This lesson describes the role of the rER and the Golgi apparatus in the formation of proteins, the transport within cells and their secretion. The PowerPoint and accompanying resources have been designed to cover point 3.3 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification and also includes key details about the role of the cytoskeleton in the transport of the vesicles that contain the protein between the organelles and the membrane. The lesson begins with the introduction of the cytoskeleton and explains how this network of protein structures transverses across the cytoplasm and is fundamental to the transport of molecules between organelles. The lesson has been planned to closely tie in with the previous lesson on the ultrastructure of eukaryotic cells and students are challenged on their knowledge of the function of the organelles involved in protein formation (and modification) through a series of exam-style questions. By comparing their answers against the mark scheme embedded in the PowerPoint, students will be able to assess their understanding of the following: Transcription in the nucleus to form an mRNA strand and the exit of this nucleic acid through the nuclear pore Translation at the ribosomes on the surface of the rER to assemble the protein Transport of the vesicles containing the protein to the Golgi apparatus Modification of the protein at the Golgi apparatus Formation of the Golgi vesicle and its transport to the cell membrane for exocytosis Time is taken to discuss the finer details of this process such as the arrival of the vesicle at the cis face and the transport away from the trans face and the requirement of ATP for the transport of the vesicles along the microtubule track and exocytosis. The remainder of the lesson uses a series of exam-style questions about digestive enzymes (extracellular proteins) to challenge the students on their recall of the structure of starch and proteins

This lesson describes the international and local conservation agreements that are made to protect species and habitats. The detailed PowerPoint and accompanying worksheets have been designed to cover point 4.2.1 (i) of the OCR A-level Biology A specification and includes details of CITES, CBD and CSS. Many hours of research have gone into the planning of this lesson to ensure that a range of interesting biological examples are included, with the aim of fully engaging the students in the material to increase its relevance. Beginning with the Convention on International Trade in Endangered Species of Wild Fauna and Flora, the students will learn that this was first agreed in 1973 and that 35000 species are currently found in appendix I, II or III. Time is taken to go through the meaning of each appendix and then the following animal and plant species are used to explain the finer details of the agreement: Tree pangolin, eastern black rhino for CITES appendix I Darwin’s orchid for CITES appendix II Four-horned antelope for CITES appendix III Exam-style questions are used to check on their understanding of the current topic as well as to challenge their knowledge of previously-covered topics such as the functions of keratin, when considering the structure of the rhino horn. Each of these questions has its own markscheme which is embedded in the PowerPoint and this allows the students to constantly assess their progress. Moving forwards, the Rio Convention on Biological Diversity is introduced and students will understand that this is a key document regarding sustainable development. The final part of the lesson considers local conservation agreements, focusing on the Countryside Stewardship Scheme and its replacement, the Environmental Stewardship Scheme. Students are told that farmers, woodland owners, foresters and land managers can apply for funding for a range of options including hedgerow management, low input grassland, buffer strips, management plans and soil protection options. The importance of the hedgerows for multiple species is discussed, and again a real-life example is used with bats to increase the likelihood of retention. The last task challenges them to use their overall knowledge of module 4.2.1 (biodiversity) to explain why buffer strips consisting of multiple types of vegetation are used and to explain why these could help when a farmer is using continuous monoculture.

This lesson describes the effect that treaties such as CITES have had on global diversity. The PowerPoint and accompanying worksheets have been primarily designed to cover point 10.4 (ii) of the Edexcel A-level Biology B specification but has been planned to constantly challenge them on their knowledge of topic 3.3 (biodiversity) as a local conservation agreement is also considered Many hours of research have gone into the planning of this lesson to ensure that a range of interesting biological examples are included, with the aim of fully engaging the students in the material to increase its relevance. The students will learn that the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) was first agreed in 1973 and that 35000 species are currently found in appendix I, II or III. Time is taken to go through the meaning of each appendix and then the following animal and plant species are used to explain the finer details of the agreement: Tree pangolin, eastern black rhino for CITES appendix I Darwin’s orchid for CITES appendix II Four-horned antelope for CITES appendix III Exam-style questions are used to check on their understanding of the current topic as well as to challenge their knowledge of previously-covered topics such as the functions of keratin, when considering the structure of the rhino horn. Each of these questions has its own markscheme which is embedded in the PowerPoint and this allows the students to constantly assess their progress. The final part of the lesson considers the Countryside Stewardship Scheme as a local conservation agreements and discusses the reasons behind some of the key points. Students are told that farmers, woodland owners, foresters and land managers can apply for funding for a range of options including hedgerow management, low input grassland, buffer strips, management plans and soil protection options. The importance of the hedgerows for multiple species is discussed, and again a real-life example is used with bats to increase the likelihood of retention. The last task challenges them to use their overall knowledge of biodiversity to explain why buffer strips consisting of multiple types of vegetation are used and to explain why these could help when a farmer is using continuous monoculture.

