This engaging lesson describes the key features of viruses and therefore explains why these microorganisms are non-cellular. The PowerPoint and accompanying resource have been designed to cover specification point 1.2 (f) of the CIE International A-level Biology specification and also includes details of HIV so that students are prepared for this lesson later in topic 10. Details of the COVID-19 epidemic are included in the lesson to increase relevance and to help students to understand this biological topic in greater depth. They will understand that the lack of cell structures results in an non-cellular classification and the fact that it is unable to reproduce without a host is one of the additional reasons that renders it as non-living. The main focus of the lesson is the nucleic acid, the capsid and the attachment proteins that are present in these microorganisms and time is taken to explain how these structures are involved in the infection of a host cell. The lipid membrane is also introduced and links are made to the previous lessons on eukaryotic cells. The final section uses a version of BBC 1’s POINTLESS to introduce a number of viral diseases in animals and the use of a glycoprotein by HIV to attach to helper T cells is briefly introduced.

This fully-resourced lesson describes the relationship between the structure and function of the structures that are found in eukaryotic cells. The engaging and detailed PowerPoint and accompanying exam-question worksheets (which are all differentiated) have been designed to cover the first part of specification point 2.1.1 of the AQA A-level Biology specification and focuses on those structures found in animal cells. The additional structures, which are found in plant cells, are described in the next lesson uploaded under the title “Structure of eukaryotic (plant) cells”. As cells are the building blocks of living organisms, it makes sense that they would be heavily involved in all of the 8 topics in the AQA course and intricate planning has ensured that these links to previously covered topics as well as upcoming ones are made throughout the lesson. A wide range of activities, that include exam-style questions, class discussion points and quick quiz competitions, will maintain motivation and engagement whilst covering the finer details of the following structures: nucleus nucleolus ribosomes rough endoplasmic reticulum Golgi apparatus lysosomes smooth endoplasmic reticulum mitochondria cell surface membrane As mentioned above, all of the worksheets have been differentiated to support students of differing abilities whilst maintaining challenge Due to the detail that is included in this lesson, it is estimated that it will take in excess of 3 hours of allocated A-level teaching time to cover the work

This resource contains a detailed and engaging PowerPoint and accompanying worksheets, all of which have been designed to cover points 2.5 (a & b) of the WJEC GCSE Biology specification. This specification point states that students should be able to apply their knowledge and understanding of sense organs responding to specific stimuli and the CNS and nerves forming the nervous system. The lesson begins by introducing the term stimuli and then a quick quiz is used to get their competitive juices flowing as they have to react 1st to recognise the 5 different stimuli. Students will learn that sense organs are groups of receptor cells that respond to one or a few of these stimuli and they will form sentences to describe this role. Moving forwards, the link is made to the nervous system and how electrical impulses conducted on neurones allows communication between these receptors and the CNS and between the CNS and the effectors. At this point, students are challenged on their understanding of the functions of the structures in a nervous reaction as they have to put them into the correct order. They are given a quick and easy way to recognise the difference between a sensory and motor neurone on a diagram and how to use the function to show the direction of conduction. Time is taken to look at the role of a synapse in a reaction. The main task challenges the students to apply their knowledge to the example of a fly being flicked off the arm by forming a full description. This lesson contains a wide range of activities which include quiz competitions to introduce key terms in a fun and memorable way as well as understanding and prior knowledge checks so that students can assess their grasp of the critical content. It has been written for students studying the WJEC GCSE Biology course but is also suitable for younger students looking at the nervous system or A-level students who need to recall the key details and structures

