This is a detailed, engaging and fully-resourced REVISION LESSON which allows students of all abilities to assess their understanding of the content in topic 6 (Nucleic acids and protein synthesis) of the CIE International A-level Biology specification. Considerable time has been taken to design the lesson to include a wide range of activities to motivate the students whilst they evaluate their knowledge of DNA, RNA and the roles of these nucleic acids in DNA replication and protein synthesis. Most of the tasks have been differentiated so that students of differing abilities can access the work and move forward as a result of the tasks at hand. This lesson has been planned to cover as much of the specification as possible but the following sub-topics have received particular attention: The structure of DNA Phosphorylated nucleotides DNA replication Transcription and translation Gene mutations and their affect on the primary structure of a polypeptide The structure of RNA In addition to a focus on the current topic, links are made throughout the lesson to other topics such as the journey of an extracellular protein following translation and the cell cycle. If you like the quality of this revision lesson, please look at the other uploaded revision lessons for this specification

This fully-resourced lesson looks at the series of small steps that form the Krebs cycle and focuses on the reactions which involve decarboxylation and dehydrogenation and the reduction of NAD and FAD. The engaging PowerPoint and accompanying resource have both been designed to cover points 12.2 (d) and (e) of the CIE International A-level Biology specification. The lesson begins with a version of the Impossible game where students have to spot the connection between 8 of the 9 terms and will ultimately learn that this next stage is called the Krebs cycle. The main part of the lesson challenges the students to use descriptions of the main steps of the cycle to continue their diagram of the reactions. Students are continually exposed to key terminology such as decarboxylation and dehydrogenation and they will learn where carbon dioxide is lost and reduced NAD and FAD are generated. They will also recognise that ATP is synthesised by substrate level phosphorylation. The final task challenges them to apply their knowledge of the cycle to work out the numbers of the different products and to calculate the number of ATP that must be produced in the next stage This lesson has been designed to tie in with the other uploaded lessons on glycolysis, the Link reaction and oxidative phosphorylation.

This lesson has been designed to act as an introduction to the anatomy of the kidney before students move on to study each structure of the nephron in more detail. The lesson considers both the gross anatomy, in terms of the renal cortex and medulla and then looks at the functional unit of the nephron. The function of the different parts of the nephron are briefly discussed and the features that relate to function are considered. This lesson has been designed for A-level students but could be used with higher ability GCSE students.

This is a fully-resourced lesson which is designed for GCSE students and explores the topic of compounds, specifically focusing on naming these chemicals based upon the elements within them and from their chemical formula. The lesson includes an engaging lesson presentation (46 slides) and a worksheet containing three tasks for the lesson. The lesson begins with some simple multiple choice questions to check that students can spot the chemical symbol and definition of an element, but more importantly pick out the formula for a compound. Time is taken to go through the explanation of why substances are elements or compounds and specific examples given. A quick understanding check, in the form of a competition called “To COM or NOT TO COM”,is used to check that students can identify elements or compounds from a name or given formula. The remainder of the lesson focuses on naming compounds. Students are challenged to spot a pattern when presented with the names of two compounds, which contain 2 elements only. For both compounds that contain 2 elements or 3 or more, the rules to naming are introduced before examples are shown so that students can visualise how to construct their answer. They are then given an opportunity to apply this to a number of questions in the set tasks. The last part of the lesson moves this forward by looking at how these same rules can be applied when the chemical formula of a compound is given and this is related to another topic as they are challenged to write a word equation containing a range of compounds when presented with the symbol equation. Progress checks are written into the lesson at regular intervals so that students can constantly assess their understanding. Although this is written for GCSE students, it is perfectly suitable for use with younger students who are learning about elements, compounds and mixtures and the teacher wants to push them along.

A considerable amount of time has been taken to design this revision resource so that the included activities engage the students whilst containing sufficient detail to enable them to assess their understanding of the content in topic 9 (Transport in animals) of the CIE IGCSE Biology specification. This resource can be used with those students taking both the 0610 and 0970 specifications and will be examined in June and November 2020 and 2021. This topic contains a lot of key details about the workings of the human body and is therefore likely to be heavily involved in the make up of upcoming examinations. The range of activities include exam questions with answers explained, differentiated tasks and quiz competitions such as “FOUND in the PLASMA” where students have to be the 1st to name the substances that are carried in this liquid and also “Is this passage on the right PATH” where students have to analyse a passage about the pathway of blood to determine if it is 100% correct. The lesson has been written to cover as much content from both the Core and Supplement sections as possible but the following have received particular attention: The functions of the different components of blood The structure of arteries and veins and how this is related to their functions The risk factors and treatments for CHD The structure of the heart and its associated blood vessels The function of the valves found in the heart and veins The double circulatory system