This lesson describes how to analyse data using the Spearman rank correlation coefficient. The PowerPoint and accompanying exam-style question are part of the second lesson in a series of 2 lessons which have been designed to cover point 10.1 (vi) of the Edexcel A-level Biology B specification. The first lesson in this series described how to analyse data using the standard deviation and the t-test As with the previous lesson, a step by step guide is used to walk the students through the use of the formula to generate the rank coefficient and to determine whether there is a positive correlation, no correlation or a negative correlation. The students are also reminded of the null hypothesis and will be shown how to accept or reject this hypothesis and to determine significance. The students will work through an example with the class and then are given the opportunity to apply their newly-acquired knowledge to an exam-style question. The mark scheme is displayed on the PowerPoint so they can assess their understanding

This lesson describes a range of methods that can be used to assess the distribution and abundance of organisms in a local area. The PowerPoint and accompanying worksheets have been designed to cover points [c] and [d] of topic 18.1 of the CIE A-level Biology specification and describe the use of frame quadrats, line and belt transects, and the mark-release-recapture method. Due to the substantial mathematical content of the A-level Biology exams, as well as descriptions of the different methods, there is a focus on the range of calculations that are used to estimate the population of either sessile or motile species. As shown by the image, step by step guides are used to walk the students through the key stages in these calculations before exam-style questions challenge them to apply their understanding and mark schemes are included in the lesson to allow them to immediately assess their progress. The precautions and assumptions associated with the mark-release-recapture method are discussed and links are made to stabilising selection as covered in topic 17 when considering how the number of species have changed over time.

This lesson describes the main stages of meiosis and has a specific focus on those events which contribute to genetic variation. The detailed PowerPoint and accompanying resources have been designed to cover point (d) in topic 6 of AS unit 1 of the WJEC A-level Biology specification and includes description of crossing over, independent assortment, independent segregation and the production of haploid gametes In order to understand how the events of meiosis like crossing over and independent assortment and independent segregation can lead to variation, students need to be clear in their understanding that DNA replication in interphase results in homologous chromosomes as pairs of sister chromatids. Therefore the beginning of the lesson focuses on the chromosomes in the parent cell and this first part of the cycle and students will be introduced to non-sister chromatids and the fact that they may contain different alleles which is important for the exchange that occurs during crossing over. Time is taken to go through this event in prophase I in a step by step guide so that the students can recognise that the result can be new combinations of alleles that were not present in the parent cell. Moving forwards, the lesson explores how the independent assortment and segregation of chromosomes and chromatids during metaphase I and II and anaphase I and II respectively results in genetically different gametes. The key events of all of the 8 phases are described and there is a focus on key terminology to ensure that students are able to describe genetic structures in the correct context. The final part of the lesson looks at the use of a mathematical expression to calculate the possible combinations of alleles in gametes as well as in a zygote following the random fertilisation of haploid gametes. Understanding and prior knowledge checks are interspersed throughout the lesson as well as a series of exam-style questions which challenge the students to apply their knowledge to potentially unfamiliar situations. This lesson has been specifically planned to lead on from the previous two lessons on the cell cycle and the main stages of mitosis and constant references are made throughout to encourage students to make links and also to highlight the differences between the two types of nuclear division

This lesson describes the key steps involved in transcription, the 1st stage of protein synthesis. The PowerPoint and accompanying resource are part of the first lesson in a series of 2 lessons which have been designed to cover the content of point 3.8 of the Edexcel GCSE Biology specification. According to the specification, the students are expected to know this process in considerable detail, and the lesson has been planned to reflect this. In a previous lesson in topic 3, the students were introduced to the definition of a gene as a section of a DNA molecule that codes for the sequence of amino acids in a protein. They will learn that this represents coding DNA, so time is then taken to explain that not all DNA codes for proteins and that there are sections of non-coding DNA located in front and behind each gene. This is vital information as it leads into the start of the process, where the binding of RNA polymerase to a section of non-coding DNA located in front of the gene is the trigger for the start of transcription of that particular gene. Moving forwards, a step by step guide describes the key steps which include the lining up of the RNA nucleotides against the exposed bases and the formation of mRNA through the reactions catalysed by RNA polymerase. Students are given key details of RNA nucleotides, specifically the inclusion of uracil bases, and an understanding check challenges them to determine the sequence of RNA bases that will line up against a template strand. These current understanding checks along with prior knowledge checks are found throughout the lesson to allow the students to assess their progress and to challenge them to make links to previous lessons.

