as well as to check on their prior knowledge of earlier A-level topics such as osmosis when considering blood water potential and the use of glucose as a respiratory substrate. Discussion points are written into the lesson at regular intervals to encourage the students to consider why a particular process or method takes place and understanding checks allow them to assess their progress. Students will recall how body temperature, blood water potential and blood glucose concentration are maintained within restricted limits and the importance of these systems are looked into in detail. Time is taken to consider the importance of maintaining these aspects, specifically with relation to the activity of enzymes. As such, students will also discuss how the pH of the blood is maintained. The key components of the control system are recalled and then time is taken to focus on the cell signalling that occurs between the coordination centre and the effectors. Students will learn to associate the response with either the use of the neuronal or hormonal system. The final part of the lesson looks at the importance of negative feedback in reversing the change in order to bring the aspect back to the optimum and the added degree of control which this provides. Positive feedback is also briefly mentioned at the end. This lesson has been written for A-level students who are studying the AQA A-level Biology course and because of the detail of this specification point, it is likely that this resource will cover 2 or more lessons in order for deep understanding to be developed.

This detailed lesson looks at the structure and function of the motor neurones that form the autonomic nervous system and is responsible for automatic responses. The engaging PowerPoint and accompanying resource have both been designed to cover the second part of point 5.1.5 (g) of the OCR A-level Biology A specification which states that students should be able to demonstrate and apply their knowledge and understanding of the functional organisation of the motor system into somatic and autonomic systems. Students will discover that this system is further divided into sympathetic and parasympathetic systems to control different aspects of a particular involuntary response. The lesson begins with a focus on the types of effectors that will be connected to the CNS by autonomic motor neurones. Students will learn that effectors which are not under voluntary control such as cardiac muscle, smooth muscle and glands will be innervated by these neurones. Moving forwards, a quick quiz competition is used to introduced ganglia as a structure which connects the two or more neurones involved in the cell signalling between the CNS and the effector. This leads into the discovery of the two divisions and students will begin to recognise the differences between the sympathetic and parasympathetic systems based on function but also structure. The remainder of the lesson looks at the differing effects of these two systems. This lesson has been written to tie in with the lesson on the organisation of the mammalian nervous system which covers the first part of specification point 5.1.5 (g)

This fully-resourced lesson explains how the transcription of target genes can be stimulated or inhibited by transcription factors. Both the PowerPoint and the accompanying resources have been designed to cover the first part of point 8.2.2 of the AQA A-level Biology specification and links are continuously made throughout the lesson to the topic of protein synthesis which was covered in topic 4.2. The lesson begins with a recall of the meaning of the terms genome and proteome so that a discussion can begin on whether a cell wants to express every gene and produce all of the possible proteins all of the time. As the answer to this is no, the idea of transcription factors is introduced. In order to fully understand this topic, students need to recall that the role of the promoter region is to bind RNA polymerase to initiate transcription. Students will learn that the factors have a DNA-binding domain and that some also have ligand-binding domains which allow molecules like hormones to bind. Moving forwards, the students are introduced to a group of substances called DELLA proteins which inhibit plant development. The way that transcription begins once the inhibition by the proteins has been removed is similar to the action of oestrogen and students are able to use this information as a guide during the final task where they have to order the sequence of events that take place once this steroid hormone binds to its transcription factor.

This fully-resourced lesson explores how projects to sequence the genomes of both simple and complex organisms can be used. Both the detailed PowerPoint and accompanying resources have been designed to cover the content of point 8.3 of the AQA A-level Biology specification. The start of the lesson describes each step of Sanger’s chain termination method and demonstrates how this method has paved the way for other projects. The use of the modified nucleotides are explained and links are made to the topic 4 and 2 where protein synthesis and DNA replication were first introduced. Students will learn how the radioactively-labelled nucleotide at the end of each fragment allows the next base to be determined. Key processes like gel electrophoresis are introduced and details provided to support the students when this is encountered in greater detail in 8.4.3. Moving forwards, the applications of sequencing in simple organisms like viruses and bacteria are explored and the students are challenged on their prior knowledge of bacterial pathogenesis and current understanding of sequencing through a series of exam-style questions. The final part of the lesson looks at the difficulties of translating genome knowledge into proteome knowledge and considers the development of automated methods. Due to the detail and extensiveness of this lesson, it is estimated that it will take in excess of 2 hours of allocated A-level teaching time to cover all of the points which have been written into the various tasks

This engaging lesson describes how the structure of the phloem enables this vascular tissue to transport organic substances in plants. Both the detailed PowerPoint and accompanying resource have been designed to cover the 3rd part of point 3.4.2 (Mass transport in plants) of the AQA A-level Biology specification. Comparative questions between the xylem and phloem are very common so the lesson begins by challenging the students to use their prior knowledge to complete the xylem column of a table with details including the presence of lignin and bordered pits and specific substances which are transported in this tissue. This has been written into the lesson to encourage the students to start to think about how the structure and function of the phloem may compare. 3 quiz rounds have been included in the lesson to maintain motivation and to introduce key terms. The first of these rounds will challenge the students to be the first to recognise descriptions of sucrose and amino acids as they learn that these are the two most common assimilate, which are the substances transported by the phloem. The focus of this lesson is the relationship between structure and function and all descriptions have these two parts highlighted to support the students to recognise the link. Moving forwards, students will be introduced to the sieve tube elements and the companion cells and time is taken to consider why the structure of these cells are so different. Current understanding checks are interspersed throughout the lesson to ensure that any misconceptions can be quickly addressed. The plasmodesmata is described to allow students to understand how assimilates move from the companion cells to the sieve tube elements as this will be particularly important for the next lesson on translocation. The final task of the lesson challenges the students to write a detailed passage about the structure and function of the phloem, incorporating all of the information that they have absorbed throughout the course of the lesson.