This is an engaging revision lesson which uses a range of exam questions, understanding checks, quick tasks and quiz competitions to enable students to assess their understanding of the content within topic 1 (Characteristics and classification of living organisms) of the CIE IGCSE Biology specification, for examination in 2020 and 2021. The lesson covers the content in both the core and supplement sections of the specification and therefore can be used with students who will be taking the extended papers as well as the core papers. The specification points that are covered in this revision lesson include: CORE Describe the characteristics of living organisms by defining the terms movement, respiration, sensitivity, growth, reproduction, excretion and nutrition State that organisms can be classified into groups by the features that they share Define and describe the binomial system of naming species as an internationally agreed system in which the scientific name of an organism is made up of two parts showing the genus and species List the main features used to place animals and plants into the appropriate kingdoms SUPPLEMENT Explain that classification systems aim to reflect evolutionary relationships Explain that classification is traditionally based on studies of morphology and anatomy Explain that the sequences of bases in DNA and of amino acids in proteins are used as a more accurate means of classification Explain that organisms which share a more recent ancestor (are more closely related) have base sequences in DNA that are more similar than those that share only a distant ancestor List the main features used to place all organisms into one of the five kingdoms: Animal, Plant, Fungus, Prokaryote, Protoctist List the features of viruses, limited to protein coat and genetic material The students will thoroughly enjoy the range of activities, which include quiz competitions such as “Are you the KING of the KINGDOMS” where they have to name the kingdoms involved based on a feature whilst crucially being able to recognise the areas of this topic which need their further attention. This lesson can be used as revision resource at the end of the topic or in the lead up to mocks or the actual IGCSE exams

This revision resource has been designed to include a range of activities that will engage the students whilst they assess their understanding of the content of topic B8 (Gas exchange and respiration) of the CIE IGCSE Combined Science specification for examination in June and November 2020 and 2021. Exam questions, quick tasks and quiz competitions such as “The BIG REVEAL” will challenge the students on their recall of the content as well as their ability to apply this knowledge. The lesson was written to cover as much of the content as possible, but the following topics have received particular attention: The role of cilia, goblet cells and mucus in the trachea and bronchi The effects of the chemicals in tobacco smoke on gas exchange Efficient gas exchange at the alveoli The composition of inhaled and exhaled air Aerobic respiration as the chemical reaction that releases energy The uses of energy in the human body This resource contains an engaging PowerPoint (54 slides) and associated worksheets and is ideal for use at the end of this topic or in the lead up to mocks or the actual terminal exams

This detailed lesson explains how the process of transcription results in the production of mRNA. Both the detailed PowerPoint and accompanying question worksheet have been designed to cover the first part of points 2.5 (i) & (ii) of the Pearson Edexcel A-level Biology A specification The lesson begins by challenging the students to work out that most of the nuclear DNA in eukaryotes does not actually code for polypeptides. This allows the promoter region and terminator region to be introduced, along with the structural gene. Through the use of an engaging quiz competition, students will learn that the strand of DNA involved in transcription is known as the template (or anti-sense) strand and the other strand is the coding (or sense) strand. Links to previous lesson on the structure of DNA and RNA are made throughout and students are continuously challenged on their prior knowledge as well as their current understanding of the lesson topic. Moving forwards, the actual process of transcription is covered in a 7 step bullet point description where the students are asked to complete each passage using the information previously provided. An exam-style question is used to check on their understanding before the final task of the lesson looks at the journey of mRNA to the ribosome for the next stage of protein synthesis, translation.

This fully-resourced lesson guides students through the interpretation of genetic pedigree diagrams for the inheritance of a single gene. The clear PowerPoint and accompanying resources have been designed to cover point 2.13 (ii) of the Pearson Edexcel A-level Biology A specification and includes the inheritance of multiple allele characteristics as well as those that demonstrate codominance. In order to minimise the likelihood of errors and misconceptions, step by step guides have been included throughout the lesson to support the students with the following: Writing parent genotypes Working out the different gametes that are made following meiosis Interpreting Punnett crosses to work out phenotypic ratios Students can often find pedigree trees the most difficult to interpret and to explain so exemplar answers are used as well as differentiated worksheets provided to support those students who need extra assistance.

