A concise lesson presentation (18 slides) that looks at the Loop of Henle within the kidney and enables students to understand how water is reabsorbed from this structure of the nephron. The lesson begins by ensuring that students know the terminology associated with this topic and that there are two limbs (descending and ascending). Moving forward, students will be given some data on the changes in concentration as the filtrate moves along the Loop and use this to work out how the permeability of the individual limbs differ. This lesson is designed for A-level students

This revision resource has been filled with a range of activities that will motivate the students whilst they assess their understanding of the content found in module 4.2.1 (Biodiversity) of the OCR A-level Biology A specification. The content of this module is regularly assessed in the exams and therefore time has been taken to design the lesson to encourage recall. The resource includes a detailed and engaging Powerpoint (80 slides) and associated worksheets, some of which are differentiated to allow students of differing abilities to access the work. The range of activities have been designed to cover as much of the content as possible but the following sub-topics have been given particular attention: Considering biodiversity at different levels including species biodiversity Calculating the biodiversity of a habitat using the Simpsons index of diversity Assessing genetic diversity by looking at polymorphic gene loci Zoos as an ex situ method of maintaining biodiversity The factors affecting biodiversity There is a real emphasis on the mathematical element of the course in this lesson as students are challenged to apply the formulae in this module as well as more general skills such as percentage change. There are also links to topics from other modules such as selection pressures and codominance so students can experience the need to make connections between modules

This fully-resourced lesson describes the relationship between the structure and the function of the heart, arteries, veins and capillaries. The engaging and detailed PowerPoint and accompanying resources have been designed to cover point 4.1 (i) as detailed in the Edexcel A-level Biology Bspecification. The structure of the heart is a topic which was covered in part at GCSE so this lesson has been written to build on that prior knowledge. The main task of the first half of the lesson involves students labelling the different structures as they are recalled. Time is taken at appropriate points to look at some of the structures and concepts in further detail. For example, students will learn that humans have a double circulatory system, which will prepare them for the next lesson, and are challenged to explain why a hole in the septum would cause health issues for an affected individual By the end of the first part of the lesson, the students will be able to identify the following structures and describe their individual functions: • right and left atria • right and left ventricles • septum • tricuspid and bicuspid valve • semi-lunar valves • pulmonary artery and pulmonary vein • vena cava • aorta Moving forwards, the lesson focuses on the link between the structure of a particular type of blood vessel and its function. Students will be able to make the connection between the narrow lumen and elastic tissue in the walls of arteries and the need to maintain the high pressure of the blood. A quick version of the GUESS WHO game is used to introduce smooth muscle and collagen in the tunica media and externa and again the reason for their presence is explored and explained. Moving forwards, the lesson considers the structure of the veins and students are challenged to explain how the differences to those observed in arteries is due to the lower blood pressure found in these vessels. The final part of the lesson looks at the role of the capillaries in exchange. Links are made to diffusion to ensure that students can explain how the red blood cells pressing against the endothelium results in a short diffusion distance. It is estimated that it will take in excess of 2 hours of allocated A-level Biology teaching time to cover the detail included in this lesson

This engaging and detailed lesson has been written to cover the content of point 5.3.5 (Contraception) as detailed in the AQA GCSE Biology & Combined Science specifications. This is a topic which can be difficult to teach due to the awkwardness of a class or students believing that they already know all of the information without really knowing the detail which is laid out in the specification. With this in mind, a wide range of activities have been included in the lesson to maintain motivation whilst ensuring that this important detail is covered. Students will learn about a range of hormonal and non-hormonal methods including oral contraceptives, progesterone patches, condoms and diaphragms and IUDs. Time is taken to look at alternative methods such as abstaining from sexual intercourse during the times around ovulation and sterilisation. Due to the clear link to the topic of hormones in human reproduction, previous knowledge checks are written into the lesson and challenge the students on their knowledge of FSH, LH, oestrogen and progesterone. There are also mathematical skills check so that students are prepared for the added mathematical element in this course. This lesson has been written for GCSE-aged students who are studying on the AQA GCSE Biology or Combined Science courses but is suitable for younger students who are looking at contraception in their Science lessons

