This fully-resourced lesson describes the process of skeletal muscle contraction in terms of the sliding filament theory. The engaging and detailed PowerPoint and accompanying resources have been designed to cover point 7.2 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification and includes the role of actin, myosin, troponin, tropomyosin, calcium ions and ATP. The lesson begins with a study of the structure of the thick and thin filaments. Students will recognise that the protruding heads of the myosin molecule are mobile and this enables this protein to bind to the binding sites when they are exposed on actin. This leads into the introduction of troponin and tropomyosin and key details about the binding of calcium to this complex is explained. Moving forwards, students are encouraged to discuss possible reasons that can explain how the sarcomere narrows during contraction when the filaments remain the same length. This main part of the lesson goes through the main steps of the sliding filament model of muscle contraction and the critical roles of the calcium ions and ATP are discussed. The final task of the lesson challenges the students to apply their knowledge by describing the immediate effect on muscle contraction when one of the elements doesn’t function correctly. This lesson has been written to tie in with another uploaded lesson on the structure of a muscle fibre which is covered in specification point 7.10

This fully-resourced lesson looks at the blood circulation in a mammal and considers how the pulmonary circulation differs from the systemic circulation. The engaging PowerPoint and accompanying resources have been designed to cover the third part of point 3.4.1 of the AQA A-level Biology specification The lesson begins with a focus on the double circulatory system and checks that students are clear in the understanding that the blood passes through the heart twice per cycle of the body. Beginning with the pulmonary circulation, students will recall that the pulmonary artery carries the blood from the right ventricle to the lungs. An opportunity is taken at this point to check on their knowledge of inhalation and the respiratory system as well as the gas exchange between the alveoli and the capillary bed. A quick quiz is used to introduce arterioles and students will learn that these blood vessels play a crucial role in the changes in blood pressure that prevent the capillaries from damage. When looking at the systemic circulation, time is taken to look at the coronary arteries and renal artery as students have to be aware of these vessels in addition to the ones associated with the heart. In the final part of the lesson, students are challenged to explain how the structure of the heart generates a higher pressure in the systemic circulation and then to explain why the differing pressures are necessary. This lesson has been written to tie in with the other uploaded lessons from topic 3.4.1 (mass transport in animals)

This fully-resourced lesson describes how the structure of the xylem tissue allows water to be transported in the stem and leaves. Written for AQA A-level Biology, the engaging and detailed PowerPoint and the accompanying worksheets cover the 1st part of specification point 3.4.2 (mass transport in plants) and includes a detailed description of the cohesion-tension theory. The first part of the lesson focuses on the relationship between the structure and function of the xylem tissue. A number of quiz competitions have been included in the lesson to maintain engagement and to introduce key terms. The 1st round does just that and results in the introduction of lignin which leads into the explanation of how the impregnation of this substance in the cell walls result in the death and subsequent decay of the cell structures. Students are encouraged to discuss how the formation of this hollow tube enables the transport of water to be effective. Moving forwards, other structures such as the bordered pits are introduced and an understanding of their function is tested later in the lesson. The remainder of the lesson focuses on the transport of water in the stem and leaves by root pressure and the transpiration pull, which includes cohesion, tension and adhesion. The lesson has been designed to make links to information covered earlier in the lesson as well to topics from earlier in the specification such as cell structures and biological molecules Due to the extensiveness of this lesson, it is estimated that it will take in excess of 2/3 A-level teaching hours to cover the detail included in this lesson.