Water is very important for living organisms because of its numerous properties and this lesson focuses on its role as a solvent in transport. The engaging and detailed PowerPoint and accompanying worksheet have been designed to cover point 1.2 of the Pearson Edexcel A-level Biology A specification and also explains the importance of the dipole nature for this role in transport. A mathematical theme runs throughout the lesson as students have to match the numbers calculated in the starter task to water statistics, such as the percentage of the volume of blood plasma that is water. This has been included to try to increase the relevance of each property so that it can be described in a biological context. Time is taken at the beginning of the lesson to describe the structure of water in terms of the covalent bonds between the oxygen and hydrogen atoms as well as the hydrogen bonds which form between molecules because of its polarity. Students will understand how water is a solvent which means that it is critical for transport in animals, a topic covered in the next few lessons but also for transport in plants as discussed in topic 4. The high heat capacity and latent heat of vaporisation of water is also discussed and explained through the examples of thermoregulation and the maintenance of a stable environment for aquatic animals. The final part of the lesson focuses on the involvement of water in condensation and hydrolysis reactions, two reactions which must be well understood for topic 1 and 2 and the formation and breakage of polysaccharides, lipids, polypeptides and polynucleotides.

This detailed lesson uses haemoglobin and collagen as examples to describe the structure, properties and functions of globular and fibrous proteins. The engaging PowerPoint and accompanying worksheet have been designed to cover point 2.9 (iv) of the Pearson Edexcel A-level Biology A specification and focuses on the shape, solubility and function of these two types of protein. The first part of the lesson looks at the structure of haemoglobin, and describes how the presence of an iron-containing haem group on the outside of the 4 polypeptide chains explains its ability to form oxyhaemoglobin. Moving forwards, the importance of the solubility of this protein is considered and related to the direction that the hydrophobic R groups point. At this point of the lesson, the students are challenged to construct a comparison table which can be filled in as the lesson progresses and as they are given more details of collagen. The section of the lesson concerning collagen begins with the introduction of its function in the artery wall so that students can recognise how fibrous proteins have roles associated with mechanical strength. Time is taken to discuss their solubility as well as the presence of repetitive amino acid sequences. The remainder of the lesson considers four more proteins and the final task challenges the students to use their completed table to write a summary passage comparing globular and fibrous proteins.

This lesson describes how the expression of a gene mutation impairs the functioning of the organ systems in people with cystic fibrosis. The detailed PowerPoint and accompanying worksheets have primarily been designed to cover point 2.16 in AS unit 1 of the Edexcel International A-level Biology specification but also challenge the students on their knowledge of previously-covered topics such as inheritance, protein synthesis and the genetic code as well as making links to the upcoming topics of loci and post-transcriptional changes. The main focus of the lesson is the CFTR gene and the functions of the ion channel that is synthesised when this gene is expressed. As well as explaining that this channel allows chloride ions to flow across the apical membrane of the epithelial cells, time is taken to emphasise the importance of its inhibition on the ENaC, which prevents the flow of sodium ions back into the cells. A step by step guide is then used to describe the sequence of events that result in mucus which is motile and can be moved by the wafting action of the cilia in healthy individuals. This leads into the section of the lesson which considers the inheritance of cystic fibrosis in an autosomal recessive manner and then focuses on the change in the primary structure of the channel which results from one of over 1500 different gene mutations. Again, the students are guided through the events that lead to the depletion of the apical surface liquid and the cilia being unable to move the viscous mucus. Although the majority of the lesson is described with reference to the gaseous exchange system, the impaired functioning of the digestive system in terms of the blockage of the pancreas and liver secretions is considered and discussed and the students are challenged on their understanding through a range of exam-style questions. All of the questions included in the lesson have mark schemes which are embedded into the PowerPoint and this allows the students to assess their progress. Due to the detailed content of this lesson, it is estimated that it will take in excess of 3 hours of allocated A-level teaching time to cover

Disaccharides are formed from the condensation of two monosaccharides and this lesson describes the formation of maltose, sucrose and lactose. The concise PowerPoint and accompanying question sheet have been designed to cover the third part of points 1.12 & 1.13 of the Pearson Edexcel A-level Biology A specification but also continually links to the previous lesson on monosaccharides when considering the different components of these three disaccharides. The first section of the lesson focuses on a prefix and a suffix so that the students can recognise that the names of the common disaccharides end in -ose. In line with this, a quick quiz round is used to introduce maltose, sucrose and lactose before students are challenged on their prior knowledge as they have to describe how condensation reactions and the formation of glycosidic bonds were involved in the synthesis of each one. The main task of the lesson again challenges the students to recall details of a previous lesson as they have to identify the monomers of each disaccharide when presented with the displayed formula. Time is taken to show how their knowledge of these simple sugars will be important in later topics such as extracellular enzymes, translocation in the phloem and the control of gene expression as exemplified by the Lac Operon. The lesson finishes with two exam-style questions where students have to demonstrate and apply their newly acquired knowledge