This fully-resourced lesson describes the differences between bacteriostatic and bactericidal antibiotics. The engaging PowerPoint and accompanying resources have been designed to cover point 6.13 of the Edexcel International A-level Biology specification but also makes continual links to earlier lessons in topic 6 as well as related topics from the previous year such as protein synthesis from topic 2 The lesson begins by challenging the students to use their knowledge of the previous topic 6 lessons to identify the suffixes cidal and static. Students will learn that when the prefix is added, these form the full names of two types of antibiotics. Their understanding of terminology is tested further as they have to recognise that Polymyxin B is an example of a bactericidal antibiotic as its actions would result in the death of the bacterial cell. Tetracycline is used as the example of a bacteriostatic antibiotic and students will discover that its prevention of the binding of tRNA that inhibits protein synthesis and this reduction and stopping of growth and reproduction is synonymous with these drugs. Students are challenged on their knowledge of translation and will also be given time for a class discussion to understand that these antibiotics encourage the body’s immune system to overcome the pathogen in natural, active immunity. The final part of the lesson uses a quick quiz competition and a series of exam-style questions to ensure that students can recognise the different antibiotics from descriptions.

This engaging and detailed lesson looks at the roles of the Link reaction and the Krebs cycle as the stages of aerobic respiration which occur in the mitochondrial matrix. Both the PowerPoint and the accompanying resource have been designed to cover point 7.5 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification. The lesson begins with a challenge, where the students have to recall the details of glycolysis in order to form the word matrix. This introduces the key point that these two stages occur in this part of the mitochondria and time is taken to explain why the reactions occur in the matrix as opposed to the cytoplasm like glycolysis. Moving forwards, the Link reaction is covered in 5 detailed bullet points and students have to add the key information to these points using their prior knowledge as well as knowledge provided in terms of NAD. The students will recognise that this reaction occurs twice per molecule of glucose and a quick quiz competition is used to test their understanding of the numbers of the different products of this stage. This is just one of the range of methods that are used to check understanding and all answers are explained to allow students to assess their progress. The rest of the lesson focuses on the Krebs cycle. In line with the detail of the specification, students will understand how decarboxylation and dehydrogenation reactions result in the regeneration of the 4C compound. It is estimated that it will take about 2 hours of A-level teaching time to cover the detail of the lesson and therefore the detail of the specification point 7.5

This is a detailed, engaging and fully-resourced REVISION LESSON which allows students of all abilities to assess their understanding of the content in topic 6 (Nucleic acids and protein synthesis) of the CIE International A-level Biology specification. Considerable time has been taken to design the lesson to include a wide range of activities to motivate the students whilst they evaluate their knowledge of DNA, RNA and the roles of these nucleic acids in DNA replication and protein synthesis. Most of the tasks have been differentiated so that students of differing abilities can access the work and move forward as a result of the tasks at hand. This lesson has been planned to cover as much of the specification as possible but the following sub-topics have received particular attention: The structure of DNA Phosphorylated nucleotides DNA replication Transcription and translation Gene mutations and their affect on the primary structure of a polypeptide The structure of RNA In addition to a focus on the current topic, links are made throughout the lesson to other topics such as the journey of an extracellular protein following translation and the cell cycle. If you like the quality of this revision lesson, please look at the other uploaded revision lessons for this specification

This fully-resourced lesson looks at the series of small steps that form the Krebs cycle and focuses on the reactions which involve decarboxylation and dehydrogenation and the reduction of NAD and FAD. The engaging PowerPoint and accompanying resource have both been designed to cover points 12.2 (d) and (e) of the CIE International A-level Biology specification. The lesson begins with a version of the Impossible game where students have to spot the connection between 8 of the 9 terms and will ultimately learn that this next stage is called the Krebs cycle. The main part of the lesson challenges the students to use descriptions of the main steps of the cycle to continue their diagram of the reactions. Students are continually exposed to key terminology such as decarboxylation and dehydrogenation and they will learn where carbon dioxide is lost and reduced NAD and FAD are generated. They will also recognise that ATP is synthesised by substrate level phosphorylation. The final task challenges them to apply their knowledge of the cycle to work out the numbers of the different products and to calculate the number of ATP that must be produced in the next stage This lesson has been designed to tie in with the other uploaded lessons on glycolysis, the Link reaction and oxidative phosphorylation.