This fully-resourced lesson explains how individuals develop immunity and includes a focus on the different types (active, passive, natural, artificial). The engaging PowerPoint and accompanying resources have been designed to cover point 6.12 of the Pearson Edexcel A-level Biology A specification and there is also a description and discussion of herd immunity to increase the relevance to the current epidemic with COVID-19. The lesson begins with a series of exam-style questions which challenge the students to demonstrate and apply their understanding of the immune response as covered in the previous lessons on topics 6.8 & 6.9. In answering and assessing their answers to these questions, the students will recognise the differences between the primary and secondary immune responses and are then encouraged to discuss how the production of a larger concentration of antibodies in a quicker time is achieved. The importance of antibodies and the production of memory cells for the development of immunity is emphasised and this will be continually referenced as the lesson progresses. The students will learn that this response of the body to a pathogen that has entered the body through natural processes is natural active immunity. Moving forwards, time is taken to look at vaccinations as an example of artificial active immunity. Another series of questions focusing on the MMR vaccine will challenge the students to explain how the deliberate exposure to antigenic material activates the immune response and leads to the retention of memory cells. A quick quiz competition is used to introduce the variety of forms that the antigenic material can take along with examples of diseases that are vaccinated against using these methods. The eradication of smallpox is used to describe the concept of herd immunity and the students are given time to consider the scientific questions and concerns that arise when the use of this pathway is a possible option for a government. The remainder of the lesson looks at the different forms of passive immunity and describes the drawbacks in terms of the need for a full response if a pathogen is reencoutered.

This fully-resourced lesson describes the behaviour of chromosomes during interphase, mitosis and cytokinesis in the cell cycle. The detailed PowerPoint and accompanying resources have been designed to cover the first half of point 2.2 as detailed in the AQA A-level Biology specification whereas uncontrolled cell division and cancer and binary fission are covered in upcoming lessons. Depending upon the exam board taken at GCSE, the knowledge and understanding of mitosis and the cell cycle will differ considerably between students and there may be a number of misconceptions. This was considered at all points during the planning of the lesson and to address existing errors, key points are emphasised throughout. The cell cycle is introduced at the start of the lesson and the quantity of DNA inside the parent cell is described as diploid and as 2n. A quiz competition has been written into the lesson and this runs throughout, challenging the students to identify the quantity of DNA in the cell (in terms of n) at different points of the cycle. Moving forwards, the first real focus is interphase and the importance of DNA replication is explained so that students can initially recognise that there are pairs of identical sister chromatids and then can understand how they are separated later in the cycle. The main part of the lesson focuses on prophase, metaphase, anaphase and telophase and describes how the chromosomes behave in these stages. Centrioles were not covered in the topic 2.1 lessons on cell structures so a quick task will introduce them to these organelles who are responsible for the production of the spindle apparatus, Students will understand how the cytoplasmic division that occurs in cytokinesis results in the production of genetically identical daughter cells. This leads into a series of understanding and application questions where students have to identify the various roles of mitosis in living organisms as well as tackling a Maths in a Biology context question. The lesson concludes with a final round of MITOSIS SNAP where they only shout out this word when a match is seen between the name of a phase, an event and a picture.

This engaging and fully-resourced lesson looks at how genetic drift can arise after a genetic bottleneck or as a result of the Founder effect. The detailed PowerPoint and accompanying resources have been designed to cover the fourth part of point 7.3 of the AQA A-level Biology specification which states that students should be able to explain the importance of genetic drift in causing changes in allele frequency in small populations A wide range of examples are used to show the students how a population that descends from a small number of parents will have a reduction in genetic variation and a change in the frequency of existing alleles. Students are encouraged to discuss new information to consider key points and understanding checks in a range of forms are used to enable them to check their progress and address any misconceptions. Students are provided with three articles on Huntington’s disease in South Africa, the Caribbean lizards and the plains bison to understand how either a sharp reduction in numbers of a new population beginning from a handful of individuals results in a small gene pool. Links to related topics are made throughout the lesson to ensure that a deep understanding is gained.