This lesson describes how the alveoli are adapted for gas exchange by diffusion between the air in the lungs and the blood capillaries. The PowerPoint and accompanying resource are part of the second lesson in a series of 2 which have been designed to cover the content of point 8.2 & 8.3 of the Edexcel GCSE Biology and Combined Science specifications. During the 1st lesson in this series, the students were shown how to calculate the surface area to volume ratio and so this lesson begins by challenging them to recall that the larger the organism, the smaller the ratio. This is done through the PLAY YOUR CARDS RIGHT format as shown in the cover picture, and leads into the key idea that complex multicellular organisms like humans have developed a range of different adaptations to increase this ratio at their exchange surfaces. Moving forwards, time is taken to consider and discuss how the following adaptations of the alveoli affect the rate of diffusion: large surface area lining of the alveoli consisting of a single layer of flattened cells maintenance of a steep concentration gradient Each feature is related to diffusion and current understanding and prior knowledge checks are used to allow the students to assess their progress and to challenge them to make links to other topics of the course. All exam questions have mark schemes embedded into the PowerPoint

This lesson introduces and explains the meaning of 11 key terms associated with the genetic inheritance topic. The PowerPoint and accompanying resources have been designed to cover point 6.1.6 of the AQA GCSE Combined Science specification and include explanations of genome, chromosome, gene, allele, genotype, homozygous, heterozygous, phenotype, dominant, recessive and gamete. The key term, genome, was met earlier in topic 6 so the lesson begins with a knowledge retrieval with the definition for this term. As the genome is the entire DNA of an organism, the next task challenges the students to identify three errors in a passage about DNA. This challenges their recall of the structure of this chemical as a double helix, its location in an eukaryotic cell in the nucleus and an understanding that the gene codes for the sequence of amino acids in a specific protein. This leads into discussions about chromosomes and genes and time is taken to explain that homologous chromosomes have the same genes at the exact same gene loci. The students will learn that alternative forms of the gene (alleles) can be found at these loci and that these structures explain the differences in inherited characteristics. Moving forwards, the main section of the lesson describes the link between the dominant and recessive alleles, homozygous and heterozygous genotypes, and the physical expression as the phenotype. The final key term is gamete, and the students are challenged to recognise a definition for this term using their knowledge of meiosis. Two progress and understanding checks complete the lesson and check on the students’ ability to recognise and write definitions for these 11 terms and to use them accurately in a written description

This lesson has been designed to cover the content as detailed in point 5.2.1 (The structure and function of the human nervous system) of the AQA GCSE Biology & Combined Science specifications. Consisting of a detailed and engaging PowerPoint (38 slides) and accompanying worksheets, the range of activities will motivate the students whilst ensuring that the content is covered in detail. Students will learn how receptors, sensory neurones, the CNS, motor neurones and effectors are involved in the detection and response to a stimulus. Reflex reactions are also considered and discussed so that students can recognise how these automatic and rapid responses avoid damage and pain to humans. Progress checks are included throughout the lesson so that students can assess their understanding of the content and any misconceptions can be addressed whilst quiz competitions, like FROM NUMBERS 2 LETTERS and YOU DO THE MATH, are used to introduce new terms and important values in a fun and memorable way. This lesson has been written for GCSE-aged students who are studying the AQA GCSE Biology or Combined Science specifications but can be used with older students who need to know the key details of the nervous system for their A level course before taking it to greater depths

This fully-resourced lesson has been designed to cover the specification point 3.21B (understanding the term co-dominance) as detailed in topic 3 (Reproduction and inheritance) of the Pearson Edexcel IGCSE Biology specification. The lesson uses the inheritance of the ABO blood group system to demonstrate co-dominance. A potentially difficult topic, time has been taken to include guidance sections where students are walked through the interpretation of the different genotypes to find out the phenotypes as well as supporting them through the construction of genetic diagrams and working out the blood groups from pedigree trees. There is a real focus on genetic terminology such as allele, locus, genotype and phenotype so that the understanding is deep and students can use this if they choose to further their studies at A-level. This lesson has been designed for GCSE-aged students studying the Pearson Edexcel IGCSE Biology course but is also suitable for older students who are learning about codominance (and multiple alleles) at A-level