This lesson has been designed to act as an introduction to the anatomy of the kidney before students move on to study each structure of the nephron in more detail. The lesson considers both the gross anatomy, in terms of the renal cortex and medulla and then looks at the functional unit of the nephron. The function of the different parts of the nephron are briefly discussed and the features that relate to function are considered. This lesson has been designed for A-level students but could be used with higher ability GCSE students.

A considerable amount of time has been taken to design this revision resource so that the included activities engage the students whilst containing sufficient detail to enable them to assess their understanding of the content in topic 9 (Transport in animals) of the CIE IGCSE Biology specification. This resource can be used with those students taking both the 0610 and 0970 specifications and will be examined in June and November 2020 and 2021. This topic contains a lot of key details about the workings of the human body and is therefore likely to be heavily involved in the make up of upcoming examinations. The range of activities include exam questions with answers explained, differentiated tasks and quiz competitions such as “FOUND in the PLASMA” where students have to be the 1st to name the substances that are carried in this liquid and also “Is this passage on the right PATH” where students have to analyse a passage about the pathway of blood to determine if it is 100% correct. The lesson has been written to cover as much content from both the Core and Supplement sections as possible but the following have received particular attention: The functions of the different components of blood The structure of arteries and veins and how this is related to their functions The risk factors and treatments for CHD The structure of the heart and its associated blood vessels The function of the valves found in the heart and veins The double circulatory system

This is an engaging revision lesson which uses a range of exam questions, understanding checks, quick tasks and quiz competitions to enable students to assess their understanding of the content within topic 1 (Characteristics and classification of living organisms) of the CIE IGCSE Biology specification, for examination in 2020 and 2021. The lesson covers the content in both the core and supplement sections of the specification and therefore can be used with students who will be taking the extended papers as well as the core papers. The specification points that are covered in this revision lesson include: CORE Describe the characteristics of living organisms by defining the terms movement, respiration, sensitivity, growth, reproduction, excretion and nutrition State that organisms can be classified into groups by the features that they share Define and describe the binomial system of naming species as an internationally agreed system in which the scientific name of an organism is made up of two parts showing the genus and species List the main features used to place animals and plants into the appropriate kingdoms SUPPLEMENT Explain that classification systems aim to reflect evolutionary relationships Explain that classification is traditionally based on studies of morphology and anatomy Explain that the sequences of bases in DNA and of amino acids in proteins are used as a more accurate means of classification Explain that organisms which share a more recent ancestor (are more closely related) have base sequences in DNA that are more similar than those that share only a distant ancestor List the main features used to place all organisms into one of the five kingdoms: Animal, Plant, Fungus, Prokaryote, Protoctist List the features of viruses, limited to protein coat and genetic material The students will thoroughly enjoy the range of activities, which include quiz competitions such as “Are you the KING of the KINGDOMS” where they have to name the kingdoms involved based on a feature whilst crucially being able to recognise the areas of this topic which need their further attention. This lesson can be used as revision resource at the end of the topic or in the lead up to mocks or the actual IGCSE exams

This revision resource has been designed to include a range of activities that will engage the students whilst they assess their understanding of the content of topic B8 (Gas exchange and respiration) of the CIE IGCSE Combined Science specification for examination in June and November 2020 and 2021. Exam questions, quick tasks and quiz competitions such as “The BIG REVEAL” will challenge the students on their recall of the content as well as their ability to apply this knowledge. The lesson was written to cover as much of the content as possible, but the following topics have received particular attention: The role of cilia, goblet cells and mucus in the trachea and bronchi The effects of the chemicals in tobacco smoke on gas exchange Efficient gas exchange at the alveoli The composition of inhaled and exhaled air Aerobic respiration as the chemical reaction that releases energy The uses of energy in the human body This resource contains an engaging PowerPoint (54 slides) and associated worksheets and is ideal for use at the end of this topic or in the lead up to mocks or the actual terminal exams

This detailed lesson explains how the process of transcription results in the production of mRNA. Both the detailed PowerPoint and accompanying question worksheet have been designed to cover the first part of points 2.5 (i) & (ii) of the Pearson Edexcel A-level Biology A specification The lesson begins by challenging the students to work out that most of the nuclear DNA in eukaryotes does not actually code for polypeptides. This allows the promoter region and terminator region to be introduced, along with the structural gene. Through the use of an engaging quiz competition, students will learn that the strand of DNA involved in transcription is known as the template (or anti-sense) strand and the other strand is the coding (or sense) strand. Links to previous lesson on the structure of DNA and RNA are made throughout and students are continuously challenged on their prior knowledge as well as their current understanding of the lesson topic. Moving forwards, the actual process of transcription is covered in a 7 step bullet point description where the students are asked to complete each passage using the information previously provided. An exam-style question is used to check on their understanding before the final task of the lesson looks at the journey of mRNA to the ribosome for the next stage of protein synthesis, translation.