This fully-resourced lesson looks at the coordination and control of heart rate by the cardiovascular centre in the medulla oblongata. The engaging and detailed PowerPoint and accompanying resources have been designed to cover the second part of point 6.1.3 of the AQA A-level Biology specification which states that students should know the roles and locations of the sensory receptors and the roles of the autonomic nervous system and effectors in the control of heart rate. This lesson begins with a prior knowledge check where students have to identify and correct any errors in a passage about the conduction system of the heart. This allows the SAN to be recalled as this structure play an important role as the effector in this control system. Moving forwards, the three key parts of a control system are recalled as the next part of the lesson will specifically look at the range of sensory receptors, the coordination centre and the effector. Students are introduced to chemoreceptors and baroreceptors and time is taken to ensure that the understanding of the stimuli detected by these receptors is complete and that they recognise the result is the conduction of an impulse along a neurone to the brain. A quick quiz is used to introduce the medulla oblongata as the location of the cardiovascular centre. The communication between this centre and the SAN through the autonomic nervous system can be poorly understood so detailed explanations are provided and the sympathetic and parasympathetic divisions compared. The final task challenges the students to demonstrate and apply their understanding by writing a detailed description of the control and this task has been differentiated three ways to allow differing abilities to access the work This lesson has been written to tie in with the previous lesson on the conducting system of the heart which is also detailed in specification point 6.1.3

This detailed lesson describes the principles of DNA sequencing and has been designed to cover the first part of point 6.1.3 (a) of the OCR A-level Biology A specification. Fred Sanger’s chain termination method is used as the example to guide the students through the details of each step. The lesson begins with a focus on the common ingredients of the process such as DNA polymerase, DNA nucleotides and primers. Links are made to module 2.1.3 where nucleic acids were initially met through a series of prior knowledge check questions. Time is then taken to explain why these short lengths of synthesised nucleotides are necessary and this will support students when primers are met in the PCR and genetic engineering. Moving forwards, students will recognise how the modification to the nucleotide means that the chain terminates once a modified nucleotide is added into the sequence and that these have been radioactively labelled. Gel electrophoresis is introduced and an outline of the process given to provide knowledge to build on when this is encountered later in the module. A series of exam-style questions allow students to assess their understanding of this potentially difficult topic before students are encouraged to consider the limitations of the method so they are prepared to meet the new methods in upcoming lessons. A number of quiz competitions run throughout the lesson to maintain engagement and to introduce terms and values in a memorable way

This engaging lesson presentation (58 slides) and associated worksheets uses exam questions with displayed mark schemes, quick tasks and quiz competitions to enable students to assess their understanding of the topics found within module B4 of the OCR Gateway A GCSE Biology specification. The topics which are specifically tested within the lesson include: Ecosystems, Competition and interdependence, Pyramids of biomass, Efficiency of biomass transfer, The carbon cycle and Decomposers Students will enjoy the competitions such as "Number CRAZY" and "Take the HOTSEAT" whilst crucially being able to recognise those areas which need their further attention

An engaging lesson presentation (64 slides) and associated worksheets that uses a combination of exam questions, quick tasks and quiz competitions to help the students to assess their understanding of the topics found within unit B1 (Cell Biology) of the AQA GCSE Combined Science specification (specification point 4.1). The topics that are tested within the lesson include: Eukaryotes and prokaryotes Animal and plant cells Microscopy Chromosomes The cell cycle including mitosis Stem cells Diffusion Osmosis Active transport Students will be engaged through the numerous activities including quiz rounds like “SPOT the CELL” and “Take the Hotseat” whilst crucially being able to recognise those areas which need further attention

An engaging lesson presentation (60 slides) and associated worksheets that uses a combination of exam questions, quick tasks and quiz competitions to help the students to assess their understanding of the topics found within unit B2 (Organisation) of the AQA GCSE Combined Science specification (specification point 4.2) The topics that are tested within the lesson include: Principles of organisation The human digestive system The heart and blood vessels Blood Coronary heart disease The effect of lifestyle on some non-communicable diseases Plant organ systems Students will be engaged through the numerous activities including quiz rounds like “SPOT the SUBSTANCE" and “Where’s LENNY” whilst crucially being able to recognise those areas which need further attention