This lesson describes the basic structure of mononucleotides and the resulting structural similarities and differences between DNA and RNA. The PowerPoint and accompanying resource have been designed to cover points 2.9 (i) and (ii) of the Edexcel International A-level Biology specification and makes regular links to upcoming lessons which cover DNA replication and protein synthesis. In a lesson in topic 1, the students were introduced to monosaccharides as an example of a monomer and were informed that a nucleotide was another example. In line with this, the start of the lesson challenges them to recognise the key term nucleotide when only the letters U, C and T are shown. The next part of the lesson describes the structure of a DNA nucleotide and an RNA nucleotide so that the pentose sugar and the bases adenine, cytosine and guanine can be recognised as similarities whilst deoxyribose and ribose and thymine and uracil are seen as the differences. Time is taken to discuss how a phosphodiester bond is formed between adjacent nucleotides and their prior knowledge and understanding of condensation reactions is tested through a series of questions. Students are then introduced to the purine and pyrimidine bases and this leads into the description of the double-helical structure of DNA and the hydrogen bonds between complementary bases. The final section of the lesson describes the structure of mRNA, tRNA and rRNA and students are challenged to explain why this single stranded polynucleotide is shorter than DNA In addition to the current understanding and prior knowledge checks, a number of quiz rounds have been written into the lesson to introduce key terms in a fun and memorable way and the final round acts as a final check on the structures of DNA and RNA.

This lesson explains the meaning of gene, allele, genotype, phenotype, recessive, dominant, codominance, homozygote and heterozygote. The engaging PowerPoint and accompanying resources have been designed to cover specification point 2.15 (i) of the Edexcel International A-level Biology but also covers the meaning of genome, gene locus, homologous chromosomes, multiple alleles, autosomes and sex chromosomes as a recognition of these will be useful for upcoming lessons. As some of these terms were met at GCSE, this fully-resourced lesson has been designed to include a wide range of activities that build on this prior knowledge and provide clear explanations as to their meanings as well as numerous examples of their use in both questions and exemplary answers. The main task provides the students with an opportunity to apply their understanding by recognising a dominance hierarchy in a multiple alleles characteristic and then calculating a phenotypic ratio when given a completed genetic diagram. Other tasks include prior knowledge checks, discussion points to encourage students to consider the implementation of the genetic terms and quiz competitions to introduce new terms, maintain engagement and to act as an understanding check.

This fully-resourced lesson describes how cells become specialised through differential gene expression. The PowerPoint and accompanying resources have been designed to cover the details of point 3.19 of the Edexcel International A-level Biology specification. This is one of the more difficult concepts in this A-level course and therefore key points are reiterated throughout this lesson to increase the likelihood of student understanding and to support them when trying to make links to actual biological examples in living organisms. There is a clear connection to transcription and translation as covered in topic 2, so the lesson begins by reminding students that in addition to the structural gene in a transcription unit, there is the promotor region where RNA polymerase binds. Students are introduced to the idea of transcription factors and will understand how these molecules can activate or repress transcription by enabling or preventing the binding of the enzyme. At this point, students are challenged on their current understanding with a series of questions about DELLA proteins so they can see how these molecules prevent the binding of RNA polymerase. The final section of the lesson looks at one further example with oestrogen and the ER receptor and explains how the binding of this chemical results in the release of the inhibitor and the production of active mRNA.