This detailed and engaging lesson focuses on the importance of the excretion of carbon dioxide and urea in humans. It also looks at how the urea is formed as a result of deamination in the liver and as such covers the Core and Supplement content of the early section of topic 13 of the CIE IGCSE Biology specification. The lesson begins with a “Crack the code” type task which will enable the students to learn the meaning of excretion and specifically how it relates to the products of metabolism. Excretion is often confused with egestion by students so this misconception is addressed immediately and as a result they will understand that carbon dioxide and urea have to be excreted whereas faeces is egested. Moving forwards, time is taken to explain why carbon dioxide needs to be excreted and links are made to the earlier topic of enzymes and how a fall in pH could affect their activity. The rest of the lesson focuses on the formation of urea in the liver. Whilst learning about deamination, students will also be introduced to the process of assimilation and the production of rge plasma protein fibrinogen is used to explain the importance of this function of the liver. In addition to understanding checks and prior knowledge checks, quiz competitions are included in the lesson to introduce key terms in a fun and memorable way. This lesson has been designed for students studying the CIE IGCSE Biology course but is also suitable for older students who are starting the topic of excretion or the functions of the liver and want to recall the key facts.

This fully-resourced lesson describes the key steps in the blood clotting process, including the roles of thromboplastin, thrombin and fibrin. The engaging PowerPoint and accompanying worksheets have been primarily designed to cover the content detailed in point 1.11 of the Edexcel A-level International specification but time has been taken to look at haemophilia as a sex-linked disease so that students are prepared for when this is covered in greater detail in topic 3. The lesson begins with the introduction of clotting factors as integral parts of the blood clotting process and explains that factor III, thromboplastin, needs to recalled as well as the events that immediately precede and follows its release. Students will learn how damage to the lining and the exposure of collagen triggers the release of this factor and how a cascade of events then results. Quick quiz rounds and tasks are used to introduce the names of the other substances involved which are prothrombin, thrombin, fibrinogen and fibrin. In a link to the upcoming topic of proteins, students will understand how the insolubility of fibrin enables this mesh of fibres to trap platelets and red blood cells and to form the permanent clot. In the previous lessons, students described the events in atherosclerosis and a link is made to the role of blood clotting in CVD. The final part of the lesson introduces haemophilia as a sex-linked disease and students are challenged to apply their knowledge to an unfamiliar situation as they have to write genotypes and determine phenotypes before explaining why men are more likely to suffer from this disease than women.

This detailed lesson looks at the structural organisation of the mammalian nervous system into the CNS and the PNS as detailed in point 5.1.5 (g) of the OCR A-level Biology A specification. Students will see how the PNS is divided into the sensory and motor systems and then further divided into the somatic and autonomic nervous systems. Prior knowledge checks are included throughout the lesson to make links to earlier topics such as the structure of neurones and the function of the hypothalamus in thermoregulation and osmoregulation. This lesson has been designed to tie in with the uploaded lesson on the autonomic nervous system which is also covered in specification point 5.1.5 (g)

A fully-resourced lesson which explores how the release of thyroxine from the thyroid gland regulates the metabolic rate and how a negative feedback loop is used as the final control. This lesson includes an engaging and detailed presentation (19 slides), a crossword and an understanding check task. The lesson begins by challenging the students knowledge of the endocrine system to get them to come up with the letters that form the name, “thyroid gland”. Students will be reminded that this gland releases thyroxine which is involved with the regulation of the metabolic rate. Students will learn that in order for the thyroid gland to release this hormone, it has to be stimulated by TSH from the pituitary gland which in turn was controlled by the hypothalamus. At this point, the students are challenged to put the order of the control mechanism in the right order on their worksheet. This leads them to the word negative which links to how a negative feedback loop is used as the final act in the mechanism. This lesson is designed for GCSE students but is suitable for A-level students too who need to know about this endocrine gland and also negative feedback