An engaging lesson presentation (54 slides) and associated worksheets that uses a combination of exam questions, quick tasks and quiz competitions to help the students to assess their understanding of the topics found within the Chemistry unit C7 (Organic chemistry) of the AQA GCSE Combined Science specification (specification point C5.7) The topics that are tested within the lesson include: Crude oil, hydrocarbons and alkanes Fractional distillation and petrochemicals Properties of hydrocarbons Cracking and alkenes Students will be engaged through the numerous activities including quiz rounds like “What FRACTION of this is correct” and “Are you on FORM” whilst crucially being able to recognise those areas which need further attention

This is a fully-resourced revision lesson that uses a combination of exam questions, understanding checks, quick differentiated tasks and quiz competitions to enable students to assess their understanding of the content found within Topic 5 (On the wild side) of the Pearson Edexcel A-level Biology A specification. The sub-topics and specification points that are tested within the lesson include: Be able to describe how to carry out a study on the ecology of a habitat Understand the stages of succession Understand the overall reaction of photosynthesis Understand the structure of chloroplasts in relation to their role in photosynthesis Understand the relationship between NPP, GPP and respiration Understand the effect of temperature on enzyme activity and its impact on plants and animals and microorganisms Know how the temperature coefficient Q10 quantifies the rate of an enzyme-catalysed reaction Understand how knowledge of the carbon cycle can be applied to methods to reduce atmopsheric levels of carbon dioxide A number of the tasks have been differentiated to allow all abilities of student to access the work and there is a big emphasis on the mathematical skills that can be tested in this topic. Students will be engaged through the numerous quiz rounds such as “Can you DEPEND on your knowledge” and “From NUMBERS 2 LETTERS” whilst crucially being able to recognise those areas which require their further attention during general revision or during the lead up to the actual A-level terminal exams

This lesson has been written to cover the part of specification point 6.4.3 of the AQA A-level Biology specification which states that students should be able to describe how water and glucose are reabsorbed in the proximal convoluted tubule. It has specifically been designed to build on the knowledge gained in the previous lessons on the structure of the nephron and ultrafiltration. The lesson begins by challenging the students to recall the substances that are found in the glomerular filtrate so that each of them can be considered over the course of the rest of the lesson. Moving forwards, the first of the numerous discussion points which are included in the lesson is used to get students to predict the component of the filtrate which won’t be found in the urine when they are presented with pie charts from each of these situations. Upon learning that glucose is 100% reabsorbed, along with most of the ions and some of the water, the rest of the lesson focuses on describing the relationship between the structure of the PCT and the function of selective reabsorption. Again, this section begins by encouraging the students to discuss and to predict which structures they would expect to find in a section of the kidney if the function is to reabsorb. They are given the chance to see the structure (as shown in the cover image) before each feature is broken down to explain its importance. Time is taken to look at the role of the cotransporter proteins to explain how this allows glucose, along with sodium ions, to be reabsorbed from the lumen of the PCT into the epithelial cells. The final part of the lesson focuses on urea and how the concentration of this substance increases along the tubule as a result of the reabsorption of some of the water. This lesson has been designed for students studying on the AQA-A level Biology course and ties in nicely with the other lessons from 6.4.3 as well as the other uploaded lessons from topic 6

This lesson guides students through the use of the chi-squared test to determine the significance of the difference between observed and expected results. It is fully-resourced with a detailed PowerPoint and differentiated task worksheets that have been designed to cover the part of point 7.1 of the AQA A-level Biology specification which states that students should be able to use the test to compare the goodness of fit between the observed phenotypic ratios and expected ratios. The lesson has been written to include a step-by-step guide that demonstrates how to carry out the test in small sections. At each step, time is taken to explain any parts which could cause confusion and helpful hints are provided to increase the likelihood of success in exam questions on this topic. Students will understand how to use the phenotypic ratio to calculate the expected numbers and then how to find the critical value in order to compare it against the chi-squared value. A worked example is used to show the working which will be required to access the marks and then the main task challenges the students to apply their knowledge to a series of questions of increasing difficulty. This is the final lesson of topic 7.1 (inheritance) and links are made throughout the lesson to earlier parts of this topic such as dihybrid inheritance as well as to earlier topics such as meiosis.