This is a fully-resourced lesson consisting of an engaging PowerPoint and differentiated worksheets which have been designed to cover the content of point 2.5 (i) as detailed on the WJEC GCSE Biology specification. This point states that students should demonstrate and apply their knowledge and understanding of how type I and II diabetes are caused and their respective treatments. There are links made throughout the lesson between this topic and the control of blood glucose concentration from specification point 2.5 (h). The lesson has been designed to take the format of a diabetic clinic where the students perform the duties of the attending doctor. They will move through the different stages of the role which includes identifying symptoms, diagnosis of type I or II and communication with the patients to reveal the findings. The wide range of activities will enable the students to learn how to spot that someone is suffering from diabetes and the similarities and differences between the different types so they can determine which one is being presented. The summary tasks challenge the students to construct a letter to a patient who is suffering from type II and to identify the correct type from another doctor’s letter. Understanding and previous knowledge checks are interspersed with quiz competitions, like the one shown in the cover image, which make the learning fun and memorable and enable the students to assess their progress. This lesson has been designed for students studying the WJEC GCSE Biology course but is suitable for both younger and older students who are focusing on this disease

The engaging PowerPoint and accompanying differentiated worksheets which come as part of this lesson resource have been designed to cover the SUPPLEMENT section of topic 13.1 of the CIE IGCSE Biology specification which states that students should be able to describe the structure and function of the kidneys. Students will initially be introduced to the gross anatomy of the kidneys with the cortex and medulla and the associated ureter before moving on to the fine anatomy of the tubules and focusing on the key functions like ultrafiltration and selective reabsorption. Lots of discussion points and student discovery have been written into the lesson to encourage students to think about why a certain process takes place before attempting to explain it using the Biology. In addition, there are lots of understanding checks and prior knowledge checks so that students are challenged on their knowledge of previously learned topics such as active transport and the components of blood. The final task of the lesson challenges the students to use their knowledge of the formation of urea from earlier in topic 13 and combine it with what they have learnt in this lesson to arrange statements about the journey of this molecule into the right order This lesson has been designed for students who are studying the CIE IGCSE Biology course but is suitable for older students who are studying the kidney at A-level and want to recall some of the key details of the structure and function of this organ

This is a highly detailed and engaging lesson that covers the detail of the 2nd part of specification point 6.2.1 of the AQA A-level Biology specification which states that students should be able to describe the establishment of resting potential, the changes in membrane potential that lead to depolarisation and the importance of the refractory period. This topic is commonly assessed in the terminal exams so a lot of time has been taken to design this resource to include a wide range of activities that motivate the students whilst ensuring that the content is covered in the depth of detail that will allow them to have a real understanding. Interspersed within the activities are understanding checks and prior knowledge checks to enable the students to not only assess their progress against the current topic but also to challenge themselves on the links to earlier topics such as methods of movements across cell membranes and saltatory conduction. There are also a number of quiz competitions which are used to introduce key terms and values in a fun and memorable way and discussion points to encourage the students to consider why a particular process or mechanism occurs. Over the course of the lesson, the students will learn and discover how the movement of ions across the membrane causes the membrane potential to change. They will see how the resting potential is maintained through the use of the sodium/potassium pump and potassium ion leakage. There is a real focus on depolarisation to allow students to understand how generator potentials can combine and if the resulting depolarisation then exceeds the threshold potential, a full depolarisation will occur. At this point in the lesson students will discover how the all or nothing response explains that action potentials have the same magnitude and that instead a stronger stimulus is linked to an increase in the frequency of the transmission. The rest of the lesson challenges the students to apply their knowledge to explain how repolarisation and hyperpolarisation result and to suggest advantages of the refractory period for nerve cells. This lesson has been designed for students studying the AQA A-level Biology course and ties in nicely with other uploaded lessons on mammalian sensory receptors and the structures and functions of the neurones.