This is a fully-resourced revision lesson that uses a combination of exam questions, understanding checks, quick differentiated tasks and quiz competitions to enable students to assess their understanding of the content found within Topic 3 (Voice of the Genome) of the Pearson Edexcel A-level Biology A specification. The sub-topics and specification points that are tested within the lesson include: Know the ultrastructure of eukaryotic cells Understand the role of the rER and the Golgi apparatus in protein transport within cells Know the ultrastructure of prokaryotic cells Be able to recognise the organelles of eukaryotic cells from EM images Know that a locus is the location of a gene on a chromosome Understand the linkage of genes on a chromosome and sex linkage Understand the role of meiosis in ensuring genetic variation Understand the role of mitosis and the cell cycle in producing identical daughter cells Understand how gene expression is controlled Understand how phenotype is the result of an interaction between genotype and the environment Know how some phenotypes are affected by multiple alleles as well as the environment and how this shows continuous variation Students will be engaged through the numerous quiz rounds such as “Is your knowledge of the Lac Operon LACKING” and “Can I have a P please Bob” whilst crucially being able to recognise those areas which require their further attention during general revision or during the lead up to the actual A-level terminal exams

This is a fully-resourced lesson that covers the content of specification point 6.3 of the AQA A-level Biology specification which states that students should understand how skeletal muscles are stimulated to contract by nerves and act as effectors. The wide range of activities included in the lesson will engage and motivate the students whilst the understanding and previous knowledge checks will not only allow them to assess their progress but also challenge them to make links to other Biology topics. The following content is covered in detail in this lesson: The ultrastructure of a myofibril The roles of actin and myosin in myofibril contraction The need for calcium ions and ATP in myofibril contraction The roles of calcium ions and tropomyosin in cross-bridge formation The roles of ATP and phosphocreatine in muscle contraction This lesson has been designed for students studying the AQA A-level Biology course and ties in nicely with the other uploaded lessons from topic 6 such as synapses and NMJs and nerve impulses

This REVISION resource has been written with the aim of motivating the students whilst they are challenged on their knowledge of the content in Biology TOPIC 7 (Animal coordination, control and homeostasis) of the Edexcel GCSE Combined Science specification. The resource contains an engaging and detailed PowerPoint (73 slides) and accompanying worksheets, some of which are differentiated to provide extra scaffolding to students when it is required. The wide range of activities have been designed to cover as much of topic 7 as possible but the following sub-topics have been given a particular focus: The causes and treatments of diabetes type I and II The control of blood glucose concentration through the release of insulin and glucagon The importance of homeostasis Calculating BMI The hormones involved in the female menstrual cycle The use of clomifene therapy and IVF in assisted reproductive therapy Hormonal and barrier methods of contraception The actions of adrenaline There is a large emphasis on mathematical skills in the new specification and these are tested throughout the lesson. This resource is suitable for use at the end of topic 7, in the lead up to mocks or in the preparation for the final GCSE exams.

This detailed lesson describes how the Link reaction and the Krebs cycle, that take place in the matrix, result in the complete oxidation of pyruvate. The PowerPoint and the accompanying resource have been designed to cover points 5.3 (i) & (ii) of the Edexcel A-level Biology B specification and describes how these reactions result in carbon dioxide, reduced NAD (and FAD) and ATP The lesson begins with a challenge, where the students have to recall the details of glycolysis in order to form the word matrix. This introduces the key point that these two stages occur in this part of the mitochondria and time is taken to explain why the reactions occur in the matrix as opposed to the cytoplasm like glycolysis. Moving forwards, the Link reaction is covered in 5 detailed bullet points and students have to add the key information to these points using their prior knowledge as well as knowledge provided in terms of NAD. The students will recognise that this reaction occurs twice per molecule of glucose and a quick quiz competition is used to test their understanding of the numbers of the different products of this stage. This is just one of the range of methods that are used to check understanding and all answers are explained to allow students to assess their progress. The rest of the lesson focuses on the Krebs cycle. In line with the detail of the specification, students will understand how decarboxylation and dehydrogenation reactions result in the regeneration of the oxaloacetate It is estimated that it will take about 2 hours of A-level teaching time to cover the detail of the lesson and therefore the detail of the specification point 5.3