This fully-resourced lesson guides students through the interpretation of genetic pedigree diagrams for the inheritance of a single gene. The clear PowerPoint and accompanying resources have been designed to cover point 2.13 (ii) of the Pearson Edexcel A-level Biology A specification and includes the inheritance of multiple allele characteristics as well as those that demonstrate codominance. In order to minimise the likelihood of errors and misconceptions, step by step guides have been included throughout the lesson to support the students with the following: Writing parent genotypes Working out the different gametes that are made following meiosis Interpreting Punnett crosses to work out phenotypic ratios Students can often find pedigree trees the most difficult to interpret and to explain so exemplar answers are used as well as differentiated worksheets provided to support those students who need extra assistance.

Water is very important for living organisms because of its numerous properties and this lesson focuses on its role as a solvent in transport. The engaging and detailed PowerPoint and accompanying worksheet have been designed to cover point 1.2 of the Pearson Edexcel A-level Biology A specification and also explains the importance of the dipole nature for this role in transport. A mathematical theme runs throughout the lesson as students have to match the numbers calculated in the starter task to water statistics, such as the percentage of the volume of blood plasma that is water. This has been included to try to increase the relevance of each property so that it can be described in a biological context. Time is taken at the beginning of the lesson to describe the structure of water in terms of the covalent bonds between the oxygen and hydrogen atoms as well as the hydrogen bonds which form between molecules because of its polarity. Students will understand how water is a solvent which means that it is critical for transport in animals, a topic covered in the next few lessons but also for transport in plants as discussed in topic 4. The high heat capacity and latent heat of vaporisation of water is also discussed and explained through the examples of thermoregulation and the maintenance of a stable environment for aquatic animals. The final part of the lesson focuses on the involvement of water in condensation and hydrolysis reactions, two reactions which must be well understood for topic 1 and 2 and the formation and breakage of polysaccharides, lipids, polypeptides and polynucleotides.

This detailed lesson uses haemoglobin and collagen as examples to describe the structure, properties and functions of globular and fibrous proteins. The engaging PowerPoint and accompanying worksheet have been designed to cover point 2.9 (iv) of the Pearson Edexcel A-level Biology A specification and focuses on the shape, solubility and function of these two types of protein. The first part of the lesson looks at the structure of haemoglobin, and describes how the presence of an iron-containing haem group on the outside of the 4 polypeptide chains explains its ability to form oxyhaemoglobin. Moving forwards, the importance of the solubility of this protein is considered and related to the direction that the hydrophobic R groups point. At this point of the lesson, the students are challenged to construct a comparison table which can be filled in as the lesson progresses and as they are given more details of collagen. The section of the lesson concerning collagen begins with the introduction of its function in the artery wall so that students can recognise how fibrous proteins have roles associated with mechanical strength. Time is taken to discuss their solubility as well as the presence of repetitive amino acid sequences. The remainder of the lesson considers four more proteins and the final task challenges the students to use their completed table to write a summary passage comparing globular and fibrous proteins.