This fully-resourced lesson covers the content of the first part of specification point 6.2.2 of the AQA A-level Biology specification that states that students should be able to describe the detailed structure of a cholinergic synapse and a neuromuscular junction and be able to compare the transmission across both of these structures. The majority of the lesson uses the cholinergic synapse as the example but other neurotransmitters and drugs are considered so students are prepared to describe the differing effects on the synapse. The lesson begins by using a version of the WALL (as shown in the cover image) which asks the students to group 12 words into three groups of 4. Not only will this challenge their prior knowledge from topics earlier in this module but it will also lead to the discovery of four of the structures that are found in a synapse. Moving forwards, students are introduced to aectylcholine as the neurotransmitter involved at cholinergic synapses and they will start to add labels to the structures found in the pre-synaptic bulb. Time is taken to focus on certain structures such as the voltage gated channels as these types of channel were met previously when looking at the depolarisation of a neurone. There is plenty of challenge and discovery as students are pushed to explain why organelles like mitochondria would be found in large numbers in the bulb. With this process being a cascade of events, a bullet point format is used to ensure that the key content is taken in by the students and again key points like exocytosis and the action of acetylcholinesterase are discussed further. The next part of the lesson challenges the application aspect of the specification as students are introduced to unfamiliar situations in terms of synapses with new drugs like MDMA and are asked to work out and explain how these affect the nervous transmission. The final part of the lesson focuses on the NMJ and challenges the students to use the knowledge gained from earlier in the lesson to develop their understanding of these junctions. Time is taken to look at the structure of the sarcolemma to enable students to understand how the binding of the acetylcholine leads to the wave of depolarisation passing to the transverse tubules. Understanding checks and prior knowledge checks are included throughout the lesson so that students can not only assess their progress against the current topic but also see whether they can make links to earlier topics. This lesson has been designed for students studying the AQA A-level Biology course but could be used with very able GCSE students who are keen to develop their understanding of synapses over and above the small detail that is provided at that level. This lesson also ties in nicely with the other uploaded lessons from topic 6

This is a highly-detailed and fully-resourced lesson which covers the part of specification point 6.4.3 of the AQA A-level Biology specification which states that students should be able to describe the roles of the hypothalamus, posterior pituitary and ADH in osmoregulation. Students learnt about the principles of homeostasis and negative feedback in an earlier lesson, so this lesson acts to build on that knowledge and challenges them to apply their knowledge. A wide range of activities have been included in the lesson to maintain motivation and engagement whilst the understanding and prior knowledge checks will allow the students to assess their progress as well as challenge themselves to make links to other Biology topics. The lesson begins with a discussion about how the percentage of water in urine can and will change depending on the blood water potential. Students will quickly be introduced to osmoregulation and they will learn that the osmoreceptors and the osmoregulatory centre are found in the hypothalamus. A considerable amount of time is taken to study the cell signalling between the hypothalamus and the posterior pituitary gland by looking at the specialised neurones (neurosecretory cells). Links are made to the topics of neurones, nerve impulses and synapses and the students are challenged to recall the cell body, axon and vesicles. The main section of the lesson forms a detailed description of the body’s detection and response to a low blood water potential. The students are guided through this section as they are given 2 or 3 options for each stage and they have to use their knowledge to select the correct statement. The final task asks the students to write a detailed description for the opposite stimulus and this task is differentiated so those who need extra assistance can still access the work. This lesson has been written for students studying on the AQA A-level Biology course and ties in nicely with the other uploaded lessons which cover this specification point as well as the whole of topic 6.

This is a highly-detailed and fully-resourced lesson which covers the detail of specification point 5.1.2 (d) of the OCR A-level Biology A specification which states that students should be able to demonstrate and apply an understanding of the roles of the hypothalamus, posterior pituitary, ADH and the collecting duct in the control of the water potential of the blood. Students learnt about the principles of homeostasis and negative feedback in an earlier module, so this lesson acts to build on that knowledge and challenges them to apply their knowledge. A wide range of activities have been included in the lesson to maintain motivation and engagement whilst the understanding and prior knowledge checks will allow the students to assess their progress as well as challenge themselves to make links to other Biology topics. The lesson begins with a discussion about how the percentage of water in urine can and will change depending on the blood water potential. Students will quickly be introduced to osmoregulation and they will learn that the osmoreceptors and the osmoregulatory centre are found in the hypothalamus. A considerable amount of time is taken to study the cell signalling between the hypothalamus and the posterior pituitary gland by looking at the specialised neurones (neurosecretory cells). Links are made to the topics of neurones, nerve impulses and synapses and the students are challenged to recall the cell body, axon and vesicles. The main section of the lesson forms a detailed description of the body’s detection and response to a low blood water potential. The students are guided through this section as they are given 2 or 3 options for each stage and they have to use their knowledge to select the correct statement. The final task asks the students to write a detailed description for the opposite stimulus and this task is differentiated so those who need extra assistance can still access the work. This lesson has been written for students studying on the OCR A-level Biology A course and ties in nicely with the other uploaded lessons in module 5.1.2 which include the structure of the nephron, ultrafiltration and selective reabsorption.