This lesson has been designed to cover the content in points 7.11 and 7.12 of the Edexcel GCSE Biology specification which states that students should be able to explain how thermoregulation takes place, with particular reference to the role of the skin. This resource contains an engaging PowerPoint and a differentiated worksheet, which together use a wide range of activities to motivate the students and to engage them in the content matter. The lesson begins by challenging the students to calculate a number from a series of biological based statements. This number is 37 which introduces the students to this temperature as the set-point at which homeostasis acts to maintain the body temperature. At this point of the lesson, a number of prior knowledge checks are used to challenge the students on their recall of the parts of a control system as well as challenging them to explain why temperatures above or below this set point can be problematic for body reactions. The main part of the lesson goes through the steps in the body’s detection and response to an increase in temperature and students will be introduced to the range of structures involved. Time is taken to focus on the role of the skin as an effector and key details about vasodilation and the production of sweat are discussed at length. The final task challenges the students to use all of the information from earlier in the lesson to write a detailed description of how the body detects and responds to a decrease in temperature. This lesson has been written for students studying on the Edexcel GCSE Biology course but is also suitable for older students who are studying thermoregulation and need to recall the key details.

This fully-resourced lesson describes the roles of the SAN, AVN, the bundle of His and Purkyne tissue in the coordination of the heartbeat. The PowerPoint and accompanying resources have been designed to cover points 7.12 (i) & (ii) of the Edexcel International A-level Biology specification and also describes the myogenic nature of cardiac muscle. The lesson begins with the introduction of the SAN as the natural pacemaker and then time is given to study each step of the conduction of the impulse as it spreads away from the myogenic tissue in a wave of excitation. The lesson has been written to make clear links to the cardiac cycle and the structure of the heart and students are challenged on their knowledge of this system from topic 1. Moving forwards, students are encouraged to consider why a delay would occur at the AVN and then they will learn that the impulse is conducted along the Bundle of His to the apex so that the contraction of the ventricles can happen from the bottom upwards. The structure of the cardiac muscle cells is discussed and the final task of the lesson challenges the students to describe the conducting tissue, with an emphasis on the use of key terminology

This detailed lesson describes the different levels of protein structure and focuses on the bonds that hold these molecules in shape. Both the engaging PowerPoint and accompanying resources have been designed to cover point (i) as detailed in AS unit 1, topic 1 of the WJEC A-level Biology specification and makes continual links to previous lessons such as amino acids & peptide bonds as well as to upcoming lessons like enzymes and antibodies. The start of the lesson focuses on a gene as a sequence of bases that code for the amino acid sequence in a polypeptide and a step by step guide is used to demonstrate how the sequences of bases in a gene acts as a template to form a sequence of codons on a mRNA strand and how this is translated into a particular sequence of amino acids known as the primary structure. The students are then challenged to apply their understanding of this process by using three more gene sequences to work out three primary structures and recognise how different genes lead to different sequences. Moving forwards, students will learn how the order of amino acids in the primary structure determines the shape of the protein molecule, through its secondary, tertiary and quaternary structure and time is taken to consider the details of each of these. There is a particular focus on the different bonds that hold the 3D shape firmly in place and a quick quiz round then introduces the importance of this shape as exemplified by enzymes, antibodies and hormones. Students will see the differences between globular and fibrous protein and again biological examples are used to increase relevance. The lesson concludes with one final quiz round called STRUC by NUMBERS where the students have to use their understanding of the protein structures to calculate a numerical answer.

This fully-resourced lesson looks at the structures of the sensory, relay and motor neurones and explains how the presence of a myelin sheath increases the speed of conduction of an impulse. The engaging PowerPoint and accompanying resources have been designed to cover point 8.1 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification which states that students should be able to apply their understanding of the structures and functions of sensory, relay and motor neurones as well as the differences between myelinated and unmyelinated neurones. This lesson also covers 8.2 (i) as the students will be able to see how conduction along a motor neurone stimulates effectors to respond to a stimulus. The PowerPoint has been designed to contain a wide range of activities that are interspersed between understanding and prior knowledge checks that allow the students to assess their progress on the current topics as well as challenge their ability to make links to topics from earlier in the modules. Quiz competitions like SAY WHAT YOU SEE are used to introduce key terms in a fun and memorable way. The students will be able to compare these neurones based on their function but also distinguish between them based on their structural features. Time is taken to look at the importance of the myelin sheath for the sensory and motor neurones. Students will be introduced to the need for the entry of ions to cause depolarisation and will learn that this is only possible at the nodes of Ranvier when there is a myelin sheath. Key terminology such as saltatory conduction is introduced and explained. The final task involves a comparison between the three neurones to check that the students have understood the structures and functions of the neurones. Throughout the lesson, links are made to related topics such the organisation of the nervous system and students will be given additional knowledge such as the differences between somatic and autonomic motor neurones.