This detailed and fully-resourced lesson describes the relationship between the structure and function of glycogen and amylose and amylopectin as components of starch. The engaging PowerPoint and accompanying resources have been designed to cover the fourth part of points 1.2 & 1.4 of the Edexcel International A-level Biology specification and links are continuously made to the previous lessons in this topic where the monosaccharides and disaccharides were introduced. The lesson begins with the CARBOHYDRATE WALL where students have to use their prior knowledge to collect the 9 carbohydrates on show into 3 groups. This results in glycogen, starch and cellulose being grouped together as polysaccharides and the structure and roles of the first two are covered over the course of the lesson. Cellulose is covered in a lesson in topic 4. Students will learn how key structural features like the 1 - 4 and 1 - 6 glycosidic bonds and the hydrogen bonds dictate whether the polysaccharide chain is branched or unbranched and also allows for spiralling. Following the description of the structure of glycogen, students are challenged to design an exam question in the form of a comparison table so that it can be completed as the lesson progresses and they learn more about starch. This includes a split in the starch section of the table so that the differing structures and properties of amylose and amylopectin can be considered. The importance of the compact structure for storage is discussed as well as the branched chains of amylopectin acting as quick source of energy when it is needed. The lesson concludes with a question and answer section that guides the students when answering a question about the importance of the lower solubility of the polysaccharides when compared to the monosaccharides.

This clear and concise lesson describes the meaning of a gene locus and explains how the inheritance of two or more genes that have loci on the same chromosome demonstrates linkage. The engaging PowerPoint and associated resource have been designed to cover points 3.9 (i) and (ii) of the Edexcel International A-level Biology specification and makes clear links to the upcoming topic of meiosis when describing the effect of crossing over on this linkage This is a topic which can cause confusion for students so time was taken in the design to split the concept into small chunks. There is a clear focus on how the number of original phenotypes and recombinants can be used to determine linkage and suggest how the loci of the two genes compare. Important links to other topics such as crossing over in meiosis are made to enable students to understand how the random formation of the chiasma determines whether new phenotypes will be seen in the offspring or not. Linkage is an important cause of variation and the difference between observed and expected results and this is emphasised on a number of occasions. The main task of the lesson acts as an understanding check where students are challenged to analyse a set of results involving the inheritance of the ABO blood group gene and the nail-patella syndrome gene to determine whether they have loci on the same chromosome and if so, how close their loci would appear to be.

This fully-resourced lesson describes the relationship between the structure of monosaccharides and their roles in living organisms. The detailed and engaging PowerPoint and accompanying resources have been designed to cover the second part of points 1.12 & 1.13 of the Pearson Edexcel A-level Biology A specification and looks at alpha-glucose, galactose, fructose, deoxyribose and ribose. The lesson begins with a made-up round of the quiz show POINTLESS, where students have to try to identify four answers to do with carbohydrates. In doing so, they will learn or recall that these molecules are made from carbon, hydrogen and oxygen, that they are a source of energy which can sometimes be rightly or wrongly associated with obesity and that the names of the three main groups is derived from the Greek word sakkharon. Using the molecular formula of glucose as a guide, students will be given the general formula for the monosaccharides and will learn that deoxyribose is an exception to the rule that the number of carbon and oxygen atoms are equal. Moving forwards, students have to study the displayed formula of glucose for two minutes without being able to note anything down before they are challenged to recreate what they saw in a test of their observational skills. At this point of the lesson, the idea of numbering the carbons is introduced so that the different glycosidic bonds can be understood in an upcoming lesson as well as the recognition of the different isomers of glucose. The difference between alpha and beta-glucose is provided but students do not need to consider the beta form until topic 4. The remainder of the lesson focuses on the roles of the monosaccharides and the final task involves a series of application questions where the students are challenged to suggest why ribose could be considered important for active transport and muscle contraction

This fully-resourced lesson uses the lac operon as an example to describe how gene expression is regulated and controls cell processes and structures. The detailed PowerPoint and accompanying resources have been designed to cover the details of specification point 3.12 of the Pearson Edexcel A-level Biology A course. This is one of the more difficult concepts in this A-level course and therefore key points are reiterated throughout this lesson to increase the likelihood of student understanding and to support them when trying to make links to actual biological examples in living organisms. There is a clear connection to transcription and translation as covered in topic 2, so the lesson begins by reminding students that in addition to the structural gene in a transcription unit, there is the promotor region where RNA polymerase binds. Students are introduced to the idea of transcription factors and will understand how these molecules can activate or repress transcription by enabling or preventing the binding of the enzyme. At this point, students are challenged on their current understanding with a series of questions about DELLA proteins so they can see how these molecules prevent the binding of RNA polymerase. The main section of the lesson focuses on the lac operon. Students will be able to visualise the different structures that are found in this unit of DNA and time is taken to go through the individual functions. A step by step guide is used to walk students through the sequence of events that occur when lactose is absent and when it is present before they are challenged to apply their understanding to an exam question. The final section of the lesson looks at one further example with oestrogen and the ER receptor.