This lesson describes how the expression of a gene mutation impairs the functioning of the organ systems in people with cystic fibrosis. The detailed PowerPoint and accompanying worksheets have primarily been designed to cover point 2.16 in AS unit 1 of the Edexcel International A-level Biology specification but also challenge the students on their knowledge of previously-covered topics such as inheritance, protein synthesis and the genetic code as well as making links to the upcoming topics of loci and post-transcriptional changes. The main focus of the lesson is the CFTR gene and the functions of the ion channel that is synthesised when this gene is expressed. As well as explaining that this channel allows chloride ions to flow across the apical membrane of the epithelial cells, time is taken to emphasise the importance of its inhibition on the ENaC, which prevents the flow of sodium ions back into the cells. A step by step guide is then used to describe the sequence of events that result in mucus which is motile and can be moved by the wafting action of the cilia in healthy individuals. This leads into the section of the lesson which considers the inheritance of cystic fibrosis in an autosomal recessive manner and then focuses on the change in the primary structure of the channel which results from one of over 1500 different gene mutations. Again, the students are guided through the events that lead to the depletion of the apical surface liquid and the cilia being unable to move the viscous mucus. Although the majority of the lesson is described with reference to the gaseous exchange system, the impaired functioning of the digestive system in terms of the blockage of the pancreas and liver secretions is considered and discussed and the students are challenged on their understanding through a range of exam-style questions. All of the questions included in the lesson have mark schemes which are embedded into the PowerPoint and this allows the students to assess their progress. Due to the detailed content of this lesson, it is estimated that it will take in excess of 3 hours of allocated A-level teaching time to cover

Disaccharides are formed from the condensation of two monosaccharides and this lesson describes the formation of maltose, sucrose and lactose. The concise PowerPoint and accompanying question sheet have been designed to cover the third part of points 1.12 & 1.13 of the Pearson Edexcel A-level Biology A specification but also continually links to the previous lesson on monosaccharides when considering the different components of these three disaccharides. The first section of the lesson focuses on a prefix and a suffix so that the students can recognise that the names of the common disaccharides end in -ose. In line with this, a quick quiz round is used to introduce maltose, sucrose and lactose before students are challenged on their prior knowledge as they have to describe how condensation reactions and the formation of glycosidic bonds were involved in the synthesis of each one. The main task of the lesson again challenges the students to recall details of a previous lesson as they have to identify the monomers of each disaccharide when presented with the displayed formula. Time is taken to show how their knowledge of these simple sugars will be important in later topics such as extracellular enzymes, translocation in the phloem and the control of gene expression as exemplified by the Lac Operon. The lesson finishes with two exam-style questions where students have to demonstrate and apply their newly acquired knowledge

This lesson describes the basic structure of mononucleotides and the resulting structural similarities and differences between DNA and RNA. The PowerPoint and accompanying resource have been designed to cover points 2.9 (i) and (ii) of the Edexcel International A-level Biology specification and makes regular links to upcoming lessons which cover DNA replication and protein synthesis. In a lesson in topic 1, the students were introduced to monosaccharides as an example of a monomer and were informed that a nucleotide was another example. In line with this, the start of the lesson challenges them to recognise the key term nucleotide when only the letters U, C and T are shown. The next part of the lesson describes the structure of a DNA nucleotide and an RNA nucleotide so that the pentose sugar and the bases adenine, cytosine and guanine can be recognised as similarities whilst deoxyribose and ribose and thymine and uracil are seen as the differences. Time is taken to discuss how a phosphodiester bond is formed between adjacent nucleotides and their prior knowledge and understanding of condensation reactions is tested through a series of questions. Students are then introduced to the purine and pyrimidine bases and this leads into the description of the double-helical structure of DNA and the hydrogen bonds between complementary bases. The final section of the lesson describes the structure of mRNA, tRNA and rRNA and students are challenged to explain why this single stranded polynucleotide is shorter than DNA In addition to the current understanding and prior knowledge checks, a number of quiz rounds have been written into the lesson to introduce key terms in a fun and memorable way and the final round acts as a final check on the structures of DNA and RNA.

This lesson explains the meaning of gene, allele, genotype, phenotype, recessive, dominant, codominance, homozygote and heterozygote. The engaging PowerPoint and accompanying resources have been designed to cover specification point 2.15 (i) of the Edexcel International A-level Biology but also covers the meaning of genome, gene locus, homologous chromosomes, multiple alleles, autosomes and sex chromosomes as a recognition of these will be useful for upcoming lessons. As some of these terms were met at GCSE, this fully-resourced lesson has been designed to include a wide range of activities that build on this prior knowledge and provide clear explanations as to their meanings as well as numerous examples of their use in both questions and exemplary answers. The main task provides the students with an opportunity to apply their understanding by recognising a dominance hierarchy in a multiple alleles characteristic and then calculating a phenotypic ratio when given a completed genetic diagram. Other tasks include prior knowledge checks, discussion points to encourage students to consider the implementation of the genetic terms and quiz competitions to introduce new terms, maintain engagement and to act as an understanding check.