This lesson describes the light-independent reactions of photosynthesis as reduction of carbon dioxide using the products of the light-dependent reactions. The detailed PowerPoint and accompanying resources have been designed to cover point 5.8 (i) of the Pearson Edexcel A-level Biology A (Salters-Nuffield) specification and therefore describes carbon fixation in the Calvin cycle and the roles of GP, GALP, RuBP and RUBISCO). The lesson begins with an existing knowledge check where the students are challenged to recall the names of structures, substances and reactions from the light-dependent stage in order to reveal the abbreviations of the main 3 substances in the light-independent stage. This immediately introduces RuBP, GP and GALP and students are then shown how these substances fit into the cycle. The main section of the lesson focuses on the three phases of the Calvin cycle and time is taken to explore the key details of each phase and includes: The role of RUBISCO in carbon fixation The role of the products of the light-dependent stage, ATP and reduced NADP, in the reduction of GP to GALP The use of the majority of the GALP in the regeneration of RuBP A step-by-step guide, with selected questions for the class to consider together, is used to show how 6 turns of the cycle are needed to form the GALP that will then be used to synthesise 1 molecule of glucose. A series of exam-style questions are included at appropriate points of the lesson and this will introduce limiting factors as well as testing their ability to answer questions about this stage when presented with an unfamiliar scientific investigation. The mark schemes are included in the PowerPoint so students can assess their understanding and any misconceptions are immediately addressed. This lesson has been specifically written to tie in with the previous lessons on the structure of a chloroplast and the light-dependent reactions as well as the upcoming lesson on the products of the light-independent reactions.

This fully-resourced lesson describes the roles of antigens, antibodies, B cells and T cells in the body’s immune response. The PowerPoint and accompanying worksheets have been designed to cover specification points 6.8 & 6.9 as detailed in the Pearson Edexcel A-level Biology A specification and includes descriptions of the involvement of plasma (effector) cells and macrophages as antigen-presenting cells. In the previous lesson on the non-specific responses, the students were introduced to macrophages and dendritic cells as antigen-presenting cells and the start of this lesson challenges their recall and understanding of this process. Time is taken to discuss how the contact between these cells and lymphocytes is critical for the initiation of the body’s (specific) immune response. Moving forwards, a quick quiz competition is used to introduce the names of the different T cells that result from differentiation. Their specific roles are described including an emphasis on the importance of the release of cytokines in cell signalling to activate other immune system cells. T memory cells are also introduced so that students can understand their role in immunological memory and active immunity as described in an upcoming lesson covering point 6.12. The next part of the lesson focuses on the B cells and describes how clonal selection and clonal expansion results in the formation of memory B cells and effector cells. A series of understanding and application questions are then used to introduce the structure of antibodies and to explain how the complementary shape of the variable region allows the antigen-antibody complex to be formed. The lesson concludes by emphasising that the pathogen will be overcome as a result of the combination of the actions of phagocytes, T killer cells and the antibodies released by the effector cells.

This fully-resourced lesson describes how genes can be switched on and off by DNA transcription factors, including hormones. The PowerPoint and accompanying resources have been designed to cover point 7.16 as detailed in the Pearson Edexcel A-level Biology A specification but also links to topic 3 when the lac operon was described in relation to differential gene expression. This is one of the more difficult concepts in this A-level course and therefore key points are reiterated throughout this lesson to increase the likelihood of student understanding and to support them when trying to make links to actual biological examples in living organisms. There is a clear connection to transcription and translation as covered in topic 2, so the lesson begins by reminding students that in addition to the structural gene in a transcription unit, there is the promotor region where RNA polymerase binds. Students are introduced to the idea of transcription factors and will understand how these molecules can activate or repress transcription by enabling or preventing the binding of the enzyme. At this point, students are challenged on their current understanding with a series of questions about DELLA proteins so they can see how these molecules prevent the binding of RNA polymerase. Their remainder of the lesson looks at the ER receptor and students will learn that this factor is normally inactive due to an inhibitor being attached. This will then introduce oestrogen as the hormone which binds to the receptor, causing the inhibitor to be released and activating the factor. The main task then challenges them to order statements containing the detailed events that follow the binding of oestrogen. The lesson in topic 3 on gene expression which describes the lac operon has also been uploaded for free.

This lesson describes the non-specific responses of the body to infection which include inflammation, lysozyme action, interferon and phagocytosis. The detailed PowerPoint and accompanying resources have been primarily designed to cover the content of point 6.8 of the Edexcel International A-level Biology specification but key details such as antigen-presentation are also introduced to prepare students for upcoming lessons on the immune response (6.9 & 6.10). At the start of the lesson, the students are challenged to recall that cytosis is a suffix associated with transport mechanisms and this introduces phagocytosis as a form of endocytosis which takes in pathogens and foreign particles. This emphasis on key terminology runs throughout the course of the lesson and students are encouraged to consider how the start or end of a word can be used to determine meaning. The process of phagocytosis is then split into 5 key steps and time is taken to discuss the role of opsonins as well as the fusion of lysosomes and the release of lysozymes. A series of application questions are used to challenge the students on their ability to make links to related topics including an understanding of how the hydrolysis of the peptidoglycan wall of a bacteria results in lysis. Students will be able to distinguish between neutrophils and monocytes from a diagram and at this point, the role of macrophages and dendritic cells as antigen-presenting cells is described so that it can be used in the next lesson. The importance of cell signalling for an effective immune response is discussed and the rest of the lesson focuses on the release of two chemicals - interferons and histamine. During the interferon section, references are made to a previous lesson on HIV structure and action so students can understand how the release of these signalling proteins helps neighbouring cells to heighten their anti-viral defences. A step by step guide is used to describe the release of histamine in the inflammatory response and the final task challenges students to use this support to form a detailed answer regarding the steps in inflammation.

This lesson describes the detailed structure of a skeletal muscle fibre and the structural and physiological differences between fast and slow twitch fibres. The engaging PowerPoint and acccompanying resources have been designed to cover points 7.10 (i) & (ii) of the Edexcel International A-level Biology specification. The start of the lesson uses an identification key to emphasise that skeletal muscle differs from cardiac and smooth muscle due to its voluntary nature. It is important that key terminology is recognised so once myology has been revealed as the study of muscles, key structural terms like myofibril, myofilament and myosin can be introduced. Moving forwards, students will be shown the striated appearance of this muscle so they can recognise that some areas appear dark where both myofilaments are found and others as light as they only contain actin or myosin. A quiz competition is used to introduce the A band, I band and H zone and students then have to use the information given to label a diagram of the myofibril. This part of the lesson has been specifically planned to prepare the students for the upcoming lesson which describes the contraction of skeletal muscles by the sliding filament mechanism The rest of the lesson focuses on the structural and physiological differences between fast and slow twitch fibres and the following characteristics are covered: Reliance on the aerobic or anaerobic pathways to generate ATP Resistance to fatigue mitochondrial density capillary density myoglobin content (and colour) fibre diameter phosphocreatine content glycogen content A wide variety of tasks are used to cover this content and include knowledge recall and application of knowledge exam-style questions with fully-displayed mark schemes as well as quick quiz competitions to maintain motivation and engagement.